02/9/2021 News Brief introduction of 105-83-9

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 105-83-9 is helpful to your research. Reference of 105-83-9

Reference of 105-83-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.105-83-9, Name is N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine, molecular formula is C7H19N3. In a Article,once mentioned of 105-83-9

In the series of 1-pyrenylmethylamines studied in this work the relationships among structure, interaction with DNA, and murine antitumor activity were examined.Binding studies show that all of these 1-pyrenylmethylamine derivatives bind to some extent to DNA by intercalation.The presence of additional basic amine groups in the side chain enhances DNA binding due to electrostatic interactions.Those compounds containing only a single basic benzylic amine bind similarly to DNA.Only the presence of bulky side chains appears to decrease the DNA interactions in the compounds examined.Although antitumor activity is seen for (1-pyrenylmethyl)amino alcohols, useful antitumor activity in the series is limited to those congeners bearing the 2-amino-1,3-propanediol-type side chain.These derivatives bind moderately to DNA.DNA binding is a necessary but not sufficient criterion for antitumor activity in the series.In addition, the strength of DNA binding does not correlate with the antitumor activity in the group of active compounds.Three related 2-<(arylmethyl)amino>-1,3-propanediol derivatives (AMAPs) are currently in clinical trials as potential antitumor agents.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 105-83-9 is helpful to your research. Reference of 105-83-9

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI