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Tacrine-based AChE and BuChE inhibitors were designed by investigating the topology of the active site gorge of the two enzymes. The homobivalent ligands characterized by a nitrogen-bridged atom at the tether level could be considered among the most potent and selective cholinesterase inhibitors described to date. The nitrogen-containing homobivalent ligands 3e,g and the sulfur-containing 3h validated the hypothesis of extra sites of interaction in the AChE and BuChE active site gorges.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Recommanded Product: N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 105-83-9
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI