Month: August 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112881-51-3,4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine,as a common compound, the synthetic route is as follows.

General procedure: Ru(1)Cl3 (0.10 g, 0.17 mmol) and ligand 3 (0.05 g, 0.17 mmol) was suspended in ethane-1,2-diol (8 cm3). The suspension heated at 150 C for 2 h. The deep red solution was poured into excess aqueous KPF6 (20 mL). A red precipitate formed and was collected on Celite, washed with H2O (5 mL), EtOH (2 mL), Et2O (5 mL), and dissolved in CH3CN. The product was purified by chromatography (SiO2, CH3CN:H2O:saturated aqueous KNO3 14:1.2:0.5). Addition of excess aqueous saturated KPF6 solution and removal of CH3CN under reduced pressure gave a red precipitate which was collected on Celite, washed with H2O (5 mL), EtOH (2 mL), Et2O (5 mL) and dissolved in CH3CN. Removal of solvent gave [Ru(1)(3)](PF6)2 as a red solid (74 mg, 68 mumol, 40%).

112881-51-3, 112881-51-3 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine 11438308, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Article; Shen, Chao; Wang, Pi; Beves, Jonathon E.; Polyhedron; vol. 103; (2016); p. 241 – 247;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

100125-12-0, 3,8-Dibromo-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The compound TP was prepared by a palladium-catalyzed cross-coupling reaction from 3-bromo-1,10- phenanthroline. First, 3-bromo-1,10-phenanthroline (2.6 g, 10 m ml) in methylbenzene (80 m ml) was stirred in N2 atmosphere. Second, Na2CO3 solution (10 ml, 20 m mol), the mixtures of thiophen-3-yl-3-boronic acid (1.54 g, 12 m mol), methylbenzene (50 m ml) and ethanol (5 ml) were carefully added in turn. Then, the new suspension was left to react for 12 h at 80 C by constant refluxing. The reaction mixture was rotating-evaporated, and was then purified by dissolving with CH2Cl2, water washing, drying with Na2SO4, filtration, concentration and column chromatography (silica gel, CHCl3). Finally, the white solid product (yield, 85%) was obtained after drying in vacuo.

100125-12-0, 100125-12-0 3,8-Dibromo-1,10-phenanthroline 10991348, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Article; Zhang, Peng; Liu, Pei; Zhao, Yong; Cao, Dongliang; Journal of Molecular Structure; vol. 1037; (2013); p. 122 – 129;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

148332-36-9, [2,2′:6′,2”-Terpyridine]-4′-carboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1.0 mmol of CuSO4 and 0.5 mmol of 2,2 ‘:6′,2″-terpyridine-4’-carboxylic acid were mixed, and placed in a stainless steel-lined stainless steel reactor. 20 mL of deionized water and 10 mL of absolute ethanol were added, mixed evenly, sealed, and hydrothermal reaction was carried out at 120-180 ¡ã C for 3 ~ 5 days under high temperature and high pressure environment to increase the reaction. The oxidation-reduction potential of the material changes significantly to improve the reaction rate. After completion of the hydrothermal reaction, the stainless steel reactor was cooled to room temperature by 5 ¡ã C per hour to obtain a blue block of 2,2 ‘: 6’, 2 ‘tripyridine-4’-carboxylic acid copper sulfate crystals. The resulting crystals were ground to 100 mesh sieve, to obtain terpyridine-4 ‘-carboxylic acid copper hydrogensulfate monoclinic blue powder having purity of not less than 99percent., 148332-36-9

The synthetic route of 148332-36-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ningbo University; Lin, Danfeng; Xu, Wei; Zhang, Beibei; Qi, Jinli; Lin, Jianli; Zhu, Honglin; Zheng, Yueqing; (7 pag.)CN103450228; (2016); B;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7173-51-5, N-Decyl-N,N-dimethyldecan-1-aminium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7173-51-5

Equimolar amounts of mandelic acid, or (R)-(-)-mandelic acid or (S)-(+)-mandelic acid or L-proline and potassium hydroxide (scale 0.1 mol) were dissolved in distilled water (100 mL). After clarity of solution equimolar amount of quaternary ammonium chloride in distilled water (80 mL) was added. The mixture was heated at 60 C for 5 h. The water was removed under reduced pressure (70 C, 30¡Á102 Pa). Anhydrous methanol was added and the mixture was allowed to stand overnight at room temperature. The crystalline potassium chloride was removed by filtration and methanol by distillation. The obtained residue was dried overnight in vacuum at 80 C.

The synthetic route of 7173-51-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cybulski, Jacek; Wi?niewska, Anna; Kulig-Adamiak, Anna; Da?browski, Zbigniew; Praczyk, Tadeusz; Michalczyk, Alicja; Walkiewicz, Filip; Materna, Katarzyna; Pernak, Juliusz; Tetrahedron Letters; vol. 52; 12; (2011); p. 1325 – 1328;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

168646-54-6, 5,6-Diamino-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5,6-Diamino-1,10-phenanthroline was synthesized according to the literature [40]. 5,6-diamino-1,10-phenanthroline (1.20 mmol, 0.25 g) and furoin (1.20 mmol, 0.23 g) were dissolved in 20.0 mL of dimethyl formamide. The mixture was refluxed for 2 days under the atmosphere of nitrogen. dpq-df was collected via filtration and recrystallization by DMF. Yield: 0.25 g, 57percent. 1H NMR [(CD3)2SO]: delta 9.43 (2H, d, J = 8.3 Hz), 9.25 (2H, d, J = 4.8 Hz), 7.98 (4H, m, J = 18.3 Hz), 7.11 (2H, d, J = 3.2 Hz), 6.82 (2H, d, J = 4.7 Hz). Anal. data for C22N4H12O2: calc. (percent): C, 72.52; H, 3.32; N, 15.38. found (percent): C, 72.56; H, 3.31; N, 15.43.

168646-54-6, The synthetic route of 168646-54-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lu, Xiao-Hui; Shi, Shuo; Yao, Jun-Liang; Gao, Xing; Huang, Hai-Liang; Yao, Tian-Ming; Journal of Inorganic Biochemistry; vol. 140; (2014); p. 64 – 71;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (2S,5 ?)-7-oxo-6-(sulfooxy)- l,6- diazabicyclo[3.2.1]octane-2-carbohydrazide (3.6 g, 12.8 mmol, prepared as per the reference WO2013030733) in dimethylformamide (18 ml) was added N,N-diisopropylethylamine (6.7 ml) under stirring at 25-30C. The lithium salt of [4-(tertiary-butyl-dimethyl-silanyloxy methyl)-2H- l,2,3-triazol-2-yl]acetic acid (3.5 g, 12.8 mmol , product from preparation 37) was added as solid under stirring followed by EDC.HCl (3.7 g, 19.3 mmol) and HOBT (1.95 g, 12.7 mmol) at 25-30 C. The progress of reaction was monitored by TLC (chloroform: methanol, 9: 1). After complete consumption of starting material a solution of tetrabutyl ammonium acetate (5.8 g, 19.2 mmol) in water (20 ml) was added and stirred for 1 hour. Dimethylformamide was distilled out completely and co-evaporated with xylene (2×25 ml). The concentrated mass thus obtained was poured on to water (36 ml) containing N-methyl morpholine (1 ml) under stirring and extracted with DCM (2×40 ml). The organic extracts were combined and washed with water (1×25 ml), dried over anhydrous sodium sulfate. The volatiles were removed under reduced pressure to get 4.5 g of crude compound which was further purified by column chromatography (100-200 mesh size silica gel) using dichloromethane: methanol as an eluent. Pure fractions were collected and concentrated to yield 1.8 g of tetrabutylammonium salt of (2S,5R)-N’-{ [4-(tertiary-butyl-dimethyl- silanyloxymethyl)-2H- l,2,3-triazol-2-yl]acetyl}-7-oxo-6-(sulfooxy)- l,6-diazabicyclo[3.2.1]octane- 2-carbohydrazide in 14% yield. Analysis: Mass: 534.4 (M- l) as free acid; for Molecular weight: 774 and Molecular formula: C34H66N808SSi.

10534-59-5, 10534-59-5 Tetrabutylammonium acetate 82707, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Patent; WOCKHARDT LIMITED; TADIPARTHI, Ravikumar; PATIL, Vijaykumar Jagdishwar; DEKHANE, Deepak; SHAIKH, Mohammad Usman; BIRAJDAR, Satish; DOND, Bharat; PATEL, Mahesh Vithalbhai; (100 pag.)WO2017/81615; (2017); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

3779-42-8, 3-Bromo-N,N,N-trimethylpropan-1-aminium bromide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[K2CO3] (0.8 g, 0.33 [MMOL)] was partly dissolved in dry DMF (4 mi) and compound 3c (0.1 [G,] 0.33 [MMOL)] and [(3-BROMPROPYL)] [TRIMETHYLAMMONIUMBROMIDE] (0.09 g, 0.33 [MMOL)] were added respectively. The mixture was heated to [80C] and the reaction was completed after 3.5 h according to TLC in ethyl acetate. The product was precipitated in ethyl acetate (20 ml) filtrated and washed with [ACETONE. 1H-NMR] : 2.35 (m, 2H), 3.05 (s, 6H), 3.25 (s, 9H), 3.55 (t, 2H), 4.30 (t, 2H), 6.25 (s, [1H),] 6.75 (s, [1H),] 6.85 (d, 1H), 7.30 (d, 1H), 7.65 (d, [1H),] 8.00 (s, [1H),] 8.10 (d, 1H).

3779-42-8, The synthetic route of 3779-42-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHALMERS TECHNOLOGY LICENSING AB; WO2003/104210; (2003); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

119-91-5, 2,2′-Biquinoline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A Zn(NO3)2*6H2O dissolution (10.3 mg, 0.0346 mmol/2 ml ethanol:water 1:1) was added to another dissolution of thiosaccharine (12.3 mg, 0.062 mmol/2 ml ethanol:water 1:1). Finally, solid 2,2′-biquinoline was added (9.4 mg, 0.0367 mmol/2 ml ethanol:water1:1). A pale yellow powder was then obtained. Yield: 90%. Molar conductivity (mS M1) = 26.3. Analytical percent composition calculated for C32H20N4O4S4Zn: C = 53.520%; H = 2.807%; N = 7.801%. Found: C = 53.884%; H = 2.761%; N = 7.698%. Soluble in DMSO and DMF. Almost insoluble in water, ethanol, methanol, acetone, dichloromethane and chloroform. [DMSO, kmaxnm]: 339 1H NMR (300 MHz, DMSO) d 8.80 (dd, 1H), 8.58 (dd, 1H), 8.19(dd, 1H), 8.08 (dd, 1H), 7.89-7.95 (m, 1H), 7.85 (td, 1H), 7.53-7.73 (m, 4H). 13C NMR (75 MHz, DMSO) d 191.54 (C1), 155.21(C16), 147.16 (C8), 137.80 (C7), 137.36 (C14), 136.32 (C2), 132.16 (C4), 130.99 (C5), 130.18 (C10), 129.31 (C12), 128.16 (C13), 128.03(C11), 127.42 (C9), 125.10 (C3), 119.05 (C6), 118.87 (C15)., 119-91-5

The synthetic route of 119-91-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Delgado, Fermin; Freire, Eleonora; Baggio, Ricardo; Gonzalez Pardo, Veronica; Dorn, Viviana; Dennehy, Mariana; Inorganica Chimica Acta; vol. 479; (2018); p. 266 – 274;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

29841-69-8, (1S,2S)-(-)-1,2-Diphenylethylenediamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound3 (0.97g, 3 . 60mmol) dissolved in dichloromethane (10 ml), 0 C stirring, add triethylamine (0.81 ml, 5 . 85mmol) and ethyl chloroformate (0.36 ml, 3 . 82mmol), maintaining 0 C stirring 30 min, then adding (1S, 2S)-bisphenylmethyl ethylenediamin (0.47g, 2 . 25mmol), 40 C reaction 24h. After the reaction, solution concentration, column chromatography (methanol/dichloromethane = 1/45, volume ratio), vacuum drying to obtain white solid4a (1.03g, 80%).

29841-69-8, The synthetic route of 29841-69-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hubei University; Lu, Cuifen; Ren, Jun; Chen, Zuxing; Yang, Guichun; Nie, Junqi; Zhou, Yuan; (11 pag.)CN105330687; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10534-59-5,Tetrabutylammonium acetate,as a common compound, the synthetic route is as follows.

To a 3-litre three necked round bottomed flask flushed with dry nitrogen the O- benzyl-chlorolactol methyl acetal (30g) was charged into dry N-methyl pyrollidinone (756mis). Anhydrous tetrabutylammonium acetate (102.57g) was also charged to the solution. The reaction mixture was then heated at 100C for 24 hours. The reaction mixture was sampled at routine intervals and directly analysed by tlc and gc/ms. The black solution was then diluted with water (150mis) and extracted with ethyl acetate (3 x 1500mis). The combined upper organic layer was then washed with water (3 x 1500mls). The aqueous portion showed no product content at this point. The layers were then separated, dried, (Na2SO4) and the solvent removed in vacuo to yield a black flowing oil (31g, 95%) containing a mixture of anomers.’H nmr CDCI31. 4-1.8 (m 4H), 2.0- 2.1 (duplicate s, 3H), 3.4 & 3.5 (s 3H), 3.8 (m 1H), 4.0 (m 1H), 4.1 (m 2H), 4.5 (m, 2H), 4.7-4. 9 (m 1H), 7.2-7. 3 (m, 5H) ; 13C nmr CDCI3 20.8 ; 30-35; 55&56; 57&64; 66&68; 69&72; 70&71; 98&99; 127-128 & 138; 170.5 ; m/z 293,262, 221,203, 156,91 and 43.

10534-59-5, 10534-59-5 Tetrabutylammonium acetate 82707, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Patent; AVECIA PHARMACEUTICALS LIMITED; WO2005/92867; (2005); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI