Day: August 17, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56100-20-0,5-Methyl-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of dry diisopropylamine (1.70 mL, 12.0 mmol, 2.40 equiv) and dry THF (12 mL) was10 added dropwise n-butyllithium (1.63 M n-hexane solution, 6.13 mL, 10.0 mmol, 2.00 equiv) at -78 oC under a nitrogen atmosphere. The solution was stirred for 30 min at 0 oC and 5-methyl-2,2-bipyridine(9) (855 mg, 5.02 mmol, 1.00 equiv) in dry THF (50 mL) was added at -78 oC. The temperature wasallowed to raise gradually over 4 h to -40 oC. The solution was recooled to -78oC and 1,10-dibromodecane (7.50 g, 25.0 mmol, 5.00 equiv) in dry THF (25 mL) was added. The solution was allowed to warm up to room temperature and stirred overnight. After the addition of water, THF wasevaporated under reduced pressure. Sodium hydrogen carbonate solution was added and the mixturewas extracted with dichloromethane. The extract was washed with brine and dried over sodium sulfate.After filtration, the solvent was removed under reduced pressure. The crude product was purified bycolumn chromatography on basic aluminum oxide (toluene) to give 10a as a white powder (1.10 g,20 56%). Analytically pure sample was obtained by recrystallization from hexane.

As the paragraph descriping shows that 56100-20-0 is playing an increasingly important role.

Reference£º
Article; Kozaki, Masatoshi; Ninomiya, Yoshikazu; Suzuki, Shuichi; Okada, Keiji; Tetrahedron Letters; vol. 54; 28; (2013); p. 3658 – 3661;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1067-33-0, Dibutyltin diacetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 11; 289 g of di-n-butyl tin diacetate and 1024 g of bis(2-ethylbutyl) carbonate were placed in a 2 L volumetric eggplant-shaped flask in a nitrogen atmosphere at atmospheric pressure, and the flask was attached to a rotary evaporator to which was connected an oil bath equipped with a temperature controller, a vacuum pump and a vacuum controller. The purge valve outlet of the rotary evaporator was connected to a line containing nitrogen gas flowing at atmospheric pressure. After replacing the inside of the system with nitrogen, the temperature of the oil bath was set to 280 C., the flask was immersed in the oil bath and rotation of the rotary evaporator was started. A low boiling point component was distilled off for about 7 hours in the presence of nitrogen at atmospheric pressure with the purge valve of the rotary evaporator left open, after which the pressure in the system was gradually reduced, and residual low boiling point component was distilled off with the pressure inside the system at 76 to 10 kPa. When the low boiling point component fraction no longer appeared, the flask was removed from the oil bath and allowed to cool. 365 g of residual liquid were obtained in the flask. Based on the results of 1H-, 13C- and 119Sn-NMR analyses, the residual liquid in the flask was a solution containing 79.7% by weight of di-n-butyl-bis(2-ethylbutyloxy) tin and 7.6% by weight of tri-n-butyl-(2-ethylbutyloxy) tin.On the other hand, 888 g of low boiling point component were recovered. When analyzed by gas chromatography, the low boiling point component contained about 25.2% by weight of (2-ethylbutyl)acetate.

1067-33-0 Dibutyltin diacetate 16682740, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Patent; Shinohata, Masaaki; Miyake, Nobuhisa; US2010/292496; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109073-77-0,[2,2′-Bipyridine]-4,4′-diyldimethanol,as a common compound, the synthetic route is as follows.

To a solution of [{Ir(mu-Cl)(ptpy)2}2] (169mg, 0.15mmol) in 25mL of a mixture of CH2Cl2/MeOH/H2O (1:1:0.5) the ligand 4,4′-bis(hydroxymethyl-2,2′-bipyridine (65mg, 0.30mmol) was added and the mixture refluxed with stirring for 3h. After cooling to room temperature KPF6 (92mg, 0.50mmol) was added and stirred for 20min. The solvent was removed in vacuo to dryness, the residue dissolved in dichloromethane and chromatographed on alumina with dichloromethane/acetone (9:1) as the eluent. The resulting solution was evaporated to dryness, the residue dissolved in 5mL of dichloromethane and the product was precipitated by slow diffusion with isohexane. (0008) Yield: 104mg (39.1%). Anal. Calc. for C36H32IrN4O2PF6: C, 48.59; H, 3.62; N, 6.30. Found: C, 48.34; H, 3.79; N, 6.46%. MS (FAB+): m/z=745.5 [M+] complex cation. 1H NMR (400MHz, CD2Cl2): delta=8.53 (s, 2H), 7.87(m, 4H), 7.70 (m, 2H), 7.59 (m, 2H), 7.44 (d, J=6.0Hz, 2H), 7.34 (d, J=5.2Hz, 2H), 6.89 (m, 4H), 6.09 (s, 2H), 4.87 (s, 4H), 2.80 (s, br, 2H), 2.11 (s, 6H). 13C{1H} NMR (400MHz, CD2Cl2): delta=167.2, 165.0, 155.8, 154.9, 150.1, 148.5, 141.0, 137.9, 132.4, 125.3, 124.8, 123.6, 122.7, 121.7, 119.4, 62.7 (CH2bpy), 21.5 (Me-ptpy). IR (KBr): nu (cm-1)=3579 w,br, 3395 w,br, 3030 w,br, 2916 w,br, 1609m, 1587m, 1563m, 1480s, 1463m, 1428m, 1418m, 1387 w, 1315 w, 1269 w, 1240 w, 1209 w, 1181 w, 1164 w, 1137 w, 1113 w, 1062 w, 1034 w, 1021 w, 985 w, 845 vs, 774m, 750 w, 739 w, 676 w, 616 w, 558s, 515m, 429 w. UV/vis (nm, M-1 cm-1): 260 (75.200), 274 (78.400), 310 (40.000), 380 (12.000), 408 (7600).

The synthetic route of 109073-77-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Graf, Marion; Siegmund, Daniel; Metzler-Nolte, Nils; Suenkel, Karlheinz; Boettcher, Hans-Christian; Inorganica Chimica Acta; vol. 487; (2019); p. 9 – 14;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56-41-7,H-Ala-OH,as a common compound, the synthetic route is as follows.

The L-alanine was used as substrate to produce (S)-alanine methyl ester hydrochloride (1a) according to the literature. (Xing et al., 2012). Add 15 mL of absolute methanol to the round bottom flask. Slow-drop 2.16 mL of SOCl2 (0.03 mol) into absolute methanol at -15 C and maintained at 0 C for an hour. Take 14 mL of absolute methanol and 1.4 mL (0.019 mol) of SOCl2 to another round bottom flask with the above steps. Then, 1.118 g of L-alanine were put into the solution and heating reflux for 1.5 h. After concentrated the solution under reduced pressure, the initial preparation of the SOCl2 solution was poured into the round bottom flask and continued reflux for 1.5 h to give 1a (yield 100%). Since the hydrochloric acid produced in this step was not conducive to the next reaction, put NaHCO3 into the round bottom flask when reflux was ended to destroy its acidity until no more bubbles are generated. Finally, the solution was concentrated to afford 1b (yield 100%).The fusaric acid (4) and 1b together with 15 mL of dichloromethane were put into a round bottom flask and stirred uniformly, then an excessof catalyst dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP) were added and reflux for 24 h. Concentrated the solution under reduced pressure and the product was purified by using preparative HPLC (25-45% CH3CN/H2O, 20 min) to obtain 1c (yield 52%).

As the paragraph descriping shows that 56-41-7 is playing an increasingly important role.

Reference£º
Article; Zhang, Pei-liang; Wang, Gang; Liu, Jin-song; Xu, Feng-qing; Zhao, Zhen-zhu; Wang, Wen-xiang; Wang, Ju-tao; Wang, Guo-kai; Wu, Pei-yun; Phytochemistry Letters; vol. 26; (2018); p. 50 – 54;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

168646-54-6, 5,6-Diamino-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The reaction and workup steps were performed air-free using standard Schlenk technique or by carrying out manipulations in a N2-filled glovebox. Compound 46 (43 mg, 0.2045 mmol, 1 eq) and Re(CO)5Cl (74 mg, 0.2045 mmol, 1 eq) were suspended in 30 rriL of toluene. The mixture was refluxed for 18 h and then cooled to RT followed by further cooling in an 8 ¡ãC fridge for 30 min. The precipitate was isolated via filtration and washed with hexane to obtain analytically pure product in 88percent yield. 1H-NMR (400 MHz, DMSO-d6) delta (ppm): 9.07 (dd, 2H), 8.90 (dd, 2H), 7.91 (dd, 2H), 5.82(s, 4H). 13C-NMR(150.9 MHz, DMSO-d6) 5 (ppm): 198.15, 190.39, 148.49, 140.17, 132.02, 124.81, 123.90, 123.57. ATR-IR(cm_1): 3460(w), 3412(w), 3363(w), 3298(w), 2020(s), 1930(s), 1895(s), 1664(m), 1617(m), 1589(m), 1489(m), 1436(m) Anal. Calcd for Ci5H10N4O3ReCl: C, 34.92; H, 1.95; N, 10.86. Found: C, 35.05; H, 1.82; N, 10.25.

168646-54-6 5,6-Diamino-1,10-phenanthroline 10910805, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; SURENDRANATH, Yogesh; FUKUSHIMA, Tomohiro; O’REILLY, Matthew, E.; OH, Seokjoon; MURRAY, Alexander T.; KAMINSKY, Corey Jarin; CHU, Sterling Ben; JACKSON, Megan N.; (161 pag.)WO2017/31050; (2017); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

3030-47-5, N1-(2-(Dimethylamino)ethyl)-N1,N2,N2-trimethylethane-1,2-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 1,1,4,7,7-pentamethyl diethylene triamine (20 mM) and 1-bromoalkanes namely:1-bromohexane, 1-bromododecane, and 1-bromooctadecane (60 mM) were charged individually in 250 mLround flask in the presence of acetone (100 mL) as a solvent. The reactionmixture was refluxed under stirring for 36 h then the reactionmixture was cooled to room temperature. The white precipitate wasfiltered, washed twice by diethyl ether and then recrystallized fromacetone to afford thewhite crystal products of the tricationic surfactants(TC6,12,18) [25], Scheme 1.

3030-47-5 N1-(2-(Dimethylamino)ethyl)-N1,N2,N2-trimethylethane-1,2-diamine 18196, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Article; Negm; Migahed; Farag; Fadda; Awad; Shaban; Journal of Molecular Liquids; vol. 262; (2018); p. 363 – 375;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.917-23-7,5,10,15,20-Tetraphenylporphyrin,as a common compound, the synthetic route is as follows.

General procedure: A solution of Cu(OAc)2¡¤H2O (4.6 mmol) in methanol (10 mL) was added to a solution of corresponding porphyrin (1.15 mmol) in methylene chloride (50 mL). The resulting mixture was stirred flor 1.5 h at room temperature with TLC monitoring (CHCl3-hexane 1:2). Then the reaction mixture was poured into water and extracted with methylene chloride. The organic layer was dried over Na2SO4, and the solvent was removed under reduced pressure. The residue was used without purification. 5,10,15,20-(tetraphenylporphyrinato)copper(II) (13) [56] (757 mg,yield 97%). UV-Vis (CH2Cl2) >max, (j10-3) nm: 414 (611), 539 (29).APCI-MS Found: [M]+ 676.16; ?C44H28CuN4? requires [M]+ 676.26.

The synthetic route of 917-23-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ol’shevskaya, Valentina A.; Alpatova, Viktoriya M.; Radchenko, Alexandra S.; Ramonova, Alla A.; Petrova, Albina S.; Tatarskiy, Victor V.; Zaitsev, Andrei V.; Kononova, Elena G.; Ikonnikov, Nikolay S.; Kostyukov, Alexey A.; Egorov, Anton E.; Moisenovich, Mikhail M.; Kuzmin, Vladimir A.; Bragina, Natalya A.; Shtil, Alexander A.; Dyes and Pigments; vol. 171; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

330680-46-1, Trimethyl [2,2′:6′,2”-terpyridine]-4,4′,4”-tricarboxylate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 150 mL of NMP (N-methylpyrrolidone), 1.22 g of compound d-1-7 and 1.62 g of compound d-1-6 were added, followed by stirring at 70 C. for 3 hours under a nitrogen atmosphere. Then, 1.63 g of compound d-1-8 was added thereto, followed by stirring under heating at 160 C. for 8 hours. Then, 10.7 g of ammonium thiocyanate was added thereto, followed by stirring at 160 C. for 8 hours. After concentration, water was added, followed by filtration. The filtrate was purified by a silica gel column chromatography to obtain compound d-1-9, followed by adding the obtained compound to a mixed solvent of 30 mL of acetone and 40 mL of a 1N sodium hydroxide aqueous solution, and stirring for 24 hours at external temperature of 65 C. After bringing the temperature to room temperature, the pH was adjusted to 1.5 with hydrochloric acid, and the precipitate was filtrated, to give 3.3 g of crude product D-1-1a. (0270) This was dissolved in a methanol solution together with TBAOH (tetrabutylammonium hydroxide), and purified by SephadexLH-20 column. The fraction of the main layer was collected and concentrated, and then a solution of 0.1M trifluoromethanesulfonic acid was added thereto so as to adjust the pH thereof to 3, and the precipitate was filtered, thereby obtaining 2.4 g of exemplified dye D-1-1a. (0271) The structure of exemplified dye D-1-1a obtained was confirmed by MS measurement. (0272) MS-ESI m/z=928.1 (M-H)+

330680-46-1 Trimethyl [2,2′:6′,2”-terpyridine]-4,4′,4”-tricarboxylate 66776557, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Patent; FUJIFILM Corporation; Tani, Yukio; Kobayashi, Katsumi; (63 pag.)US9953768; (2018); B2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

168646-54-6, 5,6-Diamino-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[Cu(CH3CN)4]ClO4 (32.6 mg, 0.100 mmol) was added to adichloromethane (DCM) solution (about 12 mL) of dap (21.4 mg,98percent, 0.100 mmol) and xantphos (59.0 mg, 98percent, 0.100 mmol) undera stream of dry argon by using Schlenk techniques at room temperatureand a vacuum-line system, then orange-red solutionwas obtained quickly and stirred for 1 h at room temperature.The above process can also be carried out in air with the existenceof oxygen. After filtration through absorbent cotton, layeringn-hexane onto the filtrate in air produced the product as orangeredcrystals in 35?44percent yield (39.1?49.3 mg). Anal. Calc. forC52H44Cl3CuN4O5P2 (1aCH2Cl2): C, 60.34; H, 4.29; N, 5.42. Found:C, 60.01; H, 4.34; N, 5.45percent. ESI-MS (m/z): 851.214[Cu(dap)(xantphos)]+ (calcd 851.212); 641.123 [Cu(xantphos)]+(calcd 641.122). 1H NMR (400 MHz, DMSO-d6, delta, ppm): 8.681 (d,2H, J = 8.4 Hz), 8.209 (d, 2H, J = 4.4 Hz), 7.852 (dd, 2H, J = 7.6 Hz,J0 = 1.2 Hz), 7.650 (dd, 2H, J = 8.4 Hz, J0 = 4.4 Hz), 7.252 (t, 6H,J = 7.6 Hz), 7.102 (t, 8H, J = 7.6 Hz), 6.888?6.844 (m, 8H), 6.476?6.438 (m, 2H), 5.758 (s, 2H, CH2Cl2), 5.638 (s, 4H, NH2), 1.745 (s,6H, CH3). 31P{1H} NMR (400 MHz, DMSO-d6, delta, ppm): 13.097.Characteristic IR spectrum (KBr, cm-1): 3444m (NH2), 3372m(NH2), 2969m (CH3), 2925w (CH3), 1101vs (ClO4).

As the paragraph descriping shows that 168646-54-6 is playing an increasingly important role.

Reference£º
Article; Yao, Xi-Xi; Guo, Ya-Meng; Liu, Rong; Feng, Xiao-Yan; Li, Hao-Huai; Liu, Nian; Yang, Feng-Lei; Li, Xiu-Ling; Polyhedron; vol. 92; (2015); p. 84 – 92;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

6249-56-5, 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Additional materials are available from related starting materials, using chemistries recognized by the skilled artisan:

The synthetic route of 6249-56-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CALIFORNIA INSTITUTE OF TECHNOLOGY; GRUBBS, ROBERT H.; STOLLER, MARSHALL L.; CHUNG, HOYONG; FITZGERALD, ALISSA M.; KENNY, THOMAS W.; THOMAS, RENEE M.; US2013/123781; (2013); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI