Day: August 24, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1662-01-7,4,7-Diphenyl-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: The precursors were synthesized according to a previously reportedmethod. A solution of [RuCl2(eta6-C10H14)]2 (0.200 g, 0.31 mmol) with an excess of the desired N-N ligand (0.75 mmol) in methanol (25 mL) was stirred for 1 h. NH4PF6 (0.30 g; 1.00 mmol) was added to this solution, also dissolved in methanol (5 mL), and the mixture was stirred at room temperature for 1 h longer. The orange-yellow solid that precipitated was filtered off, washed with cold methanol and diethyl ether, and dried under vacuum.

1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Article; Colina-Vegas, Legna; Villarreal, Wilmer; Navarro, Maribel; De Oliveira, Clayton Rodrigues; Graminha, Angelica E.; Maia, Pedro Ivo Da S.; Deflon, Victor M.; Ferreira, Antonio G.; Cominetti, Marcia Regina; Batista, Alzir A.; Journal of Inorganic Biochemistry; vol. 153; (2015); p. 150 – 161;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

139-07-1, N-Benzyl-N,N-dimethyldodecan-1-aminium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 2 STR9 12.95 g (0.05 mole) of 1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)-1-ethanol are dissolved in 100 ml of toluene, and 100 ml of 40% strength sodium hydroxide solution and 1 ml of benzyl-dodecyl-dimethylammonium chloride are added. 13.5 g (0.05 mole) of 2,4-dichlorophenoxyethyl bromide are then added dropwise and the mixture is subsequently stirred at room temperature for 48 hours. The organic phase is separated off, washed with three 100 ml portions of saturated sodium chloride solution, dried over sodium sulphate and concentrated. The residue is taken up in 100 ml of diethyl ether, and crystallizes after the mixture has stood for a short time. 7.8 g (35% of theory) of 1-(2,4-dichlorophenyl)-1-(2,4-dichlorophenoxyethoxy)-2-(1,2,4-triazol-1-yl)-1-ethanol of melting point 88-90 C. are obtained.

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Reference£º
Patent; Bayer Aktiengesellschaft; US4771065; (1988); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4730-54-5, 1,4,7-Triazacyclononane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1,4,7-triazonane (129mg, 1.0 equiv) and K2CO3 (3.6 g, 10.0equiv) was dissolved in100 mL MeCN, a solution of 1c (1.16 g, 3.6 equiv) in 15 mL MeCNwas slowly added at 0 C, then the mixture was heated under gentlereflux for 48 h. The mixture was filtered and the filtrate concentrated invacuo and purified by flash column chromatograph on silica gel(dichloromethane /methanol as the eluent) to provide 2d light yellowsolid (545.9 mg, 64% yield). 1H NMR (400 MHz, MeOD): delta 7.54 (d,J = 7.4 Hz, 3H), 7.43 (dd, J = 7.8, 1.6 Hz, 6H), 7.34 (dd, J = 7.9,1.8 Hz, 9H), 6.43 (d, J = 7.4 Hz, 3H), 5.06 (s, 6H), 4.14 (t, J = 6.4 Hz,6H), 3.75 (t, J = 6.4 Hz, 6H), 2.67 (s, 12H), 2.25 (s, 9H). 13C NMR(101 MHz, MeOD): delta 179.2, 175.2, 147.4, 145.1, 141.4, 138.5, 130.2,129.4, 117.4, 74.6, 52.2, 38.7, 29.0, 12.8. ESI-MS: calculated forC51H60N6O6, [M+H] + m/z = 853.5, found 853.5.

The synthetic route of 4730-54-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Xiaoguang; Dong, Xiuxiu; He, Chuanchuan; Zhang, Xiaojuan; Xiang, Guangya; Ma, Xiang; Bioorganic Chemistry; vol. 96; (2020);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1662-01-7,4,7-Diphenyl-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: The pentafluorinated beta-diketone ligand (3 mmol), NaOH(0.12 g, 3 mmol) and the auxiliary ligand (1 mmol) were dissolved in 30 mL ethanol and heated to 60 C under stirring. Then, the ethanolic solution of EuCl3¡¤6H2O(1 mmol) was added dropwise, and the reaction mixture was stirred at 60 C for 8 h. After cooling down, the yellow solid was precipitated and filtered off. The solidproduct was washed with deionized water and ethanol, and dried in vacuum. Yellow powder, yield 78%, mp 200-202 C; IR nu (KBr):3031(m), 2967 (m), 2843 (w), 1597 (s), 1572 (s), 1501 (s), 1258 (s), 1172 (s),1082 (m), 1013 (m), 930 (m), 845 (m), 789 (s), 588 (m), 508 (m) cm-1; 1H NMR(300 MHz, CDCl3):delta 3.70 (s, 3H, C=CH), 3.94 (s, 9H, OCH3),6.86 (br, 6H, Ar-H),7.61 (br, 6H, Ar-H), 7.96 (br, 2H, Bath-H), 8.17 (br, 4H, Bath-H), 8.58 (br, 2H,Bath-H), 8.73 (br, 4H, Bath-H), 9.24 (br, 2H, Bath-H), 12.10 (br, 2H, Bath-H) ppm.Anal. Calcd. for EuC60H40N2O9F15:C, 52.61; H, 2.94; N, 2.04; Eu, 11.09; Found C,52.94; H, 2.91; N, 2.09; Eu, 11.25.

The synthetic route of 1662-01-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wan, Yupeng; Lyu, Heng; Du, Hengyi; Wang, Dunjia; Yin, Guodong; Research on Chemical Intermediates; vol. 45; 4; (2019); p. 1669 – 1687;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1662-01-7,4,7-Diphenyl-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: The copper-phosphine complex (1.00 mmol) together with 10.0 ml of CHCl3 is placed in a Schlenk vessel. The phosphine (1.00 mmol) is added to this solution until it is completely dissolved. A solution of the N-ligand (1.00 mmol) in 2 ml of CHCl3 is then added over a period of 30 minutes. The mixture is subsequently stirred at room temperature for a further 30 minutes. After removal of the CHCl3 in vacuo, the resulting solid is recrystallized from CH2Cl2 and Et2O.Example 50 (4,7-diphenyl-1,10-phenanthroline)bis(triphenylphosphine)copper(I) nitrate (4,7-Diphenyl-1,10-phenanthroline)bis(triphenylphosphine)copper(I) nitrate was prepared from bis(triphenylphosphine)copper(I) nitrate (650 mg, 1.00 mmol), 4,7-diphenyl-1,10-phenanthroline (339 mg, 1.00 mmol) and triphenylphosphine (262 mg, 1.00 mmol). This gives (4,7-diphenyl-1,10-phenanthroline)bis(triphenylphosphine)copper(I) nitrate (980 mg, 99%) as a yellow solid. 31P NMR (162 MHz, CDCl3) delta=3.32 (s, 1P) ppm. Anal. calc. for C48H36Cl2CuN3O3P2: C, 59.8, H, 3.9, N, 4.3. Found: C, 59.0, H, 3.8, N, 4.6.

The synthetic route of 1662-01-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BASF SE; Goossen, Lukas J; Rodriguez Garrido, Nuria; Manjolinho Costa, Filipe; Lange, Paul P.; US2014/12000; (2014); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.485-71-2,Cinchonidine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of (-)-cinchonidine (1.0 mmol) and benzyl bromide 3 (1.0 mmol) having sulfonamidegroup was stirred in DMF (4 mL) at 25 C for 20 h. After the reaction was completed, the reaction mixture was added dropwise to ether (50mL) with stirring. The solid precipitated was filtered,washed with ether (20 mL) and hexane (20 mL) to afford cinchonidinium salt 5

As the paragraph descriping shows that 485-71-2 is playing an increasingly important role.

Reference£º
Article; Itsuno, Shinichi; Yamamoto, Shunya; Takata, Shohei; Tetrahedron Letters; vol. 55; 44; (2014); p. 6117 – 6120;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4568-71-2, 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 2 L four-necked flask equipped with a stirrer and a nitrogen gas inlet tube, 301.7 g (1.12 g) of 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride Mol), ion exchanged water 300.3 g and sodium thiocyanate 91.6 g (1.43 mol), and the mixture was stirred at room temperature for 3 hours. After completion of the stirring, the organic layer was separated from the reaction solution separated into an aqueous layer and an organic layer. After washing the organic layer three times with 300 g of ion exchanged water, it was placed in a rotary evaporator and concentrated. The obtained concentrate was dried under reduced pressure, dissolved with 157.48 g of methanol, heated to 65 ¡ã C. and recrystallized by cooling. The obtained crystals were separated by filtration and dried under reduced pressure to give 3-benzyl-5- (2-hydroxyethyl) -4-methylthiazolium thiocyanate248.97 g (yield: 76percent) was obtained.

4568-71-2 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride 2833352, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Patent; KOEI CHEMICAL COMPANY LIMITED; TAGATA, TSUYOSHI; KAWAMICHI, TAKEHIDE; SAITO, AYA; (17 pag.)JP5814080; (2015); B2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

170161-27-0, Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The y-carbaldehyde intermediates (29.0 muL, 500 mumol) were added to a solution of tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate (35.7 mg, 71.0 mumol) in MeOH (1.0 mL) and AcOH (100 L) under N2 and stirred for 2 h at room temperature. NaBH3CN (8.90 mg, 142 mumol) was added slowly to the reaction mixture and stirred at room temperature for 24 h. The reaction mixture was poured into saturated NaHCO3, extracted with EtOAc and dried with MgSO4. The organic layer was then washed with water and brine, dried with MgSO4 and concentrated under reduced pressure to obtain the corresponding tri-N-Boc-protected amine intermediates (68.9 mg), which were used in the next step without purification. The intermediates were then dissolved in CHCl3 (2.50 mL) and treated with 95% aqueous TFA (2.50 mL) at 0 C for 6 h. The mixture was concentrated under reduced pressure and purified by preparative HPLC to obtain the desired compounds 6-12.

170161-27-0 Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate 10940041, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Article; Sakyiamah, Maxwell M.; Kobayakawa, Takuya; Fujino, Masayuki; Konno, Makoto; Narumi, Tetsuo; Tanaka, Tomohiro; Nomura, Wataru; Yamamoto, Naoki; Murakami, Tsutomu; Tamamura, Hirokazu; Bioorganic and Medicinal Chemistry; vol. 27; 6; (2019); p. 1130 – 1138;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

2304-30-5, Tetrabutylphosphonium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Cleavage reactions of perchlorinated and methylated chlorodisilanes with n-Bu4PCI (5 w%) and 2-methylimidazole (2-MIA, 5 w%) as catalyst in a sealed glass ampoule at 175 C for 2.5 h. The starting compounds and reaction products are listed in Table 2.

As the paragraph descriping shows that 2304-30-5 is playing an increasingly important role.

Reference£º
Patent; MOMENTIVE PERFORMANCE MATERIALS INC.; AUNER, Norbert; SANTOWSKI, Tobias; STURM, Alexander, G.; (72 pag.)WO2019/60481; (2019); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1126-58-5,1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of the corresponding bis(isatin) 1-8 (5 mmol) and Girard?s reagent (2.5 mmol) in 7 mL of absolute ethanol were added three drops of trifluoroacetic acid. The reaction mixture was refluxed for 2 h. After spontaneous cooling of the solution to room temperature, the formed precipitate was filtered off, washed with absolute diethyl ether and dried in vacuum (12 mmHg).

1126-58-5 1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride 70773, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Article; Bogdanov; Zaripova; Mustafina; Voloshina; Sapunova; Kulik; Mironov; Russian Journal of General Chemistry; vol. 89; 7; (2019); p. 1368 – 1376; Zh. Obshch. Khim.; vol. 89; 7; (2019); p. 1004 – 1012,9;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI