Day: August 28, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.391604-55-0,2-(2,4-Difluorophenyl)pyridine,as a common compound, the synthetic route is as follows.,391604-55-0

2-bromopyridine (4.17g, 26.39mmol), 2,4- difluorophenyl boronic acid (5.00g, 31.66mmol), phosphorus tetrakistriphenylphosphine palladium (0.91g, 0.79mmol) and sodium carbonate (6.36g, 60.00mmol ) was dissolved in 100mL of tetrahydrofuran, 65 for 24 hours, cooling, water and dichloromethane, the organic layer was concentrated by column chromatography to obtain primary ligand (3.84g, yield 76.18%). The primary ligand (2.50g, 13.08mmol) and iridium chloride (2.30g, 6.23mmol) was dissolved in 15mL ethoxyethanol, the reaction mixture was 130 C 12h, then was added pyridine phosphate (2.72g, 12.46mmol) and sodium carbonate (3.30g, 31.15mmol), continue 130 reaction 24h. System cooling, water and dichloromethane, the organic layer was concentrated by column chromatography to obtain a yellow solid Ir1-001 (1.06g, yield: 21.5%).

The synthetic route of 391604-55-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AAC Acoustic Technology Holdings Inc.; Pan, Yi; Zheng, Youxuan; Wu, Zhengguang; Wang, Yi; Zhou, Jie; Cao, Chenhui; (7 pag.)CN105837629; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4479-74-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4479-74-7,2,2-Bipyridine-6,6-dicarboxylic Acid,as a common compound, the synthetic route is as follows.

General procedure: A mixture of Gd(NO3)3¡¤6H2O (0.023g, 0.05mmol), H2bpdc (0.024g, 0.10mmol) in distilled water (10mL) that adjusted the pH value to 5.5 with 0.5molL-1 NaOH aqueous solution was placed in a Teflon-lined stainless steel vessel (25mL), heated to 160C for 72h and then cooled to room temperature at a rate of 5C/h. The colorless crystalline product of 1 was obtained (yield: 35% based on H2bpdc).

The synthetic route of 4479-74-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ren, Ya-Lan; Wang, Fei; Hu, Huai-Ming; Chang, Zhuguo; Yang, Meng-Lin; Xue, Ganglin; Inorganica Chimica Acta; vol. 434; (2015); p. 104 – 112;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4730-54-5,1,4,7-Triazacyclononane,as a common compound, the synthetic route is as follows.,4730-54-5

20 g of triazacyclononane trihydrochloride (83.8 mmol), 35.4 g of 1-fluoro-4-nitrobenzene (251.4 mmol) and 40 g of potassium carbonate (290 mmol) are placed in 150 ml of water and the mixture is refluxed with stirring for 24 hours. After cooling to room temperature, the orange-yellow solid obtained is filtered off and rinsed with water and then with petroleum ether. After drying, 31 g of product are obtained, i.e. a yield of 99%. The results of the analyses obtained by 1H NMR and by mass spectrometry are as follows: 1H NMR (400 MHz, DMSO): 2.2 (m, 1H); 2.8 (m, 4H); 3.4 (m, 4H); 3.9 (m, 4H); 6.8 (m, 4H); 8.1 (m, 4H). Mass (ESI+): m/z=372 (MH+).

The synthetic route of 4730-54-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Vidal, Laurent; Sabelle, Stephane; Ly-Carry, Thi-My; US2005/120494; (2005); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.485-71-2,Cinchonidine,as a common compound, the synthetic route is as follows.,485-71-2

General procedure: A mixture of 2 or 3 (0.50 mmol), the corresponding acids RCOOH (0.60 mmol),DCC (0.60 mmol), DMAP (0.1 mmol) in dry dichloromethane (15 mL) was stirred atroom temperature. When the reaction was completed, and checked by TLC, the mixturewas filtered to remove urea from the reaction, and the filtrate was diluted bydichloromethane (45 mL). Subsequently, the diluted organic phase was washed bysaturated aqueous NaHCO3 (30 mL), and brine (30 mL), dried over anhydrousNa2SO4, concentrated in vacuo, and purified by CC to give the pure 9R/S-acyloxyderivatives of cinchonidine and cinchonine 5a-j,l-o and 6a,c,e-o [17-19]. The dataof target compounds are shown as follows.

The synthetic route of 485-71-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Che, Zhi-Ping; Chen, Gen-Qiang; Jiang, Jia; Lin, Xiao-Min; Liu, Sheng-Ming; Sun, Di; Tian, Yue-E; Yang, Jin-Ming; Zhang, Song; Journal of Asian Natural Products Research; (2020);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

5350-41-4, N,N,N-Trimethyl-1-phenylmethanaminium bromide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5350-41-4

EXAMPLE 3 The mixture of 50 parts of alpha-(4-biphenylyl)acetonitrile, 45.8 parts of 2-chloro-N,N-diisopropylethylamine, 80 parts by volume of 50percent sodium hydroxide, 250 parts by volume of methylene chloride and 1 part of benzyltrimethylammonium bromide is stirred at room temperature with slight cooling in an icy water bath for about 24 hours. The mixture is then poured into water and to this mixture additional quantity of methylene chloride is added. The organic layer is separated, washed with water, dried over anhydrous sodium sulfate and concentrated to afford alpha-(4-biphenylyl)-alpha-[2-(diisopropylamino)ethyl]acetonitrile, as a solid. This compound is identical to that of Example 1.

The synthetic route of 5350-41-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; G. D. Searle & Co.; US4217306; (1980); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

54761-04-5, Ytterbium(III) trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,54761-04-5

Example 6 2-(4-{3-[5-Acetyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxy-propyl}-piperazin-1-yl)-benzonitrile. A solution of 1-[1-oxiranylmethyl-3-(4-trifluoromethyl-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone (0.84 g, 2.30 mmol) in CH2Cl2 (10 mL) was treated with ytterbium(III) triflate (0.29 g, 0.46 mmol) and 1-(2-cyanophenyl)-piperazine (0.75 g, 3.5 mmol) at 25 C. and stirred for 48 h before it was diluted with CH2Cl2 (100 mL) and H2O (50 mL). The organic layer was separated, washed with H2O (2*50 mL), dried over Na2SO4, and concentrated. Column chromatography (silica, 5% MeOH/CH2Cl2) afforded 1.15 g (90%) of light yellow crystals. TLC (silica, 10% MeOH/CH2Cl2): Rf=0.30. MS (electrospray): m/z 553.3 ([M+H]+, C29H31F3N6O2 requires 552.3). 1H NMR (CDCl3, 400 MHz, a mixture of two rotamers): 7.82 and 7.68 (AB pattern, Jab=8.2 Hz, 2H), 7.76 and 7.72 (AB pattern, Jab=8.4 Hz, 2H), 7.60-7.48 (m, 2H), 7.05-7.00 (m, 2H), 4.90 and 4.78 (AB pattern, Jab=16 Hz, 1H), 4.69 (s, 1H), 4.30-3.71 (m, 6H), 3.25 (m, 4H), 3.02-2.75 (m, 4H), 2.70-2.65 (m, 2H), 2.60-2.53 (m, 2H), 2.23 (s, 1.5H), 2.18 (s, 1.5H).

The synthetic route of 54761-04-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Breitenbucher, J. Guy; Cai, Hui; Edwards, James P.; Grice, Cheryl A.; Gu, Yin; Gustin, Darin J.; Karlsson, Lars; Khatuya, Haripada; Meduna, Steven P.; Pio, Barbara A.; Sun, Siquan; Tays, Kevin L.; Thurmond, Robin L.; Wei, Jianmei; US2003/69240; (2003); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54761-04-5,Ytterbium(III) trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.,54761-04-5

4.6. Synthesis of a Complex of H3TTPTCN and Ytterbium A solution of 30.5 mg (0.05 mmol) of ytterbium triflate in 1 ml of water is admixed with a solution of 36 mg (0.05 mmol) of H3TTPTCN in 2 ml of water in which the pH is adjusted to 7 by addition of an aqueous NaOH solution. The subsequent procedure is as described in section 4.2 above. In this way a complex is isolated: [Yb(TTPTCN)].6.5H2O (yield: 30%). Elemental analysis: calculated (found): C: 33.55% (33.69%) H: 4.38% (4.37%) N: 26.08% (25.61%)

The synthetic route of 54761-04-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Giraud, Marion; Demadrille, Renaud; Mazzanti, Marinella; Andreiadis, Eugen Sorin; US2011/112289; (2011); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

554-95-0, Benzene-1,3,5-tricarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,554-95-0

Reaction of AgNO3 (33.4 mg, 0.2 mmol), pyridazine (pdz)(16.0 mg, 0.2 mmol) and 1,3,5-benzene tricarboxylic (H3btc)(44.2 mg, 0.2 mmol) took place in H2O-DMF (N,N-Dimethylformamide)solvents (6 ml, v/v = 1:1) in the presence of ammonia(0.5 mL, 14 M) under ultrasonic treatment (160 W, 40 kHz,30 min) at 40 C. The resultant colourless solution was allowed slowly to evaporate at room temperature in the dark. The yellowcrystals of complex 1 were obtained after several days.The crystals were isolated by filtration and washed by deionized water and ethanol and dried in the air. Yield based on Ag is 88%.Elemental analysis: Anal. Calc. for Ag6C26H14N4O12: C, 25.563; H,1.155; N, 4.586. Found: C, 25.37; H, 1.19; N, 4.65%. Selected IR peaks (cm1): 3283 (s), 2264 (w), 1863 (w), 1614 (s), 1557 (s),1417 (s), 1360 (s), 1099 (m), 1060 (w), 972 (w), 920 (w), 767 (s),716 (s), 660 (w), 514 (m), 455 (w).2.2.2. Synthesis of complex [Ag2(pdz)(

The synthetic route of 554-95-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Dan-Feng; Zhang, Ting; Dai, Si-Min; Huang, Rong-Bin; Zheng, Lan-Sun; Inorganica Chimica Acta; PA; (2014); p. 193 – 200;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7089-68-1,2-Chloro-1,10-phenanthroline,as a common compound, the synthetic route is as follows.,7089-68-1

In the atmosphere of nitrogen, intermediate A2 (1.6g, 5.6 mmol), 2-chlorophenanthroline (0.8g, 3.7 mmol), tetrakis(triphenylphosphine)palladium (0) (0.1g, 0.11 mmol), cesium carbonate (3.0g, 9.3 mmol) and 1,2-dimethoxyethane (37 mL) were mixed, followed by stirring at 80¡ãC for 6 hours. Water (50 mL) was added to the reaction mixture, and the precipitates were filtered out to obtain a yellow solid (compound (2-A); 0.76g, 60percent).1H-NMR (400MHz, CDCl3, TMS)delta: 3.25 (s,3H), 7.70 (d,J8.0,1H), 8.03 (d,J8.0,1H), 8.18 (d,J8.0,1H), 8.30 (d,J8.0,1 H), 8.41 (d,J8.0,1H), 8.69 (s,1H), 8.83 (d,J8.0,1 H), 9.26 (d,J8.0,1H).

The synthetic route of 7089-68-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Idemitsu Kosan Co., Ltd.; YASUKAWA, Keiichi; MAEDA, Ryoji; TOKAILIN, Hiroshi; EP2599780; (2013); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7173-51-5,N-Decyl-N,N-dimethyldecan-1-aminium chloride,as a common compound, the synthetic route is as follows.,7173-51-5

In a round-bottom flask, equipped with a magnetic stirrer, heating bath, dropping funnel, and a reflux condenser, a suspension of 0.02 mol of 3,6-dichloro-2- methoxybenzoic acid in 30 mL of distilled water, was prepared. Then 0.02 mol of 10% aqueous solution of NaOH was added to the suspension. The reaction was conducted at 50C until the all acid reacted and a homogeneous reaction mixture was obtained. Then a stoichiometric amount of didecyldimethylammonium chloride was added in a 1 to 1 (50%: 50%) water and isopropanol mixture. The product precipitated from the reaction mixture in the form of a lower liquid layer. After 24 hours, the product was isolated by separating the phases. The organic phase was washed with distilled water from the unreacted substrate and the NaCl. In the final stage the product was dried for 24 hours at 50C under reduced pressure. The yield is 90%. 1H NMR (CDC13) delta ppm = 0.88 (t, J= 6.7 Hz, 6H), 1.25 (m, 28H), 1.61 (q, J = 6.8 Hz, 4H), 3.34 (s, 6H), 3.39 (t, J= 6.3 Hz, 4H), 3.95 (s, 3H), 6.99 (d, J= 8.5 Hz, 1H), 7.08 (d, J= 8.5 Hz, 1H); 13C NMR delta ppm = 14.0; 22.5; 26.1; 29.1; 29.25; 29.27; 31.7; 50.9; 61.5; 63.1; 125.3; 125.9; 127.0; 127.8; 140.2; 151.7; 167.9. Elemental analysis CHN CsoHssOsNCb: calculated C 65.90; H 9.79; N 2.56; observed: C 65.62; H 9.65; N 2.33. DSC: T glass -47C, mp 86C, T = 178C; 1 onset 232C

The synthetic route of 7173-51-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA; PERNAK, Juliusz; SHAMSHINA, Julia; TADEUSZ, Praczyk; SYGUDA, Anna; JANISZEWSKA, Dominika; SMIGLAK, Marcin; GURAU, Gabriela; DALY, Daniel, T.; ROGERS, Robin, D.; WO2012/6313; (2012); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI