Day: September 4, 2020

56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

56-54-2, General procedure: 4.24.12 N-(3,5-Ditrifluoromethyl)benzyl-6′-hydroxyquinidi-nium bromide (4c) Ethanethiol (2.30 mL, 30.8 mmol) was added under argon atmosphere to a stirred suspension of sodium hydride (370.0 mg, 15.4 mmol) in dry DMF (15 mL). Quinidine (500 mg, 1.5 mmol) in dry DMF (7.5 mL) was added dropwise and the reaction mixture was stirred at 110 C for 13 h. The solvent and excess ethanethiol were removed under reduced pressure. Then the 3,5-ditrifluoromethylbenzyl bromide (675.4 mg, 2.2 mmol) was added in THF (9 mL). The reaction mixture was refluxed and monitored by TLC analysis. The solvent was removed under reduced pressure and the residue was purified by flash chromatography (MeOH/EtOAc = 1/20, V/V). Yield 52%; white solid; mp 258 C (decomp.); [alpha]D28 +182.3 (c 0.16, CH3OH); IR (KBr): 3369, 3234, 1622, 1531, 1469, 1217, 1181, 1135, 1003, 927, 905, 864, 842, 736, 709, 683 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 10.06 (s, 1H), 8.75 (d, J = 4.4 Hz, 1H), 8.63 (s, 2H), 8.37 (s, 1H), 7.95 (d, J = 8.8 Hz, 1H), 7.70 (d, J = 4.4 Hz, 1H), 7.67 (d, J = 2.4 Hz, 1H), 7.38 (dd, J = 9.0, 2.2 Hz, 1H), 6.68 (d, J = 3.6 Hz, 1H), 6.32 (s, 1H), 6.02 (ddd, J = 17.4, 10.5, 6.9 Hz, 1H), 5.38 (d, J = 12.4 Hz, 1H), 5.26-5.19 (m, 3H), 4.32 (t, J = 9.6 Hz, 1H), 4.13 (t, J = 9.6 Hz, 1H), 3.92 (t, J = 9.6 Hz, 1H), 3.49 (t, J = 11.2 Hz, 1H), 3.12-3.05 (m, 1H), 2.65-2.59 (m, 1H), 2.33 (t, J = 11.6 Hz, 1H), 1.89 (s, 1H), 1.83-1.78 (m, 2H), 1.17-1.09 (m, 1H); 13C NMR (100 MHz, DMSO-d6): delta = 156.5, 147.2, 143.4, 143.1, 137.7, 135.2, 131.9, 131.7, 131.2 (q, J = 33.0 Hz), 126.1, 124.6 (q, J = 3.2 Hz), 123.7 (q, J = 271.8 Hz), 122.2, 120.4, 117.6, 105.1, 68.2, 65.3, 60.9, 56.3, 54.7, 37.3, 26.9, 23.6, 21.0; HRMS calcd for [C28H27F6N2O2]+: 537.1971, found 537.1959.

56-54-2 (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol 637552, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Article; Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue; Journal of Fluorine Chemistry; vol. 148; (2013); p. 19 – 29;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1662-01-7,4,7-Diphenyl-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: Complexes were synthesized using the following general procedure: to an ethanolic (or methanolic) solution of glycine (1mmol) and NaOH (1mmol) salicylaldehyde (1mmol) was added. The resulting yellow solution was stirred for 30min at room temperature and a solution of Zn(CH3COO)2.2H2O (1mmol in 5mL of water) was added dropwise. The pH was adjusted to 7 with 1M NaOH and the mixture was stirred at room temperature for 1h. The polypyridyl (1mmol) in ethanol (10mL) was then added and the resulting solution stirred at room temperature for 1h, subsequently concentrated and left overnight at 4C. The precipitate obtained was filtered, washed with cold ethanol and diethyl ether and dried in vacuum., 1662-01-7

As the paragraph descriping shows that 1662-01-7 is playing an increasingly important role.

Reference£º
Article; Matos, Cristina P.; Addis, Yemataw; Nunes, Patrique; Barroso, Sonia; Alho, Irina; Martins, Marta; Matos, Antonio P.A.; Marques, Fernanda; Cavaco, Isabel; Costa Pessoa, Joao; Correia, Isabel; Journal of Inorganic Biochemistry; vol. 198; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

56-54-2, General procedure: An oven-dried culture tube containing the tetrayne precursor in organic solvent (initial concentration of 0.02-0.03 M) and the indicated number of equivalents of trapping component(s) was closed with a Teflon-lined cap and the solution was heated at 85-90 C for 16 h. The half-life for conversion of each of the polyynes used here to the corresponding benzyne was approx. 3-4 h. The product(s) was separated and purified by chromatography on silica gel. Full experimental details and characterization data for all new compounds (polyyne HDDA substrates andproducts) and a description of the computational methods and results are providedin the Supplementary Information.

As the paragraph descriping shows that 56-54-2 is playing an increasingly important role.

Reference£º
Article; Ross, Sean P.; Hoye, Thomas R.; Nature Chemistry; vol. 9; 6; (2017); p. 523 – 530;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17217-57-1,4,4′-Dimethoxy-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

General procedure: [Rh(bpy)2(4,4′-dmobpy)](PF6)3 was prepared as above but using cis-[Rh(bpy)2(OTf)2](OTf) (102 mg, 0.118 mmol) and4,4′-dimethoxy-2,2′-bipyridine (29.3 mg, 0.135 mmol) in 10 mL ethanol and refluxing for 30 min. Yield of analytically pure,off-white product (110 mg, 0.100 mmol), 84percent. Anal. Calcd forC32H28N6RhO4P3F18: C, 34.99; H, 2.57; N, 7.65. Found: C, 35.00; H,2.58; N, 7.55. 1H NMR (d6-DMSO, 400 MHz): d (ppm) aromaticprotons [9.04 (d, J = 8.23 Hz, 4H), 8.67 (d, J = 2.49 Hz, 2H), 8.57 (q,J = 7.95 Hz, 4H), 7.91 (d, J = 5.74 Hz, 2H), 7.84 (t, J = 8.18 Hz, 2H),7.79 (q, J = 5.82 Hz, 4H), 7.57 (d, J = 6.83 Hz, 2H), 7.30 (dd,J = 6.34 Hz, 2H)], 4.08 (s, 6H, OCH3). 13C NMR (d6-DMSO,100 MHz): d (ppm) aromatic carbons [169.8, 155.6, 154.6, 154.5,151.2, 151.0, 150.7, 143.0, 130.4, 126.7, 120.6, 115.6, 113.7], 57.7(OCH3).

17217-57-1, 17217-57-1 4,4′-Dimethoxy-2,2′-bipyridine 2733927, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Article; Amarante, Daniel; Cherian, Cheryl; Megehee, Elise G.; Inorganica Chimica Acta; vol. 461; (2017); p. 239 – 247;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170161-27-0,Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate,as a common compound, the synthetic route is as follows.

General procedure: A solution of x,y-bis(bromomethyl)-1,1′-biphenyl (x,y = 3,3? or 4,4?) (3,3′-bis(bromomethyl)-1,1′-biphenyl/ 4,4′-bis(bromomethyl)-1,1′-biphenyl)S2 (68.0 mg, 200 mumol) was added to a solution of tri-tert-butyl1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate (25.0 mg, 500 mumol), K2CO3 (6.90 mg, 500 mumol)in CH3CN (1.50 mL) under N2 and stirred for 12 hr at room temperature. The reaction mixture wasconcentrated under reduced pressure and extracted with EtOAc. The organic layer was washed with waterand brine, dried with MgSO4 and concentrated in vacuo to obtain the corresponding tri-N-Boc-protectedamine intermediates. A solution of the intermediates was added to bis(pyridin-2-ylmethyl)amine (15.3 mg,77.0 mumol), KI (2.50 mg, 15.0 mumol) and K2CO3 (2.10 mg, 15.0 mumol) in CH3CN (5.00 mL) under N2 andstirred at 80 C for 24 h. The reaction mixture was concentrated under reduced pressure and extracted withEtOAc. The organic layer was washed with water and brine, dried with MgSO4 and concentrated in vacuoto obtain the corresponding tri-N-Boc-protected amine intermediates. The intermediates were thendissolved in CHCl3 (2.50 mL) and treated with 95% aqueous TFA (2.50 mL) at 0 C for 6 h. The mixturewas concentrated under reduced pressure and purified by preparative HPLC to obtain the desiredcompounds 4-5.

170161-27-0, 170161-27-0 Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate 10940041, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Article; Sakyiamah, Maxwell M.; Kobayakawa, Takuya; Fujino, Masayuki; Konno, Makoto; Narumi, Tetsuo; Tanaka, Tomohiro; Nomura, Wataru; Yamamoto, Naoki; Murakami, Tsutomu; Tamamura, Hirokazu; Bioorganic and Medicinal Chemistry; vol. 27; 6; (2019); p. 1130 – 1138;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

29841-69-8, (1S,2S)-(-)-1,2-Diphenylethylenediamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0.440 g (2.07 mmol) of (S,S)-DPEN (MW: 212.3) was introduced into a 100-mL three-necked flask and subjected to argon-gas replacement. 20 mL of dehydrated methylene chloride and 0.303 mL (2.17 mmol) of triethylamine were added and cooled to 0 C. To this solution, a solution consisting of 0.520 g (2.07 mmol) of 3′,5′-dimethoxyphenyl methanesulfonyl chloride (MW: 250.70) and 5 mL of dehydrated methylene chloride was slowly added dropwise, and stirred at 0 C. for 3 hr. This solution was washed twice with water, the solvent in the organic layer was distilled away, and dried under reduced pressure to give a crude product. The crude product was purified by silica-gel column chromatography (silica gel 60N, n-hexane:AcOEt=1:1, then AcOEt 100%) to give 0.51 g of (S,S)-(3′,5′-dimethoxyphenyl)methane-SO2DPEN (58% yield). 1H NMR (400 MHz, CDCl3, rt, delta/ppm): 3.59 (d, J=13.7 Hz, 1H, SO2C2C6H3), 3.64 (d, J=13.7 Hz, 1H, SO2C2C6H3), 3.71 (s, 6H, (OC3)2), 4.23 (d, J=6.4 Hz, 1H, CNH2), 4.59 (d, J=6.4 Hz, 1H, CNHSO2), 6.29 (d, J=2.3 Hz, 2H, C62H (OCH3)2), 6.36 (d, J=2.3 Hz, 1H, C6H2(OCH3)2), 7.18-7.40 (m, 10H, aromatic proton)., 29841-69-8

As the paragraph descriping shows that 29841-69-8 is playing an increasingly important role.

Reference£º
Patent; Kanto Kagaku Kabushiki Kaisha; US2010/261924; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13093-04-4,N1,N6-Dimethylhexane-1,6-diamine,as a common compound, the synthetic route is as follows.

EXAMPLE III N,N’-Dimethyl-N,N’-hexamethylene-bis[3-(N,N-dibenzyl aminoxy)propionamide] A solution of 6.4 g of 3-(N,N-dibenzylaminoxy) propanoic acid in 25 ml of methylene chloride is admixed with 1.8 ml of oxalyl chloride at 0-5 C. After 2 hours, a solution of 8.61 g N,N’-dimethyl hexamethylenediamine in 25 ml of methylene chloride is added at 0 C. and the reaction mixture is stirred at room temperature for 12 hours. The insoluble salt residue is removed by filtration and methylene chloride is removed under reduced pressure. Purification by liquid chromatography affords the title compound as a thick oil.

13093-04-4, As the paragraph descriping shows that 13093-04-4 is playing an increasingly important role.

Reference£º
Patent; Ciba-Geigy Corporation; US4760179; (1988); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4730-54-5,1,4,7-Triazacyclononane,as a common compound, the synthetic route is as follows.

5 mmol of 1,4,7-triazacyclononane (645 mg) and benzaldehyde (508 muL, 5 mmol) were stirred at room temperature in distilled ethanol (80 mL) containing molecular sieve for 4 h. The solution was filtered and evaporated under reduced pressure to yield the aminal product as a white solid (980 mg, 4.5 mmol, 90%). NMR (CDCl3) 1H (300 MHz) 2.89-2.93 (m, 4H,CH2tacn) 2.99-3.03 (m, 2H,CH2tacn) 3.07-3.17 (m, 4H,CH2tacn) 3.32-3.39 (m, 2H,CH2tacn) 5.66 (s, 1H, Haminal) 7.18 (t, 1H, HPhe) 7.29 (t, 2H, HPhe) 7.50 (2H, d, HPhe); 13C (75 MHz) 49.3 49.6 58.8 (CH2tacn) 88.3 (Caminal) 126.6, 126.7 128.2 (CHPhe) 145.8 (CPhe).

4730-54-5, 4730-54-5 1,4,7-Triazacyclononane 188318, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Article; Roger, Melissa; Patinec, Veronique; Tripier, Raphael; Triki, Smail; Poul, Nicolas Le; Mest, Yves Le; Inorganica Chimica Acta; vol. 417; (2014); p. 201 – 207;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62937-45-5,D-Prolinamide,as a common compound, the synthetic route is as follows.

62937-45-5, 4,6-dichloro-2-pyrimidinamine (656 mg, 4.00 mmol) and D-prolinamide (457 mg, 4 mmol) were dissolved in 10 mL of acetonitrile, diethylaminomethyl-polystyrene (3000 mg, 9.60 mmol) was added and the contents were heated in the microwave at 160 C for 1 hr. By LCMS, reaction seems to be complete (no SM). The contents were filtered to remove the polystyrene base, rinsed with acetonitrile and the mother liquor and washings rotovapped to dryness. The crude material was briefly triturated with diethyl ether, sonicated and decanted, and dried by vacuum to give the title compound (690 mg). LC-MS (ES) m/z = 242 [M+H]+.

As the paragraph descriping shows that 62937-45-5 is playing an increasingly important role.

Reference£º
Patent; GLAXOSMITHKLINE LLC; AXTEN, Jeffrey, Michael; BRADY, Gerald, Patrick, Jr.; GALLAGHER, Timothy, Francis; HEERDING, Dirk, A.; MEDINA, Jesus, Raul; ROMERIL, Stuart, Paul; WO2010/120854; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The complex was prepared by a general synthetic method in which a mixture of bphen (1 mmol) andcopper(II) nitrate trihydrate (1 mmol) in 20 mL methanol was added dropwise to an aqueous solution(10 mL) of leu (1 mmol) and KOH (1 mmol) with stirring for about 20 min. The resulting solution wasleft to evaporate slowly at room temperature. After 6 days, dark green crystals were obtained. Yieldwas 83%. Anal. Calcd for C30H30CuN4O6 (606.12 g mol-1) (%): C, 59.45; H, 4.99; N, 9.24. Found: C, 59.37;H, 4.89; N, 9.18.

1662-01-7, As the paragraph descriping shows that 1662-01-7 is playing an increasingly important role.

Reference£º
Article; Inci, Duygu; Aydin, Rahmiye; Zorlu, Yunus; Journal of Coordination Chemistry; vol. 69; 18; (2016); p. 2677 – 2696;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI