Day: September 25, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1662-01-7,4,7-Diphenyl-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

(Cmpd 11): 4,7-Diphenyl-2-(2-pyridyl)-1,10-phenanthroline. n-Butyllithium (18.8 ml of a 1.6 M solution in hexane, 0.03 mol) is added under argon to a cold (-78C) tetrahydrofurane (100 ml). 2-Bromopyridine (4.75 g, 0.03 mol) is then added during 15 minutes while keeping the temperature at -78 C. The brown solution is stirred 50 minutes at -78C, thereafter finely powdered 4,7-diphenyl-1,10-phenanthroline (6.64g, 0.02 mol) is added and the mixture is allowed to warm to room temperature during 2 h. Methanol (20 ml) is then added and the brown solution is evaporated on a rotary evaporator. The residue is dissolved in dichloromethane (300 ml) and methanol (10 ml), manganese dioxide (30 g) is added and the mixture is stirred at room temperature 12 h. The solids are removed by filtration, the filtrate is evaporated and the residue is chromatographed on silica gel with dichloromethane-2-propanol (9:1). The pure fractions are crystallized from dichloromethane-ethanol to afford 2.12 g of the title compound. Light yellow, microcrystalline powder, mp (DSC in air, scan rate 10Cmin-1) = 227.8-233.7C. 1H-NMR (300 MHz, CD3Cl): 9.32 (d, J=4.8 Hz, 1H), 9.07 (d, J=7.8 Hz, 1H), 8.80 (s, 1H), 8.73 (d, J=6.3 Hz, 1H), 7.99-7.85 (m, 3H), 7.63-7.36 (m, 12H). MS for C29H19N3 (409.49) found M=409.69., 1662-01-7

As the paragraph descriping shows that 1662-01-7 is playing an increasingly important role.

Reference£º
Patent; BASF SE; EP2161272; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787-70-2,[1,1′-Biphenyl]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.

787-70-2, Into a vessel was placed about 10 ml of dimethyl formamide (Fisher, 99%) which contained about 0.1 millimole of 4,4′ bipyridine under ambient atmospheric conditions. Into this, with stirring at ambient temperature (about 25 C.), was added about 0.3 millimoles of the zinc precursor polymer. Stirring was continued until the mixture was homogeneous, (about 10 minutes). The mixture was transferred in air to a Parr acid digestion bomb which was then sealed. The mixture was heated to 150 C. and held at that temperature for 3 days, yielding crystals of the zinc polymeric compound in about 94% yield based on the weight of the zinc precursor polymer compound. [0113] Synthesis of the Zinc Precursor Polymer [0114] The zinc precursor polymer compound used in the synthesis of the zinc polymeric compound of Example 3 was itself synthesized according to the following procedure. At room temperature (about 25 C.), into a vessel containing about 5.5 mL of a 0.01 molar bis-sodium biphenyl-4,4′-dicarboxylate aqueous solution (about 0.55 millimoles of the dicarboxylate, prepared as described below) was placed about 10 mL of a 0.1 molar aqueous Zn(NO3)2 solution (about 1.0 millimoles of zinc nitrate hexahydrate (Fisher) dissolved in 10 ml of deionized water). This immediately precipitated a mass of the zinc polymer precursor compound (stiochiometric formula [Zn(bpdc)(H2O)2].(H2O)], where ?bpdc? is biphenyl-4,4′-dicarboxylate). The precipitate was washed with distilled water and used as prepared. Yield was about 90% based on starting zinc nitrate. [0115] Bis-sodium-biphenyl-4,4′-dicarboxylate solution was prepared as described above in the preparation of the first cobalt precursor polymer, as described above in Example 1.

As the paragraph descriping shows that 787-70-2 is playing an increasingly important role.

Reference£º
Patent; Li, Jing; Pan, Long; Huang, Xiaoying; US2004/110950; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3: Preparation of tetrabutylammonium salt of 4-{3-[(25,5/f)-6-(sulfooxy)-7-oxo-l,6-diaza- bicyclo[3.2.1]octane-2-carbonyl]-ureido}-piperidine-l-carboxylic acid tert-butyl ester: To a stirred solution of 4-{ 3-[(2S,5R)-(6-hydroxy-7-oxo-l,6-diaza-bicyclo[3.2.1]octane-2-carbonyl)-ureido] }- piperidine-l-carboxylic acid tert-butyl ester (0.41 g, 0.0009 mol) in dimethylformamide (4.1 ml), at 10C, was added dimethylformamide sulfur trioxide complex (0.183 g, 0.0019 mol) in one portion. The reaction mass was stirred at the same temperature for about 30 minutes and then allowed to warm to room temperature. After 1 hour, to the resulting reaction mixture was added slowly a solution of tetrabutylammonium acetate (0.359 g, 0.0019 mol) in dichloromethane (2 ml) under stirring. After 1 hour, the solvent from the reaction mixture was evaporated under reduced pressure to yield an oily residue. The oily mass was co-evaporated with xylene (2x10ml) to obtain a thick mass. This mass was partitioned between dichloromethane (10 ml) and water (10 ml). The combined organic extracts were washed with water (3xl0ml) and dried over anhydrous sodium sulphate.The solvent was evaporated under reduced pressure and the resulting oily mass was triturated with ether (3×10 ml), each time the ether layer was decanted and finally the residue was concentrated under reduced pressure to obtain 0.260 g of the titled product as white foam in 35% yield.Analysis:Mass: 490.4 (M-l) as free acid; for Molecular Weight: 732.9, Molecular Formula: C34H64N6O9S .

10534-59-5, As the paragraph descriping shows that 10534-59-5 is playing an increasingly important role.

Reference£º
Patent; WOCKHARDT LIMITED; TADIPARTHI, Ravikumar; PATIL, Vijaykumar Jagdishwar; KALE, Amol; SHAIKH, Mohammad Usman; PATEL, Mahesh Vithalbhai; (65 pag.)WO2016/116788; (2016); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2390-68-3,N-Decyl-N,N-dimethyldecan-1-aminium bromide,as a common compound, the synthetic route is as follows.

Didecyldimethylammonium bromide (0.003 mol) was dissolved in 100 mL of distilled water by gentle heating and stirring. Fast Green FCF (0.001 mol) was dissolved in 60 mL of distilled water by gentle heating and stirring. The two solutions were combined and the reaction mixture was heated and stirred for 30 minutes. The reaction mixture cooled to room temperature and then 60 mL of chloroform was added. The reaction mixture was stirred for an additional 30 minutes. The two phases were separated and the chloroform phase was washed several times with cool distilled water to remove any inorganic salt. The presence of chloride anions was monitored by silver nitrate test. A rotary evaporator removed the chloroform and a dark blue liquid was obtained in 65.54% yield. Melting point (hot plate apparatus)=liquid at room temperature. Thermal data determined by thermalgravimetric analysis (TGA): Tonset5%=194 C. and Tonset=200 C.

2390-68-3, The synthetic route of 2390-68-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Rogers, Robin D.; Daly, Daniel T.; Swatloski, Richard P.; Hough, Whitney L.; Davis, James Hilliard; Smiglak, Marcin; Pernak, Juliusz; Spear, Scott K.; US2007/93462; (2007); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

2304-30-5, Tetrabutylphosphonium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

200 g (0.68 mol) of tetra-n-butylphosphonium chloride,In an aqueous solution containing 80% of potassium formate was added 84 g (1.00 mol)Was added to the solution.In this state, since two phases were separated, water was added to make a homogeneous solution.This solution was concentrated under reduced pressure at 100 C.,Crystals of potassium chloride precipitated.The crystals were hot-filtered, and the filtrate containing the ionic liquid was recovered.The filtrate was dried under reduced pressure with an oil rotary pump to recover the regenerated ionic liquid.When this ionic liquid was analyzed by the Mohr method, the chloride ion concentration was 0.37 mol / kg.That is, it was found that 89% of the chloride ion in the model degraded ionic liquid was removed and replaced with formate ion.

2304-30-5, 2304-30-5 Tetrabutylphosphonium chloride 75311, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; The Doshisha; Yasaka, Yoshiro; (11 pag.)JP2015/113335; (2015); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

13104-56-8, 4′-(4-Methoxyphenyl)-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[Mn(nme2phtpy)2](ClO4)2*2CH3CN (4) was prepared in the following way: two drops of a 50% aqueous solution of Mn(NO3)2 (ca. 0.24 mmol), nme2phtpy (0.23 mmol, 0.081 g), and NaClO4 (0.48 mmol, 0.067 g) were dissolved in 30 ml of CH3CN. Then a few drops of water were added until the solution became clear. A crop of brown crystals was obtained in two weeks.

13104-56-8, 13104-56-8 4′-(4-Methoxyphenyl)-2,2′:6′,2”-terpyridine 630929, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Fu; Shu; Luo; Tang; Li; Liu; Cheng; Wang; Liu; Journal of Structural Chemistry; vol. 59; 2; (2018); p. 398 – 410; Zh. Strukt. Khim.; vol. 59; 2; (2018); p. 412 – 424,13;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103946-54-9,4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid,as a common compound, the synthetic route is as follows.

[(Cp*)Ir(mu-Cl)Cl]2 (39.8 mg, 0.05 mmol) was dissolved in methanol(20 mL) followed by addition of the 4-methyl-4?-carboxy-2,2?-bipyridine ligand (21.4 mg, 0.10 mmol). The mixture was stirred at313 K overnight. The final yellow solution was filtered, concentratedand NH4PF6 (163 mg, 1.0 mmol) was added to the solution. This solutionwas kept at 277 K overnight. The yellow precipitate was collectedby filtration and dried under vacuum. Yield 66 mg, 91%; 1H NMR(400 MHz, d4-MeOD, 298 K): delta 9.11 (d, 1H, J = 5.8 Hz), 9.00 (s, 1H),8.81 (d, 1H, J=5.8 Hz), 8.61 (s, 1H), 8.26 (d, 1H, J=5.8 Hz), 7.71 (d,1H, J = 6.1 Hz), 2.70 (s, 3H), 1.72 (s, 15H); 13C NMR (125 MHz, d4-MeOD, 298 K): 165.79, 158.15, 155.99, 155.08, 154.10, 152.47,143.72, 131.21, 129.19, 126.65, 124.58, 91.28, 21.39, 8.67; high resolutionESI-MS m/z calcd for [(M-PF6-H)+Na]+ 599.1040, found599.1038.

103946-54-9, As the paragraph descriping shows that 103946-54-9 is playing an increasingly important role.

Reference£º
Article; Zhang, Wen-Ying; Banerjee, Samya; Imberti, Cinzia; Clarkson, Guy J.; Wang, Qian; Zhong, Qian; Young, Lawrence S.; Romero-Canelon, Isolda; Zeng, Musheng; Habtemariam, Abraha; Sadler, Peter J.; Inorganica Chimica Acta; vol. 503; (2020);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2, Cinchonidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The phase-transfer catalysts (C1-C11) were synthesized according to the proceduresbelow. To a solution of cinchonidine (1.00 g, 3.4 mmol) in THF (50 mL) was addedthe aryl benzyl bromides (3.4 mmol). The mixture was heated for 6-8 h at reflux.After cooling to room temperature, the mixture was poured into MTBE (150 mL)under stirring. The precipitated solid was filtrated and recrystallized fromCH3OH/MTBE to afford C1-C11

485-71-2, 485-71-2 Cinchonidine 101744, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Li, Ruipeng; Liu, Zhenren; Chen, Liang; Pan, Jing; Zhou, Weicheng; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 1421 – 1427;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170161-27-0,Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate,as a common compound, the synthetic route is as follows.

500 mg of compound 19-3 and 1.3 g of compound 17-1 were dissolved in 20 mL of acetonitrile, and 680 mg of potassium carbonate was added thereto, and the mixture was heated to reflux overnight, cooled to room temperature, filtered, and the filtrate was concentrated and evaporated. Column chromatography (PE: EA = 20: 1-1: 1) to give a colorless waxy compound 19-4 510mg, Yield: 40.4%.

170161-27-0, The synthetic route of 170161-27-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shenzhen Xiaxiwan Pharmaceutical Technology Co., Ltd.; Qi Fei; Xia Junxia; Zhang Zaijun; Wang Liang; (27 pag.)CN109988153; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1662-01-7,4,7-Diphenyl-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 2-phenyl-3-hydroxy-4(1H)-quinolinone (237 mg, 1 mmol) in ethanol (50 mL), the corresponding bidentate N-donor ligand (L) (1 mmol) dispersed in EtOH (5 mL) was added while stirring. To this mixture, a solution of Cu(BF4)2¡¤H2O (237 mg, 1 mmol) in H2O (5 mL) was slowly added while stirring. The reaction mixture was stirred at room temperature for a few hours, and subsequently left to stand for several days at room temperature. The obtained solid product was filtered off, washed with a small amount of cold water and ethanol, and dried in the air at 40 C., 1662-01-7

The synthetic route of 1662-01-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Buchtik, Roman; Travnicek, Zdenek; Vanco, Jan; Journal of Inorganic Biochemistry; vol. 116; (2012); p. 163 – 171;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI