Month: September 2020

16011-97-5, N1,N4-Dimethylbutane-1,4-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1) Weigh 58g of hydroxyethyl acrylate in the three-necked flask, was added 50mL of methylene chloride, 90.9 g of triethylamine was added, the ice bath until the temperature drops 0 C, and after stabilization, dropwise addition of 62.7g of methacryloyl chloride, dropping control, completion of the dropwise within 120min, after completion of the dropwise addition, reaction was continued under ice-bath 3h, warmed to room temperature, the reaction was continued 24h; after completion of the reaction, stirring was stopped, the resulting solid salt was removed by filtration, and the filtrate was added to a separatory funnel, washed with deionized water 2-3 times, adding an appropriate amount of anhydrous sodium sulfate 24h, filtered, and the solvent methylene chloride was removed by rotary evaporation; (2) the reaction product weighed step (1) of 92 g, the ice bath was added dropwise N,N’-dimethyl-1,4-butanediamine 58g, addition was complete within 25min, warmed to 60 C, after the reaction 4h, 47.5g of methyl bromide was added dropwise to the reaction system, the reaction was continued 3H; (3) cooling to 40 C, deionized water was added to the reaction system to prepare a 40wt% aqueous solution.

16011-97-5, As the paragraph descriping shows that 16011-97-5 is playing an increasingly important role.

Reference£º
Patent; Anqing Bei Hua Da Science And Technology Yuan Co., Ltd.; Nie Jun; Li Sanbao; Zhu Xiaoqun; (7 pag.)CN109651296; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

13104-56-8, 4′-(4-Methoxyphenyl)-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Methanolic solution of CuCl2¡¤2H2O (1.5 mmol) was added to a methanolic solution of 4?-(3-chlorophenyl)-2,2?:6?,2?-terpyridine (L1) (1.5 mmol), followed by the addition of a previously prepared methanolic solution of sparfloxacin (1.5 mmol) in presence of CH3ONa (1.5 mmol). The pH of the reaction mixture was adjusted to ~6.8. The resulting solution was refluxed for 2 h. on a water bath, followed by concentrating to half of its volume. A fine, green amorphous product obtained was washed with ether/hexane and dried in a vacuum desiccator. The proposed reaction scheme for the synthesis of complex has been kept in the Supplementary Material.

13104-56-8, As the paragraph descriping shows that 13104-56-8 is playing an increasingly important role.

Reference£º
Article; Patel, Mohan N.; Joshi, Hardik N.; Patel, Chintan R.; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 104; (2013); p. 48 – 55;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66127-01-3,3-Bromo-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

66127-01-3, Synthesis of 3-(2-ferrocenylethynyl)-1,10-phenanthroline (L2): A mixture of 3-bromo-1,10-phenanthroline (120 mg, 0.46 mmol), ethynylferrocene (80 mg, 0.38 mmol), (PPh3)2PdCl2 (10 mg), CuI (8 mg) and Et3N (1 mL) in benzene (30 mL) and methanol (5 mL) was heated to reflux for 12 h under nitrogen atmosphere. Then the solvent was evaporated under reduced pressure, the residue was purified by column chromatography on silica, being eluted with CHCl3 to afford the desired product as an orange solid. Yield: 98 mg (66 %). 1H NMR (400 MHz, CDCl3): delta = 4.31 (s, 5H), 4.33 (s, 2H), 4.60 (s, 2H), 7.67 (t, J = 11.4 Hz, 1H), 7.69-7.86 (m, 2H), 8.26 (d, J = 6.8 Hz, 1H), 8.34 (s, 1H), 9.22 (d, J = 11.2 Hz,2H). ESI-HRMS: m/z 388.0657 (M+).

The synthetic route of 66127-01-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ren, Mingli; Cheng, Feixiang; Asian Journal of Chemistry; vol. 27; 7; (2015); p. 2555 – 2558;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7173-51-5,N-Decyl-N,N-dimethyldecan-1-aminium chloride,as a common compound, the synthetic route is as follows.

7173-51-5, EXAMPLE 3 Preparation of 2,6-dinitro-3,4-dimethyl anisole A solution of 226 g 2,6-dinitro-3,4-xylenol, 93.7%. (1 mole) in two liters 1,2-dichloroethane was placed in a three liter reaction flask. Sodium carbonate 128 g (1.2 moles) and 0.81 g Didecyldimethyl-ammonium chloride (DDAC) were added to the above solution and afterwards 151.3 (1.2 moles) of dimethylsulfate were introduced during 15 minutes at the ambient temperature. The reaction mixture was heated with stirring to reflux during two hours. Water (400 ml) was added and heating was continued for another hour. This mixture was cooled to 25 C. and allowed to separate in two phases. The lower organic phase was separated, washed with water to neutral. The solvent was next recovered by distillation and the remaining oily produce solidified by cooling. A product (225.8 g) of 94%. 2,6-dinitro-3,4-dimethylanisole was obtained at a 93.9% of the theoretical yield based on 2,6-dinitro-3,4-xylenol consumed.

As the paragraph descriping shows that 7173-51-5 is playing an increasingly important role.

Reference£º
Patent; Agan Chemical Manufacturers Ltd.; US5475148; (1995); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103946-54-9,4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid,as a common compound, the synthetic route is as follows.

As shown in Figure 1, 4′-methyl-[2,2’dipyridyl]-4-carboxylic acid (0.3 g, 1.4 mmol) (purchased from Zhengzhou Alpha) and N-hydroxysuccinimide (NHS, 0.257 g, 2.24 mmol) were used and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC, 0.322 g, 1.68 mmol) was dispersed in a 15 mL DMF (N,N-dimethylformamide) port flask , Heat to 50 C, reaction for 12h. After the reaction was completed, the DMF solution was decontaminated under reduced pressure. Deionized water (50 mL) was added and solids precipitated.Dichloromethane extraction (15 mL, extraction 3 times) takes a light yellow organic layer. Then dry with anhydrous sodium sulfate.Take the filtrate, take the filtrate, and evaporate the filtrate with a rotary evaporator.A pale white solid is obtained, which is the active ester of dipyridylcarboxyl: 2,5-dicarbonyl-1-pyrrolidinyl 4′-methyl-[2,2′-bipyridine]-4-carboxylate (product 1), yield 65.2%., 103946-54-9

103946-54-9 4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid 11127621, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Jinan University; Guangzhou Medicine Jianyansuo; Chen Tianfeng; Tian Yiqiao; Du Biying; Huang Yanyu; Gao Pan; (22 pag.)CN107573384; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2, Cinchonidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Hydroxyphenylacetic acid(40 mg, 0.263 mmol) and cinchonidine (77.4 mg, 0.263 mmol) were both dissolved in ethyl methyl ketone. Crystals were obtained afterone week.

485-71-2, 485-71-2 Cinchonidine 101744, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Amombo Noa, Francoise M.; Jacobs, Ayesha; Journal of Molecular Structure; vol. 1114; (2016); p. 30 – 37;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16011-97-5,N1,N4-Dimethylbutane-1,4-diamine,as a common compound, the synthetic route is as follows.

A mixture of 2-chloro-3-nitropyridin-4-amine (LXXXIII) (1.0 g, 5.76 mmol) and DIPEA (1.0 mL, 5.76 mmol) in THF (20 mL) was stirred at room temperature for 1 h. The reaction was concentrated to dryness and the residue was taken up in EtOAc and the organic layer was washed with 2 x water then 1 x brine solution. The organic layers were then separated and dried (MgSO4) before concentration to dryness to obtain N2-methyl-N2-(4- (methylamino)butyl)-3-nitropyridine-2,4-diamine (LXXXIV) (160 mg, 6.32 mmol, 109.6% yield) as dark brown gum which was used for next step without purification. ESIMS found for C11H19N5O2 m/z 254.1 (M+H).

16011-97-5, The synthetic route of 16011-97-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SAMUMED, LLC; KC, Sunil Kumar; MITTAPALLI, Gopi Kumar; CHIRUTA, Chandramouli; HOFILENA, Brian Joseph; (128 pag.)WO2019/241540; (2019); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

103946-54-9, 4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Bis-2,2′-bipyridine ruthenium dichloride (55 mg, 0.11 mmol) Methyl-2,2′-bipyridine-4-carboxylic acid (21 mg, 0.11 mmol) were protected from light in the presence of ethanol (10 mL, 50%) under argon for 5 hours. The reaction mixture was evaporated and the residue was dissolved in 1 mL CH3CN, Add 2 mL of saturated n-butylamine in acetone. The resulting precipitate was filtered, Washed with acetone, And vacuum dried, This gave 79 mg (85%) of Ru-CO2H as a red-orange powder. (Synthesis route shown in Figure 4)., 103946-54-9

103946-54-9 4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid 11127621, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Capital Medical University; Li, Minna; Peng, Shiqi; Zhao, Ming; (10 pag.)CN106146565; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

29841-69-8, (1S,2S)-(-)-1,2-Diphenylethylenediamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Chloro-propanoic acid (4.34 g, 0.04 mol) was dissolved in 5.0 mL of water on ice bath and carefully neutralized with cold water solution of 5.0 mL NaOH (1.60 g, 0.04 mol). Meso-1,2-diphenyl-ethylenediamine (4.24 g, 0.02 mol) was added to this solution. The mixture was being stirred for 4 h at 90 C, and during this period 5.0 mL NaOH water soltion (1.60 g, 0.04 mol) was introduced. After that, 5.6 mL 6 mol/L HCl was added and resulting solution was evaporated to the volume of 7.0 mL; 6.0 mL conc. HCl, 6.0 mL of ethanol and 6.0 mL of ether were added to the mixture. The white precipitate of meso-1,2-diphenyl-ethylenediamine-N,N’-di-3-propanoic acid dihydrochloride monohydrate, H2-1,2-dpheddp 2HCl H2O was separated by filtration and refined with solution water: ethanol = 1: 2. Yield: 4.00 g (44.69%). Anal. Calcd. for H2-1,2-dpheddp*2HCl*H2O = C20H28Cl2N2O5 (Mr = 447.344): C, 53.69; H, 6.31; N, 6.26. Found: C, 53.88; H, 6.70; N, 6.08.

29841-69-8, 29841-69-8 (1S,2S)-(-)-1,2-Diphenylethylenediamine 6931238, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Radi?, Gordana P.; Glodovi?, Verica V.; Ratkovi?, Zoran R.; Novakovi?, Sladana B.; Garcia-Granda, Santiago; Roces, Laura; Menendez-Taboada, Laura; Radojevi?, Ivana D.; Stefanovi?, Olgica D.; ?omi?, Ljiljana R.; Trifunovi?, Sre?ko R.; Journal of Molecular Structure; vol. 1029; (2012); p. 180 – 186;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

168646-54-6, 5,6-Diamino-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: [Cu(CH3CN)4]ClO4 (32.6 mg, 0.100 mmol) was added to adichloromethane (DCM) solution (about 12 mL) of dap (21.4 mg,98percent, 0.100 mmol) and xantphos (59.0 mg, 98percent, 0.100 mmol) undera stream of dry argon by using Schlenk techniques at room temperatureand a vacuum-line system, then orange-red solutionwas obtained quickly and stirred for 1 h at room temperature.The above process can also be carried out in air with the existenceof oxygen. After filtration through absorbent cotton, layeringn-hexane onto the filtrate in air produced the product as orangeredcrystals in 35?44percent yield (39.1?49.3 mg).

168646-54-6, 168646-54-6 5,6-Diamino-1,10-phenanthroline 10910805, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Yao, Xi-Xi; Guo, Ya-Meng; Liu, Rong; Feng, Xiao-Yan; Li, Hao-Huai; Liu, Nian; Yang, Feng-Lei; Li, Xiu-Ling; Polyhedron; vol. 92; (2015); p. 84 – 92;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI