Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29841-69-8,(1S,2S)-(-)-1,2-Diphenylethylenediamine,as a common compound, the synthetic route is as follows.

A solution of sulfonyl chloride B (10 mmol) in dichloromethane (25 mL) was slowlyadded to a stirred solution of diamine A (10 mmol), NEt3 (11 mmol) in dichloromethane(25 mL). The resulting mixture was stirred for another 3 hr, washed twice with water (25mL) and dried over Na2SO4. The solvent was removed in vacuo to give a white solid C. Toa solution of D in CH2Cl2 (40 mL) was added NEt3 (11 mmol), isobutyl carbonochloridate(11 mmol) at 0 oC under stirring. After 10 min, C was added. The reaction was allowed towarm to room temperature for another 3 hr. The mixture was washed with 1 M KHSO4solution, saturated NaHCO3 solution, and brine, dried over anhydrous Na2SO4 andconcentrated to get a white solid E. Then, TFA (10 mL) was added to the CH2Cl2 (10 mL)solution of E, and stirred until the reaction finished (1 hr). The pH value of the mixture wasbrought into the range of 10-12 by the addition of 2 N NaOH solution. The aqueousphase was extracted with CH2Cl2 (3 ¡Á 30 mL). The combined organic phase was washedwith brine, dried over anhydrous Na2SO4, and concentrated and purified through flashchromatograph as a white solid F (70% yield).

29841-69-8, The synthetic route of 29841-69-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Tang, Yu; Xu, Jian; Yang, Jian; Lin, Lili; Feng, Xiaoming; Liu, Xiaohua; Chem; vol. 4; 7; (2018); p. 1658 – 1672;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4730-54-5, 1,4,7-Triazacyclononane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4730-54-5

Amixture of 17 (0.448 g, 2.24 mmol), potassium carbonate (0.41 g,3.0 mmol) and TACN (0.095 g, 0.74 mmol) in acetonitrile (20 mL) wasrefluxed overnight. The mixture was then added to water (50 mL) beforeextraction with dichloromethane (3 ¡Á 50 mL). The organic extractswere washed with brine (50 mL) before being dried with magnesiumsulfate and the solvent removed in vacuo to yield a dark orange highlyviscous liquid (0.431 g, 93%). deltaH (400 MHz; CDCl3; Me4Si) 2.87 (12H,s) 3.72 (6H, s) 4.79 (6H, d, J 6.4 Hz) 5.38 (6H, m) 6.05 (3H, m) 6.15(3H, dd, J 1.4, 6.9 Hz) 6.56 (3H, dd, J 1.4, 9.2 Hz) 7.24 (3H, dd, J 6.9,9.2 Hz); deltaC (100 MHz) 55.9, 57.1, 76.7, 104.8, 120.4, 122.1, 130.5,137.9, 147.7, 159.7; (+)-ESI-MS:m/z 619.05 (M+H+); NESI: requires;m/z 619.3244, found; 619.3243 (M + H+).

4730-54-5 1,4,7-Triazacyclononane 188318, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Workman, David G.; Hunter, Michael; Dover, Lynn G.; Tetard, David; Journal of Inorganic Biochemistry; vol. 160; (2016); p. 49 – 58;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

156492-30-7, 4,7-Dibromo-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compound 73d (5.1 g, 15.0 mmol),Phenoxazine (5.8 g, 32 mmol)Tert-butylphosphine (0.35 g, 2 mmol),Palladium acetate (0.4 g, 1.8 mmol) and cesium carbonate (19.5 g, 60 mmol) were dissolved in toluene,Under a nitrogen atmosphere,The reaction was heated under reflux for 10 hours.The solvent was evaporated in vacuo,The remaining material was stirred with pentane,filter,Purification by silica gel column chromatography,To obtain solid compound 5, (5.31 g, 9.8 mmol)Yield 65%.

156492-30-7, 156492-30-7 4,7-Dibromo-1,10-phenanthroline 11393583, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Shanghai Tianma Organic Shine Display Co., Ltd.; Tianmawei Electronic Co., Ltd.; Wang Xiangcheng; Liu Ying; Ren Hongyang; He Wei; Liu Chen; (43 pag.)CN106831743; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1662-01-7,4,7-Diphenyl-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: The corresponding ligand (1mmol) was added to a MeCN solution (40mL) of the corresponding metal pivalate (1mmol). The resulting mixture was stirred at t=60C for 2h, filtered off, and slowly cooled to room temperature. The solution was kept at room temperature, and crystals precipitated for 6-48h. In some cases, single crystals suitable for X-ray diffraction studies were obtained after recrystallisation from MeCN (slow evaporation under reduced pressure).

1662-01-7, 1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Nikolaevskii, Stanislav A.; Evstifeev, Igor S.; Kiskin, Mikhail A.; Starikova, Alyona A.; Goloveshkin, Alexander S.; Novikov, Valentin V.; Gogoleva, Natalya V.; Sidorov, Alexey A.; Eremenko, Igor L.; Polyhedron; vol. 152; (2018); p. 61 – 72;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

2304-30-5, Tetrabutylphosphonium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The same procedure described above for the preparation of [nBu4P][PtBr3(C2H4)] was adopted, except for the use of PtCl2 (100.2 mg, 0.38 mmol) and nBu4PCl (102.4 mg, 0.38 mmol), with the addition of 10 mL of dry toluene. Yield: 148.4 mg, 66%. 1H NMR (CDCl3): delta 4.48 (s + d, JPt-H = 64.3 Hz, 4H, C2H4), 2.30 (m, 8H, br, PCH2), 1.60 (m, 4, br, CH2CH2), 1.05 (m, 3, br, CH3). 31P{1H} NMR: delta 33.14. 195Pt NMR: delta -2743(quint 2JPt-H = 64 Hz). Anal. % Calcd. for C18H40Cl3PPt (M = 588.930): C, 36.71; H, 6.85. Found: 37.2; H, 6.9., 2304-30-5

As the paragraph descriping shows that 2304-30-5 is playing an increasingly important role.

Reference£º
Conference Paper; Bethegnies, Aurelien; Poli, Rinaldo; Journal of Organometallic Chemistry; vol. 730; (2013); p. 165 – 167;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76089-77-5,Cerium(III) trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.

76089-77-5, Example 4The above-described ligand represented by formula (B-10) (50 mg, 0.066 mmol) and cerium trifluoromethanesulfonate (35 mg, 0.060 mmol) were charged into a flask. Then, ethanol (4 mL) was added thereto and dissolved. The mixed solution was stirred for 2.5 hours at room temperature, and then the stirring was stopped. About 4 mL of diethyl ether was added, and the resultant mixture was left to stand overnight. After that, the produced solid was collected to obtain the above-described metal complex represented by composition formula (C-10) (hereinafter, ?metal complex (C-10)?). The collected amount was 51 mg (yield 63%).Elemental analysis: Found (%) C, 44.27; H, 4.39; N, 10.30; S, 7.33. Calcd for C50H58CeF9N10O9S3 (%) C, 44.47; H, 4.33; N, 10.37; S, 7.12.The metal complex (C-10) emitted a blue color in a solid powder state and in a solution state (acetonitrile) under ultraviolet excitation (365 nm).The emission spectrum in acetonitrile had a peak at 421 nm, the emission quantum yield was 21%, and the excitation life was 73.8 ns.

76089-77-5 Cerium(III) trifluoromethanesulfonate 2733941, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; US2012/211706; (2012); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1067-33-0, Dibutyltin diacetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 7; 306 g of a residual liquid were obtained by carrying out the same method as Example 6 with the exception of using 255 g of di-n-butyl tin diacetate, and using 961 g of 3-methyl-1-butanol (Tokyo Chemical Industry Co., Ltd., Japan) instead of 2-ethyl-1-butanol. The residual liquid contained 92.7% by weight of di-n-butyl-bis(3-methylbutyloxy) tin. In addition, the low boiling point component contained 18.0% by weight of isoamyl acetate.

1067-33-0, 1067-33-0 Dibutyltin diacetate 16682740, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Shinohata, Masaaki; Miyake, Nobuhisa; US2010/292496; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.168646-54-6,5,6-Diamino-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

1) Under a nitrogen atmosphere,4,4′-dimethyldiphenylamine (1.97 g, 10 mmol)CuI (28.5 mg, 0.15 mmol),1,10-phenanthroline (54 mg, 0.3 mmol)Potassium hydroxide (1.12 g, 15 mmol),2-iodo-dithiophene (3.16 g, 12 mmol),Water (7 mL) and xylene (20 mL)The reaction was carried out at 130 ¡ã C for 24 hours,The reaction mixture was poured into methylene chloride (100 mL), washed with water, and the organic phase was collected and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was passed through a silica gel column. The mobile phase was a 1: 3 by volume mixture of dichloromethane and petroleum ether to give intermediate P3;2)The intermediate P3 (3.35 g, 10 mmol) was dissolved in dry dichloromethane (50 mL)Anhydrous aluminum trichloride (1.6 g, 12 mmol) was added portionwise at 0 ¡ã C,After stirring for 20 minutes,A solution of oxalyl chloride (5 mmol) in dichloromethane (10 mL) was slowly added dropwise,Drop finished, rose to room temperature to continue stirring 6 hours, the reaction completed,A 10percent aqueous hydrochloric acid solution (10 mL) was added dropwise to the reaction solution,The organic phases were collected, washed with saturated sodium bicarbonate solution and water, dried over anhydrous sodium sulfate,The solvent was distilled off under reduced pressure,The residue was passed through a silica gel column and the mobile phase was a 1: 1 by volume mixture of dichloromethane and petroleum ether to give intermediate P4;3) 5,6-diamino-1, 10-phenanthroline A (2.10 g, 10 mmol)Intermediate P4 (10 mmol) and glacial acetic acid (40 mL) were refluxed at 120 & lt; 0 & gt; C for 24 hours,Down to room temperature,The solvent was distilled off under reduced pressure,The residue was extracted with chloroform,Washed with 10percent sodium bicarbonate solution and saturated brine, respectively,Dried over anhydrous sodium sulfate.The solvent was distilled off under reduced pressure, the residue was passed through a silica gel column,The mobile phase is a 1: 1 by volume mixture of methylene chloride and ethyl acetate,The organic photosensitive dye D2, the yield of 56percent

168646-54-6, As the paragraph descriping shows that 168646-54-6 is playing an increasingly important role.

Reference£º
Patent; China Academy of Sciences Huaxue Academe; Zhang, Lipeng; Fan, Xinheng; Chen, Qiang; Jiang, Kejian; Yang, Lianming; (14 pag.)CN104672237; (2017); B;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1435-55-8, Hydroquinidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

From dihydroquinidine To a 0 C. solution of 1.22g dihydroquinidine (0.0037 mol) in 30mL of CH2 Cl2 was added 0.78mL of Et3 N (0.0056 mol; 1.5 eq), followed by 0.71mL of p-chlorobenzoyl chloride (0.005 mol; 2 eq) in 1mL CH2 Cl2 After stirring 30 minutes at 0 C. and 1 hour at room temperature, the reaction was quenched by the addition of 10% Na2 CO3 (20mL). After separation, the aqueous layer was extracted with three 10mL portions of CH2 Cl2. The combined organic layers were dried over Na2 S04 and the solvent removed under vacuum. The crude product was purified as described above. Dihydroquinidine p-chlorobenzoate (1) was obtained in 91% yield (1.5g) as a white foam.

1435-55-8, 1435-55-8 Hydroquinidine 16401293, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Massachusetts Institute of Technology; US4965364; (1990); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

6813-38-3, [2,2′-Bipyridine]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6813-38-3, Take the product I obtained 2g and 10mL 98% H2SO4, 100mL CH3OH into the flask with a stirrer, reflux at 105 C overnight, the end of the reaction to a large amount of water appears white flocculent precipitate, slowly adding NaOH solution adjusted to pH 9.0 , With CH2C12 extract to retain the organic phase, anhydrous Na2S04 dry, evaporated to dry the solvent to obtain white crystals, the yield of 88%.

As the paragraph descriping shows that 6813-38-3 is playing an increasingly important role.

Reference£º
Patent; Nanjing University of Posts and Telecommunications; Zhao, Qiang; Huang, Wei; Huang, Tianci; Liu, Shujuan; Xu, Wenjuan; Zhu, Yana; (10 pag.)CN106188151; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI