Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4730-54-5,1,4,7-Triazacyclononane,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 1,4,7-triazacyclononane (2 mmol) in distilled ethanol (50 mL) containing molecular sieve was added 1 equiv of aldehyde. The reaction mixture was stirred at room temperature. The solution was filtered and the filtrate was evaporated under reduced pressure to yield the aminal adduct., 4730-54-5

As the paragraph descriping shows that 4730-54-5 is playing an increasingly important role.

Reference£º
Article; Roger, Melissa; Patinec, Veronique; Bourgeois, Martine; Tripier, Raphael; Triki, Smail; Handel, Henri; Tetrahedron; vol. 68; 27-28; (2012); p. 5637 – 5643;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

66127-01-3,66127-01-3, 3-Bromo-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Compound 1: A mixture of 2-Br-phen (0.80 g, 3.10 mmol), 2-thiophenylboronic acid (0.42 g, 3.28 mmol), Pd(PPh3)4 (0.12 g, 0.10 mmol) and Cs2CO3 (3.03 g, 9.30 mmol) was dissolved in a mixture of dioxane (40 mL) and H2O (8 mL), placed into a degassed three-necked flask and refluxed under an argon atmosphere for 8 h. After the solution was cooled to room temperature, the solvent was removed under reduced pressure and the residue was dissolved in CHCl3 (50 mL), washed with excess water, and dried with anhydrous Na2SO4. The desired compound 1 was finally separated as light yellow solid by silica gel column chromatography using CHCl3/petroleum ether (v:v 5:1) as the eluent in a yield of 0.71 g (87%). Similarly, compounds 3 and L1 were obtained via the same synthetic method in the yields of 42 and 77%, respectively. Compound 3: 1H NMR (300 MHz, CDCl3) delta: 9.45 (d, 1H, J=2.3 Hz, phen), 9.20 (dd, 1H, J=4.4, 1.7 Hz, phen), 8.35 (d, 1H, J=2.3 Hz, phen), 8.25 (dd, 1H, J=8.1, 1.7 Hz, phen), 7.79 (s, 2H, phen), 7.64-7.57 (m, 2H, phenthienyl), 7.45 (dd, 1H, J=5.1, 1.1 Hz, thienyl), 7.20-7.18 (m, 1H, thienyl).

The synthetic route of 66127-01-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Peng, Yu-Xin; Xu, Dan; Wang, Na; Tao, Tao; Hu, Bin; Huang, Wei; Tetrahedron; vol. 72; 24; (2016); p. 3443 – 3453;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

54258-41-2,54258-41-2, 1,10-Phenanthrolin-5-amine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Both compounds were synthesized in the same way. A mixture ofthe appropriate aldehyde [thiophene-2,5-dicarbaldehyde (283 mg,2.02 mmol), furan-2,5-dicarbaldehyde (316 mg, 2.55 mmol)] and5-amino-1,10-phenanthroline [(1091 mg, 5.59 mmol) withthiophene-2,5-dicarbaldehyde, (1458 mg, 7.48 mmol) with furan-2,5-dicarbaldehyde] was refluxed in EtOH (50 mL) containing acatalytic amount of acetic acid for 12 h, giving a suspension. Thereaction mixture was filtered hot, and the solid was washed withEtOH to afford the desired product as a yellow solid.

As the paragraph descriping shows that 54258-41-2 is playing an increasingly important role.

Reference£º
Article; Cheng, Feixiang; He, Chixian; Yu, Shiwen; Yin, Hongju; Inorganica Chimica Acta; vol. 462; (2017); p. 43 – 49;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4568-71-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4568-71-2,3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride,as a common compound, the synthetic route is as follows.

1-(3-Methoxy-4-hydroxyethoxy-5-iodophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanedione (compound 105) 3,4,5-Trimethoxyphenylvinylketone (4.8 g, 21.6 mmol), 3-methoxy-4-hydroxyethoxy-5-iodobenzaldehyde (5.7 g. 17.8 mmol), and 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride (1.9 g, 7.0 mmol) were stirred in triethylamine (20 mL) at 60¡ã C. for 16 hours. The reaction mixture was then acidified with 10percent HCl, and extracted with dichloromethane. The organic layer was dried over MgSO4, filtered and evaporated in vacuo. The product was purified in column chromatography (silica, 1:1 hexane/ethyl acetate) as a solid (9.7 g, 51percent). 1 H NMR (CDCl3) delta3.41 (m, 4H); 3.90 (m, 2H); 3.92 (s, 3H); 3.93 (s, 9H); 4.26 (t, 2H); 7.29 (s, 2H); 7.57 (d, 1H); 8.08 (d, 1H).

4568-71-2 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride 2833352, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Cytomed, Inc.; US5463083; (1995); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The syntheses of ligands were carried out by literature procedures [48-50]. To a suspensionof KOH in dry DMSO at 50 C, ethylene glycol and its respective polymer (n = 2, 3, or 4)in excess were added. After stirring for 30 min, 4?-chloro-2,2? : 6?,2??-terpyridine was addedand the reaction mixture was stirred for 20 h at this temperature. Upon cooling to roomtemperature, the reacting mixture was treated with deionised water and filtered. The crudeproduct was extracted from the filtrate in dichloromethane (3 ¡Á 30 mL), dried overanhydrous magnesium sulfate, and then the solvent was removed., 128143-89-5

As the paragraph descriping shows that 128143-89-5 is playing an increasingly important role.

Reference£º
Article; Shaira; Jaganyi; Journal of Coordination Chemistry; vol. 67; 17; (2014); p. 2843 – 2857;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

103946-54-9, 4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

87 mg of 4′-methyl- (2,2′-bipyridine) -4-carboxylic acid was dissolved in anhydrous THF and dissolved in anhydrous DMF. Under ice bath conditions, HOBt 55mg and DCC 100mg were completely dissolved and activated for 30min.The prepared HCl ¡¤ Arg (Tos) -Gly-Asp (OBzl) -Ser-OBzl 312 mg was added and the pH adjusted to 8.0-9.0 with DMM. The reaction was stirred at room temperature for 14h,The reaction was monitored by TLC plate. 328 mg (89% of product) of a pink solid powder was obtained., 103946-54-9

The synthetic route of 103946-54-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Capital University of Medical Sciences; Cui Chunying; Lin Na; (23 pag.)CN107320736; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

62937-45-5,62937-45-5, D-Prolinamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

D-Prolinamide (42.8 mg, 375 muiotaetaomicron) and N,N-diisopropylethylamine (65 mu, 380 mumol) were added to a solution of 2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5- dihydro-lH-l,2,4-triazol-l-yl}methyl)-lH-l,2,4-triazol-l-yl]benzoyl chloride (Example 58A, 79.1 mg, 150 muiotaetaomicron) in tetrahydrofuran (2.3 ml). This reaction mixture was stirred for 1 h at room temperature. The crude product was purified by preparative HPLC (Method 4). Lyophihsation of the product containing fractions afforded 53.9 mg (57 % of th.) of the title compound. LC-MS (Method 2): Rt = 1.53 min; MS (ESIpos): m/z = 605 [M+H]+ -NMR (400 MHz, DMSO-d6) delta [ppm]: -0.215 (1.05), -0.008 (3.93), 0.008 (3.02), 0.716 (3.19), 1.701 (2.80), 1.716 (2.72), 1.742 (2.33), 1.759 (3.07), 1.776 (3.57), 1.787 (3.15), 1.798 (2.94), 1.812 (1.93), 2.053 (1.59), 2.073 (1.94), 2.709 (0.57), 3.205 (1.74), 3.231 (1.37), 3.247 (2.09), 3.287 (4.72), 3.373 (0.82), 3.441 (1.05), 3.816 (1.83), 3.824 (1.18), 3.840 (2.10), 3.852 (2.94), 3.860 (1.87), 3.877 (2.98), 3.884 (2.00), 3.974 (4.06), 3.982 (4.47), 4.010 (2.84), 4.019 (2.68), 4.217 (1.80), 4.229 (1.82), 4.309 (2.20), 5.021 (1.30), 5.061 (14.55), 5.069 (10.76), 5.109 (1.19), 6.913 (3.15), 6.928 (5.00), 6.958 (4.94), 6.973 (4.86), 7.064 (3.77), 7.297 (2.31), 7.342 (3.89), 7.411 (1.12), 7.472 (1.37), 7.492 (2.44), 7.509 (1.27), 7.539 (1.39), 7.556 (3.82), 7.577 (3.93), 7.601 (12.46), 7.614 (6.91), 7.617 (8.60), 7.622 (16.00), 7.629 (8.66), 7.635 (11.09), 7.648 (3.33), 7.676 (3.24), 7.696 (2.26), 7.723 (5.02), 7.745 (10.67), 7.752 (12.89), 7.767 (6.68), 7.773 (9.27), 8.933 (10.76).

As the paragraph descriping shows that 62937-45-5 is playing an increasingly important role.

Reference£º
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; COLLIN-KROePELIN, Marie-Pierre; KOLKHOF, Peter; NEUBAUER, Thomas; FUeRSTNER, Chantal; POOK, Elisabeth; WITTWER, Matthias, Beat; LUSTIG, Klemens; TINEL, Hanna; LINDNER, Niels; SCHIRMER, Heiko; (449 pag.)WO2019/81307; (2019); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14162-94-8,4-Chloro-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

General procedure: For compound 1, a 1.0 mL aqueous solution of Ni(ClO4)2¡¤6H2O (0.005mmol) was placed at the bottom of a tube, a mixture of methanol and water (1:2, v/v, 3 mL)was gently layered on the top of the solution, and then a 1.0 mL methanol solutionof Bu4N[Fe(Tp*)(CN)3] (0.005 mmol) and 4-chlorine-2,2?-dibipyridine (0.01 mmol)was carefully added as the top layer. After few weeks, red block crystals were obtained,washed with water and air dried.

14162-94-8, The synthetic route of 14162-94-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jiao, Yu-Shu; Jiao, Cheng-Qi; Meng, Yin-Shan; Liu, Xue-Ru; Zhao, Liang; Liu, Tao; Inorganic Chemistry Communications; vol. 93; (2018); p. 87 – 91;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

18511-72-3, 4,4-dinitro-2,2-Bipyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The structural formula of the substituted bipyridine trivalent iron complex 4 described in this embodiment is as follows:Under an argon atmosphere, add anhydrous FeCl3 (64.9 mg, 0.4 mmol) to a 50 mL Schlenk bottle, and dissolve it in 6 mL of absolute ethanol at 60 C;A solution of 4,4′-dinitro-2,2′-bipyridine (98.5 mg, 0.4 mmol) in ethanol (4 mL) was added dropwise to the system. The reaction was carried out at 60 C for 1 hour.A brown complex was precipitated from the system, filtered, washed twice with cold ethanol, concentrated to remove the solvent, and dried under vacuum for 12 h to obtain a tan solid product 4, yield 67%.

18511-72-3, 18511-72-3 4,4-dinitro-2,2-Bipyridine 11519563, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Chinese Academy Of Sciences Tsingtao Biological Energies And Process Institute; Wang Qinggang; Zhu Guangqian; Wang Liang; Zhang Xianhui; Jing Chuyang; (14 pag.)CN110305169; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787-70-2,[1,1′-Biphenyl]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.

A mixture of H2L (28.6mg, 0.1mmol), Cd(NO3)2¡¤4H2O (30.8mg, 0.1mmol), H2BPDA (24.2mg, 0.1mmol) and NaOH (8.0mg, 0.2mmol) in 10mL of H2O was sealed in a 16mL Teflon lined stainless steel container and heated at 180C for 3d. After the reaction mixture was cooled to room temperature, block crystals of 1 were collected with a yield of 32% by filtration and washed with water several times. Anal. Calc. for C32H22N4O4Cd: C, 60.15; H, 3.47; N, 8.77. Found: C, 60.52; H, 3.52; N, 8.85%. IR (KBr pellet, cm-1, Fig. S8): 1590 (s), 1573 (s), 1547 (s), 1543 (s), 1402 (m), 1126 (m), 1001 (m), 951 (s), 879 (m), 854 (w), 821 (m), 780 (m), 710 (w), 682 (w), 644 (w)., 787-70-2

As the paragraph descriping shows that 787-70-2 is playing an increasingly important role.

Reference£º
Article; Chen, Kai; Kang, Yan-Shang; Luo, Li; Zhao, Yue; Wang, Peng; Liu, Qing; Lu, Yi; Sun, Wei-Yin; Polyhedron; vol. 79; (2014); p. 239 – 249;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI