Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17217-57-1,4,4′-Dimethoxy-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

General procedure: Dried RuCl3 (0.20 g, 0.96 mmol) was dissolvedin dipropylene glycol (10 mL) and deionized water (1 mL).The solution was refluxed until the metal salt was dissolved,obtaining a dark green solution. Bipyridine (0.469 g; 3.0 mmol) wasadded, resulting in a brown solution. Ascorbic acid (0.177 g,1.0 mmol) was then added and the solution refluxed for 20 min at250 C, the brown colour changing to red. After cooling, the solutionwas diluted to 40 mL and the pH adjusted to 8 by addition of afew drops of NaOH solution (2.5 M). NaBF4 (4.0 g, 36 mmol) wasadded and the solution cooled on ice. After vacuum filtration,washing with cold water, and drying, 0.329 g [Ru(bpy)3](BF4)2product was obtained., 17217-57-1

The synthetic route of 17217-57-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; van der Westhuizen, Deidre; von Eschwege, Karel G.; Conradie, Jeanet; Electrochimica Acta; vol. 320; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2, [1,1′-Biphenyl]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,787-70-2

Step-1 : Synthesis of bis(2,5-dioxopyrrolidin-l-yl) biphenyl-4,4′-dicarboxylate (3399) [1182] To a stirred solution of biphenyl-4,4′-dicarboxylic acid (500 mg, 2.06 mmol) in 10 mL of DMF was added N-hydroxysuccinimide (594 mg, 5.16 mmol) and (3400) dicyclohexylcarbodiimide (1.06 g, 5.16 mmol) at 0C and the mixture stirred at RT overnight. The reaction mixture was filtered and the filtered cake was washed with EtOAc. The washings and filtrate were combined, washed with brine solution (3×20 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford a crude product that was dissolved in DCM and again filtered. The DCM layer was concentrated under reduced pressure to afford desired product (600 mg).

As the paragraph descriping shows that 787-70-2 is playing an increasingly important role.

Reference£º
Patent; MEDIVATION TECHNOLOGIES, INC.; HUNG, David; CHAKRAVARTY, Sarvajit; RAI, Roopa; BERNALES, Sebastian; SATHE, Balaji Dashrath; URETA, Gonzalo; MCCULLAGH, Emma; WO2015/116707; (2015); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

75714-60-2, (S)-3,3′-Dibromo-2,2′-dimethoxy-1,1′-binaphthalene is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To magnesium turnings (583 mg, 24 mmol) activated with 1,2-dibromoethane in diethyl ether (4 ml), 2-bromo-1,3,5-triethylbenzene (3.86 g, 16 mmol) and diethylether (20 ml) were added alternately during 30 min. After complete addition the mixture was refluxed (oil bath heating) for 21 h. After cooling to ambient temperature, the solution was added to a mixture of (S)-3,3′-dibromo-2,2′-dimethoxy-1,1′-binaphthalene (4, 1.89 g, 4.0 mmol) and Ni(PPh3)2Cl2 (393 mg, 0.60 mmol) in anhydrous diethyl ether (40 ml). The reaction mixture was refluxed for 28 h, cooled to ambient temperature, carefully treated with saturated aqueous NH4Cl solution (40 ml) and water (40 ml), and extracted with CH2Cl2 (100 ml, 50 ml). The combined organic layers were dried (MgSO4), filtered, and the solvent removed under reduced pressure. The residue was purified by column chromatography on silica gel using 10-15% CH2Cl2/hexane as the eluent yielding the title compound as a colorless solid (1.22 g, 48%). 1H-NMR (400 MHz, CD2Cl2): delta 7.89 (d, J = 8.1 Hz, 2H), 7.74 (s, 2H), 7.44-7.40 (m, 2H), 7.32-7.25 (m, 4H), 7.06 (s, 2H), 7.05 (m, 2H), 3.10 (s, 6H), 2.70 (q, J = 7.6 Hz, 4H), 2.51 (q, J = 7.6 Hz, 4H), 2.46 (q, J = 7.6 Hz, 4H), 1.30 (t, J = 7.6 Hz, 6H), 1.15 (t, J = 7.6 Hz, 6H), 1.08 (t, J = 7.6 Hz, 6H); 13C-NMR (100 MHz, CD2Cl2): delta 155.0, 144.0, 142.9, 142.8, 134.9, 134.4, 134.2, 131.4, 130.8, 128.3, 126.4, 125.9, 125.4 (2C), 125.3, 125.0, 60.1, 29.1, 27.4, 27.3, 15.8, 15.6, 15.4; HRMS (ESI+) (m/z): [M+Na] calcd for C46H50O2Na, 657.3703; found, 657.3708., 75714-60-2

The synthetic route of 75714-60-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Studiengesellschaft Kohle mbH; Coric, Ilija; List, Benjamin; Vellalath, Sreekumar; EP2615098; (2013); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

144222-34-4, N-((1R,2R)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The catalyst could also be generated in situ by mixing 0.02 mol equiv of [RuCl2(f>-cymene)2] and 0.04 mol equiv of the (i?,/?)-N-Tosyl-l,2-diphenylethylene-l,2-diamine in DCM (dichloromethane) in the presence of 0.04 mol equiv of IM solution KOtBu in THF. After aging for 10 min at RT(room temperature), Et3N was added followed by HCO2H and a solution of the enone in DCM.

144222-34-4, As the paragraph descriping shows that 144222-34-4 is playing an increasingly important role.

Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2007/14454; (2007); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2, Cinchonidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: (Part 1) To a stirred solution of Cinchona alkaloid (either Quinine, Quinidine, Cinchonine or Cinchonidine) (1 equiv.) in THF (0.1 M) was added the required arylmethyl halide compound (1.2 equiv.) at room temperature. The reaction mixture was refluxed overnight, cooled to room temperature and all volatiles were removed invacuo. The residue was then dissolved in CH2Cl2 (typically 2 mL for 1 mmol of starting material) and the resulting solution was added dropwise onto Et2O (typically 30 mL for 1 mmol of starting material) with vigorous stirring. The resulting precipitate was then filtered, washed thoroughly with Et2O, and further dried under high vacuum for 2 hours, yielding the intermediate alcohol product in an excellent yield. (Part2) This product (1 equiv.) was dissolved in CH2Cl2 (0.2 M). Methyl iodide (3 equiv.) and an aqueous sodium hydroxide solution (50 %w, 5 equiv.) were successively added at room temperature. The reaction mixturewas stirred at room temperature for 4 h, before water (typically 20 mL for 1 mmol of starting material) was added to quench the reaction. The organic layer was separated and the aqueous layer was extracted with CH2Cl2. The combined organic extracts were dried over Na2SO4, and concentrated in vacuo (N.B: washing with brine is prohibited to avoid the I/Cl anion exchange). Purification by column chromatography on silica gel, eluting with MeOH/Acetone/CH2Cl2 (0:10:90 to 10:10:90), afforded the desired Cinchona alkaloid quaternary ammonium salt in a moderate to excellent yield.

485-71-2, As the paragraph descriping shows that 485-71-2 is playing an increasingly important role.

Reference£º
Article; Antien, Kevin; Viault, Guillaume; Pouysegu, Laurent; Peixoto, Philippe A.; Quideau, Stephane; Tetrahedron; vol. 73; 26; (2017); p. 3684 – 3690;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.168646-54-6,5,6-Diamino-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

In a 1000 ml three-vial bottle,Under nitrogen protection,Add 200 ml of anhydrous ethanol,200 ml of toluene,21 g (0.1 mol) of 1,10-phenanthroline-5,6-diamine, 10.6 g (0.1 mol) of benzaldehyde,1 ml glacial acetic acid,After the addition, the temperature was gradually raised to reflux for 6 hours.After cooling, the reaction solution was concentrated to dryness under reduced pressure.The resulting solid was recrystallized from a mixed solvent of chloroform and ethanol.27.1 g of 2-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline was obtained.Yield 91.55percent.

168646-54-6, 168646-54-6 5,6-Diamino-1,10-phenanthroline 10910805, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Li Xianwei; (29 pag.)CN107973811; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

13104-56-8, 4′-(4-Methoxyphenyl)-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Re(CO)5Cl (0.10 g, 0.27 mmol) and suitable Ln ligand (0.27 mmol) were dissolved in argon-saturated acetonitrile (20 mL). The resulting solution was placed in 25 mL teflon lined hydrothermal synthesis autoclave reactor and heated to 150 C. The reaction was stopped after 20 h and the autoclave was gradually cooled to room temperature for 30 h. The resulting yellow (1, 4, 7) or orange (2, 3, 5, 6, 8, 9) solid was collected by filtration, washed with diethyl ether and dried. X-ray quality orange (2 and 8) crystals were obtained by recrystallization from mixture of acetonitrile/methanol. To synthetize the complexes 1-9, standard procedure based on the heating under reflux of [Re(CO)5Cl] with molar equivalent of Ln ligand in argon-saturated acetonitrile also may be used. [ReCl(CO)3(L1)] (1): Yield: 75%. IR (KBr, cm-1): 2022(vs),1936(vs) and 1910(vs) nu(C^O); 1604(m) nu(C]N) and nu(C]C). 1HNMR (400 MHz, DMSO-d6) delta/ppm=9.11 (d, J=8.2 Hz, 1H, HC4),9.07-9.04 (m, 2H, HC1+B2), 8.79 (d, J=4.5 Hz, 1H, HA1), 8.39 (t,J=7.7 Hz, 1H, HC3), 8.22 (d, J=8.7 Hz, 2H, HD2), 8.15 (s, 1H, HB4),8.05 (t, J=8.0 Hz, 1H, HA3), 7.89 (d, J=7.6 Hz, 1H, HA4), 7.77 (t,J=6.2 Hz, 1H, HC2), 7.65-7.60 (m, 1H, HA2), 7.16 (d, J=8.6 Hz, 2H,HD3), 3.88 (s, 3H, HD5). 13C NMR (100 MHz, DMSO-d6): delta/ppm=198.25, 194.94, 191.50 (3CO), 162.18, 161.77, 158.39, 157.44,156.83, 153.13, 150.66, 149.67, 140.39, 137.37, 129.95, 127.85,127.18, 125.83, 125.59, 125.36, 123.86, 120.18, 115.29, 55.99. DSC: (Irun) Tm=308 C; (II run) Tg=246 C. C25H17N3O4ClRe(645.08 g mol-1): calcd C, 46.55; H, 2.66; N, 6.51; found: C, 46.18; H,2.80; N, 6.24.

13104-56-8, The synthetic route of 13104-56-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Klemens, Tomasz; ?witlicka, Anna; Machura, Barbara; Kula, S?awomir; Krompiec, Stanis?aw; ?aba, Katarzyna; Korzec, Mateusz; Siwy, Mariola; Janeczek, Henryk; Schab-Balcerzak, Ewa; Szalkowski, Marcin; Grzelak, Justyna; Ma?kowski, Sebastian; Dyes and Pigments; vol. 163; (2019); p. 86 – 101;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

137076-54-1, 2-(4,7,10-Tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(11) To a solution of tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (25.1 mg) in DMF (150 muL) and DIEA (30 muL), a solution of HBTU (16.7 mg) in DMF (150 muL) was added, then the mixture was added to a solution of compound (Q10) (13.9 mg) in DMF (400 muL) and DIEA (20 muL), and the resulting mixture was stirred at room temperature for 45 minutes. Water (300 muL) was added thereto, and the mixture was purified by preparative HPLC to obtain compound (Q11) (11.1 mg). HPLC (SunFire) rt (min): 10.80 LC/MS (ACQUITY) rt (min): 1.24 MS (ESI, m/z): 1504.6 [M+H]+, 1502.6 [M-H]-, 137076-54-1

The synthetic route of 137076-54-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FUJIFILM Corporation; FUJIFILM RI PHARMA CO., LTD.; FUKUNAGA, Hirofumi; DOZONO, Hiroyuki; HINO, Akihiro; OSHIKIRI, Shinobu; NAGANO, Akio; (99 pag.)US2016/199520; (2016); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

139-07-1, N-Benzyl-N,N-dimethyldodecan-1-aminium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 6 211.0 g of m-nitrobenzaldehyde dimethylacetal of composition as in Example 4 were reacted according to Example 4. 10.0 g of benzyl-dodecyl-dimethyl-ammonium chloride were used as the emulsifier. After drying, 145.2 g of m-nitrobenzaldehyde were obtained., 139-07-1

As the paragraph descriping shows that 139-07-1 is playing an increasingly important role.

Reference£º
Patent; Bayer Aktiengesellschaft; US4910345; (1990); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

115754-62-6, ((1,3-Dioxolan-2-yl)methyl)tributylphosphonium bromide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,115754-62-6

General procedure: The compounds 4ab were synthesized via modified literature procedure [34]. Aldehyde 3a or 3b (2 mmol) and tributyl(1,3- dioxolan-2-ylmethyl)phosphonium bromide (1.63 g, 4.4 mmol) were dissolved in dry THF (50 mL). Argon was bubbled through the solution for 15 min, NaH (144 mg, 6 mmol) was added and the reaction mixture was stirred at room temperature for 24 h. The reaction mixture was diluted with water (100 mL) and extracted with EtOAc (3 100 mL). The combined organic layers were dried (Na2SO4) and the solvents were evaporated in vacuo. The residue was dissolved in THF (100 mL), 12% HCl (50 mL) was added and the solution was stirred for 1 h. The reaction mixture was diluted with water (100 mL) and extracted with EtOAc (3 100 mL). Both products 4a and 4b are sparingly soluble in common organic solvents. Therefore, the collected organic suspensions was concentrated in vacuo and precipitate was filtered off. The crude product 4a or 4b was suspended in EtOAc (50 mL), the suspension was refluxed for 30 min, cooled to 25 C and the product was isolated by filtration. After drying, products 4a and 4b were used in the following reaction step without further purification. A full purification of small quantities is possible by column chromatography (SiO2, CH2Cl2/EtOAc 10:1) using large excess of the eluting solvents.

115754-62-6 ((1,3-Dioxolan-2-yl)methyl)tributylphosphonium bromide 22292430, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Speratova, Michaela; Jedyrka, Jaroslaw; Pytela, Old?ich; Kityk, Iwan V.; Reshak; Bure?; Klikar; Tetrahedron; vol. 75; 34; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI