Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3779-42-8,3-Bromo-N,N,N-trimethylpropan-1-aminium bromide,as a common compound, the synthetic route is as follows.

Compound 45 (50 mg, 0.062 mmol) and (3-bromopropyl)- trimethylammonium bromide (162mg, 0.62 mmol, LOEQV.) are dissolved and potassium carbonate (128 mg, 0.93 mmol, 15 eqv. ) is suspended under argon in absolute DMF (30 ML) and the mixture is stirred at 55C for 12 h. The solvent is removed in vacuo at 50C and the residue re- dissolved in a little methanol and applied to a pad of silica (2 cm deep). The unreacted ammonium salts are washed off with methanol (LOOOML). The product is eluted with acetic acid: methanol: water (3: 2: 1 by vol.). The solvents are removed under reduced pressure and the product further purified by chromatography on a column (lOOg) of Sephadex LH-20 eluting with n-butanol: water: acetic acid (4: 5: 1 by vol. , upper phase). The solvents are removed under reduced pressure, the residue re-dissolved in a little methanol and the solution is passed through a short column of anion exchange resin (Amberlite IRC 400, chloride form) using methanol as eluent. After removal of solvent, the product is dried at high vacuum to give a violet solid. 1H-NMR : 6H (300MHZ, CD30D) : 0. 89 (t, 3H, 3J= 7.5 Hz), 1.18-1. 34 (m, LOH), 1.41 (bs, 2H), 1.73 (quint, 2H, 3J= 7.5 Hz), 2.30-2. 44 (m, 6H), 3,31 (bs, 27H), 3.65-3. 73 (m, 6H), 3.93 (t, 2H, 3J= 7.5 Hz), 4.25-4. 42 (m, 6H), 7.08 (d, 2H, 3J= 7.5 Hz), 7. 30 (d, 6H, 3J= 7.5 Hz), 7.93 (d, 2H, 3J= 7.5 Hz), 8.05 (d, 6H, 3J= 7.5 Hz), 8.94 (bs, 8H)

3779-42-8, The synthetic route of 3779-42-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DESTINY PHARMA LIMITED; SOLVIAS AG; WO2004/56828; (2004); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of (25,5 ?)-Lambda^- [(5-ieri-butoxycarbonylamino-lH-tetrazol-l-yl)acetyl]-7-oxo-6-oxy-l,6-diazabicyclo[3.2.1] octane-2-carbohydrazide (4.65 g, 1.5 mmol, product from Step 6) in dimethylformamide (30 ml) was added dimethylformamide sulfur trioxide complex (2.76 g, 1.8 mmol) in one portion at 0C under argon atmosphere. The reaction mass was stirred at the same temperature for 30 minutes and allowed to attain ambient temperature. The reaction was monitored by thin layer chromatography using mixture of chloroform and methanol (9: 1) as solvent. After complete consumption of starting material tetrabutyl ammonium acetate (5.42 g, 1.8 mmol) dissolved in 20 ml of water was added to it at 25-30 C under stirring. The reaction was monitored by thin layer chromatography using mixture of chloroform and methanol (9: 1) as solvent. After complete consumption of starting material the volatiles were removed under reduced pressure. The residue was partitioned between dichloromethane (200 ml) and water (100 ml). The water layer was separated and organic layer washed with water (100 ml). The organic extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure to provide 7.8 g of tetrabutyl ammonium salt of (2S,5R)-6- (sulfooxy)-7-oxo-N’-(lH-tetrazol- l-ylacetyl)- l,6-diaza bicycle [3.2.1]octane-2-carbohydrazide in 82% yield. Analysis: 9.3 (M- l) for free acid; for Molecular weight: 631 and Molecular formula: CioHi3N807S. (400MHz, DMSO-d6): S 7.93 (s, 1H), 5.33 (s, 2H), 3.97 (bs, 1H), 3.83(m, 1H), 3.14-3.10 (m, 9H), 2.87(m, 1H), 2.11- 1.5 (m, 4H), 1.54 (m, 8H), 1.33- 1.24 (m, 8H), 0.93-0.89 (m, 12H)., 10534-59-5

The synthetic route of 10534-59-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WOCKHARDT LIMITED; TADIPARTHI, Ravikumar; PATIL, Vijaykumar Jagdishwar; DEKHANE, Deepak; SHAIKH, Mohammad Usman; BIRAJDAR, Satish; DOND, Bharat; PATEL, Mahesh Vithalbhai; (100 pag.)WO2017/81615; (2017); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1662-01-7, General procedure: The formerly reported protocol for the preparation of complex Ru-Cl [1] was modified,as described below, and this modification was used also for the Os(II) analogue Os-Cl. Thestarting dimer [M(mu-Cl)(eta6-pcym)Cl]2 (0.10 mmol; M = Ru or Os) reacted with an excess (0.15mmol) of bphen in 5 mL of MeOH in a microwave reaction system (100 C, 1 min). Theobtained solutions were cooled to ambient temperature, and an excess of NH4PF6 (3.0 mmol)was added. The solvent volume was reduced after 15 min of stirring at ambient temperature,until the solid formed. The obtained chlorido complexes [Ru(eta6-pcym)(bphen)Cl]PF6 (Ru-Cl)and [Os(eta6-pcym)(bphen)Cl]PF6 (Os-Cl) were collected by filtration, washed (1 ¡Á 0.5 mL ofMeOH and 3 ¡Á 1 mL of diethyl ether) and dried under vacuum.

As the paragraph descriping shows that 1662-01-7 is playing an increasingly important role.

Reference£º
Article; Starha, Pavel; Travni?ek, Zden?k; Van?o, Jan; Dvo?ak, Zden?k; Molecules; vol. 23; 2; (2018);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

168646-54-6, 5,6-Diamino-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen protection,A solution of 5-bromo-1-phenylindole-2,3-dione (Intermediate a) (30.2 g, 0.1 mol) and 1,10-phenanthroline-5,6-diamine (Intermediate b ) (21.0 g, 0.1 mol) was added to 200 mL of absolute ethanol.The reaction was allowed to warm to 70-75 ¡ã C for 24 hours.Reaction is completed, cooled to room temperature after the direct suction filter,The filter cake was rinsed with absolute ethanol and the crude product was crystallized from dichloroethane / absolute ethanol to give a yellow solid,That is the intermediate c, the yield of 70percent.

168646-54-6, As the paragraph descriping shows that 168646-54-6 is playing an increasingly important role.

Reference£º
Patent; Wanrun Pharmaceutical Co., Ltd.; Zhang, Xueheng; Ju, Chengliang; Shi, Yu; Yang, Teng; Chi, Pengli; Yang, Hao; (17 pag.)CN106366083; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.167316-27-0,N-((1S,2S)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide,as a common compound, the synthetic route is as follows.

Under an atmosphere of argon, 134 mg (0.2 mmol) of [RuCl2(hexamethylbenzene)]2 147 mg (0.4 mmol) of (S,S)-TsDPEN, 183 mg (2.8 mmol ) of potassium hydroxide, 3 mL of methylene chloride, and 3 mL of water were placed in a 20 mL Schlenk tube and stirred at room temperature for 1 hour. The organic phase was washed with water several times, and sodium sulfate was then added to the organic phase to dry it. The organic phase was further dried with CaH2 and then filtered, the solvent was removed by distillation, and the residue was dried under vacuum. The violet crystals thus obtained were used directly in a reaction as a catalyst. By the same procedure as in Reference Example 1, Ru[(S,S)-Tsdpen] (1,2,3,4,5-pentamethylbenzene), Ru[(S,S)-Tsdpen] (1,2,4,5-tetramethylbenzene), Ru[(S,S)-Tsdpen] (1,3,5-trimethylbenzene), Ru[(S,S)-Tsdpen] (p-cymene), and Ru[(S,S)-Msdpen] (hexamethylbenzene) were synthesized. Furthermore, RuH[(R,R)-Tsdpen] (1,3,5-trimethylbenzene) was synthesized by carrying out the reaction of Reference Example 1 in 2-propanol.

167316-27-0, As the paragraph descriping shows that 167316-27-0 is playing an increasingly important role.

Reference£º
Patent; Kanto Kagaku Kabushiki Kaisha; EP1439159; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

62937-45-5, D-Prolinamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62937-45-5, A solution of 5-(4-chlorophenyl)-2-{ [l-(2-chloropyridin-3-yl) H-l,2,4-triazol-3-yl]methyl}-4- [(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-l,2,4-triazol-3-one (Example 44A; 70.0 mg, 140 muiotaetaomicron) in ethanol (280 mu) was treated with D-prolinamide (160 mg, 1.40 mmol) and stirred overnight at reflux. The reaction mixture was diluted with methanol and purified by preparative HPLC (Method 4) affording 56.3 mg (70 % of th.) of the title compound. LC-MS (Method 2): Rt = 1.52 min; MS (ESIpos): m/z = 578.2 [M+H]+ -NMR (400 MHz, DMSO-d6) delta [ppm]: 8.80 (s, 1H), 8.19 (dd, 1H), 7.79-7.52 (m, 5H), 7.06 (br s, 1H), 6.95-6.71 (m, 3H), 5.18-5.02 (m, 2H), 4.48-4.21 (m, 2H), 4.06-3.78 (m, 2H), 2.77-2.58 (m, 2H), 2.04-1.87 (m, 1H), 1.75-1.42 (m, 3H).

62937-45-5 D-Prolinamide 447554, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; COLLIN-KROePELIN, Marie-Pierre; KOLKHOF, Peter; NEUBAUER, Thomas; FUeRSTNER, Chantal; POOK, Elisabeth; WITTWER, Matthias, Beat; LUSTIG, Klemens; TINEL, Hanna; LINDNER, Niels; SCHIRMER, Heiko; (449 pag.)WO2019/81307; (2019); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

581-50-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.581-50-0,2,3′-Bipyridine,as a common compound, the synthetic route is as follows.

General procedure: Complexes 3-6 were prepared according to the following procedure:after stirring for 1 h a methanolic solution (20 mL) ofHindo (0.4 mmol, 143 mg) and KOH (0.4 mmol, 23 mg), the solutionwas added to a methanolic solution (5 mL) of NiCl26H2O(0.2 mmol, 47 mg) simultaneously with a methanolic solution(5 mL) of bipy (0.2 mmol, 31 mg) for 3, bipyam (0.2 mmol,34 mg) for 4, phen (0.2 mmol, 36 mg) for 5 and Hpko (0.4 mmol,79 mg) for 6. The resultant solution was stirred for 30 min andwas left to evaporate slowly. Light-green microcrystalline product of complex 4 (105 mg, 55%) was collected after two weeks. Anal. Calc. for [Ni(indo)2(bipyam)], 4 (C48H39Cl2N5NiO8) (MW = 943.48) C, 61.11; H, 4.17; N, 7.42 found: C, 60.98; H, 4.04; N, 7.31%. IR (KBr disk): numax, cm-1; nu(C=O)indo, 1678(vs); nuasym(CO2), 1590 (vs); nusym(CO2), 1414 (s); Deltanu(CO2) = 176 cm-1; rho(C-H)bipyam: 765 (m). UV-Vis: as Nujol mull, lambda(nm): 995 (sh), 657, 418 (sh), 324, 308 (sh); in DMSO, lambda(nm) (epsilon, M-1cm-1): 997 (sh) (20), 662 (60), 424 (sh) (230), 324 (12740), 293 (17020); 10Dq = 10030 cm-1, B = 573 cm-1, 10Dq/B = 17.5. mueff at room temperature = 3.25 BM. Soluble in CHCl3 and DMSO (LambdaM = 5 S¡¤cm2¡¤mol-1, in 1 mM DMSO solution).

581-50-0 2,3′-Bipyridine 11389, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Perontsis, Spyros; Tialiou, Alexia; Hatzidimitriou, Antonios G.; Papadopoulos, Athanasios N.; Psomas, George; Polyhedron; vol. 138; (2017); p. 258 – 269;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

134030-21-0, N1,N2-Dimesitylethane-1,2-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 14 Synthesis of carbene precursor 8 (2-pentafluorophenyl-1,3-bis-(2,4,6-trimethyl-phenyl)-imidazolidine): mesityldiamine (512 mg, 1.7 mmol) was placed into a vial, equipped with a stirbar, with pentafluorobenzaldehyde (340 mg, 1.7 mmol).glacial acetic acid (5 ML) was added and the reaction was stirred at room temperature for 24 h.The acetic acid was removed under reduced pressure and the product was washed several times with cold methanol to afford the product as a white crystalline solid (543 mg, 65%).1H NMR: (400 MHz, CDCl3, 25 C.) delta: 2.2 (s, 12H), 2.3 (s, 6H), 3.5-3.6 (m, 2H), 3.9-3.4 (m, 2H), 6.4 (s, 1H), 6.9 (s, 4H).19F NMR: -136.3–136.4 (m, 1F), -148.6–148.7 (m, 1F), -155.8–155.9 (m, 1F), -163.0–163.3 (m, 2F).

134030-21-0, As the paragraph descriping shows that 134030-21-0 is playing an increasingly important role.

Reference£º
Patent; Hedrick, James Lupton; Kilickiran, Pinar; Nyce, Gregory Walker; Waymouth, Robert M.; US2004/127720; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29176-55-4,2,9-Dichloro-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

2,9-Dichloro-1,10-phenanthroline was prepared as described in Bull. Chem. Soc. Jpn. 65, 2007-2009 (1992). 1,2-phenylene [bis (2-methylphenyl)] phosphine was synthesized by the method described in Organometallics, 23, 6077-6079 (2004). Under an argon atmosphere, 1,2-phenylenebis [bis (2-methylphenyl)] phosphine (81.3 mg, 0.6 mmol) was added to a 1 mL solution of silver tetrafluoroborate (I) (31.5 mg, 0.162 mmol) in dichloromethane. 162 mmol), and the mixture was stirred at room temperature for 10 minutes. To the reaction mixture was added 2,9-dichloro-1,10-phenanthroline (46.4 mg, 0.186 mmol), and the mixture was stirred at room temperature for 10 minutes. The reaction solution was filtered, the filtrate was concentrated, recrystallized by slow diffusion with dichloroethane-ether, and dried to obtain 130 mg (yield: 85.2%) of a pale yellow solid complex.

29176-55-4, 29176-55-4 2,9-Dichloro-1,10-phenanthroline 355196, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; KOBAYASHI, NORIFUMI; HIGASHIMURA, HIDEYUKI; (18 pag.)JP5670835; (2015); B2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

168646-54-6, 5,6-Diamino-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4,7-phenanthroline-5,6-dione (1 eq, 0.096 mol) and 1,10-phenanthroline-5,6-diamine (1.1 eq, 0.106 mol) after mixing, these were added to 300 mL of acetic acid and dissolved, followed by stirring under reflux for 12 hours. Thereafter, the reaction solution was put into distilled water, and the obtained solid was filtered, washed several times with distilled water,the residue was purified by rum chromatography to obtain an A-4 compound (yield: 43percent)., 168646-54-6

The synthetic route of 168646-54-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LG Display Co., Ltd.; Hyeong Min-seok; Choi Seul-gi; Lee Tae-yang; (40 pag.)KR2019/42882; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI