Month: October 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99970-84-0,[2,2′-Bipyridine]-4,4′-dicarbaldehyde,as a common compound, the synthetic route is as follows.,99970-84-0

General procedure: 4-methyl-2,2?-bipyridine-4-formaldehyde (200mg, 1.01mmol) anddichloromethane (10 mL) were added into a 50 mL two-neck roundbottle flask under nitrogen. Then ethyl mercaptan (250 muL) and borontrifluoride ether solution (98%, 700 muL) were added into the flask.After the mixture was stirring at room temperature for one night, thesolvent were removed with rotary evaporator in vacuum. Then the saturatedsodium bicarbonate solution (50 mL) were added, the aqueoussolution was extracted with ethyl acetate five times. All organic layerswere collected and dried with anhydrous sodium sulfate, filtered andevaporated to dryness. The residue was purified by column chromatographyon silica gelwith dichloromethane as eluent to give the first bandas the product. The product is a colorless transparent oil (200mg) witha yield of 64.5%.

The synthetic route of 99970-84-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xu, Jiru; Liu, Yonghua; Li, Mei-Jin; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 219; (2019); p. 141 – 146;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13104-56-8,4′-(4-Methoxyphenyl)-2,2′:6′,2”-terpyridine,as a common compound, the synthetic route is as follows.

General procedure: MnCl2.4H2O (1 mmol) was dissolved in alcohol (10 mL), Ligand(1 mmol) was dissolved in CHCl3 and was added dropwise to the above solution with stirring at room temperature in 1 h. Then the solution was refluxed for 4 h. The mixture was allowed to stay overnight at -10C, after which the precipitate was filtered off, washed with diethyl ether, and dried under vacuum.

13104-56-8, As the paragraph descriping shows that 13104-56-8 is playing an increasingly important role.

Reference£º
Article; Liu, Bingqing; Luo, Wei; Li, Haixia; Qi, Xiaoyun; Hu, Quanyuan; Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry; vol. 45; 8; (2015); p. 1097 – 1101;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29841-69-8,(1S,2S)-(-)-1,2-Diphenylethylenediamine,as a common compound, the synthetic route is as follows.

To a solution of (S,S)-diphenylethylenediamine (250 mg, 1.2 MMOL) and triethylamine (0.5 ml) in THF is added dropwise a solution of dansyl chloride (318 mg, 1.2 MMOL) in THF (2 ml) at 0 C. After stirring 16 h at RT the solvent is removed in vacuum and the residue is resolved in METHYLENCHLORIDE (20 ml). The organic solution is washed with NaHCO3 SOLUTION (5 ml), dried over Na2SO4 AND after filtration the solvent is removed. Flash chromatographie afford (S,S)-5-dimethylamino-naphthalene-1-sulfonic acid (2-amino-1,2- diphenyl-ethyl)-amide as yellow oil which crystallizes by drying in vacuum. M: 445. 59. 1H-NMR (400 MHz, CDCI3): 8.36 (t, J=7.5 Hz, 2H), 8.17 (dd, J=7.2, 1.2 Hz, 1H), 7.47 (dd, J=8.8 Hz, 1H), 7.34 (dd, J=8.5 Hz, 1H), 7.24-7.16 (m, 4 H), 7.11 (d, J=7.5 Hz, 1H), 6.99-6.74 (m, 6 H), 4.61 (d, J=8.5 Hz, 1 H), 4.20 (d, J=8.5Hz, 1 H), 2.80 (s, 6 H)., 29841-69-8

29841-69-8 (1S,2S)-(-)-1,2-Diphenylethylenediamine 6931238, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Novartis AG; Novartis Pharma GmbH; WO2004/31155; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4733-39-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4733-39-5,2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

[CuI(MeCN)4](ClO4) (50mg, 0.15mmol), PPh3 (80.4mg, 0.30mmol) and Ph2dmp (60.7mg, 0.18mmol) in MeCN (15ml) are stirred at room temperature for 1h. Slow evaporation of a MeCN solution of 4 afforded analytically pure complex as yellow crystalline solid. Yield (93.4mg, 62.9%). Elemental analysis for C62H50ClCuN2O4P2: calcd. C 71.06, H 4.81, N 2.67%; found: C 71.12, H 4.90, N 2.62%. Selected IR (KBr, cm-1): v(Cl-O) 1110. ESI-MS (positive): m/z 947 (M+). 1H NMR (300MHz, CDCl3): delta 7.98 (s, 2H, Phen H); 7.60 (m, 6H, phenyl H); 7.57-7.53 (m, 4H, phenyl H); 7.44 (s, 2H, phen H); 7.38-7.42 (m, 6H, phenyl H); 7.26-7.21 (m, 24H, phenyl H); 2.31 (s, 6H, -CH3). 31P{1H} NMR (162MHz, CDCl3): delta 0.87 (s, PPh3). UV/Vis (CH3CN): lambdamax/nm (epsilon/mol-1dm3cm-1): 228 (68830), 287 (53890), 369 sh (3950).

4733-39-5 2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline 65149, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Hu, Lin-Li; Shen, Chang; Chu, Wing-Kin; Xiang, Jing; Yu, Fei; Xiang, Ge; Nie, Yan; Kwok, Chun-Leung; Leung, Chi-Fai; Ko, Chi-Chiu; Polyhedron; vol. 127; (2017); p. 203 – 211;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

63-68-3, H-Met-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

L-Methionine (0.5 g, 1 equivalent) was suspended in methanol (30 ml C=0.1M) in a 100 ml flask equipped with a magnetic stirrer and placed under nitrogen. Thionyl chloride (0.5 ml, 2 equivalents) was added to the solution dropwise at 0 C. then heated under reflux for 16 hours. The reaction mixture was then evaporated to yield a pale yellow solid. The solid was triturated with hot diethyl ether and the solution discarded to leave the title compound 2? a white solid which was further dried under vacuum. (0.65561 g, 98% yield). [0377] 1H NMR (D2O, 500 MHz) deltaH: 4.24 (1H, m, 3) 3.79 (3H, s, 1), 2.63 (2H, t, 5), 2.25 (1H, m, 4), 2.16 (1H, m, 4), 2.06 (1H, s, 6) [0378] 13C NMR (D2O, 125 MHz) deltac: 170.58 (2), 53.64 (1), 51.70 (3), 28.71 (4), 28.41 (5), 13.85 (6). [0379] IR (neat, vmax, cm-1): 2880.8/2676.2 (CH3, CH2, CH), 2016.2, 1742.2 (C?O, ester), 1483.6, 1443.5, 1227+1194.7+1149.8+1079.5 (C-O). [0380] HRMS m/z (+ESI): C6H14NO2S, mass found=164.074 (Error=0.071 ppm), 63-68-3

The synthetic route of 63-68-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; The University of Sussex; Viseux, Eddy Michel Elie; Gallop, Christopher; Bobin, Mariusz; US2014/39200; (2014); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1126-58-5,1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of the corresponding bis(isatin) 1-8 (5 mmol) and Girard?s reagent (2.5 mmol) in 7 mL of absolute ethanol were added three drops of trifluoroacetic acid. The reaction mixture was refluxed for 2 h. After spontaneous cooling of the solution to room temperature, the formed precipitate was filtered off, washed with absolute diethyl ether and dried in vacuum (12 mmHg)., 1126-58-5

As the paragraph descriping shows that 1126-58-5 is playing an increasingly important role.

Reference£º
Article; Bogdanov; Zaripova; Mustafina; Voloshina; Sapunova; Kulik; Mironov; Russian Journal of General Chemistry; vol. 89; 7; (2019); p. 1368 – 1376; Zh. Obshch. Khim.; vol. 89; 7; (2019); p. 1004 – 1012,9;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1126-58-5,1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride,as a common compound, the synthetic route is as follows.

1126-58-5, General procedure: To a magnetically stirred solution of substituted isatin (5mmol) in 7ml of absolute ethanol, a corresponding pyridinium acetohydrazide (5mmol) and three drops of trifluoroacetic acid were successively added. The reaction mixture was heated under reflux for 3h. After spontaneously cooling the solution to room temperature, the precipitate formed was filtered, washed with absolute ether and dried in vacuo.

1126-58-5 1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride 70773, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Bogdanov, Andrei V.; Zaripova, Ilyuza F.; Voloshina, Alexandra D.; Sapunova, Anastasia S.; Kulik, Natalia V.; Tsivunina, Irina V.; Dobrynin, Alexey B.; Mironov, Vladimir F.; Journal of Fluorine Chemistry; vol. 227; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

29841-69-8, (1S,2S)-(-)-1,2-Diphenylethylenediamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (S, S)-diphenylethylenediamine (250 mg, 1.2 mmol) and triethylamine (0.5 ml) in THF is added dropwise a solution of dansyl chloride (318 mg, 1.2 mmol) in THF (2 mi) at 0C. After stirring for 16 h at RT the solvent is removed in vacuum and the residue is resolved in methylenchloride (20 ml). The organic solution is washed with NaHCO3 solution (5 ml), dried over Na2SO4, and after filtration the solvent is removed. Flash chromatography affords (S, S)-5-dimethylamino-naphthalene-1-sulfonic acid (2-amino-1, 2-diphenyl-ethyl)- amide as yellow oil, which crystallizes by drying in vacuum. Molecular weight: 445. 59.’H- NMR (400 MHz, CDCI3) : 8.36 (t, J = 7.5 Hz, 2 H), 8.17 (dd, J = 7.2 Hz, 1.2 Hz, 1 H), 7.47 (dd, J = 8. 8 Hz, 1 H), 7.34 (dd, J = 8. 5 Hz, 1 H), 7.24-7. 16 (m, 4 H), 7.11 (d, J = 7. 5 Hz, 1 H), 6.99-6. 74 (m, 6 H), 4.61 (d, J = 8.5 Hz, 1 H), 4.20 (d, J = 8.5 Hz, 1 H), 2.80 (s, 6 H).

29841-69-8, As the paragraph descriping shows that 29841-69-8 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2005/92290; (2005); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.153-94-6,H-D-Trp-OH,as a common compound, the synthetic route is as follows.

Example 1 To a 1L three-necked flask was added 200mL of tetrahydrofuran, 20g D-tryptophan, 7.7g methylaminoacetonitrile, 38.2g EDC ¡¤ HCl and 1g 4-dimethylaminopyridine. The reaction was stirred at room temperature for 5 hours. After completion of the reaction, 300mL of ethyl acetate and 300mL water was added. The ethyl acetate layer was washed with 200mL saturated sodium chloride and stirred. Still stratification of the ethyl acetate layer was distilled under reduced pressure at 30C to a volume of about 200ml. The solution was recrystallized with 700ml of petroleum ether, filtered and vacuum dried at 40C to give 22.25g of compound III. HPLC purity 98%, Yield 91%., 153-94-6

153-94-6 H-D-Trp-OH 9060, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Zhejiang Yongning Pharmaceutical Co., Ltd.; Ye, Tianjian; Yuan, Youting; Chen, Xin; Zhang, Hongxun; (7 pag.)CN105348283; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a ethanolic solution of CHME (0.82 g, 3 mmol) add an aqueous solution of Eu(NO3)3*H2O (0.33 g, 1 mmol) was added with constant stirring on magnetic stirrer. The solution was neutralized with 0.05 M NaOH solution and adjusted pH of mixture 7-8. The mixture was stirred for 3 h at 35 C and then allowed to stand for 1 h. During stirring white precipitates appeared, which were filtered and washed with doubly distilled water and then with ethanol to remove the free ligand, after that dried in air and then in vacuum desiccators. Finally the complex was dried at 50 C in hot air oven to obtain the complex. The obtained complex Eu(CHME)3*2H2O was white power with 86 %yield. The elemental analysis data for Eu(CHME)3.2H2O(C45H40O11Cl3Eu) was found (calc.) % C, 53.21 (53.24); H,4.06 (3.97); Eu, 14.92 (14.97)., 1662-01-7

1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Nandal, Poonam; Khatkar; Kumar, Rajesh; Khatkar, Avni; Taxak; Journal of Fluorescence; vol. 27; 1; (2017);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI