Day: October 13, 2020

1126-58-5, 1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a magnetically stirred solution of substituted isatin (5mmol) in 7ml of absolute ethanol, a corresponding pyridinium acetohydrazide (5mmol) and three drops of trifluoroacetic acid were successively added. The reaction mixture was heated under reflux for 3h. After spontaneously cooling the solution to room temperature, the precipitate formed was filtered, washed with absolute ether and dried in vacuo., 1126-58-5

As the paragraph descriping shows that 1126-58-5 is playing an increasingly important role.

Reference£º
Article; Bogdanov, Andrei V.; Zaripova, Ilyuza F.; Voloshina, Alexandra D.; Sapunova, Anastasia S.; Kulik, Natalia V.; Tsivunina, Irina V.; Dobrynin, Alexey B.; Mironov, Vladimir F.; Journal of Fluorine Chemistry; vol. 227; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6249-56-5,3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride,as a common compound, the synthetic route is as follows.

6249-56-5, Example 620-Oxo-5p-pregnan-3a-yl 4-(trimethylammonium) butanoate chloride3-Carboxy-N,N,N-trimethylpropan-l -ammonium chloride (prepared according to Lindstedt and Lindstedt, 1965, 69 mg; 0.38 mmol) was suspended in anhydrous CH2C12 (1 mL) under argon. The reaction flask was cooled in ice bath and oxalyl chloride (0.5 mL; 5.82 mmol) was added dropwise, followed by catalytic amount of dry DMF (3 mu; 0.03 mmol). The heterogeneous mixture was then brought to r.t. and stirred for 16 hrs, during which all the solids dissolved. The mixture was evaporated under the reduced pressure and solid residue was dissolved in dry nitromethane (2 mL) and dry pyridine (0.10 mL; 1.24 mmol) under argon. Compound II (100 mg; 0.31 mmol) was added to this reaction mixture, which was then stirred for 4 hrs. Reaction was quenched with water (10 mL) and acidified to pH 4 with 5percent aq. HC1. Product was extracted with CHC13 (3 x 20 mL), solution was washed with brine (10 mL, dried with anhydrous MgS04 and evaporated under the reduced pressure. Trituration with benzene removed the unreacted starting steroide II and the remaining product was subsequently crystallized from CHC13 : n-heptane (1 : 1) to give needle-like crystals (134 mg; 89percent).[a]D = +88.4 (c 0.243); NMR (500 MHz, CDC13) delta 4.76-4.68 (m, 1H, 3-CH), 3.73-3.73 (bm, 2H, 4′-CH2), 3.47 (s, 9H, NCH3), 2.55 (t, 1H, J = 9.0 Hz, 17-CH), 2.49 (t, 2H, J = 6.2 Hz, 2′-CH2), 2.12 (s, 3H, 21- CH3), 0.94 (s, 3H, 19-CH3), 0.60 (s, 3H, 18-CH3). 13C NMR (101 MHz, CDC13) delta 209.47, 171.49, 75.20, 65.61, 63.79, 56.62, 53.45, 44.26, 41.83, 40.41, 39.13, 35.76, 34.96, 34.59, 32.19, 31.46, 30.27, 26.87, 26.59, 26.24, 24.37, 23.22, 22.89, 20.82, 18.46, 13.38.IR (CHC13): 2956 (NMe3+), 1722 (C=0, ester), 1699 (C=0, ketone), 1478 (NMe3+) 1386 (CH3), 1360(COCH3), 1230 (NMe3+), 1188 (CO), cm”1.ESI m/z 446.6 (100percent, [M-C1]+); HRMS-ESI m/z 446.3624 ([M-C1]+, C28H4803N requires 446.3629).For C28H48C1N03 (482,1) calculated: 69.75percent C; 10.03percent H, 7.35percent CI, 2.91percent N; found: 69.59percent C, 9.99percent H, 7.12 percent CI, 2.82percent N.

6249-56-5 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride 22620, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE V?D ?ESKE REPUBLIKY, V.V.I.; FYZIOLOGICKY USTAV AKADEMIE V?D ?ESKE REPUBLIKY, V.V.I.; CHODOUNSKA, Hana; KAPRAS, Vojt?ch; VYKLICKY, Ladislav; BOROVSKA, Ji?ina; VYKLICKY, Vojt?ch; VALE?, Karel; STUCHLIK, Ale?; RAMBOUSEK, Luka?; WO2012/110010; (2012); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

13093-04-4, N1,N6-Dimethylhexane-1,6-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a four-neck 2000 mL RBF fitted with overhead stirrer, addition funnel, reflux condenser, and thermocouple, under N2, was added maleic anhydride (75g, 0.734 mol, 2.5 eq.) and dry acetonitrile (400 mL), followed by the dropwise addition of N,N’-dimethyl-1,6-hexanediamine (51.9 mL, 0.294 mol, 1 eq.), maintaining <30C. The reaction turned an orange color as the addition progressed. The reaction was heated to 450C for 2 hours, then stirred overnight at room temperature. By morning, a tan solid had precipitated. It was filtered, then dried to constant weight, giving 87.6 g (87%) of the desired product as an off-white solid. 13093-04-4, As the paragraph descriping shows that 13093-04-4 is playing an increasingly important role.

Reference£º
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WO2006/66031; (2006); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

554-95-0,554-95-0, Benzene-1,3,5-tricarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Trimesic acid (5 g, 23.8 mmol) was suspended in methanol (15 mL) and heated to reflux. When a clear solution obtained,1.6 mL of con.H2SO4 was added slowly and the mixture was refluxed for 6 h. After 3 h, white solid get precipitated from the solution. The mixture was cooled to room temperature, slowly neutralized with saturated NaHCO3 solution, filtered and washed with excess water until the aqueous layer turned neutral. It was then dried to yield a white solid of trimethyl-1,3,5-benzenetricarboxylate (5.72 g). LiAlH4 tablets (2.5 g, 66 mmol) were suspended and refluxed in dry THF (50 mL) under an inert N2 atmosphere. Trimethyl-1,3,5-benzenetricarboxylate (5 g, 20 mmol) was dissolved in 100 mL dry THF and added to the suspension in 1 h. The solution was then refluxed for 24 h, cooled to 0 C and acidified with 1MHCl. THFwas removed under reduced pressure and the aqueous suspension (100 mL) thus obtained was extracted with ethyl acetate for 48 h in a liquideliquid extractor to yield 1,3,5-trimethylolbenzene which appeared as colorless crystals in room temperature. The mother liquor was concentrated to yield second fraction. Both the fractions were NMR pure and the combined yield was 4.96 g.

The synthetic route of 554-95-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Siyad; Kumar, G.S. Vinod; Polymer; vol. 53; 19; (2012); p. 4076 – 4090;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2, [1,1′-Biphenyl]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

787-70-2, In a typical preparation, a solid mixture of H2BPDC (H2BPDC = 4,4′-biphenyldicarboxylic acid; 0.1039 g, 0.4 mmol), bpy (bpy = 4,4′-bipyridine; 0.033 g, 0.2 mmol), and Cu(NO3)2¡¤3H2O (0.105 g, 0.4 mmol) was dissolved in a mixture of DMF (DMF = N,N’-dimethylformamide; 30 ml), pyridine (0.3 ml), and methanol (3 ml). The resulting solution was stirred at 70 C for 5 min and then distributed to four 20-ml vials. The vials were then heated at 120 C in an isothermal oven for 24 h. After cooling the vials to room temperature, the solid product was removed by decanting with mother liquor and washed in DMF (3 x 10 ml) for 3 days. Solvent exchange was carried out with methanol (3 x 10 ml) at room temperature for 3 days. The material was then evacuated under vacuum at 140 C for 6 h, yielding 0.103 g of Cu2(BPDC)2(BPY) in the form of blue crystals (67.5% based on copper nitrate).

As the paragraph descriping shows that 787-70-2 is playing an increasingly important role.

Reference£º
Article; Phan, Nam T.S.; Vu, Phuong H.L.; Nguyen, Tung T.; Journal of Catalysis; vol. 306; (2013); p. 38 – 46;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1351279-73-6,4,4′,4”,4”’-(Ethene-1,1,2,2-tetrayl)tetrabenzoic acid,as a common compound, the synthetic route is as follows.

Weigh H4TCPE (30mg, 0.06mmol), Ni(NO3)2?6H2O (166mg, 0.57mmol) and L-Pro (12mg, 0.1mmol) was dissolved in 2mL water and 4mL N, N- dimethylformamide mixed solution, stirred for 12 hours until homogeneity, placed in an oven, heated at 100 deg. C for 72 hours, the oven was turned off, cooled to room temperature, a green bulk crystal was produced, filtered and dried, yield 10%.

1351279-73-6, 1351279-73-6 4,4′,4”,4”’-(Ethene-1,1,2,2-tetrayl)tetrabenzoic acid 101553689, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Dalian University of Technology; Duan, Chunying; Zhou, Zhen; Lu, Yang; He, Cheng; (12 pag.)CN105348071; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

170161-27-0, Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

500 mg of compound 17-3 and 1.3 g of compound 17-1 were dissolved in 20 mL of acetonitrile, 680 mg of potassium carbonate was added, and the mixture was heated to reflux overnight, cooled to room temperature, filtered, and concentrated. Mix sample was dissolved in dichloromethane, separated by column chromatography (PE: EA = 20: 1-1: 1) to give a colorless waxy compound 17-4 500mg, Yield: 39.6%., 170161-27-0

As the paragraph descriping shows that 170161-27-0 is playing an increasingly important role.

Reference£º
Patent; Shenzhen Xiaxiwan Pharmaceutical Technology Co., Ltd.; Qi Fei; Xia Junxia; Zhang Zaijun; Wang Liang; (27 pag.)CN109988153; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

294-90-6, 1,4,7,10-Tetraazacyclododecane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,294-90-6

To a 100 mL round bottom flask fitted with a reflux condenser and stir bar was added 1.4696 g Cyclen (8.5 mmol). 5.44 11 g of 2-bromoacetamide (39.4 mmol, 4.6 eq) was added with 4.5748 g triethylamine (44.9 mmol, 5.3 eq) in 30 mL absolute ethanol. The contents were refluxed for 4 hours at 80 C, after which time a white precipitate formed in the flask. After cooling to room temperature, the precipitate was decanted and placed in a 250 mL round bottom flask, then dissolved in 200 mL of hot 80 % ethanol/20 % water. The volume was reduced by approximately 30 % on a roto-evaporator, then placed in the refrigerator overnight to produce white crystals. The remaining solvent was removed by filtration and the crystals were transferred to a 50 mL round bottom flask to dry on a Schlenk line under vacuum for several hours (66 % yield). ESI-MS: m/z = 401.3 (100 %), 402.3 (15 %) [M + H]+; 423.4 (25 %), 424.4 (< 10 %) [M + Na]+. 1H NMR (500 MHz, D20), ppm: 3.02 (s, amide pendent CH28H), 2.57 (s, Cyclen ring 16 H). 13C NMR (125 MHz, D20), ppm: 174.07 (carbonyl C),55.86 (amide CH2), 50.42 (ring CH2). As the paragraph descriping shows that 294-90-6 is playing an increasingly important role. Reference£º
Patent; THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK UNIVERSITY AT BUFFALO; HEALTH RESEARCH, INC.; MORROW, Janet, R.; TSITOVICH, Pavel, B.; DORAZIO, Sarina, J.; OLATUNDE, Abiola, O.; SNYDER, Eric, M.; SPERNYAK, Joseph, A.; BURNS, Patrick; BOND, Christopher, J.; WO2015/38943; (2015); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

13104-56-8, 4′-(4-Methoxyphenyl)-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Accurately weighed Eu(TTA)2.4H2O 1.375 g, terpyridine (Tpy-OCH3) 0.658 g. Then added to a round-bottomed flask, completely dissolved in 50 ml of THF (tetrahydrofuran) and then warmed to 75 C. The reaction was heated for 3 hours under a magnetic stirrer. After the completion of the reaction, the solvent was removed, (TTA)2Tpy-OCH3 was prepared by vacuum drying at 60 C for 24 hours, and the calculated yield was weighed.

13104-56-8, As the paragraph descriping shows that 13104-56-8 is playing an increasingly important role.

Reference£º
Patent; Chongqing University Of Technology; Yang, Zhaolong; Liu, Shaojun; Zhang, Zhiming; Shang, Mingyong; Li, Chuan; Wang, Guoxia; Gao Bao; (10 pag.)CN104059093; (2016); B;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1435-55-8, Hydroquinidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

From dihydroquinidine To a 0 C. solution of 1.22 g dihydroquinidine (0.0037 mol) in 30 mL of CH2 Cl2 was added 0.78 mL of Et3 N (0.0056 mol; 1.5 eq), followed by 0.71 mL of p-chlorobenzoyl chloride (0.005 mol; 1.2 eq) in 1 mL CH2 Cl2. After stirring 30 minutes at 0 C. and 1 hour at room temperature, the reaction was quenched by the addition of 10% Na2 CO3 (20 mL). After separation, the aqueous layer was extracted with three 10 mL portions of CH2 Cl2. The combined organic layers were dried over Na2 SO4 and the solvent removed under vacuum. The crude product was purified as described above. Dihydroquinidine p-chlorobenzoate (1) was obtained in 91% yield (1.5g) as a white foam., 1435-55-8

The synthetic route of 1435-55-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Massachusetts Institute of Technology; US4871855; (1989); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI