Day: October 16, 2020

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solutionof 5 (1 mmol, 1 eq.), 1-bromo-3,5-dimethoxybenzene(1.5 eq.), TBAA (6.0 eq.), Pd(OAc)2 (0.1 eq.) were dissolvedin 2 cm3 of NMP under an argon atmosphere. The wholewas heated at 110 C for 24 h. After cooling, a saturatedsolution of Na2CO3 was added and the resulting solutionwas extracted thrice with ethyl acetate. The organic layerswere then dried over Na2SO4 and evaporated to give anoil, from which residual NMP was evacuated using a lyophilizer.Chromatography of the resulting oil on silica geleluted with hexane/ethyl acetate (v/v: 60/40) gave 7 (tracesin these conditions). Further elution gave 6 in 75% yield asan orange oil. MS (ESI): m/z = 412.10 ([M+H]+); 1H NMR(400 MHz CDCl3):= 1.77 (s, 3H), 2.80 (t, 2H, J = 6.9 Hz),3.55 (s, 6H), 3.58 (s, 3H), 4.14 (t, 2H, J = 6.9 Hz), 5.29(s, 2H), 6.21 (d, 2H, J = 2.3 Hz), 6.46 (t, 1H, J = 2.3 Hz),6.72 (d, 2H, J = 8.7 Hz), 6.93 (d, 2H, J = 8.7 Hz) ppm; 13CNMR (100 MHz, CDCl3):= 20.7, 24.8, 51.5; 55.1, 55.3,63.3, 101.3, 107.6, 113.9,127.6,128.6, 128.8, 135.1, 141.6,159.3, 160.9, 170.6 ppm.

10534-59-5, As the paragraph descriping shows that 10534-59-5 is playing an increasingly important role.

Reference£º
Article; Praud-Tabaries, Annie; Bottzeck, Olivier; Blache, Yves; Monatshefte fur Chemie; vol. 150; 4; (2019); p. 649 – 654;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

767-60-2, 3-Methyl-1H-indene is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(6/5-tert-Butyl-2-methyl-1H-inden-4/7-yl)(cyclopenta-2,4-dien-1-yl)dimethylsilane To a solution of 971 mg (13.5 mmol) of CpLi in 100 ml of THF a solution of 3.77 g (13.5 mmol) of chloro(dimethyl)(2-methyl-5-tert-buthyl-1H-inden-7-yl)silane in 10 ml of THF was added dropwise by vigorous stirring for 5 min at -80 C. This mixture was additionally stirred for 1 h at room temperature, and 1 ml of water was added. The mixture was evaporated to dryness, and 100 ml of water was added to the residue. The crude product was extracted with 3*50 ml of dichloromethane. The combined organic extract was dried over Na2SO4 and evaporated to dryness. The product was isolated from the residue by flash chromatography using a short column with Silica Gel 60 (40-63 um, d 60 mm, l 50 mm; eluent: hexanes). Yield 3.85 g (86%) of pure cyclopenta-2,4-dien-1-yl(dimethyl)(2-methyl-5-tert-buthyl-1H-inden-7-yl)silane. Anal. calc. for C21H28Si: C, 81.75; H, 9.15. Found: C, 81.52; H, 9.09. 1H NMR (CDCl3): delta 7.35-7.39 (m, 2H, 4,6-H in indenyl), 6.65 (br.s, 2H, 3,4-H in Cp), 6.50-6.56 (m, 3H, 3-H in indenyl and 2,5-H in Cp), 3.78 (br.s, 1H, 1-H in Cp), 3.36 (s, 2H, 1,1′-H in indenyl), 2.19 (s, 3H, 2-Me in indenyl), 1.39 (s, 9H, C(CH3)3 in indenyl), 0.25 (s, 6H, SiMe2). 13C{1H} NMR (CDCl3): delta 148.6, 145.9, 145.7, 145.4, 133.5 (br.), 131.7, 130.6 (br.), 127.3, 126.2, 118.3, 51.1, 43.7, 31.6, 29.7, 16.8, -3.5.Complex 22-Zr (0413) (0414) To a solution of 3.73 g (10.0 mmol) of (6/5-tert-butyl-2-methyl-1H-inden-4/7-yl)(dimethyl)(3-methyl-1H-inden-1-yl)silane in 200 ml of ether 8.0 ml of 2.5 M (20 mmol) of n-BuLi in hexanes was added by vigorous stirring for 5 min at room temperature. This mixture was stirred for 12 h, then cooled to -30 C., and 3.77 g (10 mmol) of ZrCl4(THF)2. The resulting mixture was stirred for 24 h at room temperature and then evaporated to dryness. A mixture of the residue obtained and 200 ml of toluene was stirred for 6 h at 80 C. and then filtered through glass frit (G4). The precipitate was additionally washed by 3¡Á50 ml of hot toluene. The combined extract was evaporated to dryness, and the residue was re-crystallized from 30 ml of toluene. Crystals precipitated at -30 C. were collected, washed by 3¡Á4 ml of cold toluene, 2¡Á7 ml of hexanes, and dried in vacuum. Yield 2.61 g (49%) of one pure isomer. (0415) Anal. calc. for C26H30Cl2SiZr: C, 58.62; H, 5.68. Found: C, 58.89; H, 5.79. (0416) 1H NMR (CD2Cl2): delta 7.35-7.40 (m, 3H, 5,7-H in 2-methylindenyl and 4-H in 3-methylindenyl), 7.10 (m, 1H, 5-H in 3-methylinden-1-yl), 6.88 (m, 1H, 6-H in 3-methylinden-1-yl), 6.75 (d, J=7.6 Hz, 7-H in 3-methylindenyl) 6.48 (m, 1H, 3-H in 2-methylindenyl), 6.45 (m, 1H, 1-H in 2-methylindenyl), 6.27 (m, 1H, 2-H in 3-methylindenyl), 2.49 (s, 3H, Me in 3-methylinden-1-yl), 2.24 (s, 3H, Me in 2-methylinden), 1.34 (s, 9H, 5-C(CH3)3 in 2-methylindenyl), 1.02 (s, 3H, SiMeMe?), 0.89 (s, 3H, SiMeMe?). (0417) 13C{1H} NMR (CD2Cl2): delta 149.9, 139.7, 133.8, 132.1, 131.3, 129.3, 127.0, 126.6, 126.4, 126.1, 125.8, 123.5, 121.0, 119.3, 117.4, 108.7, 99.2, 98.9, 34.8, 30.6, 16.8, 13.7, -1.9, -4.0.

767-60-2, As the paragraph descriping shows that 767-60-2 is playing an increasingly important role.

Reference£º
Patent; Borealis Technology Oy; Voskoboynik, Alexander Zelmanovich; Asachenko, Andrei Fyodorovich; Konanovich, Dmitry; Nikulin, Mikhail V.; Tzarev, Alexey; Maaranen, Janne; Vanne, Tiina; Kauhanen, Jyrki; Mansner, Erik; Kokko, Esa; Saarinen, Laura; US8569532; (2013); B2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6813-38-3,[2,2′-Bipyridine]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.,6813-38-3

Weigh 4,4′-dicarboxy-2,2′-bipyridine 500mg (2.05mmol) was added to the reaction flask, 100mL of methanol was added, 8mL of concentrated sulfuric acid was slowly added dropwise and stirred at 105 for 12h. After the reaction was completed and cooled to room temperature, the reaction was added to 500 mL of water, and the pH was adjusted to 9 using saturated NaOH solution. After the pH was adjusted, 200 mL of dichloromethane solution was added and allowed to stand still. At this time, a white flocculent precipitate was formed and the supernatant was poured out. The lower layer was extracted with dichloromethane and water (3 ¡Á 100 mL), the organic phase was extracted and dried to give the product , Yield 76%.

As the paragraph descriping shows that 6813-38-3 is playing an increasingly important role.

Reference£º
Patent; Nanjing University of Posts and Telecommunications; Zhang Yin; Zhang Taiwei; Sun Guanglan; Gao Pengli; Chen Xiaojiao; Zhao Qiang; Liu Shujuan; Huang Wei; (16 pag.)CN107417737; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-91-5,2,2′-Biquinoline,as a common compound, the synthetic route is as follows.

To a solution of cis-[Pt(p-MeC6H4)2(SMe2)2] (0.040 g, 0.078 mmol) in acetone (6 mL) was added a solution of biquinoline (0.020 g, 0.078 mmol) in acetone (6 mL) and the mixture was stirred for 2 h. The solvent was evaporated and a red precipitate product separated and washed twice with n-hexane. Then, the precipitate was dried in vacuum. (Yield: 84%), red, m.p: 160 C (decomp.), Anal. Calc. for [C32H26N2Pt] (1): (M.W: 633.654), C, 60.66; H, 4.14; N, 4.42%. Found: C, 60.09; H, 4.25; N, 4.17%; IR (KBr, y/cm1): (C]C) and (C]N) 1594sh, 1508sh, 1481s, 1431w, (CeH) 815sh, 800s, 746w, (MCl) 509w. 1H NMR (400 MHz, DMSO-d6, d/ppm): 2.17 (6H, s, C6H5CH3), 6.66 (4H, d, 3J(HoHm) 7.60 Hz, 7.23 (d, 4H, 3J(HmHo) 8.00 Hz, 7.29 (3J(PtHo) 17.21 Hz), 8.88 (d, 2H, 3J(H3H4) 8.40 Hz, H3 and H30 of biq), 8.63 (d, 2H, 3J(H4H3) 8.80 Hz, H4 and H40 of biq), 8.33 (dd, 2H, 3J(H8H7) 8.80 Hz, 3J(H8H6) 8.80 Hz, H8 and H80 of biq), 7.86 (d, 2H, 3J(H5H6) 8.00 Hz, H5 and H50 of biq), 7.51 (t, 2H, 3J(H6H5), 3J(H6H7) 16.0 Hz, H6 and H60 of biq). 7.61 (t, 2H, 3J(H7H6), 3J(H7H8) 16.81 Hz, H7 and H70 of biq)., 119-91-5

The synthetic route of 119-91-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shafaatian, Bita; Heidari, Bahareh; Journal of Organometallic Chemistry; vol. 780; (2015); p. 34 – 42;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4730-54-5, 1,4,7-Triazacyclononane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A three necked flask was charged with TACN (5.0 g, 39 mmol), followed by the additionof deoxygenated ethanol (150 mL), LiOHH2O (0.4 g, 9.5 mmol) in deoxygenated H2O (50 mL).The resulting solution was slightly cloudy and was allowed to stir at 50 C for 30 min. 4-Vinylbenzylchloride (1.1 g, 7.5 mmol) in ethanol was added dropwise to the mixture. The reaction mixture wasrefluxed under N2. After 2 h, the reaction mixture was concentrated to 50 mL on a rotary evaporator.Water was added to the residue and the solution was extracted 3-times with dichloromethane (30 mL).The combined dichloromethane extracts were washed with brine, dried with anhydrous Na2SO4,and concentrated under reduced pressure. The residue was loaded onto a silica column and elutedusing chloroform-methanol (50:50, v/v, and 1% of triethylamine). Upon removal of the solvents,the chromatographically purified N-(4-vinylbenzyl)-1,4,7-triaza-cyclononane (0.5 g) was obtainedas a light brown viscous oil and used immediately for the preparation of the grafted polystyreneparticles. Typical recovered yields of the purified N-(4-vinylbenzyl)-1,4,7-triaza-cyclononane were5%, 1H-NMR (CDCl3), delta (ppm), 2.65-3.1 (m, 12H, ring CH2) 3.68 (s, 2H, benzyl CH2), 5.18 (d, 1H,CH=CH2), 5.65 (d, 1H, CH=CH2), 6.65 (dd, 1H, CH=CH2), 7.20 (d, 2H, aromatic CH), 7.30 (d, 2H,aromatic CH), FT-IR (KBr) 3361, 2918, 2849, 1654, 1559 cm-1.

4730-54-5, The synthetic route of 4730-54-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

168646-54-6, 5,6-Diamino-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1,10-phenanthroline-5,6-diamine (1 mmol), 2,3-dihydroxybenzaldehyde (1 mmol) and EtOH (10 mL) was heated at 70-80 ¡ãC for 24 h. The reaction mixture was cooled to room temperature, dried and concentrated in vacuo. Yield: 89percent. Anal. Calcd for C19H12N4O2: C, 69.51; H, 3.68; N, 17.06. Found: C, 69.39; H, 3.72; N, 17.10. ESI-MS: 328 ([Mr+H]+). 1H NMR (300 MHz, CD3OD-d6): delta 8.91 (d, J = 9.0 Hz, 2H), 8.52 (d, J = 9.0 Hz, 2H), 8.03 (t, J = 8.1 Hz, 2H), 7.22 (d, J = 7.2 Hz, 2H,), 7.12 (d, J = 6.9 Hz, 2H,), 5.79 (s, 1H). 13C NMR (300 MHz, CD3OD-d6): delta 165.19, 160.92, 154.56, 150.56, 143.36, 141.25, 138.11, 134.75, 133.58, 133.24, 131.56, 127.85, 125.56, 124.36, 123.78, 122.56, 121.45, 120.21.

168646-54-6, As the paragraph descriping shows that 168646-54-6 is playing an increasingly important role.

Reference£º
Article; Zhang, Pingyu; Huang, Wenxiu; Wang, Yi; Li, Haihang; Liang, Chunmei; He, Chuanxin; Wang, Haitao; Zhang, Qianling; Inorganica Chimica Acta; vol. 469; (2018); p. 593 – 599;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2, [1,1′-Biphenyl]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,787-70-2

A mixture of Co(NO3)26H2O (0.2 mmol, 58.2 mg), 1,3-bip(0.20 mmol, 35.2 mg), NaOH(0.2 mmol, 8 mg) and H2bpdc(0.20 mmol, 58.2 mg) in DMF-H2O (6 mL, V:V 1:1) binary solventwas placed in a 25 mL Telfon-lined stainless steel container, whichwas heated to 150 C for 3 days, and then cooled to room temperatureover 24 h. Purple block crystals of 1 were collected. Yield:54% based on Cobalt. Elemental analysis (%): calcd for C30H25CoN4O6(Mr 596.47): C 60.36, H 4.19, N 9.39; found: C60.23, H4.12, N 9.81. IR (cm1): 3446(w), 3125(m), 2928(w), 2760(w),1698(s), 1607(s), 1524(s), 1386(s), 1250(s), 1106(m), 947(w), and765(m).

The synthetic route of 787-70-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lu, Jiu-Fu; Wang, Min-Zhen; Liu, Zhi-Hong; Journal of Molecular Structure; vol. 1098; (2015); p. 41 – 46;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139-07-1,N-Benzyl-N,N-dimethyldodecan-1-aminium chloride,as a common compound, the synthetic route is as follows.

Adopts the following conditions: Extracting the organic phase: The extractant: 0.4 mol/L; synergic reagent: 0.2 mol/L methyl trioctylphosphine ammonium chloride; diluent: chloroform. The aqueous phase: 0.4 mol/L LiCl; 0.5 mol/L NaOH; Axial center: 3:1; To 30 level enriching lithium isotope centrifugal extractor process test, after a long-term test operation, the extractant chemical stability is excellent, lithium isotope have realized multistage enrichment separation, from the initial7 Li isotope abundance 92.5%, after being enriched rose to 94.1%.

139-07-1, As the paragraph descriping shows that 139-07-1 is playing an increasingly important role.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; Hu Jinbo; Zhang Wei; Zheng Weiqin; Shi Xiao; Xu Yongchang; Lv Honggui; Yuan Chengye; (20 pag.)CN104140379; (2017); B;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Step-2 product (100 mg, 0.268 mmol) in a mixture of dichloromethane and N,N’-dimethylformamide (250 mu?^ each) was added 10% palladium on carbon (25 mg) and the resulting mixture was stirred under hydrogen atmosphere for 1 hour at 25C to 35C. The catalyst was filtered through micron filter and the filtrate was concentrated under vacuum below 40C to provide a residue. The residue was dissolved in N,N-dimethylformamide (500 mu?^) and N,N-dimethylformamide sulfurtrioxide complex (50 mg, 0.321 mmol) was added in one lot at 0C temperature. The mixture was stirred for 1 hour. The aqueous tetrabutyl ammonium acetate solution (97 mg, 0.321 mmol dissolved in 350 mu?^ water) was then added to it. The reaction mixture was allowed to warm to 25C to 35C. and stirred further for 1 hour. The volatiles were removed under vacuum to provide a residue and residue was triturated with xylene (10 ml) to remove traces of N,N- dimethylformamide. Residue was partitioned between water (10 ml) and dichloromethane (10 ml). Aqueous layer was re-extracted with dichloromethane (10 ml). Combined organic extracts were washed with water (10 ml) and brine (10 ml). Organic layer was dried over sodium sulfate and concentrated under vacuum to obtain yellow oil as the Step-3 product, in 100 mg quantity (yield 62%). Analysis: MS: 361.2 (M-H) of free sulfonic acid; M.W: 603: M.F:

10534-59-5, The synthetic route of 10534-59-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WOCKHARDT LIMITED; BHAGWAT, Sachin; DESHPANDE, Prasad Keshav; BHAWASAR, Satish; PATIL, Vijaykumar Jagdishwar; TADIPARTHI, Ravikumar; PAWAR, Shivaji Sampatrao; JADHAV, Sunil Bhaginath; DABHADE, Sanjay Kisan; DESHMUKH, Vikas Vitthalrao; DHOND, Bharat; BIRAJDAR, Satish; SHAIKH, Mohammad Usman; DEKHANE, Deepak; PATEL, Piyush Ambalal; WO2013/30735; (2013); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

54761-04-5, Ytterbium(III) trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

54761-04-5, General procedure: ReBr(CO)3(N,N’-Phd-O,O’)Ln(OTf)3(THF) (III Y, Ln = Y; III Eu, Ln = Eu; III Yb, Ln = Yb) heterobimetallic complexes were synthesised by allowing 1.0 mmol (0.560 g) of fac-ReBr(CO)3(Phd) to react with 1.0 mmol of the respective anhydrous triflate salt Ln(OTf)3 in 20 mL of THF. After 72 h of stirring at ambient temperature, the solvent was evaporated under reduced pressure and diethyl ether (10 mL) was added. The solid thus separated was filtered, washed with a small amount of diethyl ether and dried.

The synthetic route of 54761-04-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bortoluzzi, Marco; Battistel, Dario; Albertin, Gabriele; Daniele, Salvatore; Enrichi, Francesco; Rumonato, Riccardo; Chemical Papers; vol. 70; 1; (2016); p. 43 – 52;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI