Month: October 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.135616-36-3,(S,S)-(+)-N,N’-Bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine,as a common compound, the synthetic route is as follows.

Reference Example 1 [(R,R)-N,N’-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine] (hereinafter, referred to as L3 when it is a ligand of a complex) (10.9 g, 20.0 mmol) was dissolved in dichloromethane (80mL), the solution was added to a methanol solution (80 mL) of cobalt acetate tetrahydrate (5.98 g, 24.0 mmol), the mixture was stirred at room temperature for 15 minutes, and as a result, a red solid was precipitated. After stirred at 0 C. for 30 minutes, the red solid was collected and dried to obtain Co(L3) (11.6 g, red solid) (yield: 96%)., 135616-36-3

The synthetic route of 135616-36-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Japan Science and Technology Agency; Takasago International Corporation; US2006/173210; (2006); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

5350-41-4, N,N,N-Trimethyl-1-phenylmethanaminium bromide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5350-41-4, General procedure: Ammonium salt 6 (1 equiv.) was suspended in dry THF (0.05 M) andstirred at 40 ¡ãC. t-BuOK (4 equiv.) was added and the mixture was stirred vigorously. After 10 minutes 2 equiv. of aldehyde 2 were added and the mixture was stirred for 3 hours at 40 ¡ãC. The reaction was then quenched by addition of a half-saturated NaCl solution. After phase separation, the aqueous phase was extracted three times with DCM and the combined organic phases were dried with Na2SO4 and evaporated to dryness. Purification by columnchromatography (gradient of heptanes and EtOAc) gave the corresponding epoxides in the reported yields as a mixture of diastereomers.

5350-41-4 N,N,N-Trimethyl-1-phenylmethanaminium bromide 21449, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Roiser, Lukas; Robiette, Raphael; Waser, Mario; Synlett; vol. 27; 13; (2016); p. 1963 – 1968;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The solution containing the sulfate (X) was re-cooled to 0 C. and a solution of Tetra butyl ammonium acetate (9 gm, 0.0301 mol dissolved in 30 ml water) was added to it. The reaction mixture was allowed to warm to 25 C. and stirred for 1 hour. The volatiles were removed under reduced pressure and residue was co-evaporated with 2¡Á50 ml Xylene to remove traces of N,N?-Dimethyl formamide. The residue was partitioned between a 1:1 mixture of water and dichloromethane (120 ml). The aqueous layer was re-extracted with dichloromethane (30 ml). The combined organic extracts were washed with water (2¡Á30 ml), brine (30 ml). And dried over Na2SO4 and the solvent evaporated under reduced pressure to obtain the crude TBA sulfate (5.2 gm). Crude compound was triturated with hexane (2¡Á30 ml) & dried on rotavapor under 4 mmHg pressure to obtain the TBA salt (XI), 5.0 g, yield-44%. [0109] Mass: 246 ((M-H)) of sulfate M.W: 488, M.F: C23H44N4O5S., 10534-59-5

10534-59-5 Tetrabutylammonium acetate 82707, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Patil, Vijaykumar Jagdishwar; Tadiparthi, Ravikumar; Birajdar, Satish; Bhagwat, Sachin; US2014/88070; (2014); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

23616-79-7, N-Benzyl-N,N-dibutylbutan-1-aminium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

23616-79-7, REFERENCE EXAMPLE 5 To a mixture of 4-[4-[(5-methyl-2-phenyl-4-thiazolyl)methoxy]phenyl]butylaldehyde (4.68 g), benzyl tributylammonium chloride (2.07 g), ethyl acetate (150 mL) and water (30 mL) was added sodium cyanide (650 mg) at room temperature. After stirring for 1.5 hr at room temperature, 2N hydrochloric acid (10 mL) was added to the reaction mixture to make the mixture acidic. The ethyl acetate layer was separated, washed successively with water (80 mL) and saturated brine (50 mL) and dried (MgSO4). The solvent was evaporated under reduced pressure, and the residue was subjected to silica gel column chromatography and eluted with hexane-ethyl acetate (2:1, v/v) to give 2-hydroxy-5-[4-[(5-methyl-2-phenyl-4-thiazolyl)methoxy]phenyl]pentanenitrile (4.22 g, 84%). Recrystallization from ethyl acetate-hexane gave a colorless prism crystal. melting point: 101-102 C.

As the paragraph descriping shows that 23616-79-7 is playing an increasingly important role.

Reference£º
Patent; Hazama, Masatoshi; Miyazaki, Takeshi; Sugiyama, Yasuo; US2003/134884; (2003); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1662-01-7,4,7-Diphenyl-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: A solution of [Rh2Cl2(COD)2] (0.1mmol), 1,10-phenanthroline (0.2mmol) and HBF4 (0.025ml, 40% water solution) in 5mL of ethanol was stirred at room temperature for 18h. The red-orange product was filtrated off, washed with ethanol and dried under vacuum., 1662-01-7

1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; ?liwi?ska-Hill, Urszula; Pruchnik, Florian P.; Latocha, Ma?gorzata; Nawrocka-Musia?, Dominika; U?aszewski, Stanis?aw; Inorganica Chimica Acta; vol. 400; (2013); p. 26 – 31;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

39069-02-8, 2,9-Dibromo-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

31.9 g (0.101 mol) of intermediate 233-3 was dissolved in 320 ml of toluene solvent.Stir under nitrogen,16 g (0.0505 mol) of 2,9-dibromo-phenanthroline 19.6 g (0.202 mol) was added in sequence.Sodium tert-butoxide, 0.45 g (0.000505 mol) (DBA) 3Pd21.01 ml (0.000505 mol) of tri-tert-butylphosphine, heated to reflux.After 6 hours of reaction, the reaction was completed, the reaction was stopped, and the reaction solution was dried under reduced pressure.The residue obtained was recrystallized from xylene to give 20.3 g of Compound 233 (yield 52%)., 39069-02-8

39069-02-8 2,9-Dibromo-1,10-phenanthroline 15448099, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Beijing Lv Ren Science And Technology Co., Ltd.; Lv Yao; Feng Yu; Jia Xueyi; (53 pag.)CN108659010; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1067-33-0, Dibutyltin diacetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1; 240 g of di-n-butyl tin diacetate (Aldrich Corp., USA) and 692 g of the bis(3-methylbutyl) carbonate produced in step (A-2) of Reference Example 1 were placed in a 2 L volumetric eggplant-shaped flask in a nitrogen atmosphere at atmospheric pressure, and a Dimroth condenser and three-way valve were attached to the flask. The flask was immersed in an oil bath heated to 150 C. and heated for 5 hours while stirring the contents. The flask was attached to a rotary evaporator to which was connected an oil bath equipped with a temperature controller, a vacuum pump and a vacuum controller. The purge valve outlet of the rotary evaporator was connected to a line containing nitrogen gas flowing at atmospheric pressure. After replacing the inside of the system with nitrogen, the temperature of the oil bath was set to be 150 C., the flask was immersed in the oil bath and rotation of the rotary evaporator was started. A low boiling point component was distilled off for about 7 hours in the presence of nitrogen at atmospheric pressure with the purge valve of the rotary evaporator left open, after which the pressure in the system was gradually reduced, and residual low boiling point component was distilled off with the pressure inside the system at 76 to 10 kPa. When the low boiling point component fraction no longer appeared, the flask was removed from the oil bath and allowed to cool. 287 g of residual liquid were obtained in the flask. Based on the results of 1H-, 13C- and 119Sn-NMR analyses, the residual liquid in the flask was a solution containing 92.0% by weight of di-n-butyl-bis(3-methylbutyloxy) tin.On the other hand, 598 g of low boiling point component were recovered. When analyzed by gas chromatography, the low boiling point component contained about 28% by weight of isoamyl acetate.

1067-33-0, As the paragraph descriping shows that 1067-33-0 is playing an increasingly important role.

Reference£º
Patent; Shinohata, Masaaki; Miyake, Nobuhisa; US2010/292496; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

115754-62-6, ((1,3-Dioxolan-2-yl)methyl)tributylphosphonium bromide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3,5-dibromobenzaldehyde (16.1 g, 61.0 mmol) was added to a cold (ice-water bath) solution of tert-butoxide (13.0 g, 116 mmol), (l,3-dioxolan-2-ylmethyl)tri-n-butylphosphine bromide salt (4.5 M, 32 cm3, 144 mmol) in 400 cm3 of ether under argon. The mixture was stirred at 0-2 C for 2 h. 1.0 M HCl(aq) (300 cm3) was added to the mixture. The reaction was gradually warmed to room temperature and stirred at room temperature for 21 h. The two layers were separated. The aqueous layer was extracted with ether (3 x 200 cm3). The organic layer and the ether extracts were combined, washed with brine (1 x 300 cm3) and dried over anhydrous magnesium sulfate. The solvents were completely removed to leave a yellow solid. The solid was purified by column chromatography of silica gel using ethyl acetate-light petroleum (40-60 C) as eluent to give 3.36 g (19%) of A-1 as a colourless solid; deltaH(200 MHz; CDCl3) 6.68 (1 H, dd, J1A & 16 Hz, vinylH), 7.33 (1 H, d, J16 Hz, vinylH), 7.33 (2 H, m, ArH), 7.63 (1 H, m, ArH), and 9.72 (1 H, d, J7.6 Hz, CHO); m/z [CI(NH3)] 306, 308, 310 (MNH4+), and 288, 290, 292 (M+)., 115754-62-6

The synthetic route of 115754-62-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ISIS INNOVATION LIMITED; THE UNIVERSITY COURT OF THE UNIVERSTIY OF ST ANDREWS; WO2004/20448; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

13104-56-8, 4′-(4-Methoxyphenyl)-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

13104-56-8, 4,4?-bipyridine (23mg, 0.15 mmol) and atpy (51 mg, 0.15 mmol) in CH2Cl2 was added to a solution of Cu(CH3COO)2¡¤H2O (30 mg, 0.15 mmol) in methanol (15 mL). After stirring for 10min, an excess of NH4PF6 (60 mg, 0.37 mmol) was added to solution. The reaction mixture was then stirred for 2 h. The solvent was removed at reduced pressure and the green residue was precipitated using diethyl ether. Yield: 32mg, 31%; m.p. 233-235 C (dec.). Anal. Calc. for C58H48Cu2F12N8O6P2¡¤1.5H2O. CH2Cl2: C, 47.72; H, 3.54; N, 7.42. Found: C, 47.26; H, 3.03; N, 7.99%. TGA-DTA: calc. by formula C58H48Cu2F12N8O6P2¡¤0.5H2O: H2O%=0.64, 2(CH3COO)%=8.44, 4,4?-bpy%=12.18, Cu(CH3COO)2%=16.18. Determined H2O%=0.71, 2(CH3COO)%=6.15, 4,4?-bpy%=12.81, Cu(CH3COO)2%=16.91. IR data (KBr, cm-1): 3389, 3055, 1598, 1470, 1407, 1243, 1189, 1019, 835, 794, 688, 641, 586, 519. Green crystals of 3 were obtained from a MeOH/diethyl ether solution.

The synthetic route of 13104-56-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Momeni, Badri Z.; Heydari, Sepideh; Polyhedron; vol. 97; (2015); p. 94 – 102;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25316-59-0,Benzyltributylammonium bromide,as a common compound, the synthetic route is as follows.

EXAMPLE 36 3,4-Dihydro-6-(4-hydroxyphenyl)-1-methylpyrrolo[1,2-a]pyrazine (5.0 g), 100 ml of methylene chloride, 5.3 ml of benzyl bromide and 0.8 g of benzyltributylammonium bromide was added in succession to a solution of 1.8 g of sodium hydroxide in 100 ml of water under argon. The mixture was boiled under reflux overnight and stirred and subsequently cooled. After the addition of 100 ml of methylene chloride and 100 ml of water the phases were separated and the aqueous phase was extracted twice with 100 ml of methylene chloride each time. The organic phases were combined, dried with MgSO4 and freed from solvent. The residue, 10.3 g of brown oil, was chromatographed on 500 g of silica gel with methylene chloride/methanol mixtures (99:1 to 9:1) as the eluent. The crude product, 4.9 g of brown, amorphous material, was dissolved in a 10-fold amount of hot ethanol and treated with 1.1 equivalents of a saturated solution of fumaric acid in ethanol. The product, 2.2 g of yellow crystals, was recrystallized from a 20-fold amount of ethanol. There were obtained 1.8 g (19%) of 6-[p-(benzyloxy)phenyl]-3,4-dihydro-1-methylpyrrolo[1,2-a]pyrazine fumarate (1:1); m.pt.: 165-168 C. (dec.).

25316-59-0, The synthetic route of 25316-59-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hoffmann-La Roche Inc.; US5292732; (1994); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI