Month: October 2020

56-41-7, H-Ala-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of thionyl chloride (2.18 mL, 0.03 mol) inmethanol (10 mL), the appropriate amino acid (0.01 mol)was added. The resulting solution was refluxed for 5 h. Afterthis time, the solution was cooled to room temperature, thesolvent was removed under reduced pressure and the residuewas recrystallized from ethyl acetate. Yield of obtainedproducts: methyl L-phenylalanine hydrochloride – 89%,methyl L-alanine hydrochloride – 65%, methyl L-valinehydrochloride – 90%, methyl L-leucine hydrochloride -91%, methyl L-cysteine hydrochloride – 38%, methyl L-tryptophanhydrochloride – 82%., 56-41-7

56-41-7 H-Ala-OH 5950, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Majewska, Paulina; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 194; 4-6; (2019); p. 585 – 590;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17217-57-1,4,4′-Dimethoxy-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

General procedure: [Cu(MeCN)4]PF6 (75 mg, 0.20mmol) was added to dppp (82 mg, 0.20mmol) in 5mL of dichloromethane. Then, bpy (32 mg, 0.20mmol) was added and the solution immediately changed to yellow. The reaction mixture was stirred for 30 min at room temperature. Diethyl ether was added to the solution to precipitate the product as a yellow solid, which was filtered and washed with diethyl ether: yield, 126 mg (0.162mmol, 81percent)., 17217-57-1

As the paragraph descriping shows that 17217-57-1 is playing an increasingly important role.

Reference£º
Article; Nishikawa, Michihiro; Tsubomura, Taro; Bulletin of the Chemical Society of Japan; vol. 87; 8; (2014); p. 912 – 914;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Powdered KOH (280mg, 5mmol) was added to 10mL dry dimethyl sulfoxide (DMSO) and 8-Amino-1-octanol (152.5mg, 1.05mmol) was then added and stirred at 60C for 1h. Then, 4?-Chloro-2,2′:6?,2?-terpyridine (268mg, 1.0mmol) was added, and the resulting mixture was stirred at 60C for 48h. After cooled to room temperature, the reaction mixture was poured into deionized water (200mL) to yield precipitation, which was collected by filtration. The yellow solid was washed with deionized water, and then dried under vacuum overnight to afford 290mg of the desired product in 77% yield [30]. 1H NMR (400MHz, CDCl3) delta 8.74-8.66 (m, 2H), 8.62 (d, J=8.0Hz, 2H), 8.02 (d, J=9.1Hz, 2H), 7.85 (td, J=7.8, 1.8Hz, 2H), 7.33 (ddd, J=7.5, 4.8, 1.1Hz, 2H), 4.22 (t, J=6.4Hz, 2H), 2.69 (t, J=7.0Hz, 2H), 1.90-1.81 (m, 2H), 1.56-1.28 (m, 10H). HRMS [M+ H]+ calcd for C23H29N4O+ 377.2341; found: 377.2340. Anal Cald for C23H28N4O: C, 73.37; H, 7.50; N, 14.88; Found: C, 73.32; H, 7.85; N, 14.75., 128143-89-5

The synthetic route of 128143-89-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hou, Zhaohui; Li, Peng; Wang, Huan-Yu; Li, Zhiqiang; Li, Huanrong; Dyes and Pigments; vol. 147; (2017); p. 429 – 435;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The pentafluorinated beta-diketone ligand (3 mmol), NaOH(0.12 g, 3 mmol) and the auxiliary ligand (1 mmol) were dissolved in 30 mL ethanol and heated to 60 C under stirring. Then, the ethanolic solution of EuCl3¡¤6H2O(1 mmol) was added dropwise, and the reaction mixture was stirred at 60 C for 8 h. After cooling down, the yellow solid was precipitated and filtered off. The solidproduct was washed with deionized water and ethanol, and dried in vacuum. Yellow powder, yield 75%, mp 180-182 C; IR nu (KBr):3027(m), 2922 (m), 2853 (m), 1592 (s), 1552 (s), 1506 (s), 1281 (s), 1187 (s), 1079(m), 928 (m), 783 (s), 588 (m), 507 (m) cm-1; 1H NMR (300 MHz, CDCl3):delta 2.98(s, 3H, C=CH), delta 3.23 (s, 18H, N(CH3)2), 6.58 (br, 6H, Ar-H), 7.57 (br, 6H, Ar-H),7.99 (br, 2H, Bath-H), 8.22 (br, 4H, Bath-H), 8.68 (br, 2H, Bath-H), 8.87 (br, 4H,Bath-H), 9.53 (br, 2H, Bath-H), 11.74 (br, 2H, Bath-H) ppm. Anal. Calcd. forEuC63H49N5O6F15:C, 53.70; H, 3.51; N, 4.97; Eu, 10.79; Found C, 53.47; H, 3.47;N, 5.02; Eu, 10.93., 1662-01-7

1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Wan, Yupeng; Lyu, Heng; Du, Hengyi; Wang, Dunjia; Yin, Guodong; Research on Chemical Intermediates; vol. 45; 4; (2019); p. 1669 – 1687;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2,56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a flame-dried flask equipped with a magnetic stirring bar and a condenser was added with cinchona alkaloids (1 mmol), toluene (5 mL), and benzyl bromide derivatives (1.2 mmol, 1.2 equiv.). The mixture was heated at 80 8C until a TLC analysis showing that the starting material was completely consumed. Cooled to room temperature and poured onto Et2O (30 mL) with stirring, the resulting suspension was stirred for another 1 h. Then the precipitate was purified by flash chromatography (MeOH/EtOAc = 1/10, V/V). 4.24.2 N-(4-Trifluoromethylbenzyl)quinidinium bromide (1b) [25] Yield: 87%; white solid; mp 218 C (decomp.); [alpha]D28 +184.2 (c 0.15, CH3OH); IR (KBr): 3398, 3209, 2954, 1621, 1589, 1509, 1373, 1427, 1325, 1227, 1241, 1170, 1125, 1068, 1021, 1003, 934, 864, 832 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 8.82 (d, J = 4.4 Hz, 1H), 8.02 (d, J = 9.2 Hz, 1H), 7.97 (dd, J = 10.4, 9.2 Hz, 4H), 7.77 (d, J = 4.4 Hz, 1H), 7.51 (dd, J = 9.2, 2.4 Hz, 1H), 7.44 (d, J = 2.4 Hz, 1H), 6.84 (d, J = 3.6 Hz, 1H), 6.52 (s, 1H), 6.03 (ddd, J = 17.4, 10.5, 6.9 Hz, 1H), 5.25 (s, 1H), 5.10 (d, J = 8.4 Hz, 2H), 4.85 (d, J = 12.8 Hz, 1H), 4.28-4.22 (m, 1H), 4.06 (s, 3H), 4.02-4.00 (m, 1H), 3.86 (t, J = 9.4 Hz, 1H), 3.50 (t, J = 11.4 Hz, 1H), 3.00-2.90 (m, 1H), 2.69-2.63 (m, 1H), 2.40 (t, J = 11.4 Hz, 1H), 1.91 (s, 1H), 1.79-1.75 (m, 2H), 1.15-1.07 (m, 1H). 13C NMR (100 MHz, DMSO-d6): delta = 158.0, 147.9, 144.2, 143.8, 137.7, 135.1, 133.0, 131.9, 130.9 (q, J = 31.8 Hz), 126.4, 126.3, 125.9, 123.1, 121.7, 120.8, 117.5, 103.0, 68.1, 65.2, 62.9, 56.5, 56.2, 54.5, 37.2, 26.8, 23.6, 21.1.

56-54-2 (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol 637552, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue; Journal of Fluorine Chemistry; vol. 148; (2013); p. 19 – 29;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,128143-89-5

was added to a stirred suspensionof KOH (1.05 g, 18.7 mmol) in anhydrous DMSO(20 mL) at 60 C. After 60 min, 40-chloro-2,20:60,200-terpyridine (1.00 g, 3.7 mmol) was added to the mixture,which was maintained with stirring for 4 h at 70 C. Distilledwater (600 mL) was then added to the reaction mixture,and the product was extracted with CH2Cl2(3 ¡Á 200 mL). Residual water in the CH2Cl2 was removedusing Na2SO4, and the CH2Cl2 was removed using a rotaryevaporator. The desired product was recrystallized fromethyl acetate to give 0.72 g (72%) of 4. 1H NMR(300 MHz, CDCl3-d) 8.7 (d, 2H, J = 4.7 Hz), 8.6 (d, 2H,J = 7.4 Hz), 8.0 (m, 4H), 7.5 (m, 2H), 4.0 (m, 2H), 3.2(dd, 1H, J = 6.3 Hz and J = 12.5 Hz) 1.7 (s, 2H), 1.1 (d,3H, J = 6.4 Hz). 13C NMR (125 MHz, CDCl3-d) 160.2,156.5, 154.2, 148.9, 123.7, 120.8, 105.2, 70.1, 48.1, 21.4.ESI-MS (m/z) calcd. For C18H18N4O: 306.2; 307.307[M + H]+. Elemental analysis: calculated for C18H18N4O:C 70.6, H 5.9, N 18.3. Found: C 70.2, H 5.5, N 18.1.

128143-89-5 4′-Chloro-2,2′:6′,2”-terpyridine 667748, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Kim, Ka Young; Kim, Jaehyeong; Park, Hyesong; Choi, Yeonweon; Kwon, Ki-Young; Jung, Jong Hwa; Bulletin of the Korean Chemical Society; vol. 39; 8; (2018); p. 988 – 994;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76089-77-5,Cerium(III) trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.

76089-77-5, Cerium trifluoromethanesulfonate (0.22 g, 3.7 ¡Á 10-4mol) and ntb (0.30 g, 7.4 ¡Á 10-4 mol) were added in 100 cm3 methanol and stirred overnight under reflux. The reaction solution was filtered and left at rest. After evaporation of solvent, white fiber solid was obtained. The solid was collected by filtration and dried in vacuo. Yield: 75%. 1H NMR (DMSO-d6, 400 MHz, 298 K) delta 7.6-7.5 (q, 2H), 7.3-7.2 (q, 2H), 4.1 (s, 2H) ppm. FT-IR (ATR): 3186-2897, 1990-1623 (aromatic, comb), 1539, 1471, 1456, 1435, 1396, 1362, 1340, 1315, 1271, 1244-1171 (-CF3), 1117, 1099, 1049, 1028, 964, 935, 906, 889, 849,737, 636 cm-1. Anal. Found: C, 43.78; H, 3.27; N, 14.04%. Calcd. for C51H42CeF9N14O9S3: C,43.68; H, 3.02; N, 13.98%.

As the paragraph descriping shows that 76089-77-5 is playing an increasingly important role.

Reference£º
Article; Harada, Takashi; Hasegawa, Ryo; Nishiyama, Katsura; Chemistry Letters; vol. 43; 9; (2014); p. 1496 – 1498;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 2.0 mmol of CoBr2*H2O, 2.0 mmol of H2bpb (1) and 4.0 mmol triethylamine were dissolved in 20 ml of DMF and stirred at RT and air for 20 min. Then 4.42 mmol of NEt4Br was added and the solution was stirred at RT and air an additional 12 h. DMF was removed in vacuo and the residue was dissolved in 30 ml of acetonitrile and filtered. Through adding 30 ml of diethyl ether to the solution and cooling down to 2 C a brown precipitate was formed. After filtering, washing with diethyl ether and drying under vacuo the product was yielded as a brown powder (56%). The complex is air-stable in the solid state and can be stored for months without degradation.

10534-59-5, As the paragraph descriping shows that 10534-59-5 is playing an increasingly important role.

Reference£º
Article; Adolph; Zevaco; Walter; Dinjus; Doering; Polyhedron; vol. 48; 1; (2012); p. 92 – 98;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1866-16-6, S-Butyrylthiocholine iodide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The method was adapted for measurement of very low cholinesterase activity in samples, high throughput screening and serial assays. Thus, measurements on enzyme samples of 10 mul were performed either in a Peltier thermostated spectrofluorimeter F-7100 (Hitachi Ltd.,Japan) using standard spectrofluorimetic cuvettes of 1 cm-path length in a total volume of 1.5 ml, or in a titration microplate reader (TecanInfinite F Plex) using a total volume of 200 mul per well (96-well titration plate, 7.5mm well ?). Stock solutions of substrates were 100mM ATC or BTC prepared inwater. These solutions were stored at -20 C. Because of thioester unstability, only freshly thawed solutions were used. Final substrate concentrations ranged between 2 and 1000 muM. Stock solution of Probe IV was 1mM made in DMSO and stored at -20 C. The solution is light sensitive. The final concentration of Probe IV in current assays was 10 muM. During the time-course of assays for determination of ChE activity, the fluorescence stops increasing when 1% of substrate is consumed, i.e. 10 muM thiocholine released. Thus, under steady-state conditions, [S] is almost constant and remains much larger than the enzyme concentration, i.e. >0.798mM for [S0]=800 muM. Then, the initial rate is linear until consumption of all probe. The final DMSO concentration in assay was 1% v/v. Though DMSO is known as a reversible ChE inhibitor (e.g. for human AChE,IC50=2.6% v/v in the presence of 1mM ATC), the inhibitory effect of 1% DMSO was considered as weak. The current volume of pure enzymes per assay was 15 mul in spectrofluorimetric cuvette and 10 mul per plate reader well. However, assays were also performed with sample volumes ranging from 5 to 30 mul. The final concentration in active sites per assay was as low as 10-12 M. For most kinetic studies, the active site concentration was 1.3¡Á10-10 M for BChE, 2.5¡Á10-11M for AChE, 3¡Á10-9M for BChE mutant E197Q and 1.5¡Á10-9M for mutant E197G. Measurements of activity were performed at the optimum pH of both enzymes and 25 C, the standard temperature for kinetic and thermodynamic studies. The rate of hydrolysis of ATC or BTC wasmonitored in 0.1M sodium phosphate buffer pH 8 for AChE and pH 7 for wild-type and mutants of BChE at 25 C for 3 min in spectrofluorimeter and for 2 min in microplate reader by the fluorescence emission of Probe IV-thiocholine conjugate (Scheme 2) (DeltaIF/dt) withlambdaex=400 nm and lambdaem =465 nm. On Hitachi spectrofluorimeter, lambdaex slit was 5.0 nm and lambdaem slit 10.0 nm. The Tecan titration plate readerwas equipped with light filters with bandwith of lambdaex ¡À 35 nm andlambdaem ¡À 35 nm. The fluorescence background of Probe IV was substracted. In addition, owing to the spontaneous hydrolysis of ATC and BTC, the fluorescence background due to spontaneous substrate hydrolysis was substracted for each concentration. Assays of human plasma BChE in a total volume of 2 ml were performed using 0.8mM BTC in 0.1M sodium phosphate buffer at 25 C. 1to 100 mul of plasma samples were taken for measurements using the classical Ellman’s method. For determination of BChE activity using the Probe IV method, plasma was diluted 100 or 1000 times in 0.1M phosphate buffer pH 7.0, and 1-100 mul samples of diluted plasma wereassayed in spectrofluorimeter. For both methods, reaction rates were recorded for 2 min.

1866-16-6, The synthetic route of 1866-16-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Mukhametgalieva, Aliya R.; Zueva, Irina V.; Aglyamova, Aliya R.; Lushchekina, Sofya V.; Masson, Patrick; Biochimica et Biophysica Acta – Proteins and Proteomics; vol. 1868; 1; (2020);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10581-12-1, Tetramethylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2 In a round flask, 2 mL of methyl cyanide (acetonitrile) as an organic solvent was introduced, 0.145 g (1 mmol) of 5-chloromethylfurfural (CMF, compound I) was dissolved in the organic solvent, 0.133 g (1 mmol) of tetramethylammonium acetate was added to the solution, and then the mixed solution was reacted at normal pressure and room temperature for 5 minutes. After the reaction, the reaction product was extracted by the addition of a small amount of water (5 mL) and ethyl acetate (added twice by 20 mL) to obtain an organic layer. The obtained organic layer was concentrated under reduced pressure to obtain light yellow liquid 5-acetoxymethylfurfural (AcHMF, compound II). The yield thereof is 95%. It was ascertained by 1H-NMR that the light yellow liquid is a target material. Analysis data is as follows. AcHMF: 1H NMR (400 MHz, CDCl3) 9.65 (s, 1H), 7.25 (d, J=3.6, 1H), 6.62 (d, J=3.6, 1H), 5.13 (s, 2H), 2.12 (s, 3H)

10581-12-1, 10581-12-1 Tetramethylammonium acetate 82741, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Kim, Baek Jin; Cho, Jin Ku; Kim, Sangyong; Lee, Do Hoon; Kim, Young Gyu; Kang, Eun-Sil; Hong, Yeon-Woo; Chae, Da Won; US2015/51413; (2015); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI