Day: November 2, 2020

135616-40-9, (R,R)-(-)-N,N’-Bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Beispiel 1 244,3 g (0.448 moi) (R, R)-2, 2 – [1, 2-CYCLOHEXANDIYL) bis (nitrilomethylidyn)] bis [4,6-di- tert.-butyl)-phenol] (Illa) werden in 1500 ML Dichlormethan geloest und mit einer Loesung von 60,0 g (0,237 mol) Vanadylsulfat-Pentahydrat in 2000 ml Methanol versetzt. Die Reaktionsmischung ruehrt fuer 24 h bei Raumtemperatur. Anschliessend wird das Loesungsmittel abdestilliert, der Rueckstand in 1000 ml Dichlormethan aufgenommen und mit 1000 ml Wasser gewaschen. Nach Phasentrennung, Trocknen der organischen Loesung mit Natriumsulfat und Abdestillieren des Loesungsmittels erhaelt man 247,7 g gruenes, amorphes Pulver. Zusammensetzung des Gemischs nach HPLC (Gew. -%) : Komponente (I) : (II) : (III) =68% : 13% : 19%. [A] D20 =-400 (c = 0,01, Chloroform). Beispiel 2 5,46 g (0.01 mol) (R, R)-2, 2 – [1, 2-CYCLOHEXANDIYL) bis (nitrilomethylidyn)] bis [4,6-di- tert.-butyl)-phenol] (Illa) werden in 12,5 ml Dichlormethan geloest und mit einer Loesung von 1,26 g (0,005 mol) VANADYLSULFAT-PENTAHYDRAT in 12,5 ML Methanol versetzt. Die Reaktionsmischung ruehrt fuer eine Stunde bei 40 C. Anschliessend wird das Loesungsmittel abdestilliert, der Rueckstand in 50 ml Dichlormethan aufgenommen und mit 100 ml Wasser gewaschen. Nach Phasentrennung, Trocknen der organischen Loesung mit Natriumsulfat und Abdestillieren des Loesungsmittels erhaelt man 3,5 g gruenes, amorphes Pulver. Zusammensetzung des Gemischs nach HPLC (Gew. -%) : Komponente (I) : (H) : (III) = 71 % : 10% : 19%.

135616-40-9, The synthetic route of 135616-40-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CLARIANT GMBH; WO2004/55028; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1671-87-0,3,6-Di(pyridin-2-yl)-1,2,4,5-tetrazine,as a common compound, the synthetic route is as follows.

A 5¡Á10-6 M solution of compound 4 in 1:1 ethanol:H20 and a 5¡Á10-6 M solution of compound 12 in ethanol were prepared separately. 1 mL of each solution was added to a 3-mL UV cuvette, and the absorbance was measured every five minutes at room temperature for 40 minutes. Tetrazine 4 has an absorption maximum at 292 nm, and the product 13 has an absorption maximum at 312 nm. Also, product 13 displays significant absorption at 340 nm (e=12000), whereas tetrazine 4 displays minimal absorption (e=3000) at 340 nm. With monitoring at 292, 312 and 340 nm, the reaction was considered to be completed in 40 min

1671-87-0, 1671-87-0 3,6-Di(pyridin-2-yl)-1,2,4,5-tetrazine 315109, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; University of Delaware; US2009/23916; (2009); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7328-91-8, 2,2-Dimethylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Pyridine-2-carbaldehyde (30 mmol, 3.21 g)And 2,2-dimethyl-1,3-propanediamine (15 mmol, 1.53 g)30mL of methanol mixed,After 7.0 hours at room temperature,Slowly add NaBH4 (120 mmol, 4.54 g) slowly while stirring in an ice-water bath Slowly warmed to 70 for 5 hours.Stop the reaction,Cool to room temperature,Rotate the reaction solution.Then 50mL CH2Cl2 dissolved, filtered, Filtrate spin dry,Have yellow oily sticky substance.After dissolving the above yellow oily dope in 30 mL of methanol,To this was added an equimolar amount of aqueous formaldehyde solution,After stirring at room temperature for 3 hours,The solvent was removed under reduced pressure,Isolated and purified by column chromatography to give 3,3-dimethyl-1,3-bis (2-picolyl) hexahydropyrimidine (3.96 g, yield 89percent)., 7328-91-8

Big data shows that 7328-91-8 is playing an increasingly important role.

Reference£º
Patent; Henan University of Technology; Yang Liangru; Mai Wenpeng; Mao Pu; Xiao Yongmei; Yuan Jinwei; Qu Lingbo; (12 pag.)CN104744519; (2017); B;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10534-59-5,Tetrabutylammonium acetate,as a common compound, the synthetic route is as follows.

Step 4: Preparation of tetrabutylammonium salt of (2S,5R)-N-[(3/?)-l-(ferf-butoxycarbonyl) piperidine-3-carbonyl]-6-(sulfooxy)-7-oxo-l,6-diazabicyclo[3.2.1]octane-2-carboxamide: To a stirred solution of (2S,5 ?)-N-[(3^)-l-(ieri-butoxycarbonyl)piperidine-3-carbonyl]-6-hydroxy-7-oxo- l,6-diazabicyclo[3.2.1]octane-2-carboxamide (0.480 g, 0.0012mol) in dimethylformamide (4.8 ml), at about 10C, was added dimethylformamide sulphur trioxide complex (0.207 g, 0.0013mol) in one portion. The reaction mass was stirred at the same temperature for 30 minutes and allowed to warm to room temperature. After 1 hour of stirring, to the reaction mixture was added, slowly, a solution of tetrabutylammonium acetate (0.408 g, 0.0013 mol) in dichloro methane (2 ml) and the stirring continued further. After 1 hour, the solvent from the reaction mixture was evaporated under reduced pressure to obtain an oily residue. The oily mass was co-evaporated with xylene (2×10 ml) resulting in a thick mass. This mass was partitioned between dichloromethane (10 ml) and water (10 ml) for three times. The combined organic extracts were washed with water (3×10 ml), dried (over anhydrous sodium sulphate) and the solvent was evaporated under reduced pressure. The resulting oily mass was triturated with ether (3×10 ml), each time the ether layer was decanted and finally the residue was concentrated under reduced pressure to obtain 0.7 g of the titled product as white foam in 80% yield.Analysis:475.4 (M-l) as free acid; for Molecular Weight: 717.95 and Molecular Formula:

10534-59-5, The synthetic route of 10534-59-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WOCKHARDT LIMITED; TADIPARTHI, Ravikumar; PATIL, Vijaykumar Jagdishwar; KALE, Amol; SHAIKH, Mohammad Usman; PATEL, Mahesh Vithalbhai; (65 pag.)WO2016/116788; (2016); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The synthetic route of binary and ternary europium complexes C1-C5 is demonstrated in Scheme 2. A solution of EFBA (3 mmol) in ethanol was added dropwise to the aqueous solution of europium nitrate (1 mmol) with constant stirring on magnetic stirrer at room temperature. pH of the resulting mixture was set between 6-7 by using dilute NaOH (0.05 M) and white color precipitates were obtained. The resulting precipitates were vaccum filtered along with washing of water and ethanol to remove the unreacted ligand and then dried in vaccum desiccator to obtain the white powder of Eu(EFBA)3(H2O)2 (C1) complex. Complexes C2-C5 were prepared by the same procedure as adopted for the synthesis of complex C1 but in addition to the reaction mixture of EFBA (3 mmol) and europium nitrate (1 mmol) there is extra addition of ethanolic solution of neo (1 mmol), batho (1 mmol), phen (1 mmol), and bipy (1 mmol) for the synthesis of ternary europium complexes C2-C5, respectively., 1662-01-7

1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Devi, Rekha; Bala, Manju; Khatkar, S. P.; Taxak, V. B.; Boora, Priti; Journal of Fluorine Chemistry; vol. 181; (2016); p. 36 – 44;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7328-91-8, 2,2-Dimethylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N1-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-yl)-2,2-dimethylpropane-1,3-diamineA suspension of 3-(2,5-dichloropyrimidin-4-yl)-l-(phenylsulfonyl)-1H-indole (0.590g, 1.46mmol), 3,3-dimethylaminopropyldiamine (149mg, 1.46mmol) in EtOH/DMF (4: 1, lOmL) was heated at 130¡ãC (mW) for 20min. The mixture was diluted with EtOAc (30mL), washed with sat. NaHC03 (5mL), brine (5mL) dried (MgS04), filtered and concentrated under reduced pressure to afford the title compound (600mg, 1.28mmol, 87percent) as a white solid which was used in the next step without any further purification.

7328-91-8, The synthetic route of 7328-91-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SYROS PHARMACEUTICALS, INC.; PARAZA PHARMA, INC.; CIBLAT, Stephane; DEROY, Patrick; LEBLANC, Melissa; MARINEAU, Jason, J.; MOORE, Joel; ROY, Stephanie; SIDDIQUI, M., Arshad; SPROTT, Kevin; WINTER, Dana, K.; KABRO, Anzheliika; LEGER, Serge; MILLER, Tom; SCHMIDT, Darby; BRADLEY, Michael; WO2015/58163; (2015); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

C1. D-Tryptophan methyl ester; The title compound can be obtained by methylesterification of D-tryptophan in methanol with the aid of thionylchloride according to standard procedures., 153-94-6

153-94-6 H-D-Trp-OH 9060, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; ALTANA PHARMA AG; WO2006/79645; (2006); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

144222-34-4, N-((1R,2R)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0219] To a solution of the enone (450 mg, 1 mmol, 1.0 equiv) in 0.5 M/4.5 mL/g anhydrous PhCH3 or dichloromethane (DCM) under N2 atmosphere was added Et3N (0.14 mL, 1 mmol, 1.0 equiv) and HCO2H (0.05 mL, 1.2 mmol, 1.2 equiv) at room temperature (RT). The resulting solution was stirred for 10 min and then treated with solid (R,R)-(-)-Ru-TsDPEN-cymene complex1 (19 mg, 0.03 mmol, 0.03 equiv) all at once. The reaction mixture was then aged at RT for 2 h, at which a complete consumption of starting material was observed. Tert-butyl methyl ether-MTBE (5 mL) was added followed by 1N HCl (2 mL). The organic layer was separated, washed with saturated Na2CO3, brine, dried over MgSO4, filtered and concentrated in vacuo to give the final compound as viscous oil. [0220] The catalyst can also be generated in situ by mixing 0.02 mol equiv of [RuCl2(p-cymene)2] and 0.04 mol equiv of the (R,R)-N-Tosyl-1,2-diphenylethylene-1,2-diamine in DCM (dichloromethane) in the presence of 0.04 mol equiv of 1M solution KOtBu in THF (tetrahydrofuran). After aging for 10 min at RT, Et3N was added followed by HCO2H and a solution of the enone in DCM). [0221] The catalyst was prepared by mixing 1 mol equiv of [RuCl2(p-cymene)2], 2 mol equiv (R,R)-N-Tosyl-1,2-diphenylethylene-1,2-diamine and 4.2 mol equiv of Et3N in iPrOH at 80 C. for 1 h (hour). After solvent removal, the solid was washed with cold H2O and the recrystallized from MeOH to give the catalyst as orange solid., 144222-34-4

144222-34-4 N-((1R,2R)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide 2734565, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Billot, Xavier; Colucci, John; Han, Yongxin; Wilson, Marie-Claire; Young, Robert N.; US2004/198701; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33454-82-9,Lithium trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.

Preparation 4: Ethyl Z-5-methyl-3-(trifluoromethylsulfonyloxy)-2-hexenoateA 20L jacketed reactor was charged with DCM (2.45L), ethyl 3-oxo-5- methylhexanoate (163.3g; 1 eq) and lithiunn triflate (295.86g; 2eq) under an inert atmosphere. The resulting white suspension was stirred and cooled to 0C. N, N- Diisopropylethylamine (134.8g; 182ml; 1 .1 eq) was added over 10 minutes at <10C. The suspension was stirred for 20 minutes at 0C, then triflic anhydride (294.28g; 175ml; 1 .1 eq) was added slowly to the mixture over 30 minutes at <10C. The suspension was stirred at 0C for 1 hour.A sample of the reaction mixture was taken and partitioned between MTBE and sat. NH4CI (1 ml each). The aqueous layer was extracted with MTBE (1 ml) and the combined organic extracts were filtered through cotton wool/MgSO . Analysis by GC indicated that less than 2% starting material remained.The mixture was allowed to warm from 0 to 25C over 1 hr whilst quenching with sat. NH4CI (980ml). DCM (490ml) was added and the mixture was stirred for 5 minutes, then allowed to settle and the layers were separated. The aqueous layer was extracted with DCM (490ml). The combined organic phases were then washed with 1 M HCI (2 490ml), water (490ml) and 20% brine (490ml), then stirred for 30 minutes with MgSO4 (~165g) for 15-30 minutes. The solids were removed by filtration and washed with DCM (165ml). The filtrate was concentrated under vacuum at <40C to give an orange/brown oil containing crystalline solids. The crude product was triturated with MTBE (980ml). The mixture was filtered and the solids were washed with MTBE (2 x 165ml). The filtrate was concentrated under vacuum at <40C to give the title product as an orange/brown oil: overall yield 271 g (94%; corrected for 2.1 %w/w MTBE content); 87.7% area purity by GC. 1 H NMR (CDCI3, delta= 7.20): delta 0.94 (6H, d, J = 6.7 Hz), 1 .24 (3H, t, J = 7.2 Hz), 1 .89 (1 H, hept, J = 6.8 Hz), 2.17 (2H, d, J = 7.2 Hz), 4.18 (2H, q, J = 7.2 Hz), 5.67 (1 H, s) ppm., 33454-82-9

As the paragraph descriping shows that 33454-82-9 is playing an increasingly important role.

Reference£º
Patent; PFIZER MANUFACTURING IRELAND; BURRELL, Adam James Musgrave; MARTINEZ, Carlos Alberto; MCDAID, Paul Oliver; O’NEILL, Padraig Mary; WONG, John Wing; WO2012/25861; (2012); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

76089-77-5,76089-77-5, Cerium(III) trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 7The above-described ligand represented by formula (B-13) (50 mg, 0.062 mmol) and cerium trifluoromethanesulfonate (35 mg, 0.060 mmol) were charged into a flask. Then, ethanol (5 mL) was added thereto and dissolved. The mixed solution was stirred for 2 hours at room temperature, and then the stirring was stopped. About 20 mL of diethyl ether was added, and the resultant mixture was left to stand overnight. After that, the produced solid was collected to obtain the above-described metal complex represented by composition formula (C-13) (hereinafter, ?metal complex (C-13)?). The collected amount was 41 mg (yield 43%).Elemental analysis: Found (%) C, 45.67; H, 4.71; N, 9.93; S, 6.54. Calcd for C53H62CeF9N10O9S3 (%) C, 45.78; H, 4.49; N, 10.07; S, 6.92.The metal complex (C-13) emitted a blue color in a solid powder state and in a solution state (acetonitrile) under ultraviolet excitation (365 nm).The emission spectrum in acetonitrile had a peak at 428.5 nm, the emission quantum yield was 25%, and the excitation life was 56 ns.

76089-77-5 Cerium(III) trifluoromethanesulfonate 2733941, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; US2012/211706; (2012); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI