Day: November 18, 2020

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To 4mL of ice-bath cooled methanol was added drop-wise 1mL of thionyl chloride in 5min under nitrogen, the resulting mixture was stirred for 0.5h and amine derivatives 3a-3f were added. The reaction mixture was stirred at room temperature overnight until complete disappearance of the materials indicated by TLC. The solvent and the surplus SOCl2 were removed in vacuum. The residue was dissolved in 20mL of methanol and evaporated under reduced pressure. The procedure was repeated for three times. Then 20mL of ether was added to the residue and evaporated in vacuum, which also took three times. Target compounds 4a-4f were obtained in 86%-95% yield and used without further purification for the following step., 153-94-6

As the paragraph descriping shows that 153-94-6 is playing an increasingly important role.

Reference£º
Article; Tang, Hong-Jin; Zhang, Xiao-Wei; Yang, Lin; Li, Wei; Li, Jia-Huang; Wang, Jin-Xin; Chen, Jun; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 637 – 648;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.391604-55-0,2-(2,4-Difluorophenyl)pyridine,as a common compound, the synthetic route is as follows.

In a Schlenk’s flask were placed iridium(III) trichloride hydrate (500 mg, 1.42 mmol, 1 equivalent) and silver(I) trifluoromethanesulfonate (1.09 g, 4.26 mmol, 3.0 equivalents), and the interior of the flask was substituted with nitrogen. There were added 2-(2,4-difluorophenyl)pyridine (2 mL, s/s=4) and water (1 mL, s/s=2), and the mixture was heated at 200C on an oil bath with stirring for 3 hours. The resulting black mixture was evaporated to dryness, and the residue was purified by silica gel column chromatography (eluent: dichloromethane). The column fractions were condensed, and recrystallized from hexane/dichloromethane to give 571 mg of the title compound (5-6) as yellow green powder in 52.7% yield. NMR data of the product was identical to that of Example 12.

391604-55-0, 391604-55-0 2-(2,4-Difluorophenyl)pyridine 11263359, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; TAKASAGO INTERNATIONAL CORPORATION; WO2004/43974; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

3030-47-5, N1-(2-(Dimethylamino)ethyl)-N1,N2,N2-trimethylethane-1,2-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A general method was used to synthesize the copper(II) complexes 1-5: To a pre-heated equimolar amounts of Cu(ClO4)2¡¤6H2O (0.190g, 0.50mmol) and the amine ligand (pmedien or DPA, 0.50mmol) dissolved in H2O (15mL), an aqueous solution of the sodium salt of the polycarboxylate compound (0.25mmol) was added. The resulting intense blue solution was heated on a steam-bath for 15min, filtered through Celite and then allowed to crystallize at room temperature. The crystalline solid which separated over a period of 4-12days was collected by filtration, washed with propan-2-ol, ether and allowed to dry in air. Single crystals suitable for X-ray structure analysis were obtained from dilute solutions by crystallization from H2O.

3030-47-5, 3030-47-5 N1-(2-(Dimethylamino)ethyl)-N1,N2,N2-trimethylethane-1,2-diamine 18196, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Mautner, Franz A.; Albering, Joerg H.; Vicente, Ramon; Andrepont, Chase; Gautreaux, Jacob G.; Gallo, August A.; Massoud, Salah S.; Polyhedron; vol. 54; (2013); p. 158 – 163;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.100125-12-0,3,8-Dibromo-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: Activated Mg turnings (0.71 g, 29.21 mmol) in anhydrous thf (5 mL) and a catalytic amount of iodine were added to a flame-dried 100 mL three-necked flask and stirred vigorously at room temperature under argon. Then a solution of 2-bromo-5- methylthiophene (1.7 mL, 15.10 mmol) in anhydrous thf (5 mL) was slowly added dropwise to the reaction mixture. Once the vigorous reaction had started, the rest of the 2-bromo-5-methylthiophene solution was added dropwise to keep the mixture at reflux. The mixture was then heated at reflux for 30 min and added through a cannula into an ice-cooled solution of 3,8-dibromo-1,10- phenanthroline (2.01 g, 5.95 mmol) and [Ni(dppp)Cl2] (0.09 g, 0.17 mmol) in dry thf (50 mL). After stirring at room temperature for 2 h, the reaction mixture was heated at reflux for another 12 h, cooled to room temperature, quenched with saturated NH4Cl aqueous solution, and extracted thoroughly with chloroform (CHCl3) until no more products could be detected by TLC. The organic layer was washed with brine and purified by column chromatography (silica gel; CHCl3/petroleum ether, 1:1).

100125-12-0, The synthetic route of 100125-12-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Bo; Cao, Kou-Sen; Xu, Ze-An; Yang, Zhe-Qin; Chen, Hao-Wen; Huang, Wei; Yin, Gui; You, Xiao-Zeng; European Journal of Inorganic Chemistry; 24; (2012); p. 3844 – 3851;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56-54-2,(S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol,as a common compound, the synthetic route is as follows.

56-54-2, General procedure: 4.24.13 N-(3,5-Ditrifluoromethyl)benzyl-9-O-benzyl-6′-hydroxyquinidinium bromide (4d) Sodium hydride (96.0 mg, 4.0 mmol) was added to a solution of quinidine (324.4 mg, 1.0 mmol) in dry DMF (5 mL). Benzyl chloride (173 muL, 1.5 mmol) was added dropwise. The reaction mixture was stirred at room temperature for 20 h and quenched by water. The aqueous phase was extracted with ethyl acetate. The organic layer was washed with brine, dried over Na2SO4, concentrated in vacuo to afford yellowish oil, which was used without purification. Ethanethiol (434.0 muL, 5.8 mmol) was added to a stirred suspension of sodium hydride (139.3 mg, 5.8 mmol) in dry DMF (3 mL). The yellowish oil (300 mg) in dry DMF (3 mL) was added dropwise and the reaction mixture was stirred at 110 C for 15 h. The solvent and excess ethanethiol were removed under reduced pressure. The crude product was added the 3,5-ditrifluoromethylbenzyl bromide (336.2 mg, 1.1 mmol) in THF (6 mL). The reaction mixture was refluxed and monitored by TLC analysis. The solvent was removed under reduced pressure and the residue was purified by flash chromatography (MeOH/EtOAc = 1/20, V/V). The product was obtained as pale white solid.

As the paragraph descriping shows that 56-54-2 is playing an increasingly important role.

Reference£º
Article; Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue; Journal of Fluorine Chemistry; vol. 148; (2013); p. 19 – 29;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (25,5 ?)-6-benzyloxy-N’-{ [5-(2-tert- butyldimethysilanyloxyethyl)- lH-tetrazol- l-yl]acetyl}-7-oxo- l,6-diazabicyclo[3.2.1]octane-2- carbohydrazide (8 g, 14.3 mmol) in dimethylformamide (40 ml) and dichloromethane (40 ml) was added 10% Pd/C(50% wet basis) 2.4 g at 25- 30 C. The H2 gas was bubbled through the reaction mixture under stirring. The progress of reaction was monitored by TLC (chloroform: methanol, 9: 1). The catalyst was removed by filtration on celite bed and washed with mixture of dichloromethane and dimethylformamide (1 : 1, 2×20 ml). The filtrate was concentrated under reduced pressure yielded (25,5 ?)-6-hydoxy-N’-{ [5-(2-tert-butyldimethysilanyloxyethyl)- lH- tetrazol- l-yl]acetyl}-7-oxo- l,6-diazabicyclo[3.2.1]octane-2-carbohydrazide (6.6 g, c.a 100% yield used for next reaction as such). The product (25,5 ?)-6-hydoxy-N’-{ [5-(2-tert- butyldimethysilanyloxyethyl)- lH-tetrazol- l-yl]acetyl}-7-oxo- l,6-diazabicyclo[3.2.1]octane-2- carbohydrazide (6.6 g, 14.3 mmol) thus obtained was dissolved in dimethylformamide (40 ml) was added dimethylformamide sulfur trioxide complex (2.63 g, 17.20 mmol) in argon atmosphere at 0C under stirring. The progress of reaction was monitored by TLC (chloroform: methanol, 9: 1). After completion of the reaction added a solution of tetra-butyl ammonium acetate (5.18 g, 17.20 mmol) dissolved in water (18 ml) at 25-30C. The reaction mixture was stirred for 3 hours and concentrated under reduced pressure. The residue obtained was taken in dichloromethane (80 ml) and washed with water (2×40 ml). The organic extract was dried on anhydrous sodium sulfate and concentrated to yield crude tetrabutylammonium salt of (2S,5 ?)- V-{ [5-(2-tert- butyldimethysilanyloxyethyl)- lH-tetrazol- l-yl]acetyl}-7-oxo-6-sulfooxy- l,6-diazabicyclo[3.2.1] octane-2-carbohydrazide. This material was purified by column chromatography (silica gel 100-200 mesh size) using chloroform: methanol as an eluent. The fractions containing the product obtained at 5% methanol in chloroform. The pure fractions were combined and concentrated to get 7.5 g of tetrabutylammonium salt of (25,5 ?)-N’-{ [5-(2-tert-butyldimethysilanyloxyethyl)- lH-tetrazol- l- yl]acetyl}-7-oxo-6-sulfooxy- l,6-diazabicyclo[3.2.1]octane-2-carbohydrazide as off-white foam solid in 66% yield.

10534-59-5, As the paragraph descriping shows that 10534-59-5 is playing an increasingly important role.

Reference£º
Patent; WOCKHARDT LIMITED; TADIPARTHI, Ravikumar; PATIL, Vijaykumar Jagdishwar; DEKHANE, Deepak; SHAIKH, Mohammad Usman; BIRAJDAR, Satish; DOND, Bharat; PATEL, Mahesh Vithalbhai; (100 pag.)WO2017/81615; (2017); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

112881-51-3, 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ru(bbp)Cl3 (259 mg, 0.5 m mol) was added to a dmf solution (80 ml) of 4-(4-pyridyl) terpyridine (pyterpy) (155 mg, 0.5 m mol). Most of the Ru(bbp)Cl3 remained in suspended condition. The reaction mixture was refluxed under stirring condition. With the progress of the reaction, color of the reaction mixture changed from deep brown to pink. The mixture was refluxed for 20 h and filtered. The volume of the solution was reduced to 5 ml and a 2 ml saturated aqueous solution of NH4PF6 was added to give a pink colored solid. The solid was filtered and throughly washed with water (3 * 5 ml). The pink colored solid was dried under vacuum. Yield: 419 mg, 41%. Pure product was obtained from a silica gel column using methanol as eluent. 253 mg, 25% wrt reactants. Anal. Calc. Found: C, 45.95 (46.24); H, 2.58 (2.67); N, 12.92 (12.45)%. ESI MS: 722.12 (M+2-H+), 1H NMR (d6-DMSO) (delta/ppm): 9.60 (2H,s), 8.96 (4H,t), 8.59 (2H,d), 8.50 (2H,d), 8.34 (1H,t), 7.85 (2H,t), 7.83 (2H,t), 7.41 (2H,d), 7.38 (2H,d), 7.20 (2H,t), 6.79 (2H,t), 6.55 (2H,t), 5.75 (2H,d)., 112881-51-3

112881-51-3 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine 11438308, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Naskar, Sumita; Pakhira, Bholanath; Mishra, Dipankar; Mitra, Partha; Chattopadhyay, Shyamal Kumar; Naskar, Subhendu; Polyhedron; vol. 100; (2015); p. 170 – 179;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

62937-45-5, D-Prolinamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62937-45-5, General procedure: A stirred suspension of 2-chloro-N-(1-methyl-1H-imidazol-4-yl)furo[3,2-d]pyrimidin-4-amine (1b) (100 mg, 0.40 mmol), (S)-pyrrolidin-2-ylmethanol (122 mg, 1.20 mmol) in N-Methyl-2-pyrrolidinone (1 mL) was subjected to microwave irradiation at 150 C for 2 h. The reaction mixture was diluted with ethyl acetate (50 mL), washed with brine (2 x 20 mL), dried, filtered and concentrated in vacuum. The crude residue was purified by combiflash (silica gel, 12 g, eluting with chloroform/CMA-80) to afford (S)-(1-(4-((1-methyl-1H-imidazol-4-yl)amino)furo[3,2-d]pyrimidin-2-yl)pyrrolidin-2-yl)methanol (2a) (43 mg, 34 % yield) as a light yellow solid; NMR (300 MHz, DMSO-i) delta 9.90 (s, 1H, D20 exchangeable), 8.00 (d, J = 2.1 Hz, 1H), 7.44 (s, 1H), 7.42 (d, J = 1.4 Hz, 1H), 6.71 (d, J = 2.1 Hz, 1H), 4.94 (s, 1H, D2O exchangeable), 4.13 (s, 1H), 3.83 – 3.69 (m, 1H), 3.64 (s, 3H), 3.62 – 3.49 (m, 1H), 3.48 – 3.23 (m, 2H), 2.07 – 1.83 (m, 4H); MS (ES+): 315.4 (M+l), 337.5 (M+Na), (ES-): 313.4 (M- 1). HPLC purity: 98.70%.

62937-45-5 D-Prolinamide 447554, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; BIOCRYST PHARMACEUTICALS, INC.; KOTIAN, Pravin, L.; BABU, Yarlagadda, S.; KUMAR, V., Satish; ZHANG, Weihe; LU, Peng-Cheng; RAMAN, Krishnan; (747 pag.)WO2018/232094; (2018); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-91-5,2,2′-Biquinoline,as a common compound, the synthetic route is as follows.

Under argon atmosphere, 1,2-bis(diphenylphosphino)benzene (91.7 mg, 0.205 mmol) was added to 5 mL of the suspension of silver(I) tetrafluoroborate (40.0 mg, 0.205 mmol) in dry dichloromethane, and the mixture was stirred at room temperature for one hour. Then, 2,2′-biquinoline (52.7 mg, 0.205 mmol) was added to the reaction solution, which was stirred at room temperature for another one hour. The pale yellow reaction solution was filtrated, and the filtrate was concentrated, subjected to recrystallization by slow diffusion of chloroform-ether, and dried to provide 171 mg of the pale yellow solid complex. The result of elemental analysis for the obtained complex is shown in Table 2-2, and the composition ratio of the complex was obtained. The present complex corresponds to the above composition formula (5).

119-91-5, 119-91-5 2,2′-Biquinoline 8412, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

33454-82-9, Lithium trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 1-Methoxy/1,6-dimethoxy pyridinium bromide (1.0 equiv./1.784×10-3 mmol) and 1.03 equiv. inorganic salt (NaBF4, K4PF6, and LiCF3SO3) are mixed with 10 mL of deionized water at room temperature with stirring for about 1 h to give anion exchanged products 3-8., 33454-82-9

The synthetic route of 33454-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Manikandan, Chitrarasu; Ganesan, Kilivelu; Synthetic Communications; vol. 44; 23; (2014); p. 3362 – 3367;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI