Month: November 2020

33454-82-9, Lithium trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 100ml two-necked flask, a suspension of 14 (910 mg, 1.91 mmol) in 30ml of EtOH is brought to reflux and MeOH is added until complete dissolution is obtained (35ml). A solution of LiOTf (2.986g, 19.1mmol) in 3ml of MeOH is added to the mixture, which is then kept at reflux for 30 min. The volume of the mixture is reduced to 20 ml by evaporating the solvent at low pressure, and the white precipitate thus obtained is filtered by washing with EtOH (856mg, 1.57mmol, yield 82%, p.f.: 206-207C)., 33454-82-9

The synthetic route of 33454-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI; UNIVERSITA DEGLI STUDI DI MILANO-BICOCCA; PAGANI, Giorgio, A.; BEVERINA, Luca; SASSI, Mauro; SALAMONE, Matteo, Marco; MARI, Claudio, Maria; RUFFO, Riccardo; WO2013/38243; (2013); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7089-68-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7089-68-1,2-Chloro-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

Synthesis of 2-(1H-pyrazol-1-yl)-1,10-phenanthroline: 2-chloro-1,10-phenanthroline (2.13 g,10 mM), pyrazole (0.70 g, 10 mM), and potassium carbonate (1.50 g, 0.011 mM) weredissolved in 20mL of DMF. The mixture was refluxed for 24 h, then another batch ofpyrazole (0.34 g, 5.0 mM) and potassium carbonate (1.00 g, 7.2 mM) was added into theDMF solution and the reaction continued to reflux for another 48 h. After that, a fraction ofDMF was distilled out by vacuum and 40mL of ice water with crushed ice was added into the solution. The raw product then appeared and was separated by filtration. Then, theproduct was washed with ice water until the filtrate was neutral and the final product wasobtained by vacuum drying. 1H NMR (300MHz, CDCl3, 25 ¡ãC): delta = 9.19 (s, 2H), 8.40 (brs,2H), 8.28 (s, 1H), 7.82 (brs, 3H), 7.66 (s, 1H), 6.56 (s, 1H). HRMS (ESI): m/z calcd forC15H10N4+H+: 247.0978 [M+H+]; found: 247.0982. All other chemicals are analyticalgrade and used without purification.

As the paragraph descriping shows that 7089-68-1 is playing an increasingly important role.

Reference£º
Article; Li, Hong-Nan; Wei, Rui-Zheng; Chi, Yan-Hui; Wei, Wei; Du, Hua; Zhang, Shi-Guo; Shi, Jing-Min; Journal of Coordination Chemistry; vol. 66; 17; (2013); p. 3063 – 3071;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.917-23-7,5,10,15,20-Tetraphenylporphyrin,as a common compound, the synthetic route is as follows.

General procedure: In a 250mL distillation flask, 5,10,15,20-tetraphenylporphyrin (H2TPP) (0.50g, 0.81mmol) and NaOAc (0.30g, 3.6mmol) was stirred in 75mL of chlorobenzene and 50mL of DMF. After the addition of two equivalents of metal acetate, a Soxhlet extractor with a cellulose filter thimble filled with ?3g of K2CO3 was attached to the distillation flask. The assembly was completed with a condenser on the top of the extractor; and then the mixture was heated to reflux at 150C overnight. The reaction extent was monitored by TLC or UV-Vis until all the H2TPP was consumed. After the reaction was compete, the solvent was removed under vacuum. The remaining solid was dissolved in 150mL of chloroform, and washed with water (50mL¡Á3). The organic layer was further washed with a saturated sodium bicarbonate solution (50mL¡Á3), and then dried over K2SO4. After removal of the solvent in vacuo, the solid was recrystallized from chloroform/heptane., 917-23-7

917-23-7 5,10,15,20-Tetraphenylporphyrin 86280046, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Yao, Shu A.; Hansen, Christopher B.; Berry, John F.; Polyhedron; vol. 58; (2013); p. 2 – 6;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.168646-54-6,5,6-Diamino-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

[Cu(CH3CN)4]ClO4 (32.6 mg, 0.100 mmol) was added to a DCMsolution (about 12 mL) of dap (10.7 mg, 98percent, 0.0500 mmol) andxantphos (59.0 mg, 98percent, 0.100 mmol) under a stream of dry argonby using Schlenk techniques at room temperature and a vacuumlinesystem, then orange-red solution was obtained quickly andstirred for 1 h at room temperature. The above process can alsobe carried out in air with the existence of oxygen. After filtrationthrough absorbent cotton, layering n-hexane onto the DCM solutionin air produced the product as bluish violet to black-blue blockcrystals in 76percent yield (63.0 mg). Anal. Calc. for C90H72Cl2Cu2N4O10P4(1b): C, 63.97; H, 4.30; N, 3.32. Found: C, 64.25; H, 4.35; N, 3.26percent.ESI-MS (m/z): 1589.25 {[Cu2(l-pdi)(xantphos)2]ClO4}+ (calcd1589.27); 849.1963 [Cu(pdi)(xantphos)]+ (calcd 849.1968);745.153 [Cu2(l-pdi)(xantphos)2]2+ (calcd 745.159); 641.1222[Cu(xantphos)]+ (calcd 641.1224). 1H NMR (400 MHz, DMSO-d6,delta, ppm): 13.190 (s, 2H, CNH), 9.030 (d, 2H, J = 8.0 Hz), 8.452 (d,2H, J = 4.8 Hz), 7.888 (dd, 2H, J = 8.0 Hz, J0 = 1.2 and 0.8 Hz),7.846?7.814 (m, 4H), 7.340?7.149 (m, 36H), 6.983?6.938 (m, 8H),6.729?6.694 (m, 2H), 6.650?6.615 (m, 2H), 1.732 (s, 6H, CH3),1.653 (s, 6H, CH3). 31P{1H} NMR (400 MHz, DMSO-d6, delta, ppm):5.980, 12.816. Characteristic IR spectrum (KBr, cm-1): 3258m(NH), 2961m (CH3), 2923w (CH3), 2858w (CH3); 1097s (ClO4).

168646-54-6, The synthetic route of 168646-54-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yao, Xi-Xi; Guo, Ya-Meng; Liu, Rong; Feng, Xiao-Yan; Li, Hao-Huai; Liu, Nian; Yang, Feng-Lei; Li, Xiu-Ling; Polyhedron; vol. 92; (2015); p. 84 – 92;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4′-(2-Aminoethanesulfanyl)-2,2′:6′,2”-terpyridine (2a) was prepared from reaction of the 4′-chloroterpyridine 8a (at 50 C for 3 h) or the 4′-iodoterpyridine 7a (at 70 C for 2 h) with 2-aminoethanethiol hydrochloride and sodium hydride in DMF. The reactions gave the target compound 2a in 75% and 86% yields, respectively.The 1H and 13C NMR spectral data of 2a were consistentwith literature data., 128143-89-5

The synthetic route of 128143-89-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lin, Chih-Pei; Florio, Pas; Campi, Eva M.; Zhang, Chunfang; Fredericks, Dale P.; Saito, Kei; Jackson, W. Roy; Hearn, Milton T.W.; Tetrahedron; vol. 70; 45; (2014); p. 8520 – 8531;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10581-12-1,Tetramethylammonium acetate,as a common compound, the synthetic route is as follows.

General procedure: The appropriate ligand (H3LR)(0.18 mmol, R=OMe, Me H, Cl, Br), was deprotonated with 3.1 molar equiv. KH in3mL of DMA in a 25-50-mL round bottom flask. After H2 evolution ceased (?5-10 min), an excess 1.2 eq of Mn(OAc)2 was added along with 1mL of DMA andstirred for 30 min. Then 2.1 equivalents of [Me4N][OAc] were added along with 1mL ofDMA and the reaction was stirred at room temperature overnight. The mixture was filteredthrough a glass fritted funnel to remove insoluble material. The filtrate was layeredunder Et2O and allowed to stand for recrystallization. In most cases a whitecrystalline solid was obtained and isolated by filtration. In some cases, an oily residuewas obtained that through trituration with Et2O and scraping yields a white solid. Ineither case, the solids from DMA/Et2O was then redissolved in acetonitrile and filteredto remove insoluble material. Recrystallization was accomplished by slow vapor diffusionof Et2O into acetonitrile. The solids obtained were washed with diethyl ether anddried under vacuum. See below for characterization data for the remainingMn(II) complexes.

10581-12-1, The synthetic route of 10581-12-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cannella, Anthony F.; Surendhran, Roshaan; MacMillan, Samantha N.; Gupta, Rupal; Lacy, David C.; Journal of Coordination Chemistry; vol. 72; 8; (2019); p. 1287 – 1297;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2304-30-5,Tetrabutylphosphonium chloride,as a common compound, the synthetic route is as follows.

EXAMPLE 1 Preparation of 2,4,6-tris(o-aminophenylthiomethyl)mesitylene A 2-liter glass reaction vessel equipped with a Teflon stirrer, reflux condenser, addition funnel, 2-thermometers and an electrical heater was charged with 243 g water and 104.2 g sodium hydroxide pellets. After boiling under a nitrogen atmosphere for 5 minutes, 167.8 g benzothiazole was gradually added to the contents of the reactor over 50 minutes. The resultant mixture was then heated at the boiling point for 2 hours. A solution of 0.5 g tetrabutyl phosphonium chloride (50% in toluene) and 50 g toluene was then added, which cooled the reaction mixture to 90 C. A solution of 100 g 2,4,6-tris(chloromethyl)mesitylene in 300 g of warm toluene was added over a 15 minute period and the resultant mixture was heated at the boiling point for 2 hours. The aqueous phase of the reaction mixture was then removed and the organic phase washed with 100 g hot water. The residual water was removed by azeotropic distillation. After being filtered the toluene solution gradually cooled to room temperature, during which time a slightly off-white solid crystallized. The solid was filtered off, washed sequentially with cold toluene and heptane and then dried under reduced pressure at 90 C. The product weighed 164.7 g melted from 161 to 166 C. and exhibited an amine equivalent of 181. The theoretical amine equivalent for the expected product, 1,3,5-tris(o-aminophenylthiomethyl)mesitylene is 178.

2304-30-5, As the paragraph descriping shows that 2304-30-5 is playing an increasingly important role.

Reference£º
Patent; M&T Chemicals Inc.; US4187250; (1980); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2, [1,1′-Biphenyl]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

787-70-2, General procedure: A mixture of 1,3-BPEB(14.2 mg, 0.05 mmol), 1,4-BDC (8.3 mg, 0.05 mmol),Cd(NO3)24H2O (15.5 mg, 0.05 mmol), and DMF (1.5 mL) – water(0.5 mL) mixture were placed in a 10 mL glass bottle. This bottlewas sealed and kept at 100 C for 48 h, followed by cooling to roomtemperature over 24 h. Orange block crystals 1 were obtained in a61.4% yield (17.6 mg, based on cadmium). Anal. calc. forC84H64N6O14 Cd3: C 58.70, H 3.75, N 4.89. Found: C 58.64, H 3.70, N4.81.

787-70-2 [1,1′-Biphenyl]-4,4′-dicarboxylic acid 13084, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Liang, Rui; Yue, Fangfang; Wang, Yuting; Guo, Yongkang; Xuan, Xiaopeng; Journal of Molecular Structure; vol. 1119; (2016); p. 301 – 307;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4062-60-6,N1,N2-Di-tert-butylethane-1,2-diamine,as a common compound, the synthetic route is as follows.

General procedure: Toluene (5 mL), secondary diamine (2a,b or 4-c) (1 mmol), paraformaldehyde or 4-fluorobenzaldehyde (2 mmol), alpha,omega-diacetylene (2 mmol), and CuCl (10 mol.%, 0.1 mg) were placed under argon into a Schlenk flask (10 mL) mounted on a magnetic stirrer, and the mixture was stirred for 8 h at 100 C under argon atmosphere.The resulting mixture was cooled, filtered through a layer ofsilica gel, dried over Na2SO4. The solvent was evaporated. The product was purified by column chromatography, the eluent is indicated in the description of the compound., 4062-60-6

The synthetic route of 4062-60-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Khabibullina; Zaynullina; Tyumkina; Yanybin; Ibragimov; Russian Chemical Bulletin; vol. 68; 7; (2019); p. 1407 – 1413; Izv. Akad. Nauk, Ser. Khim.; 7; (2019); p. 1407 – 1413,7;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7328-91-8, 2,2-Dimethylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General synthesis procedure: (for example, 3a) To a solution of ninhydrin (1 mmol) and malononitrile in EtOH (4 mL) was added triethylamine (0.1 mmol), and the solution was stirred for 1 h at room temperature. Then, nitro ketene dithioacetal 1 (1 mmol) and propyldiamine 2 (1 mmol) were added in sequence. Upon completion (11 h), monitored by TLC, the mixture was filtered and the precipitate washed with EtOH (4 mL) to afford the pure product 3a., 7328-91-8

Big data shows that 7328-91-8 is playing an increasingly important role.

Reference£º
Article; Rezvanian, Atieh; Alizadeh, Abdolali; Tetrahedron; vol. 68; 49; (2012); p. 10164 – 10168,5;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI