Month: November 2020

4045-44-7, 1,2,3,4,5-Pentamethylcyclopenta-1,3-diene is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a flame-dried, N2-purged three neck round-bottom flask, fit with a condenser, was added paraformaldehyde (580 mg) and dry THF (10.5 mL). The resulting suspension was heated at reflux under N2 for 2 h and then cooled to RT. To a separate flame-dried, N2-purged round bottom flask was added 1,2,3,4,5-pentamethylcyclopentadiene (0.6 mL, 3.83 mmol, 1.0 mol equiv.), tetrabutylammonium iodide (140 mg, 0.38 mmol, 0.1 mol equiv.), dry THF (8.0 mL), and a stir bar. The solution was cooled to 0 C and n-butyllithium (2.33 M, 4.6 mmol, 1.2 equiv) was added dropwise. A white precipitate immediately began to form. The suspension was stirred for 45 min at 0 C, and then the paraformaldehyde solution (230 mg, 7.66 mmol, 2.0 mol equiv.) was added and the resulting mixture was then stirred for 18 h, letting the ice bath expire. The solvent was then removed under reduced pressure and the solids were taken up in diethyl ether. This mixture was washed sequentially with 1.0 M HCl, sat. NaHCO3 aq., and H2O. The organic solution was dried over Na2SO4 and the solvent was removed under reduced pressure. The crude mixture was then purified by flash column chromatography to give a light yellow oil in 56% yield. 1H NMR (300 MHz, CDCl3) delta 3.50 (s, 2H), 1.77 (d, J = 18.8 Hz, 12H), 0.87 (s, 3H). 13C NMR (126 MHz, CDCl3) delta 138.0, 136.2, 65.3, 58.4, 16.8, 11.3, 9.7., 4045-44-7

As the paragraph descriping shows that 4045-44-7 is playing an increasingly important role.

Reference£º
Article; Peterson, Gregory I.; Church, Derek C.; Yakelis, Neal A.; Boydston, Andrew J.; Polymer; vol. 55; 23; (2014); p. 5980 – 5985;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

33454-82-9, Lithium trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1-3Synthesis of Compound No. 3A 200 ml four-necked flask was charged with 72.08 g (0.75 mol) of methanesulfonic acid and 7.10 g (0.05 mol) of phosphorous pentoxide. After purging with nitrogen, the contents were heated to 100 C. to dissolve. After cooling, 9.76 g (0.05 mol) of acridone was added thereto, and 11.91 g (0.05 mol) of bis(fluorophenyl) sulfoxide dissolved in 11.91 g of chlorobenzene was then added dropwise, followed by causing the system to react at 50 C. for 2 hours. The reaction mixture was poured into a mixture of 200 g of ice water, 80 g of methanol, and 200 g of toluene in a 1 L beaker, stirred for 1 hour, and left to stand. The upper layer was discarded. To the lower layer were added 200 g of methylene chloride and 9.36 g (0.06 mol) of lithium trifluoromethanesulfonate, followed by stirring for 1 hour. The methylene chloride layer was washed with three 300 ml portions of water and concentrated under reduced pressure to give 28.27 g of compound No. 3 of the invention composed of cation No. 19 and a nonafluorobutanesulfonate anion (yield: 100%; HPLC purity: 95.5%)., 33454-82-9

33454-82-9 Lithium trifluoromethanesulfonate 3664839, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; ADEKA CORPORATION; US2012/136155; (2012); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2, [1,1′-Biphenyl]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a typical preparation a solid mixture of H2BPDC (H2BPDC = 4,4′-biphenyldicarboxylic acid; 0.630 g, 2.4 mmol), bpy (bpy = 4,4′-bipyridine; 0.198 g, 1.2 mmol), and Cu(NO3)2¡¤3H2O (0.630 g, 2.4 mmol) was dissolved in a mixture of DMF (DMF = N,N’-dimethylformamide; 180 mL), pyridine (1.8 mL), and methanol (18 mL). The resulting solution was stirred at 70C for 5 min, and then distributed to 20 mL vials. The vials were then heated at 120C in an isothermal oven for 24 h. After cooling the vials to room temperature, the solid product was removed by decanting with mother liquor and washed in DMF (3 * 20 mL) for 3 days. Solvent exchange was carried out with methanol (3 * 20 mL) at room temperature for 3 days. The material was then evacuated under vacuum at 140C for 6 h, yielding 0.605 g of Cu2(BPDC)2(BPY) in the form of blue crystals, correspond to 66% based on copper., 787-70-2

787-70-2 [1,1′-Biphenyl]-4,4′-dicarboxylic acid 13084, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Dang, Giao H.; Le, Dung T.; Truong, Thanh; Phan, Nam T.S.; Journal of Molecular Catalysis A: Chemical; vol. 400; (2015); p. 162 – 169;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348-67-4,H-D-Met-OH,as a common compound, the synthetic route is as follows.

Methionine (0.3 mmol,)And NaOH (0.3 mmol) were dissolved in 30 ml of a mixed solvent (VC2H5OH: VH2O = 5: 1)Stirring for 5 hours,So that it is fully dissolved; then add CuCl2 (0.3mmol),Stirring for 24 hours;Then, 3,4,7,8-tetramethyl-1,10-phenanthroline (0.3 mmol) was added,Stirring for 48 hours;Filter, take its clear liquid into 20ml of small test tube, the ether added to the filtrate above the filtrate and ether volume ratio is about 1: 2.5, standing, about a week after the blue crystal., 348-67-4

The synthetic route of 348-67-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Capital Normal University; Lu, Xiaoming; Zhang, Bo; Zhang, Weichuan; Cheng, Yifeng; Sun, Xiaojing; (60 pag.)CN105440059; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3030-47-5,N1-(2-(Dimethylamino)ethyl)-N1,N2,N2-trimethylethane-1,2-diamine,as a common compound, the synthetic route is as follows.

The ligand pmdien (0.2 ml, 1 mmol) was added to a stirred solutionof Ni(ClO4)2*6H2O (0.36 g, 1 mmol) in methanol (35 ml). The colour of solution turned to violet. Solution of tdaH2 (0.075 g,0.5 mmol) neutralized with KOH (0.056 g, 1 mmol) in water (5 ml) was added. Violet colour turned to green and after a while white precipitate was formed. Precipitate was removed by filtration and filtrate was left for crystallization. After a week green crystals (suitable for X-ray analyses) were collected on a frit funnel, washed with methanol and dried in air., 3030-47-5

3030-47-5 N1-(2-(Dimethylamino)ethyl)-N1,N2,N2-trimethylethane-1,2-diamine 18196, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Bie?ko, Alina; Kopel, Pavel; Kizek, Rene; Kruszy?ski, Rafa?; Bie?ko, Dariusz; Titi?, Jan; Bo?a, Roman; Inorganica Chimica Acta; vol. 416; (2014); p. 147 – 156;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

5350-41-4, N,N,N-Trimethyl-1-phenylmethanaminium bromide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The desired amount of substrate, boronic acid (3 equiv), base (3equiv), Pd(OAc)2 (2.5 molpercent) and ligand (5 molpercent) were weighed out as solids, the vial was sealed and purged with argon, then solvent was added and the vial was purged again. The reactions were run for 14 h at the specified temperature. The crude material was filtered through a pad of Celite and washed three times with CHCl3. The solvent was removed under reduced pressure, an internal standard was added and the reaction was analysed by 1H NMR spectroscopy. For purification, the analysed mixture was concentrated, the product extracted with Et2O and filtered through anhydrous MgSO4 and further purified by flash column chromatography., 5350-41-4

The synthetic route of 5350-41-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Tuertscher, Paul L.; Davis, Holly J.; Phipps, Robert J.; Synthesis; vol. 50; 4; (2018); p. 793 – 803;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4730-54-5, 1,4,7-Triazacyclononane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1,4,7-triazonane (100 mg, 0.77 mmol, 1.0 eq) in DCM (2 mL, 20 vol) was cooled to 0-5 C. and added DIPEA (0.40 mL, 2.32 mmol, 3.0 eq) and Chloroacetyl chloride (0.18 mL, 2.32 mmol, 3.0 eq). The reaction mass was slowly warmed to 25-30 C. and stirred for 4 h. The progress of the reaction was monitored by TLC (10% methanol in DCM). After complete consumption of the 1,4,7-triazonane, water was added to the reaction mass and layers separated. The separated organic layer was evaporated under vacuum to get a syrupy mass. The crude product was purified through silica gel chromatography. 114 mg (60.0%) 1H NMR (400 MHz, CDCl3): delta 4.09 (s, 6H), 3.78 (t, 6H), 3.57 (t, 6H). Purity by LC-MS: 95.32%, RT: 1.33

4730-54-5, As the paragraph descriping shows that 4730-54-5 is playing an increasingly important role.

Reference£º
Patent; BicycleTx Limited; Beswick, Paul John; Ivanova-Berndt, Gabriela; Mudd, Gemma Elizabeth; Pavan, Silvia; Skynner, Michael; Teufel, Daniel Paul; Van Rietschoten, Katerine; (88 pag.)US2018/311300; (2018); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of compounds (1.5 mg) in 6 M HCl (1 ml) was heated to 120 C for 24 h. The solution was then evaporated to dryness and the residue redissolved in H2O (100 mul) and was then placed in a 1 ml reaction vial and treated with a 2% solution of FDAA (200 mul) in acetone followed by 1.0 M NaHCO3 (40 mul). The reaction mixture was heated at 47 C for 1 h, cooled to room temperature, and then acidified with 2.0 M HCl (20 mul). In a similar fashion, standard D- and L-amino acids were derivatized separately. The derivatives of the hydrolysates and standard amino acids were subjected to analytical HPLC analysis (Shimadzu LC-20AD, C18 column; 5 mum, 4.6 mm ¡Á 250 mm; 1.0 ml/min) at 30 C using the following gradient program: solvent A, water + 0.2% TFA; solvent B, MeCN; linear gradient 0 min 25% B, 40 min 60% B, 45 min 100% B; UV detection at 340 nm [39]., 153-94-6

As the paragraph descriping shows that 153-94-6 is playing an increasingly important role.

Reference£º
Article; Nishanth Kumar; Mohandas; Nambisan, Bala; Peptides; vol. 53; (2014); p. 48 – 58;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

53344-72-2,53344-72-2, 6,6′-Dichloro-2,2′-bipyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: An oven-dried Schlenk flask was evacuated and back-filled with argon three times. (Hetero)aryl (di)halide (1 equiv), base (1.5 equiv per halogen) and a solution of SPO (1.2 equiv per halogen) in anhydrous solvent (5 mL/mmol per halogen) were added to the flask. The solution was bubbled with argon for 10 min and Pd(OAc)2 (1 mol% per halogen) and ferrocene-based bidentate phosphine ligand (2 mol% per halogen) were added to the flask simultaneously [2.5 mol% Pd(OAc)2 per halogen and 5 mol% dppf per halogen for compounds 2j, 2l, 2r, 2t, 2w]. The resulting mixture was heated at the indicated temperature for the given time. Workup procedures are described below for two different conditions. Final purification of crude products was achieved by column chromatography on silica gel (40-60 mum) using CH2Cl2-MeOH as eluent. Reaction scale and yields are shown in Table 1 (2a-w), Scheme 1 (3a-h) and Scheme 2 (4a-g). Notice that all compounds with two phosphine oxide groups are beige-to-brown solids or slowly solidifying viscous brown oils. Conditions I: ligand: dppf, solvent: DMF, base: Cs2CO3 (2d-n, 2q, 2r, 2t-w, 4a-g) or K2CO3 (3a-h), temperature: 120 C, time: 7 h (20 h for 2j, 2l, 2r, 2w). Workup: after cooling, the reaction mixture was poured into a fourfold excess of brine. The mixture was extracted three times with CH2Cl2 (40 mL/mmol each). The combined organic layers were washed with brine to remove traces of DMF, dried over Na2SO4 and then evaporated to dryness. Conditions II: ligand: dippf, solvent: toluene, base: t-BuOK, temperature: 110 C, time: 7 h. Workup: after cooling, the reaction mixture was evaporated to dryness. Then, the mixture was diluted with CH2Cl2 (40 mL/mmol) and washed with water and brine (40 mL/mmol). The organic layer was dried over Na2SO4 and the CH2Cl2 was removed under reduced pressure.

As the paragraph descriping shows that 53344-72-2 is playing an increasingly important role.

Reference£º
Article; Zakirova, Gladis G.; Mladentsev, Dmitrii Yu.; Borisova, Nataliya E.; Synthesis; vol. 51; 11; (2019); p. 2379 – 2386;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4730-54-5,1,4,7-Triazacyclononane,as a common compound, the synthetic route is as follows.

General procedure: To a solution of amine or its hydrochloride salt (1.0 mmol) in MeOH (7 mL) K2CO3(1.0 mmol for morpholine and aniline, 2.0 mmol for benzylamine and propargylamine, 3.0 mmol for valine methyl ester hydrochloride and tacd, 4.0 mmol for cyclam, 6.0 mmol for tacn tryhydrochloride) was added and the mixture was stirred for 30 min. Then alpha-halohydrazone (1.0 mmol for morpholine and aniline, 2.0 mmol for benzylamine, propargylamine and valine methyl ester hydrochloride, 3.1 mmol for tacn and tacd or 4.2 mmol for cyclam) was added in one portion with vigorous stirring. The reaction mixture was stirred for 1 h and evaporated in vacuo.Water (50 mL) was added to the residue and further purification was performed as following:For products 2a-d, 3-9: The precipitate was filtered off and washed with appropriate solvent (water for 2a-c, MeOH for 7-9, Et2O for 3-6, acetone for 2d) and dried with air.For products 2f,g: EtOAc (50 mL) was added, the organic extract was separated, washed with brine (50 mL), dried with Na2SO4and evaporated. The residue was purified by column chromatography on silica gel (hexane-EtOAc (5:1) ? EtOAc) to give products 2fand 2g.

4730-54-5, As the paragraph descriping shows that 4730-54-5 is playing an increasingly important role.

Reference£º
Article; Semakin, Artem N.; Kokuev, Aleksandr O.; Nelyubina, Yulia V.; Sukhorukov, Alexey Yu.; Zhmurov, Petr A.; Ioffe, Sema L.; Tartakovsky, Vladimir A.; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2471 – 2477;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI