Month: November 2020

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: [(C^N)2Ir(mu-Cl)]2 (small excess) and N^N ligand in CH2Cl2/CH3OH (20/4 mL) were stirred overnight at 40 C to give yellow/orange solution. It was evaporated. The residue was purified by column chromatography (silica, 20-25 g). Elution with 2.0-4.0% CH3OH in CH2Cl2 removed the impurities. Elution with 4.0-5.0% CH3OH in CH2Cl2 recovered the product as yellow or orange fraction. The product was preceded and/or followed by coloured/luminescent impurity fractions. The desired fractions were evaporated. The product was dissolved in CH3OH (4 mL), and added drop-wise to a stirred aqueous solution of KPF6 (1-1.3 g, 5.4-7.1 mmol, in 30 mL of water, large excess; Alfa Aesar) in order to convert the complex to a hexafluorophosphate salt. The resulting suspension was stirred for 30 min and filtered. Washed with water and ether. Anal. Calc. for C48H30F12IrN4P (MW 1113.95): C, 51.75; H, 2.71; N, 5.03. Found: C, 52.07; H, 2.84; N, 4.66%

1662-01-7, The synthetic route of 1662-01-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shavaleev, Nail M.; Scopelliti, Rosario; Graetzel, Michael; Nazeeruddin, Mohammad K.; Inorganica Chimica Acta; vol. 396; (2013); p. 17 – 20;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1126-58-5,1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of the corresponding bis(isatin) 1-8 (5 mmol) and Girard?s reagent (2.5 mmol) in 7 mL of absolute ethanol were added three drops of trifluoroacetic acid. The reaction mixture was refluxed for 2 h. After spontaneous cooling of the solution to room temperature, the formed precipitate was filtered off, washed with absolute diethyl ether and dried in vacuum (12 mmHg)., 1126-58-5

The synthetic route of 1126-58-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bogdanov; Zaripova; Mustafina; Voloshina; Sapunova; Kulik; Mironov; Russian Journal of General Chemistry; vol. 89; 7; (2019); p. 1368 – 1376; Zh. Obshch. Khim.; vol. 89; 7; (2019); p. 1004 – 1012,9;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

62937-45-5, D-Prolinamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62937-45-5, Example 66; 1-f5-4- (2-Methoxv- (1 R)-methvl-ethoxv)-phenyll-4- (6-methoxy-pyridin-3-vl)-4H- f . 2, 41triazol-3-vlmethvlLpyrrolidine- (2R)-carboxylic acid amide; A mixture of the product of preparation 62 (100mg, 0. 26mol), L-prolinamide (44mg, 0. 39mmol) and potassium carbonate (72mg, 0. 51mmol) were stirred in acetonitrile (10mi), for 18 hours at room temperature, and for 6 hours at 45C. The solvent was then evaporated under reduced pressure and the residue was taken up in ethyl acetate and washed with water and brine. The organic phase was dried over sodium sulfate, concentrated in vacuo, and purified by column chromatography on silica gel, eluting with dichloromethane : methanol : 0.88 ammonia, 98: 2: 0.2, to yield the title compound, 24mg. ‘H NMR (CDC13, 400MHz) d : 1.30 (d, 3H), 1.80 (m, 2H), 2.20 (t, 1H), 2.60 (m, 1H), 3. 10 (t, 1H), 3.20 (m, 1H) 3.40 (s, 3H), 3.50 (m, 1H), 3.60 (m, 1H), 3.80 (d, 1H), 3.90 (d, 1H) 4.00 (s, 3H) 4.60 (m, 1H), 5.10 (s, 1H), 6.80 (d, 1H), 6.90 (d, 2H), 7.30 (d, 2H), 7.40 (d, 1H), 8. 10 (s, 1 H). MS APCI+ m/z 467 [MH] +

62937-45-5 D-Prolinamide 447554, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/82866; (2005); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.294-90-6,1,4,7,10-Tetraazacyclododecane,as a common compound, the synthetic route is as follows.

To a suspension of cyclen (500 g, 29 rnrnol) and sodium acetate (7.86 g, 96 mrnol) in N,N-dirnethylacetarnide (DMA, 60 rnL) at 2O C was added a solution of t-butyl bromoacetate (18.7 g, 14.1 mL, 96 mmol) in DMA (20 rnL) dropwise over a period of 0.5 h. The temperature was maintained at -20 C during the addition, after which the reaction mixture was allowed to come to room temperature. After 24 h of vigorous stirring, thereaction mixture was poured into water (300 rnL) to give a clear solution. Solid KHCO3 (15 g, 150 rnrnol) was added portion wise, and 4 precipitated as a white solid. The precipitate was collected by filtration and dissolved in CHCI3 (250 mL). The solution was washed with water (100 mL), dried (MgSO4), filtered, and concentrated to about 2O3O tnL. Ether (250 mE) was added, after which HHY-330 crystallized as a white fluffy solid.Yield: 12.5 g (73%). ESI-MS found: [M+Ht = 515.5 (Moore, D. A. Org. Synth. 2008, 85,1O-14).

294-90-6, The synthetic route of 294-90-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANOFI; EUROPEAN MOLECULAR BIOLOGY LABORATORY; HU, Hai-Yu; NAZARE, Marc; HAN LIM, Ngee; DING-PFENNIGDORFF, Danping; PLETTENBURG, Oliver; RITZELER, olaf; JURETSCHKE, Hans-Paul; SAAS, Joachim; BARTNIK, Eckart; FLORIAN, Peter; WENDT, Ulrich; SCHULTZ, Carsten; NAGASE, Hideaki; WO2015/75699; (2015); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4733-39-5, 2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4733-39-5

Synthesis of the hexafluorophosphate salt of the ruthenium complexes 1-6 and 8 The ruthenium complex 1(PF6)2 was synthesized by the following procedure. [Ru(bpy)2Cl2]¡¤ (0.242 g, 0.5 mmol) and phen (0.090 g, 0.5 mmol) were mixed in ethylene glycol (15 ml). After the suspended mixture was refluxed for 7 min in the microwave oven under purging nitrogen atmosphere. The reaction mixture was cooled to room temperature and then the saturated aqueous solution of KPF6 (20 ml) was added. An orange-red product 1 began to precipitate and was collected in 60% yield. Complexes 2, 3, 4, 5, 6, and 8 were synthesized in the similar way. Complex 1¡¤(PF6)2: ESI-MS (in CH3CN, positive): m/z = 738.95 ([M-(PF6)]+ requires 738.61). 297.01 ([M]2+ requires 296.82); Anal. Calcd for RuC32H24N6P2F12: C, 43.50; H, 2.74; N, 9.51; Found: C, 43.02; H, 3.29; N, 9.40; 1H NMR (400 MHz, CD3CN): delta 7.20 (dd, 1H, J = 5.6 Hz and 6.8 Hz), 7.43 (dd, 1H, J = 6.4 Hz and 6.8 Hz), 7.52 (d, 1H, J = 5.2 Hz), 7.72 (dd, 1H, J = 4.8 Hz and 3.2 Hz), 7.83 (d, 1H, J = 5.6 Hz), 7.97 (dd, 1H, J = 7.6 Hz and 8.0 Hz), 8.07 (d, 1H, J = 5.2 Hz), 8.09 (d, 1H, J = 8.0 Hz), 8.23 (s, 1H), 8.47 (d, 1H, J = 8.0 Hz), 8.51 (d, 1H, J = 8.0 Hz), 8.60 (d, 1H, J = 8.4 Hz).

As the paragraph descriping shows that 4733-39-5 is playing an increasingly important role.

Reference£º
Article; Yoshikawa, Naokazu; Yamabe, Shinichi; Sakaki, Shigeyoshi; Kanehisa, Nobuko; Inoue, Tsuyoshi; Takashima, Hiroshi; Journal of Molecular Structure; vol. 1094; (2015); p. 98 – 108;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7089-68-1, 2-Chloro-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7089-68-1, 2-(1H-Imidazol-1-yl)-1,10-phenanthroline was prepared according to the followingmethod. 2-Chloro-1,10-phenanthroline (4.29 g, 0.02 mol) and imidazole (1.63 g,0.024 mol) were dissolved with 100 mL of DMF and potassium carbonate (4.16 g, 0.030 mol) was added into the solution. After the reactants were refluxed for 72 h at110 ¡ãC, the solvent was removed by reduced pressure distillation. The pale yellow sediment appeared after 30 mL iced water was added into the remains and fully stirred.The pale yellow solid 2-(1H-imidazol-1-yl)-1,10-phenanthroline (4.5 g, yield: 91.8percent) was obtained after the sediment was washed with iced water until the pH value of the filtratewas 7. IR (cm-1): 3086 (w), 1593 (m), 1471 (vs), 1400 (m), 1295 (m), 1229 (m),1153 (m), 1049 (m), 973 (m), 820 (s), 765 (s), 726 (m), 648 (m); 1H NMR (300 MHz,CDCl3): 9.19?9.20 (m, 1H), 8.65 (s, 1H), 8.37?8.40 (d, 1H), 8.26?8.29 (d, 1H), 8.03 (s, 1H),7.73?7.81 (m, 5H); HRMS (ESI): C15H10N4 for MH, calculated 247.0984, found247.0985; Elemental Anal. Calcd for C15H10N4 (FW 246.0905): C, 73.20; H, 4.10; N,22.77percent. Found: C, 73.46; H, 4.25; N, 23.08percent.

7089-68-1 2-Chloro-1,10-phenanthroline 355193, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Zheng, Lu-Yi; Chi, Yan-Hui; Liang, Yuan; Cottrill, Ethan; Pan, Ning; Shi, Jing-Min; Journal of Coordination Chemistry; vol. 71; 23; (2018); p. 3947 – 3954;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56-54-2,(S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol,as a common compound, the synthetic route is as follows.,56-54-2

General procedure: (Part 1) To a stirred solution of Cinchona alkaloid (either Quinine, Quinidine, Cinchonine or Cinchonidine) (1 equiv.) in THF (0.1 M) was added the required arylmethyl halide compound (1.2 equiv.) at room temperature. The reaction mixture was refluxed overnight, cooled to room temperature and all volatiles were removed invacuo. The residue was then dissolved in CH2Cl2 (typically 2 mL for 1 mmol of starting material) and the resulting solution was added dropwise onto Et2O (typically 30 mL for 1 mmol of starting material) with vigorous stirring. The resulting precipitate was then filtered, washed thoroughly with Et2O, and further dried under high vacuum for 2 hours, yielding the intermediate alcohol product in an excellent yield. (Part2) This product (1 equiv.) was dissolved in CH2Cl2 (0.2 M). Methyl iodide (3 equiv.) and an aqueous sodium hydroxide solution (50 %w, 5 equiv.) were successively added at room temperature. The reaction mixturewas stirred at room temperature for 4 h, before water (typically 20 mL for 1 mmol of starting material) was added to quench the reaction. The organic layer was separated and the aqueous layer was extracted with CH2Cl2. The combined organic extracts were dried over Na2SO4, and concentrated in vacuo (N.B: washing with brine is prohibited to avoid the I/Cl anion exchange). Purification by column chromatography on silica gel, eluting with MeOH/Acetone/CH2Cl2 (0:10:90 to 10:10:90), afforded the desired Cinchona alkaloid quaternary ammonium salt in a moderate to excellent yield.

The synthetic route of 56-54-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Antien, Kevin; Viault, Guillaume; Pouysegu, Laurent; Peixoto, Philippe A.; Quideau, Stephane; Tetrahedron; vol. 73; 26; (2017); p. 3684 – 3690;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23616-79-7,N-Benzyl-N,N-dibutylbutan-1-aminium chloride,as a common compound, the synthetic route is as follows.

Reference Example 3 Potassium carbonate (414 g) is suspended in chloroform (1.3 l), and thereto is added dropwise water (29 ml) gradually. To the mixture are added tributylbenzylammonium chloride (37 g), 2′,6′-dihydroxy-4′-methylacetophenone (100 g), and 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide (419 g), and the mixture is stirred at room temperature for 27 hours. To the mixture is added water (21 ml), and the mixture is stirred for further 2.5 hours. The mixture is neutralized with 18% hydrochloric acid (about 500 ml) under ice-cooling. To the mixture are added 18% hydrochloric acid (about 200 ml) and water (500 ml), and the chloroform layer is separated, washed with water and a saturated aqueous sodium chloride solution, dried, and concentrated. To the residue is added methanol (400 ml), and the mixture is concentrated under reduced pressure to about a half volume thereof. To the resultant is added methanol (2 l), and the mixture is heated a little, and stirred under ice-cooling for 30 minutes. The precipitates are collected by filtration, and dried under reduced pressure to give 2′-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyloxy)-6′-hydroxy-4′-methylacetophenone (239.75 g). The physicochemical properties of the compound are the same as those of the compound obtained in Reference Example 2.

23616-79-7, As the paragraph descriping shows that 23616-79-7 is playing an increasingly important role.

Reference£º
Patent; Tanabe Seiyaku Co., Ltd.; US6048842; (2000); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33454-82-9,Lithium trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.

In an Ar filled flask, 0.150 g (0.24 mmol) of [RuCI(p- cymene)(R,R-TsDPEN)] and 0.037 g (0.24 mmol) of LiOTf were combined. CH2CI2 (10 ml_) was added and the resulting orange mixture was left to stir at ambient temperature. 0.046 g of AgBF4 was then added. The orange suspension gradually darkened to brown and eventually to deep purple in colour. After 21 hours, the suspension was filtered through a 0.45 mm PTFE syringe filter. The brown filtrate was concentrated to dryness leaving a brown residue. Yield: 0.120 g (68 %). 1H and 19F(1HJ NMR (ppm, CD2CI2) showed that the product was obtained (ratio of the products: 1 :1).

33454-82-9, As the paragraph descriping shows that 33454-82-9 is playing an increasingly important role.

Reference£º
Patent; KANATA CHEMICAL TECHNOLOGIES INC.; WO2009/132443; (2009); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

130-95-0, Quinine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example: 11a-(-)-3-(Carbamoylmethyl)-5-methylhexanoic Acid Quinine Salt Aqueous acetone (795ml) was added to the amide II (53 g, 283.42 mmole) at room temperature and the reaction mixture was heated until it became homogenous. Quinine (91 .8 g, 283.42 mmole) was added to the mixture at 80 C. After 15 minutes at this temperature, another batch of quinine (5.3 g, 28.34 mmole) was added to the reaction mixture and heating was continued until the mixture became homogenous. The reaction mixture was allowed to cool down to room temperature. The precipitated solid was filtered, dried and purified to furnish the diastereoisomeric salt of the amide I as a solid which was broken down to obtain enantiomerically enriched amide I; yield: 18 g; 67.9%; HPLC purity: 99.97%., 130-95-0

130-95-0 Quinine 3034034, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Dr. Braja Sundar Pradhan; WO2012/93411; (2012); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI