Month: November 2020

485-71-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.485-71-2,Cinchonidine,as a common compound, the synthetic route is as follows.

4-Hydroxyphenylacetic acid (40 mg, 0.263 mmol) and cinchonidine (77.4 mg, 0.263 mmol) were dissolved in isopropanol (IPA). The solution was left to evaporate and crystals were obtained after one week

The synthetic route of 485-71-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Amombo Noa, Francoise M.; Jacobs, Ayesha; Journal of Molecular Structure; vol. 1114; (2016); p. 30 – 37;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6813-38-3,[2,2′-Bipyridine]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.,6813-38-3

Thionyl chloride (300muL, 4.08mmol) was added to a suspension of 16 (400mg, 1.62mmol) in MeOH (30mL) in a dropwise fashion. The mixture was heated at reflux temperature overnight. Then, the solvent was removed under reduced pressure and the residue was partitioned between CH2Cl2 and water. The organic layer was washed with saturated aqueous NaHCO3 solution and dried over Na2SO4. Filtration, evaporation in vacuo, and recrystallization in AcOEt gave 17 (400mg, 91%): mp 200-202C; 1H NMR (CDCl3, 300MHz, delta; ppm), 8.92 (2H, d, J=4.2Hz), 8.85 (2H, s), 7.91 (2H, d, J=3.3Hz); 13C NMR (CDCl3, 75MHz, delta; ppm), 166.5, 156.0, 151.1, 140.0, 123.9, 120.0; MS (ESI) m/z 273.0 (MH+).

The synthetic route of 6813-38-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Miyake, Yuka; Itoh, Yukihiro; Hatanaka, Atsushi; Suzuma, Yoshinori; Suzuki, Miki; Kodama, Hidehiko; Arai, Yoshinobu; Suzuki, Takayoshi; Bioorganic and Medicinal Chemistry; vol. 27; 6; (2019); p. 1119 – 1129;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139-07-1,N-Benzyl-N,N-dimethyldodecan-1-aminium chloride,as a common compound, the synthetic route is as follows.

EXAMPLE 3 Preparation of 2-methoxybenzenesulfochloride A diazonium salt solution, prepared similarly to Example 1 from o-anisidine, was brought into intimate contact, at 0 C., with a solution of 100 ml of 1,2-dichloroethane and 21 g (0.33 mole) of SO2, and was then decomposed using 0.5 g of CuCl2 and 1 g of dodecyldimethylbenzylammonium chloride at 40 C. 4.3 g of a 30% strength by weight aqueous hydrogen peroxide solution (=38 millimoles of H2 O2) were then added to the mixture, and after a reaction time of 3 minutes the batch was worked up in a conventional manner. The yield of 2-methoxybenzenesulfochloride was 80%; boiling point 134-138 C./0.7 mbar.

139-07-1, As the paragraph descriping shows that 139-07-1 is playing an increasingly important role.

Reference£º
Patent; BASF Aktiengesellschaft; US4393211; (1983); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130-95-0,Quinine,as a common compound, the synthetic route is as follows.

To a solution of quinine (78.2 mg, 0.2 mmol) in methanol (10 mL), a solution of ZnCl2 (27.2 mg, 0.2 mmol) in methanol (10 mL) was added. The mixture was stirred and heated at 50C for 2 h, and cooled to room temperature. The resulting solution was treated with aqueous HCl and filtered to remove staring materials. By slow evaporation of the filtrate at room temperature, white single crystals suitablefor X-ray diffraction were obtained after two weeks.The complex was identified as [(Quin)ZnCl3] (I). The yield was 78.8 mg (79.3%). IR (nu, cm-1): 3356 nu(OH), 3074 nu(CHar), 2971nu(CHaliph). For C20H25N2O2Cl3Zn anal. calcd., % C, 48.32 H, 5.07 N, 5.63Found, % C, 48.24 H, 5.02 N, 5.59, 130-95-0

The synthetic route of 130-95-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gu; Jia; Zhang; Russian Journal of Coordination Chemistry; vol. 44; 1; (2018); p. 52 – 58; Koord. Khim.; vol. 44; 1; (2018); p. 52 – 58,7;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

348-67-4, H-D-Met-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step (1): To a 2 L four-necked flask was added 153.10 g of D-methionine, 420 g of water, 200 mL of methanol and 158.21 g of diethyl sulfate, and the mixture was stirred at room temperature, and 45 g of concentrated sulfuric acid After the end of heating to 30 ~ 40 , 10h, the recovery of methanol under reduced pressure.After the reaction with anhydrous sodium carbonate solid to adjust the pH to 8 ~ 9, continue 40 reaction 10h.After the reaction is over,The solvent was distilled off under reduced pressure.

348-67-4, 348-67-4 H-D-Met-OH 84815, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Anhui Zhishan New Materials Co., Ltd.; Wei Kaiju; Ren Mingxiu; Cui Yang; Chen Zhongming; Xie Yineng; (9 pag.)CN106928110; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

92149-07-0,92149-07-0, 4,7-Dimethoxy-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under an argon atmosphere, add anhydrous Fe(acac)2 (127.0mg, 0.5mmol) to a 50mL Schlenk flask, and dissolve it in 6mL of anhydrous ethanol at 60 C; Then, a solution of 4,7-dimethoxy-1,10-phenanthroline (120 mg, 0.5 mmol) in ethanol (4 mL) was added dropwise to the system. The reaction was carried out at 60 C for half an hour, and then returned to room temperature and stirred overnight. The filtrate was collected by filtration, concentrated, washed twice with cold ethanol, and dried under vacuum for 12 h to obtain a dark brown solid product 17, with a yield of 60%.

The synthetic route of 92149-07-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Sciences Tsingtao Biological Energies And Process Institute; Wang Qinggang; Wang Liang; Zhu Guangqian; Zhang Xianhui; Jing Chuyang; (29 pag.)CN110452272; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

33454-82-9, Lithium trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1.55 parts by mass of 4-methoxythioanisole, 1.95parts by mass of silver borofluoride, 1.77 parts by mass of 1 -chloromethyl naphthalene, and 10.0 parts by mass of acetone were uniformly mixed and reacted at 25 C. for 24 hours. Afier removal of silver chloride, the reaction solution was transferred to a rotary evaporator, and the solvent was distilled off. The obtained residue was reprecipitated with 10.0 parts by mass of acetone and 10.0 parts by mass of hexane. 3.44 parts by mass of the obtained precipitate, 1.56 parts by mass of lithium trifluoromethanesulfonate, and 10.0 parts by mass of acetone were uniformly mixed and reacted at 25C. for 24 hours. 10.0 parts by mass of distilled water were added to the reaction solution to wash the product. The solvent was distilled off under reduced pressure from the organic layer to obtain 3.87 parts by mass of compound 23. The ratio of the mass of the compound B to the total mass of the compound B and the compound A was 0.965. The yield with respect to 4-methoxythioanisole was 87%. The mass of the compound B was 3.73 g, and the mass of the compoundA was0.14g., 33454-82-9

The synthetic route of 33454-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASAHI KASEI E-MATERIALS CORPORATION; SHIMURA, Tadashi; KAMIMURA, Naoya; OTANI, Akira; SHIMADA, Hitoshi; (69 pag.)US2016/229801; (2016); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

72914-19-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72914-19-3,4,4′-Di-tert-butyl-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

A magnetically stirred suspension of 4,4?-di-tert-butyl-2,2?-dipyridyl (118 mg, 0.44 mmol) and tetrakis(2-phenylpyridine-C2,N?)(mu-dichloro)-diiridium (214 mg, 0.2 mmol) in 10 mL of 1,2-ethanediol under nitrogen was heated to 150 C. The mixture was kept at this temperature for 15h. All the solids dissolved to yield a clear, yellow solution. After cooling the mixture to room temperature, 150 mL of water was added. The excess of bipyridine ligand was removed through three extractions with diethyl ether (50 mL), and the aqueous layer was subsequently heated to 60-70 C. NH4PF6 (1 g) in 10 mL of water was added, and the PF6 salt of the chromophore immediately precipitated. After cooling the suspension to 5 C, the yellow solid was separated through filtration, dried, and recrystallized through acetonitrile/ether diffusion. Yield: 280 mg (77%).

The synthetic route of 72914-19-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ye, Hongqiang; Ye, Qianwen; Cheng, Dongping; Li, Xiaonian; Xu, Xiaoliang; Tetrahedron Letters; vol. 59; 21; (2018); p. 2046 – 2049;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

35132-20-8, (1R,2R)-1,2-Diphenylethane-1,2-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

trans-RuH(eta1-BH4)[(R)-tolbinap][(R,R)-dpen] was synthesized. First, trans-RuCl2[(R)-tolbinap][(R,R)-dpen] was synthesized. That is, [RuCl2(benzene)]2 (129 mg; 0.258 mmol) (made by Aldrich Inc.) and (R)-TolBINAP (373 mg; 0.55 mmol) (made by AZmax Co., Ltd.) were weighed and placed in a 50 mL Schlenk reaction tube equipped with a stirrer coated with polytetrafluoroethylene, and after depressurizing the interior of the vessel to eliminate air, argon was introduced. After then adding DMF (9 mL) with a syringe, heating in an oil bath set to 100 C. was performed for 10 minutes under an argon atmosphere. After cooling the reaction solution to room temperature, (R, R)-DPEN (117 mg; 0.55 mmol) (made by Kankyo Kagaku Center Co., Ltd.) was added under an argon gas flow to the reddish-brown RuCl2[(R)-tolbinap](dmf)n solution, and stirring at 25 C. was performed for 3 hours. To a green-colored crude product obtained by distilling off the DMF under reduced pressure (1 mmHg), methylene chloride (10 mL) was added, and after dissolving as much of a yellow product as possible, a green impurity was removed by filtration. The yellow solution that was obtained by filtration whereafter concentrated to approximately 1 mL and then diethyl ether (5 mL) was added to precipitate solids. The solids obtained were separated by filtration and dried under reduced pressure(1 mmHg)to obtain trans-RuCl2[(R)-tolbinap][(R,R)-dpen] (340 mg; 0.32 mmol; yield: 58%) as a yellow powder. [TolBINAP] and [tolbinap] are abbreviations for 2,2′-bis(di-4-tolylphosphino)-1,1′-binaphthyl, ?DMF? and ?dmf? are abbreviations for N,N-dimethylformamide, and ?DPEN? and ?dpen? are abbreviations for 1,2-diphenylethylenediamine. [00030] The abovementioned trans-RuCl2[(R)-tolbinap] [(R,R)-dpen] (106.3 mg; 0.1 mmol) and sodium borohydride (94.6 mg; 2.5 mmol) (made by Nacalai Tesque, Inc.) were then weighed and placed in a 50 mL Schlenk reaction tube equipped with a stirrer coated with polytetrafluoroethylene, and after depressurizing the interior of the vessel to eliminate air, argon was introduced. After then adding a 1:1 volume ratio mixed solvent of benzene/ethanol (4 mL) with a syringe, heating in an oil bath set to 65 C. was performed for 5 minutes under an argon atmosphere. The reaction solution was thereafter stirred for 30 minutes at room temperature. After then drying and solidifying the crude product by distilling off the solvent under reduced pressure (1 mmHg), benzene (6 mL) was added under an argon gas flow to dissolve as much of a yellow product as possible and then the excess sodium borohydride was eliminated by filtration by celite (0.5 g). A yellow filtrate thus obtained was concentrated to approximately 1 ml by depressurization (1 mm Hg) and hexane (6 mL) was then added under an argon gas flow. Yellow solids thus precipitated were separated by filtration through a glass filter and dried under reduced pressure (1 mmHg) to obtain trans-RuH(eta1-BH4)[(R)-tolbinap] [(R,R)-dpen] (76.0 mg; yield: 70%; see formula (3) below) as a yellow powder. Decomposition temperature: 164 C.; 1HNMR(400 MHZ, C6D6) delta-13.60(t, 1, J=22.4 Hz, RuH), -0.40(brs, 4, BH4), 1.45(s, 3, CH3), 1.55(s, 3, CH3), 1.62(s, 3, CH3), 1.63(s, 3, CH3), 1.95(dd, 1, J=7.2 and 8.4 Hz, NHH), 2.38(d, 1, J=8.2 Hz, NHH) ,3.65(dd, 1, J=7.9 and 11.2 Hz, CHNH2), 3.82-3.88(m, 2, 2 NHH), 4.00(ddd, 1, J=7.9, 8.4 and 11.6 Hz, CHNH2), 6.13-8.12(m, 38, aromatics) ;31PNMR(161.7 MHz, C6D6) delta71.2(d, J=41.4 Hz), 75.2(d, J=41.4 Hz);IR(toluene)2316(s), 1862(s), 1092(s), 1080(s)cm-1; ESI-MS m/z1007.26([M-H]+), theoretical value (C62H60BN2P2Ru): 1007.34. The powder obtained was then recrystallized from a THF/hexane mixed solvent of a volume ratio of approximately 1:5 to obtain yellow prismatic crystals, and these were used for X-ray crystallography.

35132-20-8, 35132-20-8 (1R,2R)-1,2-Diphenylethane-1,2-diamine 2724998, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Nagoya Industrial Science Research Institute; US6720439; (2004); B1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148332-36-9,[2,2′:6′,2”-Terpyridine]-4′-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: Typically, 2-(4-carboxyphenyl)-4,6-dipyrid-2-yltriazine (1.0 g,2.81 mmol) was heated to reflux in thionyl chloride (30 mL) for0.5 h, after which no solid suspension remained. The excess thionylchloride was removed by distillation and the residue was driedunder vacuum, dry methanol (60 mL) was added and the reactionmixture was heated to reflux until no solid suspension remained(2 h). The solution was cooled to room temperature and addedto H2O (300 mL) forming a voluminous precipitate of the methylester ligand which was isolated by filtration and dried in vacuowithout further purification. Typically, the ligand (0.25 g,0.68 mmol) was heated to reflux in DMF with RuCl3 (0.07 g,0.34 mmol) and AgNO3 (0.173 g, 1.02 mmol) after which the solutionwas filtered to remove AgCl(s). The filtrate was then decantedinto a solution of NH4PF6 (aq) (300 mL), and the resultant heavyprecipitate was isolated by filtration and washed with water, thendissolved in a minimal amount of acetonitrile for chromatographicpurification using silica and a 7:2 CH3CN/KNO3 (aq, sat) mixture aseluent. The collected fractions are combined, and to this addedNH4PF6 and enough DCM to effect a phase separation. After washingthe organic phase, the aqueous phase was discarded and theprocess repeated, with a final washing with water alone. Theorganic phase was dried and the residue taken up in a minimalamount of acetonitrile, then poured into H2O (300 mL) to give aheavy precipitate which was filtered and dried in vacuo. Yield:0.263 g (69percent), Rf = 0.55 (silica, 7:2 CH3CN/KNO3 (sat, aq) as eluent).1H NMR (400 MHz, CD3CN) d ppm 9.19 (d, J = 8.4 Hz, 4H), 9.14 (d,J = 7.7 Hz, 4H), 8.44 (d, J = 8.4 Hz, 4H), 8.16 (m, 4H), 7.73 (d,J = 5.3 Hz, 4H), 7.41 (m, 4H), 4.02 (s, 3H). ESI-MS: [M]2+ Cald. forC42H30N10O4Ru: 420.07475. Found: 420.07499.

148332-36-9, As the paragraph descriping shows that 148332-36-9 is playing an increasingly important role.

Reference£º
Article; Cooke, Michael W.; Santoni, Marie-Pierre; Loiseau, Frederique; Hasenknopf, Bernold; Hanan, Garry S.; Inorganica Chimica Acta; vol. 454; (2017); p. 208 – 215;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI