Month: November 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17217-57-1,4,4′-Dimethoxy-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 10 mL methanolic solution of pyridine-2-carboxamide (0.3663 g, 3 mmol) and 10 mL methanolic solution of 4,4′-dimethoxy-2,2′-bipyridine (0.2162 g, 1 mmol) was stirred at room temperature for half an hour. Solution of EuCl3 was prepared by dissolving 1 mmol (0.2583 g) of EuCl3 in 10 mL of methanol and this solution was added to the ligands solution drop by drop with continuous stirring. The pH of resulting solution was maintained between 6 and 7. The reaction mixture was refluxed at 70 ¡ãC for 4 h. After refluxing for 4 h, the solution was cooled to room temperature and left as such overnight. Complex C1 was obtained as white precipitate which was filtered off, washed with methanol nd then dried under vacuum. The synthesis of complexes C2-C4 were done by adopting the same method as given above. Complex C2 was obtained from 3 mmol PCAO (0.3663 g), 1 mmol DMBP (0.2162 g) and1 mmol EuCl3 (0.2583 g), complex C3 was obtained from 3 mmol PDCA(0.4473 g), 1 mmol DMBP (0.2162 g) and 1 mmol EuCl3 (0.2583 g) and complex C4 was obtained from 3 mmol PM (0.3 mL), 1 mmol DMBP(0.2162 g) and 1 mmol EuCl3 (0.2583 g)., 17217-57-1

The synthetic route of 17217-57-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sengar, Manju; Narula, Anudeep Kumar; Materials Research Bulletin; vol. 112; (2019); p. 242 – 250;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7173-51-5, N-Decyl-N,N-dimethyldecan-1-aminium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7173-51-5, Didecyldimethylammonium chloride (0.025 mol) was dissolved in 40 mL distilled water and the folic acid sodium salt (0.01 mol) was added. The solution was stirred at room temperature for 30 min. After separation of the phases, the organic phase was washed with distilled, cold water until chloride ions were no longer detected using AgNO3. The organic phase was separated and solvent was evaporated. The product (90% yield), didecyldimethylammonium N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoy]-L-glutamate, was dried at 50 C. under vacuum. Product is soluble in chloroform, acetone, DMSO. It lacks miscibility with water and hexane. 1H and 13C NMR (DMSO) were obtained. Thermogravimetric analysis: Tonset5%=153 C., and Tonset=201 C. 1H and 13C NMR (DMSO) were obtained.

As the paragraph descriping shows that 7173-51-5 is playing an increasingly important role.

Reference£º
Patent; Rogers, Robin D.; Daly, Daniel T.; Swatloski, Richard P.; Hough, Whitney L.; Davis, James Hilliard; Smiglak, Marcin; Pernak, Juliusz; Spear, Scott K.; US2007/93462; (2007); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-41-7, H-Ala-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

SOCl2 (21.8mL, 0.3mol) and (S)-alanine ((S)-19, 8.91g, 0.1mol) were added to CH3OH (100mL) and the mixture was stirred at RT for 2h. The solvent was removed in vacuo, the residue was dissolved in methanol (30mL) and the organic solvent was removed in vacuo again. This procedure was repeated twice. Colorless amorphous solid, mp 103C (Ref. 39 mp 98-99C), yield 14.3g (>99%). [alpha]589=+7.9 (c=0.94, CH3OH) [Ref. 38 [alpha]589=+7.4 (c=1.76, CH3OH)].

56-41-7, The synthetic route of 56-41-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Fanter, Lena; Mueller, Christoph; Schepmann, Dirk; Bracher, Franz; Wuensch, Bernhard; Bioorganic and Medicinal Chemistry; vol. 25; 17; (2017); p. 4778 – 4799;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56-54-2,(S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol,as a common compound, the synthetic route is as follows.

General procedure: To a flame-dried flask equipped with a magnetic stirring bar and a condenser was added with cinchona alkaloids (1 mmol), toluene (5 mL), and benzyl bromide derivatives (1.2 mmol, 1.2 equiv.). The mixture was heated at 80 8C until a TLC analysis showing that the starting material was completely consumed. Cooled to room temperature and poured onto Et2O (30 mL) with stirring, the resulting suspension was stirred for another 1 h. Then the precipitate was purified by flash chromatography (MeOH/EtOAc = 1/10, V/V). 4.24.6 N-(3,5-Ditrifluoromethylbenzyl)quinidinium bromide (1f) [27] Yield: 85%; white solid; mp 177 C (decomp.); [alpha]D28 +176.1 (c 0.19, CH3OH); IR (KBr): 3394, 3201, 2954, 2664, 1622, 1509, 1473, 1432, 1374, 1281, 1214, 1226, 1178, 1135, 1027, 1005, 866, 905, 843, 828, 709, 682 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 8.82 (d, J = 4.8 Hz, 1H), 8.56 (s, 2H), 8.38 (s, 1H), 8.04 (d, J = 9.2 Hz, 1H), 7.77 (d, J = 4.4 Hz, 1H), 7.53 (dd, J = 7.2, 2.4 Hz 1H), 7.44 (d, J = 2.4 Hz, 1H), 6.78 (d, J = 3.2 Hz, 1H), 6.48 (s, 1H), 6.04 (ddd, J = 17.4, 10.2, 7.2 Hz, 1H), 5.28 (d, J = 2.8 Hz, 1H), 5.22 (d, J = 12.4 Hz, 2H), 5.01 (d, J = 12.8 Hz, 1H), 4.34 (t, J = 10.0 Hz, 1H), 4.10-4.13 (m, 1H), 4.06 (s, 3H), 3.80 (t, J = 9.4 Hz, 1H), 3.48 (t, J = 11.4 Hz, 1H), 3.04 (q, J = 9.6 Hz, 1H), 2.62 (q, J = 8.4 Hz, 1H), 2.42 (t, J = 11.6 Hz, 1H), 1.91 (s, 1H), 1.85-1.72 (m, 2H), 1.20-1.13 (m, 1H); 13C NMR (100 MHz, DMSO-d6): delta = 158.1, 147.9, 144.2, 143.7, 137.8, 135.1, 132.0, 131.7, 131.3 (q, J = 33.1 Hz), 130.1, 126.0, 125.0, 124.6 (q, J = 4.1 Hz), 123.7 (q, J = 271.3 Hz), 121.5, 120.9, 117.6, 103.1, 68.4, 65.2, 61.8, 56.3, 56.2, 54.7, 37.4, 26.9, 23.6, 21.1.

The synthetic route of 56-54-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue; Journal of Fluorine Chemistry; vol. 148; (2013); p. 19 – 29;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

33454-82-9, Lithium trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Quaternary ammonium bromide 2(a-b) (1.0 equi.) is mixed withNaBF4/KPF6/LiCF3SO3 (3.05 equi.) in the presence of 10 mL deionizedwater at room temperature with stirring for about 1 h afforded theanion exchanged di/trimeric imidazolium salts. After the anion exchangedreaction, Soxhlet extraction is carried out to remove metallicbromide., 33454-82-9

As the paragraph descriping shows that 33454-82-9 is playing an increasingly important role.

Reference£º
Article; Ganapathi, Pandurangan; Ganesan, Kilivelu; Journal of Molecular Liquids; vol. 233; (2017); p. 452 – 464;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29841-69-8,(1S,2S)-(-)-1,2-Diphenylethylenediamine,as a common compound, the synthetic route is as follows.

(2); Synthesis of Rh+{2,2′-bis(diphenylphosphinyl)benzophenone} {(S,S)-DPEN}(SbF6-); Into [Rh+{2,2′-bis(diphenylphosphinyl)benzophenone}(cod)](SbF6-) obtained in the (1) after the distillation under reduced pressure were added 21.2 mg (0.1 mmol) of (S,S)-DPEN and 2 ml of methylene chloride, and then the solution was stirred under hydrogen atmosphere for 1 hour. The solvent was distilled off under reduced pressure and then the residue was dried to give 110 mg (yield: > 99%) of the title compound. 31p NMR (CDCl3) delta ppm; 48.28, 57.04 (2dd, Jp-p = 40.5 Hzo, Jp-Rh = 157.9 Hzo).

29841-69-8, As the paragraph descriping shows that 29841-69-8 is playing an increasingly important role.

Reference£º
Patent; Takasago International Corporation; EP1661903; (2006); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

56-54-2, General procedure: To a flame-dried flask equipped with a magnetic stirring bar and a condenser was added with cinchona alkaloids (1 mmol), toluene (5 mL), and benzyl bromide derivatives (1.2 mmol, 1.2 equiv.). The mixture was heated at 80 8C until a TLC analysis showing that the starting material was completely consumed. Cooled to room temperature and poured onto Et2O (30 mL) with stirring, the resulting suspension was stirred for another 1 h. Then the precipitate was purified by flash chromatography (MeOH/EtOAc = 1/10, V/V). 4.24.4 N-(2-F-4-Br-benzyl)quinidinium bromide (1d) Yield: 79%; white solid; m.p. 174-176 C (decomp.); [alpha]D28 +143.3 (c 0.14, CH3OH); IR (KBr): 3387, 3198, 3006, 1621, 1520, 1473, 1460, 1431, 1338, 1259, 1241, 1205, 1113, 1026, 851, 828, 719 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 8.81 (d, J = 4.4 Hz, 1H), 8.02 (d, J = 9.2 Hz, 1H), 7.87-7.76 (m, 3H), 7.67 (dd, J = 8.4, 1.6 Hz, 1H), 7.50 (dd, J = 9.2, 2.0 Hz, 1H), 7.41 (d, J = 2.4 Hz, 1H), 6.86 (d, J = 2.8 Hz, 1H), 6.51 (s, 1H), 6.03 (ddd, J = 17.2, 10.4, 6.8 Hz, 1H), 5.25-5.23 (m, 2H), 5.06 (d, J = 12.4 Hz, 1H), 4.77 (d, J = 12.4 Hz, 1H), 4.19 (t, J = 9.6 Hz, 1H), 4.06 (s, 3H), 3.97-3.85 (m, 2H), 3.44 (t, J = 11.2 Hz, 1H), 3.12 (q, J = 10.0 Hz, 1H), 2.68-2.62 (m,1H), 2.36 (t, J = 11.2 Hz, 1H), 2.00 (s, 1H), 1.82-1.75 (m, 2H), 1.10-1.03 (m, 1H); 13C NMR (100 MHz, DMSO-d6): delta = 162.1 (d, J = 252.2 Hz), 157.9, 147.9, 144.2, 143.8, 137.6, 131.9, 129.0, 125.8, 125.5 (d, J = 10.1 Hz), 121.9, 120.7, 120.3 (d, J = 25.7 Hz), 117.5, 115.4 (d, J = 13.7 Hz), 102.8, 67.9, 65.3, 56.8, 56.1, 54.7, 37.4, 26.6, 23.7, 21.0; HRMS calcd for [C33H35F6N2O2]+: 511.1391, found 511.1398.

The synthetic route of 56-54-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue; Journal of Fluorine Chemistry; vol. 148; (2013); p. 19 – 29;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

D-Tryptophan (100 g), and PTSA.H20 (186.28 g) were added to allyl alcohol (1000 ml) stirred at 25 to 35C, followed by addition of toluene (500ml). The resulting mixture was stirred at 80-95C till completion of reaction, as monitored by TLC. After completion, the mass was cooled, and 5% aqueous sodium bicarbonate solution was added to it. Extraction with ethyl acetate followed by separation and concentration of the organic layer gave a residue containing H-D-Trp-OAll (11). Yield: 108.01 g (90.3%) Purity: > 95% (HPLC)

153-94-6, As the paragraph descriping shows that 153-94-6 is playing an increasingly important role.

Reference£º
Patent; EMCURE PHARMACEUTICALS LIMITED; GURJAR, Mukund Keshav; TRIPATHY, Narendra Kumar; PRAMANIK, Chinmoy Mriganka; DESHPANDE, Ashish Pramod; (25 pag.)WO2017/178950; (2017); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

76089-77-5, Cerium(III) trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

76089-77-5, General procedure: A mixture of Ce(OTf)3 (0.1388g, 0.2mmol) and C12H8N2 (phen) (0.005g) was dissolved in a mixture of CH3CN (10ml) and DMF (three drops). After the mixture was stirred for 1h, the ligand L (0.2752g, 0.8mmol) was added to this mixture. Stirring was continued for 4h at ambient temperature. After this time, any insoluble residues were removed by filtration, and the filtrate was evaporated slowly at room temperature for about one month to yield colorless crystalline products.

The synthetic route of 76089-77-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xu, Shan; Liu, Min; Yang, Yu-Ping; Jiang, Yu-Han; Li, Zhong-Feng; Jin, Qiong-Hua; Wang, Xin; Xue, Xiao-Nan; Polyhedron; vol. 87; (2014); p. 293 – 301;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3: Preparation of tert-butyl-(35)-3-[({[25,5R)-6-(sulfooxy)-7-oxo-l,6- diazabicylco[3.2.1]oct-2-yl]carbonyl}amino)oxy]pyrrolidine-l-carboxylate, tetrabutyl ammonium salt (VI): To a stirred solution of ieri-butyl(35)-3-[({ [25,5i?)-6-hydroxy-7-oxo-l,6- diazabicylco[3.2.1]oct-2-yl]carbonyl}amino)oxy]pyrrolidine-l-carboxylate (V) (8.04 g, 0.0217 mol) in dimethylformamide (50 ml), was added sulfur trioxide dimethyl formamide complex (3.98 g, 0.0260 mol) in one portion, at about 10C. The stirring was continued further for 30 minute and then the reaction mixture was allowed to warm to room temperature. After 2 hour, a solution of tetrabutylammonium acetate (7.83 g, 0.0260 mol) in water (25.8 ml) was added to the resulting reaction mass under stirring. After additional 2 hour of stirring, the solvent from the reaction mixture was evaporated under reduced pressure to obtain an oily residue. The oily mass was co-evaporated with xylene (2 x 20 ml) to obtain thick mass. This mass was partitioned between dichloromethane (100 ml) and water (100 ml). The organic layer was separated and the aqueous layer re-extracted with dichloromethane (50 ml). The combined organic extracts were washed with water (3 x 50 ml), dried over anhydrous sodium sulphate and the solvent evaporated under reduced pressure. The residual oily mass was triturated with ether (3 x 50 ml), each time the ether layer was decanted and finally the residue was concentrated under reduced pressure to obtain 11.3 g of tert-butyl(3S)-3-[({ [2S,5R)-6- (sulfooxy)-7-oxo-l,6-diazabicylco[3.2.1]oct-2-yl]carbonyl}amino)oxy] pyrrolidine- 1- carboxylate, tetrabutylammonium salt (VI), as a white foam, in 75 % yield. Analysis: Mass: 449.3 (M-l, without TBA); for Molecular weight of 691.94 and Molecular formula of C32H61N5O9S; and 1H NMR (400MHz, CDC13): 59.14-9.10 (d, 1H), 4.63 (s, 1H), 4.35 (s, 1H), 3.94- 3.92 (d, 1H), 3.66-3.35 (m, 5H), 3.29-3.27 (m, 8H), 2.83-2.80 (d, 1H), 2.35-2.17 (m, 3H), 1.98-1.87 (m, 2H), 1.73 (m, 1H), 1.70-1.62 (m, 8H), 1.49-1.40 (m, 17H), 1.02-0.99 (t, 12H).

10534-59-5, As the paragraph descriping shows that 10534-59-5 is playing an increasingly important role.

Reference£º
Patent; WOCKHARDT LIMITED; TADIPARTHI, Ravikumar; BIRAJDAR, Satish; DOND, Bharat; PATIL, Vijaykumar Jagdishwar; PATEL, Mahesh Vithalbhai; WO2015/110886; (2015); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI