Simple exploration of 1119-97-7

1119-97-7 MitMAB 14250, acatalyst-ligand compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1119-97-7,MitMAB,as a common compound, the synthetic route is as follows.

General procedure: A 100mL round-bottom flask was equipped with a magnetic stir bar and a reflux condenser. To xylene (10.0mL), tetradecyltrimethylammonium bromide (1.1mmol) and a heterocyclic compound (1.0mmol) were added, followed bya solution of NaOH 50% (5.0 mL). The mixture was stirred at reflux temperature for 2-18 h. After completion of thereaction, the mixture was air-jet cooled to 25 C and TLC indicated the disappearance of the starting material. The reaction mix was treated with AcOEt (4 ¡Á 20 mL), and the organic phase separated and removed under reduced pressure. The residue was purified to analytical purity by column chromatography., 1119-97-7

1119-97-7 MitMAB 14250, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Gonzalez-Gonzalez, Carlos A.; Vega, Juan Javier Mejia; Monroy, Ricardo Garcia; Gonzalez-Calderon, Davir; Corona-Becerril, David; Fuentes-Benites, Aydee; Mascarua, Joaquin Tamariz; Gonzalez-Romero, Carlos; Journal of Chemistry; vol. 2017; (2017);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Brief introduction of 1662-01-7

1662-01-7, 1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Stock 0.5M solution of EuCl3 was prepared by the treatment of Eu2O3(4.400 g, 12.50 mmol) by minimum amount of concentrated HCl in aquartz crucible. The resulting solution was evaporated to dryness at 90 Cand the residue was dissolved in a minimum amount of distilled water.After that, the solution was transferred quantitatively to a volumetric flaskand the volume was adjusted to 50 mL. This solution was then kept in apolypropylene flask. To a stirred warm (40 C) solution of the ligand(3 mmol) and (1 mmol) bathophenanthroline (0.33 g) in 30 mL of ethanol,2 mL of an 0.5M aqueous solution of EuCl3 (1 mmol) were added dropwise,followed by careful addition of 3 mL (3 mmol) of an 1.0M NaOHsolution in water until the pH of the mixture reached 6-7. The mixture washeated at 50 C during 4 h in a closed flask and cooled. Further operationsdepended upon the properties of the reaction products.

1662-01-7, 1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Korshunov; Ambrozevich; Taydakov; Vashchenko; Goriachiy; Selyukov; Dmitrienko; Dyes and Pigments; vol. 163; (2019); p. 291 – 299;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Brief introduction of 170161-27-0

170161-27-0 Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate 10940041, acatalyst-ligand compound, is more and more widely used in various fields.

170161-27-0, Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tri-Boc cyclam S7 (437 mg, 0.873 mmol) in anhydrous CH3CN (26 mL)were added Na2CO3 (370 mg, 3.49 mmol) and propargyl bromide (-80% in toluene, 156pL, 1 .05 mmol). The reaction mixture was heated at reflux under N2 overnight. Theinsoluble salts were filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, EtOAc:hexane =7:3) to give S11 as a white foam (446 mg, 95%). RF (EtOAc:hexane = 7:3) 0.58. m.p.47-48 C (lit.45?66 m.p. 4749 C). IR Vmax/cm1 3305, 3243, 2976, 2932, 2871, 2826,1681, 1463, 1410, 1365, 1240, 1150. 1H NMR (200 MHz, CDCI3) 5 1.40 (5, 27H, 3 xC(CH), 1.55-1.75 (m, 2H, CH2CH2CH2), 1.75-1.95 (m, 2H, CH2CH2CH2), 2.12 (5, 1H,CCH), 2.46 (t, 2H, J 5.4, CH2N(CH2CCH)CH2), 2.55-2.70 (m, 2H, CH2N(CH2CCH)CH2), 3.10-3.50 (br m, 14H, 3 x CH2N(Boc)CH2 & NCH2CCH). MS (ESI) m/z539.4 ([M+H], 100%), 561.5 ([M+Na], 28%). The spectroscopic data were inagreement with those in the literature.25?26, 170161-27-0

170161-27-0 Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate 10940041, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; THE UNIVERSITY OF SYDNEY; RUTLEDGE, Peter; TODD, Matthew; TRICCAS, James Anthony; WO2014/153624; (2014); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Simple exploration of 153-94-6

153-94-6 H-D-Trp-OH 9060, acatalyst-ligand compound, is more and more widely used in various fields.

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of methyl esters of L- and D-tryptophanes chlorohydrates; :1a,b 2a,b a : D b : L[0344] Thionylchloride (0.064 mol) was slowly added to a cooled (O0C) suspension of tryptophane (0.049 mol) in methanol (150 mL). The reaction mixture was warmed up to 4O0C and stirred at this temperature for six hours. All solvents were removed and the solid residue was triturated with ether. The solid was filtered off to give the required product.[0345] D-tryptophane (2a): yield 98 %, M.p. 232-233C. NMR1H (delta, ppm,DMSO-dtheta, 300 MHz): 3.39 (2H, m, CH2); 3.63 (3H, s, CH3O); 4.20 (1 H1 t, CH, JHH = 5.5 Hz); 7.07 (2H, dt, Ar, JHH = 21 Hz, 6 Hz); 7.26 (1 H, d, H2, JHH = 3 Hz); 7.39 (1 H, d, Ar, JHH = 7.8 Hz); 7.53 (1 H, d, Ar, JHH = 7.8 Hz). NMR13C (delta, ppm, DMSO-d6, 125.76 MHz): 26.01 (s), 52.61 (d), 106.26(s), 111.45(s), 117.84(s), 118.50(s), 121.05(s), 124.80(s), 126.79(s), 136.13(s), 169.57(s). m/z 218(M+)., 153-94-6

153-94-6 H-D-Trp-OH 9060, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; WO2008/103470; (2008); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Analyzing the synthesis route of 7328-91-8

As the paragraph descriping shows that 7328-91-8 is playing an increasingly important role.

7328-91-8, 2,2-Dimethylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,2-dimethylpropane-1,3-diamine (5.0?g, Aldrich) was added to a solution of HCOOH (10 equiv) and HCHO (37% aqueous solution, 10?equiv), and was heated at reflux overnight, whereupon the solution was made basic by addition of NaOH (2?M, aqueous) and extracted into diethyl ether (4?*?25?mL). The ether solution was dried over K2CO3, and the solvent removed by rotary evaporation. The resulting oil was distilled in vacuo from CaH2 to afford the product as a colorless oil (75%). 1H NMR (CDCl3, 400?MHz): delta 0.9 (m, 6H); 2.0 (m, 4H); 2.2 (m, 12H). GC-MS: [60?C (1?min) to 180?C (2?min) at 30?C¡¤min-1]; tr?=?5.2?min (158, M+)., 7328-91-8

As the paragraph descriping shows that 7328-91-8 is playing an increasingly important role.

Reference£º
Article; Large, Tao A.G.; Mahadevan, Viswanath; Keown, William; Stack, T. Daniel P.; Inorganica Chimica Acta; vol. 486; (2019); p. 782 – 792;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Downstream synthetic route of 448-61-3

448-61-3 2,4,6-Triphenylpyrylium tetrafluoroborate 9930615, acatalyst-ligand compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.448-61-3,2,4,6-Triphenylpyrylium tetrafluoroborate,as a common compound, the synthetic route is as follows.

General procedure: To a suspension of the corresponding amine (2.0 mmol) and 2,4,6-triphenylpyrylium tetrafluoroborate (2.0 mmol) in EtOH (20 mL) in a round bottle flask was added Et3N (2.0 mmol). The mixture turned deep-brown while the educts dissolved and was stirred for 30 min at rt followed by the addition of AcOH (4.0 mmol) and heating under reflux conditions for additional 2 h. The product precipitated during the reaction. The product was dissolved directly in the flask with little acetone at the reflux temperature after the reaction was finished (no further precipitate occurred). After cooling down to rt the product crystallized as a yellow solid, which was filtered off, washed with cold EtOH and pentane and dried in vacuo., 448-61-3

448-61-3 2,4,6-Triphenylpyrylium tetrafluoroborate 9930615, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Menzel, Roberto; Kupfer, Stephan; Mede, Ralf; Goerls, Helmar; Gonzalez, Leticia; Beckert, Rainer; Tetrahedron; vol. 69; 5; (2013); p. 1489 – 1498;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Some tips on 168646-54-6

As the paragraph descriping shows that 168646-54-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.168646-54-6,5,6-Diamino-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: [Cu(CH3CN)4]ClO4 (32.6 mg, 0.100 mmol) was added to a DCMsolution (about 12 mL) of dap (10.7 mg, 98percent, 0.0500 mmol) andxantphos (59.0 mg, 98percent, 0.100 mmol) under a stream of dry argonby using Schlenk techniques at room temperature and a vacuumlinesystem, then orange-red solution was obtained quickly andstirred for 1 h at room temperature. The above process can alsobe carried out in air with the existence of oxygen. After filtrationthrough absorbent cotton, layering n-hexane onto the DCM solutionin air produced the product as bluish violet to black-blue blockcrystals in 76percent yield (63.0 mg)., 168646-54-6

As the paragraph descriping shows that 168646-54-6 is playing an increasingly important role.

Reference£º
Article; Yao, Xi-Xi; Guo, Ya-Meng; Liu, Rong; Feng, Xiao-Yan; Li, Hao-Huai; Liu, Nian; Yang, Feng-Lei; Li, Xiu-Ling; Polyhedron; vol. 92; (2015); p. 84 – 92;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Simple exploration of 7173-51-5

The synthetic route of 7173-51-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7173-51-5,N-Decyl-N,N-dimethyldecan-1-aminium chloride,as a common compound, the synthetic route is as follows.,7173-51-5

General procedure: In a round-bottom flask equipped with dropping funnel and reflux condenser 0.01 mol of (4-chloro-2-methylphenoxy)acetic acid, 40 mL of distilled water and 0.011 mol of 10% aqueous solution of NaOH was heated at 50 C until the mixture became a clear solution. Then a stoichiometric amount of quaternary ammonium chloride was added and the mixture was stirred for 30 min at room temperature. The product deposited as the bottom layer, which was separated. Then it was dissolved in 50 mL of chloroform. The organic phase was washed with distilled water until no chloride was present in water. After removal of chloroform the product was dried under reduced pressure at 60 C for 24 h.

The synthetic route of 7173-51-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pernak, Juliusz; Syguda, Anna; Janiszewska, Dominika; Materna, Katarzyna; Praczyk, Tadeusz; Tetrahedron; vol. 67; 26; (2011); p. 4838 – 4844;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

New learning discoveries about 54258-41-2

54258-41-2 1,10-Phenanthrolin-5-amine 606970, acatalyst-ligand compound, is more and more widely used in various fields.

54258-41-2,54258-41-2, 1,10-Phenanthrolin-5-amine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

YC-2 (0.5000 g, 1.236 mmol) and HATU (0.5091 g, 1.339 mmol) were dissolved in 7.5 mL of DMF, and TEA (0.1355 g, 1.339 mmol).Under a nitrogen atmosphere, after stirring at room temperature for 1-2 hours, 5-amino-1,10-phenanthroline was added.(0.2010 g, 1.030 mmol), warmed to 60 C, and allowed to react overnight.After the reaction was cooled to room temperature, the DMF was removed by spin-drying, the mixture was applied to silica gel, and the column was separated by chromatography (DCM:MeOH = 40:1).0.3235 g of a pale yellow solid was obtained with a yield of 54%.

54258-41-2 1,10-Phenanthrolin-5-amine 606970, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Suzhou University of Science and Technology; Sun Yanyan; (8 pag.)CN108558866; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Analyzing the synthesis route of 4045-44-7

4045-44-7, As the paragraph descriping shows that 4045-44-7 is playing an increasingly important role.

4045-44-7, 1,2,3,4,5-Pentamethylcyclopenta-1,3-diene is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

All glassware was dried in a 10000C oven, assembled and kept under a nitrogen purge throughout reaction. All solvents used were anhydrous. To a 100 mL, three-neck round bottom flask equipped with a reflux condenser, teflon stir bar, gas inlet, glass stopper and septum was added cobalt octacarbonyl (6.Og; 17.5 mmol) . The septum was replaced and assembled reaction flask purged an additional 5 minutes. Dichloromethane (50 mL) was then canulated into reaction flask and solution stirred for 5 minutes. To the reaction solution was added 1,2,3,4,5- pentamethylcyclopentadiene (3.1g; 22.7 mmol) and 1,3- cyclohexadiene ((2.5 mL; 26.2 mmol) . Septum was replaced with glass stopper and reaction mixture was stirred and brought to a gentle reflux which was maintained for one (1) hour. The reaction was cooled just until reflux stopped followed by a second addition of 1, 2, 3, 4, 5-pentamethylcyclopentadiene (2.4 g; 17.6 mmol) . Reflux was then continued for another two (2) hours. The reaction was then cooled and stirred overnight at room temperature.The condenser was and replaced with a gas inlet and the volatile material removed under reduced pressure maintaining a flask temperature of 15 – 20C. The dark red crude material (7.89g) was then transferred into a glovebox. The crude material was dissolved in hexanes (30 mL) and loaded into a column of alumina (Brockman I – neutral) previously rinsed with hexanes (200 mL) . The title compound was then eluted as an orange-brown band with hexanes (80OmL) . The solvent was removed under reduced pressure yielding deep red crystals of the title compound (6.09g; 70% based on Co2 (CO) 8) .The synthesis can be represented as follows: Co2(CO)8 + 2C5Me5H + C6H8 ? 2 [Co (omega5-C5Me5) (CO)2] + C6Hi0 + 4C0Analytical Characterization: 1H NMR spectrum was taken using a Bruker Avance 300 Spectrometer 1H NMR (C6D6) delta 1.6 (s, 5 CH3)

4045-44-7, As the paragraph descriping shows that 4045-44-7 is playing an increasingly important role.

Reference£º
Patent; PRAXAIR TECHNOLOGY, INC.; WO2008/124599; (2008); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI