Day: June 22, 2021

Related Products of 1416881-52-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1416881-52-1, Name is 2,4,5,6-Tetra(9H-carbazol-9-yl)isophthalonitrile, molecular formula is C56H32N6. In a Article，once mentioned of 1416881-52-1

The inherent flexibility afforded by molecular design has accelerated the development of a wide variety of organic semiconductors over the past two decades. In particular, great advances have been made in the development of materials for organic light-emitting diodes (OLEDs), from early devices based on fluorescent molecules to those using phosphorescent molecules. In OLEDs, electrically injected charge carriers recombine to form singlet and triplet excitons in a 1:3 ratio; the use of phosphorescent metal-organic complexes exploits the normally non-radiative triplet excitons and so enhances the overall electroluminescence efficiency. Here we report a class of metal-free organic electroluminescent molecules in which the energy gap between the singlet and triplet excited states is minimized by design, thereby promoting highly efficient spin up-conversion from non-radiative triplet states to radiative singlet states while maintaining high radiative decay rates, of more than 10 6 decays per second. In other words, these molecules harness both singlet and triplet excitons for light emission through fluorescence decay channels, leading to an intrinsic fluorescence efficiency in excess of 90 per cent and a very high external electroluminescence efficiency, of more than 19 per cent, which is comparable to that achieved in high-efficiency phosphorescence-based OLEDs.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Electric Literature of 10495-73-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.10495-73-5, Name is 6-Bromo-2,2′-bipyridine, molecular formula is C10H7BrN2. In a Article，once mentioned of 10495-73-5

Cyclometalating ligands 6-(1-phenylethyl)-2,2?-bipyridine (L4), 6-(1-phenylvinyl)-2,2?-bipyridine (L5), and 6-(prop-1-en-2-yl)-2,2?-bipyridine (L6) were synthesized by the Negishi coupling of 6-bromo-2,2?-bipyridine with the corresponding organozinc reagents. The reaction of L4 with K2PtCl4 produced only the cycloplatinated compound 4a via sp2 C-H bond activation. The reactions of L5 and L6 produced exclusively the cycloplatinated compounds 5b and 6a, respectively, via vinylic C-H bond activation. DFT calculations were performed on 12 possible cycloplatination products from the reaction of N-alkyl-N-phenyl-2,2?-bipyridin-6-amine (alkyl = methyl (L1), ethyl (L2), and isopropyl (L3)) and L4-L6. The results show that compounds 1b-3b resulting from the sp3 C-H bond activation of L1-L3 are thermodynamic products, and their relative stability is attributed to the planar geometry that allows for a better conjugation. Similar reasoning also applies to the stability of products from vinylic C-H bond activation of L5 and L6. The relative stability of isomeric cycloplatinated compounds 4a and 4b may be due to the different strengths of C-Pt bonds. The steric interaction is the major cause of severe distortion from a planar coordination geometry in the cycloplatinated compounds, which leads to instability of the corresponding cyclometalated products and a higher kinetic barrier for C-H bond activation.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， category: catalyst-ligand, Which mentioned a new discovery about 1120-02-1

In this paper, the voltammetric properties of diethylstilbestrol (DES) at the carbon paste electrode were described. The oxidation peak currents of DES increase significantly in the presence of surfactant cetylpyridine bromide (CPB), compared with that in the absence of CPB. Based on this fact, a voltammetric technique for determining DES is proposed. The accumulation potential has no effects on the peak current of the DES. An open-circuit accumulation is carried out. The experimental parameters, such as pH value of buffer, scan rate, and accumulation time were optimized. The interferences of some metal ions and organic compounds have also been studied, and some metal ions almost do not interfere with the determination of DES. Using this voltammetric method, DES in the injection sample was measured. The results show that this voltammetric method is reliable for the practice determination of DES.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 344-25-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.344-25-2, Name is H-D-Pro-OH, molecular formula is C5H9NO2. In a Review，once mentioned of 344-25-2

Enantiopure diarylmethanols, propargylic and allylic alcohols are important building blocks for the synthesis of a plethora of natural products and pharmaceutically relevant compounds. Among several methods employed for their synthesis, the enantioselective addition of diorganozinc compounds to carbonyl compounds in the presence of appropriate ligands becomes increasingly significant. In this comprehensive review, methods based on the use of readily available diethyl- and dimethylzinc for the formation of more complex compounds are compared and discussed. Available data on the mechanisms and transition states of reactions are presented.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 6249-56-5, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 6249-56-5, Name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, molecular formula is C7H16ClNO2. In a Article，once mentioned of 6249-56-5

Meldonium (3-(2,2,2-trimethylhydrazinium)propionate) is the most potent clinically used inhibitor of organic cation transporter 2 (OCTN2). Inhibition of OCTN2 leads to a decrease in carnitine and acylcarnitine contents in tissues and energy metabolism optimization-related cardioprotective effects. The recent inclusion of meldonium in the World Anti-Doping Agency List of Prohibited Substances and Methods has raised questions about the pharmacokinetics of meldonium and its unusually long elimination time. Therefore, in this study, the rate of meldonium washout after the end of the treatment was tested with and without administration of carnitine, gamma-butyrobetaine (GBB) and furosemide to evaluate the importance of competition for OCTN2 transport in mice. Here, we show that carnitine and GBB administration during the washout period effectively stimulated the elimination of meldonium. GBB induced a more pronounced effect on meldonium elimination than carnitine due to the higher affinity of GBB for OCTN2. The diuretic effect of furosemide did not significantly affect the elimination of meldonium, carnitine and GBB. In conclusion, the competition of meldonium, carnitine and GBB for OCTN2-mediated transport determines the pharmacokinetic properties of meldonium. Thus, due to their affinity for OCTN2, GBB and carnitine but not furosemide stimulated meldonium elimination. During long-term treatment, OCTN2-mediated transport ensures a high muscle content of meldonium, while tissue clearance depends on relatively slow diffusion, thus resulting in the unusually long complete elimination period of meldonium.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Electric Literature of 4408-64-4, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4408-64-4, Name is 2,2′-(Methylazanediyl)diacetic acid, molecular formula is C5H9NO4. In a Chapter，once mentioned of 4408-64-4

Bis(catecholato)silicates have emerged as robust alkyl radical sources under photocatalysis. This chapter describes the preparation of various silicates and their utilization under photocatalytic conditions for the formation of C-C and C-O bonds. The last section focuses on the use of silicates in photoredox/nickel dual catalysis.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Application of 112068-01-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.112068-01-6, Name is (S)-Diphenyl(pyrrolidin-2-yl)methanol, molecular formula is C17H19NO. In a Article，once mentioned of 112068-01-6

This paper reports a new method for the generation of chiral Lewis superacids by protonation of a non-Lewis acidic oxazaborolidine (1) with triflic acid. The resulting cationic species (3) are powerful and highly enantioselective catalysts for the Diels-Alder reaction of various 1,3-dienes with alpha,beta-enals. An optimization study (see Table 1) led to the selection of reaction conditions and catalysts (6A and 6B) which are very effective. The reactions are simple to conduct, reproducible, and economical, since only ca. 6 mol% of catalyst is required. In addition, the chiral catalyst precursor is readily recovered for reuse (>95% efficiency) and is commercially available. The broad scope of the process is documented by the 14 examples listed in Table 2. The absolute stereochemical course of the Diels-Alder reactions catalyzed by 6A and 6B was successfully predicted on the basis of the mechanistic principles which have recently been formulated for this type of catalytic enantioselective reaction involving re-face attack by the diene on complex 7. The mode of generation of Lewis superacids 6A and 6B allows an approximate comparison (or scale) connecting the catalytic power Lewis and protic acids. Copyright

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 51207-66-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.51207-66-0, Name is (S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine, molecular formula is C9H18N2. In a Article，once mentioned of 51207-66-0

The synthesis and ? receptor affinity of a series of conformationally restricted derivatives of 2-(1-pyrrolidinyl)-N-<2-(3,4-dichlorophenyl)ethyl>-N-methylethylenediamine (1) is described.The pyrrolidinyl (or N,N-dialkyl), ethylenediamine, N-alkyl, and phenylethyl portions of this ? receptor pharmacophore were restricted by its incorporation into 1,2-cyclohexanediamine-, pyrrolidine-, piperidine-, homopiperidine-, and tetrahydroisoquinoline-containing ligands.The ? receptor binding affinities of these compounds were determined using <3H>(+)-pentazocine in guinea pig brain homogenates.The synthesis of all but one class was achieved by acylation and alane reduction of the appropriate diamine precursors whose synthesis is also reported. ? receptor affinities ranged from 1.34 nM for 6,7-dichloro-2-<2-(1-pyrrolidinyl)ethyl>tetrahydroisoquinoline (12) to 455 nM for (1R,2R)-trans-N-<2-(3,4-dichlorophenyl)ethyl>-N-methyl-2-(1-pyrrolidinyl)cyclohexylamine <(-)-4>.In this displacement assay, (+)-pentazocine exhibited a Ki of 3.1 nM while DTG and haloperidol showed Ki values of 27.7 and 3.7 nM, respectively.The conformationally free parent compound 1 exhibited a Ki value of 2.1 nM.Comparison of both the ? receptor affinities and nitrogen atom geometry of the compounds revealed that a gauche relation of the nitrogen atoms of cis-1,2-cyclohexanediamines is not imperative for high affinity as we had previously thought.It is highly likely that nitrogen lone pair orientations and steric factors on the aliphatic portions of these ligands play a major role in the ? receptor binding of this pharmacophore.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of 2926-30-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2926-30-9, Name is Sodium trifluoromethanesulfonate, molecular formula is CF3NaO3S. In a Article，once mentioned of 2926-30-9

A macrocyclic tetraamido ligand 5,6:(3-pyrido)-12,12-diethyl-2,2,9,9-tetramethyl-3,8,11,13-tetraoxo-1,4,7,10-tet raazacyclotridecane, H41, has been designed to incorporate CoII and CoIII in the primary coordination site and has a secondary bidentate site, comprising pyridine-N and amido-O donor atoms, that coordinates Lewis acids. The complex PPh4[2] was obtained by deprotonation of H41 with lithium diisopropylamide in the presence of CoCl2, followed by air oxidation and precipitation from water by addition of PPh4Cl. The X-ray crystal structure of PPh4[2] was obtained. The compound crystallizes in the space group P1 (No. 2) with unit cell dimensions a = 12.936(4) A , b = 13.253(5) A , c = 13.288(2) A , alpha = 93.75(2), beta = 90.91-(2), gamma = 91.53(3), V = 2272.1(1.2) A 3, and Z = 2. Lewis acids can be bound either reversibly as in the case of alkali and alkaline earth cations or irreversibly as found for [(bpy)2Ru]2+ (bpy is 2,2?-bipyridine) and [(Me2bpy)2Ru]2+ (Me2bpy is 4,4?-(CH3)2-2,2?-bipyridine). The Lewis acid in the secondary coordination site broadly modifies the chemistry at CoIII and CoII in [2]- and [2]2-, respectively. The axial binding affinity of the CoIII center for 1-CH3-imidazole was 1 to 2 orders of magnitude larger when divalent Lewis acids were in the secondary coordination site than that for [2]-. The reactivities of [2]2-, Ca2+/[2]2-, and [(bpy)2Ru[2]] toward O2 were significantly different. The reaction of [2]2- with O2 rapidly generated [2]-, apparently by an outer-sphere electron-transfer pathway. In contrast, the oxidation of Ca2+/[2]2- by O2 was a complex reaction in which some of the Ca2+ was consumed and the final species depended on the amount of Ca2+ present at the start of the reaction. Finally, in the case of [(bpy)2Ru[2]], it appeared as though the dinuclear complex [(bpy)2Ru[2]]2(mu-O2) formed upon reaction with O2.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Application of 1119-97-7, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1119-97-7, Name is MitMAB, molecular formula is C17H38BrN. In a Article，once mentioned of 1119-97-7

Cyclic voltammograms (CVs) of C60 films and C60 embedded in cast films of triple-tailed cationic surfactant solutions and salt-free zero-charged cationic/anionic (catanionic) surfactant vesicles on glassy carbon electrode in a typical room-temperature ionic liquid (RT-IL), 1-n-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]), were examined. CVs show typically electrochemical oxidation and reduction. The salt-free zero-charged catanionic surfactant bilayer vesicles were determined by freeze-fracture transmission electron microscopy (FF-TEM) images and small-angle X-ray scattering (SAXS) measurements. The cast films of the salt-free zero-charged catanionic surfactant vesicles incorporated C 60 molecules were employed to study the electrochemical properties in RT-ILs, which would open new fields for the bulk electronic properties of fullerenes or their derivatives in ionic liquids.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI