Discovery of H-D-Pro-OH

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The beta-diketonate-based achiral polymer P-1 could be synthesized by the polymerization of 3,7-dibromo-2,8-dimethoxy-5,5-dioctyl-5H-dibenzo[b,d]silole (M1) with (Z)-1,3-bis(4-ethynylphenyl)-3-hydroxyprop-en-1-one (M2) via typical Sonogashira coupling reaction. The beta-diketonate unit in the main chain backbone of P-1 can further coordinate with Eu(TTA)x [TTA-=4,4,4-trifluoro-1-(thiophen-2-yl)butane-1,3-dionate anion, X=1, 2, 3] to afford corresponding Eu(III)-containing polymer complexes. The resulting achiral polymer complex P-2 (X=2) can exhibit strong circular dichroism (CD) response toward both N-Boc-l and d-proline enantiomers. The CD signal was preliminarily attributed to coordination induction between chiral N-Boc-proline and the Eu(III) complex moiety. The linear regression analysis of CD sensing shows a good agreement between the magnitude of molar ellipticity and concentration of chiral N-Boc-l or d-proline, which indicates this kind Eu(III)-containing achiral polymer complex can be used as a chiral probe for enantioselective recognition of N-Boc-l or d-proline enantiomers based on Cotton effect of CD spectra.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Discovery of 150-61-8

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Use of water instead of chlorofluorocarbons in foaming processes results in increased slabstock temperature and concomitant scorching which often occur more easily in the fire retardant foams. However, not all fire retardants aggravate scorch. Interaction of a number of fire retardants with aniline, which was chosen as a model compound simulating the -NH2 groups always present in water-blown polyurethane foams, has been examined by several experimental techniques. The reported results highlight that this interaction leads to alkylation of the amine and to the formation of phosphoric acid or alkyl phosphoric acids or hydrogen chloride in the case of chloroalkyl phosphates. As this interaction occurs the scorch phenomenon occurs as well in the fire retardant foams, therefore the scorch could be possibly connected with this interaction. It is likely that N-alkyl anilines or HCl or phosphoric acids can promote scorch.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Extracurricular laboratory:new discovery of (S)-[1,1′-Binaphthalene]-2,2′-diol

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Organic solutions of poly-gamma-(benzyl-L-glutamate) (PBLG) generate a sufficient differential ordering effect (DOE) to discriminate enantiomers using proton decoupled carbon-13 NMR in natural abundance. Discrimination between enantiomers is observed through the carbon-13 chemical shift anisotropy (CSA) differences. This method is successfully applied to a large number of chiral molecules including a case of axial chirality and offers the advantage that no labeling or chemical modification of molecules is needed. In most cases, the chemical shift differences are large enough to measure the enantiomeric excess with accuracy. We show that this new tool is an attractive and powerful alternative to the existing enantiomeric analytical techniques.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Awesome Chemistry Experiments For H-D-Pro-OH

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3-Carboxy-3,4-dehydropyrrolidine was found to bind with affinity equal to that of glycine in a [3H]strychnine binding assay. Simple substitution of the 1-, 2-, 4-, or 5-position resulted in marked loss of affinity. A decline in affinity was also found upon enlargement, contraction, or saturation of the 5-membered ring. However, beta-proline and azetidine-3-carboxylic acid retained significant binding affinity. Despite its good affinity in [3H]strychnine binding, 3-carboxy-3,4-dehydropyrrolidine showed only weak agonist activity in intracellular recordings of cultured murine spinal cord neurons. This apparent lack of correlation between binding and functional results is discussed in light of the current models of the strychnine- sensitive glycine receptor.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Top Picks: new discover of 79815-20-6

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[reaction: see text] A stereoselective total synthesis of (+)-benzastatin E (1) is described. The synthesis involves a diastereoselective Grignard addition to 2-acylindoline 2, which is derived from commercially available (S)-2-indolinecarboxylic acid (3). The unknown absolute configuration of (+)-1 is determined as (9S,10R).

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Discovery of OctMAB

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Two-dimensional transition-metal carbide materials (termed MXene) have attracted huge attention in the field of electrochemical energy storage due to their excellent electrical conductivity, high volumetric capacity, etc. Herein, with inspiration from the interesting structure of pillared interlayered clays, we attempt to fabricate pillared Ti3C2 MXene (CTAB-Sn(IV)@Ti3C2) via a facile liquid-phase cetyltrimethylammonium bromide (CTAB) prepillaring and Sn4+ pillaring method. The interlayer spacing of Ti3C2 MXene can be controlled according to the size of the intercalated prepillaring agent (cationic surfactant) and can reach 2.708 nm with 177% increase compared with the original spacing of 0.977 nm, which is currently the maximum value according to our knowledge. Because of the pillar effect, the assembled LIC exhibits a superior energy density of 239.50 Wh kg-1 based on the weight of CTAB-Sn(IV)@Ti3C2 even under higher power density of 10.8 kW kg-1. When CTAB-Sn(IV)@Ti3C2 anode couples with commercial AC cathode, LIC reveals higher energy density and power density compared with conventional MXene materials.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Top Picks: new discover of (S)-[1,1′-Binaphthalene]-2,2′-diol

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An economic and practical method for preparing enantiomerically pure [1,1?-binaphthalene]-2,2?-diols is reported. Thus, a condensate of threo-(1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol and cyclohexanone (CHANP) was used as a resolving agent. A 2:1:1 mixture of racemic [1,1?-binaphthalene]-2,2?-diol, boric acid, and CHANP was refluxed for several hours in THF or MeCN to give a white precipitate of bis((R)-[1,1?-binaphthalene]-2,2?-diol}boric acid CHANP derivative, from the precipitate, and a filtrate separated from the precipitate, (R)- and (S)-[1,1?-binaphthalene]-2,2?-diol of 100% ee were obtained in ca. 65% yield, respectively.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Discovery of 112068-01-6

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent, Application In Synthesis of (S)-Diphenyl(pyrrolidin-2-yl)methanol, Which mentioned a new discovery about 112068-01-6

A study was conducted to demonstrate highly enantioselective synthesis of beta-amino acid derivatives by the Lewis base catalyzed hydrosilylation of betaenamino esters. It was found that these catalyst and its analogue displayed excellent activities and enantioselectivities in promoting hydrosilylation of N-aryl beta-enamino esters. N-picolinoylpyrrolidine derivatives and N-picolioylephedrine were also evaluated in hydrosilylation of (Z)-methyl 3-phenyl-3-(phenylamino)acrylate. The generality of the Lewis base organocatalyzed hydrosilylation of various beta-enamino esters were examined under the optimized conditions. It was observed that the catalytic system exhibited a high sensitivity to the N-substituents, while all the N-aryl beta-enamino esters underwent the hydrosilylation smoothly to give corresponding beta-amino esters.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Extracurricular laboratory:new discovery of 1723-00-8

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An alternative asymmetric synthesis of ropivacaine and analogues employing the ‘cation pool’ strategy and host/guest supramolecular co-catalysis approach is presented. In this study, chiral auxiliaries, several soft nucleophiles as well as one-pot conditions for anodic oxidation, followed by nucleophilic addition, have been applied.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The Absolute Best Science Experiment for N1,N2-Di-tert-butylethane-1,2-diamine

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Chemistry is traditionally divided into organic and inorganic chemistry. category: catalyst-ligand. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 4062-60-6

A highly enantioselective gold(I)-catalyzed intermolecular tandem cyclization/[3 + 2] cycloaddition of 2-(1-alkynyl)-2-alken-1-ones with 3-stylindoles was achieved by using Ming-Phos as a chiral ligand. A variety of chiral highly substituted cyclopenta[c]furans were obtained in good yields (up to 99%) with excellent diastereoselectivities (>20:1) and enantioselectivities (up to 97% ee). The salient features of the present protocol include mild conditions, excellent yields, and high diastereo- and enantioselectivities, using readily available starting materials and a chiral ligand.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI