Month: February 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118949-61-4,2,6-Bis((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine,as a common compound, the synthetic route is as follows.

General procedure: (R)-LiPr (50mg, 0.17mmol) was dissolved in acetonitrile (15cm3). Zinc(II) tetrafluoroborate hydrate (20mg, 0.083mmol) was then added and the solution stirred at room temperature for one hour. A large excess of diethyl ether was added and the resultant precipitate was isolated by vacuum filtration leaving a white powder. Single crystals suitable for X-ray diffraction analysis were grown by vapour diffusion of diethyl ether into a concentrated solution of the product in acetonitrile. Yield: 0.054g, 78%.

118949-61-4, As the paragraph descriping shows that 118949-61-4 is playing an increasingly important role.

Reference：
Article; Burrows, Kay E.; Kulmaczewski, Rafal; Cespedes, Oscar; Barrett, Simon A.; Halcrow, Malcolm A.; Polyhedron; vol. 149; (2018); p. 134 – 141;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15862-19-8,5-Bromo-2,2′-bipyridine,as a common compound, the synthetic route is as follows.,15862-19-8

5-bromo-2,2-bipyridine (0.480 g, 2 mmol), 2-methylthiophene (0.401 g, 4 mmol) and KOAc (0.401 g, 4 mmol) in dryDMA (5 mL) were stirred under N2 at 150 C for 20 h in thepresence of Pd(OAc)2 (0.009 g, 2 mol%). After cooling the solution to room temperature, CH2Cl2 (15 mL) and an aqueoussaturated NH4Cl solution (10 mL) were added. The reactionsolution was extracted three times with 15 mL of CH2Cl2, andthe combined organic layers were washed three times with 10mL of water. The solvent was evaporated under reduced pressure, and the crude product was purified by using columnchromatography (silica; 5:1 v/v hexane:EtOAc) to afford compound 1 in 22% yield (111 mg). 1H NMR (CDCl3, 500 MHz): 8.89 (dd, 1H, J = 2.3 and 0.6 Hz, ArH), 8.68 (ddd, 1H, J = 4.7,1.7 and 0.8 Hz, ArH), 8.448.36 (m, 2H, ArH), 7.93 (dd, 1H,J = 8.3 and 2.4 Hz, ArH), 7.82 (td, 1H, J = 7.8 and 1.8 Hz,ArH), 7.30 (ddd, 1H, J = 7.4, 4.8 and 1.1 Hz, ArH), 7.24(d, 1H, J = 3.5 Hz, ArH), 6.826.77 (m, 1H, ArH), 2.54 (s,3H, ArCH3) ppm. HR-MS (ESI+) m/z [M + H]+ calcd. for[C15H13N2S]+ 253.0799; found: 253.0803.

As the paragraph descriping shows that 15862-19-8 is playing an increasingly important role.

Reference：
Article; Kamila, Mritunjoy; Cosquer, Goulven; Breedlove, Brian K.; Yamashita, Masahiro; Bulletin of the Chemical Society of Japan; vol. 90; 5; (2017); p. 595 – 603;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.216018-58-5,[2,2′:6′,2”-Terpyridine]-4,4′,4”-tricarboxylic acid,as a common compound, the synthetic route is as follows.,216018-58-5

2,2 ‘: 6’, 2 “-terpyridyl-4,4 ‘, 4” -tricarboxylic acid3.65 g (10.0 mmol) of the compound (manufactured by Tateyama Kasei)Was placed in a 500 mL eggplant flask. continue,2,2 ‘: 6’, 2 “-terpyridyl-4,4 ‘, 4” -tricarboxylic acid,5 mL of concentrated sulfuric acid and 300 mL of methanol were added,The resulting solution was heated to reflux for 6 hours.The reaction solution thus obtained was filtered off and the resulting solid was dried under vacuum to give 3.42 g ofTo obtain trimethyl 2,2 ‘: 6’, 2 “-terpyridyl-4,4 ‘, 4” -tricarboxylate.

The synthetic route of 216018-58-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; FUJIKURA LIMITED; YAMAGUCHI, TAKESHI; (16 pag.)JP5901496; (2016); B2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128249-70-7,2,6-Bis((R)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridine,as a common compound, the synthetic route is as follows.

Cobalt(II) tetrafluoroborate hydrate (25mg, 0.0675mmol) was added to a solution of (R)-LPh (50mg, 0.135mmol) in acetonitrile (15cm3). The resultant orange solution was stirred at room temperature for one hour. The product was precipitated using an excess of diethyl ether and the precipitate was collected by vacuum filtration, leaving an orange powder. A vapour diffusion of diethyl ether into a concentrated solution of the complex in acetonitrile gave orange crystals suitable for X-ray diffraction. Yield: 0.056g, 84%. Elemental microanalysis: found C, 56.6; H, 3.81; N, 8.53%: calcd for C46H38B2CoF8N6O4 C, 56.9; H, 3.94; N, 8.65%. 1H NMR (CD3CN): delta 2.7 (8H, Ph H2/6), 3.0 (4H, Ph H4), 7.7 (8H, Ph H3/5), 20.0 and 36.8 (both 4H, Ox H5), 40.5 (4H, Py H3/5), 84.7 (4H, Ox H4). No peak from the Py H4 proton environment was observed, which may be obscured by the CHD2CN solvent peak., 128249-70-7

The synthetic route of 128249-70-7 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Burrows, Kay E.; Kulmaczewski, Rafal; Cespedes, Oscar; Barrett, Simon A.; Halcrow, Malcolm A.; Polyhedron; vol. 149; (2018); p. 134 – 141;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1148-79-4, 2,2′:6′,2”-Terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

UO2Cl2(terpy) (3): A mixture of 1.7 ml (0.2 mmol) UCl4/HCl 0.12 M, 93 mg (0.4 mmol) 2,2???:6???,2???-terpyridine, 2.3 ml (19 mmol) acetonitrile and 1.1 ml (12 mmol) pyridine was placed in a Parr vessel and then heated statically at 120 ?°C for 48 h. The resulting yellow product was then filtered off, washed with water and dried at room temperature (reaction yield 79percent). XRD powder pattern indicated that the compound was obtained as a pure phase (Supplementary Information S3)., 1148-79-4

As the paragraph descriping shows that 1148-79-4 is playing an increasingly important role.

Reference：
Article; Lhoste, Jerome; Henry, Natacha; Loiseau, Thierry; Guyot, Yannick; Abraham, Francis; Polyhedron; vol. 50; 1; (2013); p. 321 – 327;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

118949-61-4, 2,6-Bis((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of [Ru(p-cymene)Cl2]2 (306 mg, 0.5 mmol) and pybox-ip (301 mg, 1.0 mmol) in MeOH (7.0 mL) wasadded a solution of disodium pyridine-2,6-dicarboxylate (1.0 mmol) in MeOH-H2O (2:1 v/v, 15 mL) under argonatmosphere. The mixture was stirred at 60 oC for 1 h. The product was extracted with CH2Cl2 (40 mL). The combinedorganic layers were concentrated and the residue was purified by silica gel column chromatography withCH2Cl2MeOH (50:1 v/v) to give A* as a dark greenish-violet solid (444.0 mg, 0.78 mmol) in 78% yield.

118949-61-4, 118949-61-4 2,6-Bis((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine 688211, acatalyst-ligand compound, is more and more widely used in various fields.

Reference：
Article; Fakhruddin, Ahmad; Abu-Elfotoh, Abdel-Moneim; Shibatomi, Kazutaka; Iwasa, Seiji; Letters in Organic Chemistry; vol. 15; 3; (2018); p. 196 – 205;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128249-70-7, 2,6-Bis((R)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Zinc(II)tetrafluoroborate hydrate (16mg, 0.068mmol) was added to a solution of (R)-LPh (50mg, 0.135mmol) in acetonitrile (15cm3). The resultant colourless solution was stirred at room temperature for one hour, before the product was precipitated using excess diethyl ether. The white precipitate was collected using vacuum filtration. Single crystals suitable for X-ray diffraction analysis were grown by vapour diffusion of diethyl ether into a concentrated solution of the product in acetonitrile. Yield: 0.056g, 84%. Elemental microanalysis: found C, 56.7; H, 3.38; N, 8.99%: calcd for C46H38B2F8N6O4Zn C, 56.5; H, 3.92; N, 8.59%. 1H NMR (CD3CN): delta 4.75 (dd, 4H, 10.8, 8,9 Hz, CH), 5.23 (dd, 4H, 10.4, 8.9Hz, ox-H), 5.15 (t, 4H, 10.6Hz, ox-H), 6.76 (d, 8H, 7.2Hz, Ph H2/6), 7.09 (t, 8H, 7.2Hz, Ph H3/5), 7.22 (m, 4H, Ph H4), 8.04 (d, 4H, 7.9Hz, Py H3/5), 8.47 (t, 2H, 7.9Hz, Py H4)., 128249-70-7

As the paragraph descriping shows that 128249-70-7 is playing an increasingly important role.

Reference：
Article; Burrows, Kay E.; Kulmaczewski, Rafal; Cespedes, Oscar; Barrett, Simon A.; Halcrow, Malcolm A.; Polyhedron; vol. 149; (2018); p. 134 – 141;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

22348-32-9, (R)-Diphenyl(pyrrolidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3A. Preparation of TMS-prolinolTo a mixture of prolinol (10.0 g, 39.5 mmol) and imidazole (4.57 g, 67.1 mmol) in THF (100 mL) was added chlorotrimethylsilane (5.57 g, 51.3 mmol) over 15 min while maintaining the batch temperature below 30 0C. The resulting slurry was aged at 50 0C for 3-5 h. The reaction mixture was cooled to ambient tempearture and quenched by addition of MTBE (50 mL) and 15% aq NaCl (100 mL). The organic layer was washed with 15% aq NaCl (50 mL). The solution was azeotropically dried at the constant volume by feeding THF.HPLC MethodColumn: Ascentis Express Cl 8 (100×4.6mm, 2.7um)Column temperature: 45 0CFlow rate: 1.5 ml/minDetection: UV at 210nmGradient:Time(min) 0.1% H^PO4 (0A) MeCN (0A)0 95 51 95 512 10 90Retention times (minutes): prolinol (4.8 min); TMS prolinol (7.3 min)

22348-32-9, The synthetic route of 22348-32-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK SHARP &; DOHME CORP.; XU, Feng; DESMOND, Richard; HOERRNER, R. Scott; HUMPHREY, Guy, R.; ITOH, Tetsuji; JOURNET, Michel; YOSHIKAWA, Naoki; ZACUTO, Michael, J.; WO2010/144293; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71071-46-0,Dimethyl [2,2′-bipyridine]-4,4′-dicarboxylate,as a common compound, the synthetic route is as follows.

71071-46-0, A solution of compound 9 (200mg, 0.39mmol), dimethyl 2,2?-bipyridine-4,4?-dicarboxylate (212mg, 0.78mmol), and potassium hexafluorophosphate (108mg, 0.585mmol) in dry 1,2-dichloroethane (20mL) was stirred at 40°C for 24h. The reaction mixture was concentrated under reduced pressure and the crude product was purified by column chromatography using ethyl acetate/ dichloromethane (1:1) to give compound 10 as a dark red solid (198mg, 50percent). 1H NMR (300MHz, CDCl3): delta 8.88 (s, 1H), 8.83 (s, 1H), 8.75 (s, 2H), 8.27 (d, J=6Hz, 1H), 8.02 (dd, J=1.5Hz, 1.5Hz, 1H), 7.80 (d, J=5.4Hz, 1H), 7.84 (d, J=6.3Hz, 1H), 7.76(dd, J=1.5Hz, 1.5Hz, 1H), 7.69 (dd, J=1.5Hz, 1.5Hz, 1H), 7.59?7.64 (m, 5H), 7.30(d, J=5.4Hz, 1H), 7.01?7.16 (m, 1H), 6.89 (q, J=5.4Hz, 1H), 6.52 (q, J=7.8Hz, 1H), 4.00 (s, 3H), 3.99 (s, 3H), 3.98 (s, 3H), 3.96 (s, 3H); 13C NMR (125MHz, CDCl3): delta 181.4, 164.3, 164.3, 164.1, 163.9, 162.1, 159.5 (d, JCF=252.1Hz), 157.9, 157.3, 156.6, 156.4, 155.4, 151.6, 150.7, 150.4, 145.6, 138.4, 137.2, 136.3, 135.8, 135.7, 135.4, 135.2, 128.1, 126.2, 126.1, 125.8, 125.7, 125.1, 122.8, 122.7, 122.1, 121.9, 121.6, 120.0, 119.0, 109.5 (d, JCF=22.7Hz), 53.4, 53.3, 53.2; HRMS (FAB): calcd. for C41H31FN5O8SRu [M+] 874.0921, found 874.0923.

71071-46-0 Dimethyl [2,2′-bipyridine]-4,4′-dicarboxylate 326419, acatalyst-ligand compound, is more and more widely used in various fields.

Reference：
Article; Li, Chung-Yen; Su, Chaochin; Wang, Hsiou-Hsuan; Kumaresan, Prabakaran; Hsu, Chia-Hsuan; Lee, I-Ting; Chang, Wei-Chun; Tingare, Yogesh S.; Li, Ting-Yu; Lin, Chia-Feng; Li, Wen-Ren; Dyes and Pigments; vol. 100; 1; (2014); p. 57 – 65;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3002-77-5,2-Methyl-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

0.29 g of Cu (NO3) 2 · 3H2O and 0.174 g of 2-methyl-1,10-phenanthroline were sequentially added to a mixed solution of 25 mL of methanol and 25 mL of acetonitrile,Stir constantly.After 8 hours the reaction was filtered,The mother liquor with ether diffusion,Let stand at room temperature,Several days to give a green bulk crystal Z5., 3002-77-5

As the paragraph descriping shows that 3002-77-5 is playing an increasingly important role.

Reference：
Patent; Capital Normal University; Lu Xiaoming; (52 pag.)CN106543209; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI