Month: March 2022

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Castor Oil-Based Bioplastics via Polyesterification: Synthesis, Characterization, and Functionalization, the main research direction is castor oil based bioplastics polyesterification functionalization.COA of Formula: C11H21BrO2.

Synthesis and application of biobased polymers are at the forefront of polymer science. Herein, we report the synthesis, characterization, and functionalization of castor oil-based bioplastics. At first, polymer P1 was synthesized via polyesterification by using monomer 11-bromoundecanoic acid (1) to demonstrate the feasibility of this step-growth polymerization method. The success of this polycondensation technique relies on the high substitution efficiency between terminal groups, carboxylic acid, and carbon-bromide moieties under alk. conditions. Subsequently, copolymers P2-P5 with varied compositions were obtained by random copolymerization of monomers 1 and 6-bromohexanoic acid (2) in different feed ratios. Linear pos. correlation is disclosed between the crystallization (Tc) and melting (Tm) temperatures of P1-P5 and the molar fraction of 1 within these specimens. Differential scanning calorimetry (DSC) and wide-angle X-ray diffraction (WAXD) results illustrate good crystallinity of these bioplastics. Furthermore, the degradation of polymers P1-P5 is propelled by an external basic environment while hindered by their intrinsic hydrophobicity, indicating that alkalinity and composition are two essential factors to manipulate the degradation behaviors of biobased polyesters in the bulk state. Ultimately, polymerization of 1 in the presence of 1-pyrenebutyric acid (3), an end-capping agent, was carried out to yield α-pyrene functionalized polymer P7. This material is capable of serving as a practical fluorescent probe and multiwalled carbon nanotube (MWNT) dispersion stabilizer. Polyesterification reported herein represents a facile and cost-effective synthetic strategy and shows great prospects in sustainable polymer materials.

Here is a brief introduction to this compound(2834-05-1)COA of Formula: C11H21BrO2, if you want to know about other compounds related to this compound(2834-05-1), you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine(SMILESS: CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1,cas:89972-77-0) is researched.Quality Control of (S)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)-methylamine. The article 《Bis-tridendate Ir(III) polymer-metallocomplexes: hybrid, main-chain polymer phosphors for orange-red light emission》 in relation to this compound, is published in Polymers (Basel, Switzerland). Let’s take a look at the latest research on this compound (cas:89972-77-0).

In this work, hybrid polymeric bis-tridentate iridium(III) complexes bearing derivatives of terpyridine (tpy) and 2,6-di(phenyl) pyridine as ligands were successfully synthesized and evaluated as red-light emitters. At first, the synthesis of small mol. bis-tridendate Ir(III) complexes bearing alkoxy-, methyl-, or hydroxy-functionalized terpyridines and a dihydroxyphenyl-pyridine moiety was accomplished. Mol. complexes bearing two polymerizable end-hydroxyl groups and methyl- or alkoxy-decorated terpyridines were copolymerized with difluorodiphenyl-sulfone under high temperature polyetherification conditions. Alternatively, the post-polymerization complexation of the terpyridine-iridium(III) monocomplexes onto the biphenyl-pyridine main chain homopolymer was explored. Both cases afforded solution-processable metallocomplex-polymers possessing the advantages of phosphorescent emitters in addition to high mol. weights and excellent film-forming ability via solution casting. The structural, optical, and electrochem. properties of the monomeric and polymeric heteroleptic iridium complexes were thoroughly investigated. The polymeric metallocomplexes were found to emit in the orange-red region (550-600 nm) with appropriate HOMO and LUMO levels to be used in conjunction with blue-emitting hosts. By varying the metal loading on the polymeric backbone, the emitter′s specific emission maxima could be successfully tuned.

Here is a brief introduction to this compound(89972-77-0)Formula: C22H17N3, if you want to know about other compounds related to this compound(89972-77-0), you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine( cas:89972-77-0 ) is researched.Quality Control of 4-(p-Tolyl)-2,2:6,2-terpyridine.Turonek, Mary L.; Moore, Peter; Errington, William published the article 《Synthesis of the terpyridyl pendant-arm azamacrocycle 4′-(p-1,4,7-triazacyclonon-1-ylmethylphenyl)-2,2′:6′,2”-terpyridine (L) and complexes of L with copper(II) and nickel(II). Crystal structure of [Cu(HL)(H2O)2][PF6]3》 about this compound( cas:89972-77-0 ) in Dalton. Keywords: triazacyclononylmethylphenylterpyridine preparation complexation copper nickel; crystal structure copper triazacyclononylmethylphenylterpyridine complex; copper triazacyclononylmethylphenylterpyridine complex preparation structure electrochem redox; nickel triazacyclononylmethylphenylterpyridine complex preparation electrochem reduction; electrochem redox copper nickel triazacyclononylmethylphenylterpyridine complex. Let’s learn more about this compound (cas:89972-77-0).

The azamacrocyclic ligand 4′-(p-1,4,7-triazacyclonon-1-ylmethylphenyl)-2,2′:6′,2”-terpyridine (L) was prepared, some of the complexes it forms with hydrated Cu(II) and Ni(II) were isolated as the [PF6]- salts. X-ray crystallog. was used to determine the solid state structure of the distorted trigonal bipyramidal complex [Cu(HL)(H2O)2][PF6]3, in which the Cu(II) is coordinated to the terpyridyl group and the azamacrocycle is monoprotonated and noncoordinating. A bis(2,2′:6′,2”-terpyridine)nickel(II) complex, [Ni(H2L2)2][PF6]6 also was isolated, in which each azamacrocycle is diprotonated. Both complexes were studied by cyclic voltammetry.

Here is a brief introduction to this compound(89972-77-0)Quality Control of 4-(p-Tolyl)-2,2:6,2-terpyridine, if you want to know about other compounds related to this compound(89972-77-0), you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A highly stereoselective synthesis of anti-HIV 2′,3′-dideoxy- and 2′,3′-didehydro-2′,3′-dideoxynucleosides, published in 1992-07-03, which mentions a compound: 32780-06-6, Name is (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, Molecular C5H8O3, Category: catalyst-ligand.

A general total synthetic method for the stereocontrolled synthesis of 2′,3′-dideoxy- and 2′,3′-didehydro-2′,3′-dideoxynucleosides, is presented. Introduction of an α-phenylselenenyl group at the 2-position of 2,3-dideoxyribosyl acetate directs the glycosyl bond formation to give ≥95% β-isomer. This 2′-phenylselenenyl nucleoside may be converted to either the 2′,3′-dideoxynucleoside by treatment with n-Bu3SnH and Et3B at room temperature or to the unsaturated derivative by treatment with H2O2/cat. pyridine. The application of this method to the syntheses of pyrimidines (ddU, ddT, ddC), 6-substituted purines (ddA, ddT, 6-chloro-ddP, N6-Me-ddA), and 2,6-disubstituted pruines(2-F-ddA, 6-chloro-2-amino-ddP) as well as selected 2′,3′-didehydro-2′,3′-dideoxy derivatives, is reported.

Here is a brief introduction to this compound(32780-06-6)Category: catalyst-ligand, if you want to know about other compounds related to this compound(32780-06-6), you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of C22H17N3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Synthesis and properties of trinuclear polypyridyl complexes Ru(II)-Co(II)-Ru(II) and Ru(II)-Co(III)-Ru(II): Their photoinduced interconversion. Author is Lombard, Jean; Boulaouche, Rachid; Amilan Jose, D.; Chauvin, Jerome; Collomb, Marie-Noelle; Deronzier, Alain.

The trinuclear [{RuII(bpy)2(bpy-terpy)}2CoII]6+ complex (16+) in which a Co(II)-bis-terpyridine-like center is covalently linked to two Ru(II)-tris-bipyridine-like moieties by a bridging bipyridine-terpyridine ligand has been synthesized and characterized. Its electrochem., photophys. and photochem. properties have been investigated in CH3CN. The cyclic voltammetry exhibits two successive reversible oxidation processes, corresponding to the CoIII/CoII and RuIII/RuII redox couples at E 1/2 = -0.06 and 0.91 V vs Ag/Ag+ 10 mM, resp. The one-electron oxidized form of the complex, [{RuII(bpy)2(bpy-terpy)}2CoIII]7+ (17+) obtained after exhaustive electrolysis carried out at 0.2 V is fully stable. 16+ and 17+ are only poorly luminescent, indicating that the covalent linkage of the Ru(II)-tris-bipyridine center to the cobalt subunit leads to a strong quenching of the RuII excited state by an intramol. process. Luminescence lifetime experiments carried out at different temperatures indicate that the transfer is more efficient for 17+ compare to 16+ due to lower activation energy. Continuous irradiation of 17+ performed at 405 nm in the presence of P(Ph)3 acting as sacrificial electron donor leads to its quant. reduction into 16+, whereas similar experiment starting from 16+ with a sulfonium salt as sacrificial electron acceptor converts 16+ into 17+ with a slower rate and a maximum yield of 80%. These photoinduced electron transfers were followed by UV-Visible spectroscopy and compared with those obtained with a simple mixture of both mononuclear parent complexes i.e. [RuII(bpy)3]2+ and [CoII(tolyl-terpy)2]2+ or [CoIII(tolyl-terpy)2]3+ (tolyl-terpy = 4′-(4-methylphenyl)-2,2′:6′,2”-terpyridine).

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The effect of toxic pyridine-alkaloid secondary metabolites on the sunbird gut microbiome》. Authors are Gunasekaran, Mohanraj; Lalzar, Maya; Sharaby, Yehonatan; Izhaki, Ido; Halpern, Malka.The article about the compound:(S)-3-(Piperidin-2-yl)pyridinecas:494-52-0,SMILESS:C1(C=NC=CC=1)[C@@H]1CCCCN1).COA of Formula: C10H14N2. Through the article, more information about this compound (cas:494-52-0) is conveyed.

Abstract: Sunbirds feed on tobacco tree nectar which contains toxic nicotine and anabasine secondary metabolites. Our aim was to understand the effect of nicotine and anabasine on the gut microbiota composition of sunbirds. Sixteen captive sunbirds were randomly assigned to two diets: artificial nectar either with (treatment) or without (control) added nicotine and anabasine. Excreta were collected at 0, 2, 4 and 7 wk of treatment and samples were processed for bacterial culture and high-throughput amplicon sequencing of the 16S rRNA gene. The gut microbiome diversity of the treated and control birds changed differently along the seven-week experiment While the diversity decreased in the control group along the first three samplings (0, 2 and 4 wk), it increased in the treatment group. The microbiota composition analyses demonstrated that a diet with nicotine and anabasine, significantly changed the birds′ gut microbiota composition compared to the control birds. The abundance of nicotine- and anabasine- degrading bacteria in the excreta of the treated birds, was significantly higher after four and seven weeks compared to the control group. Furthermore, anal. of culturable isolates, including Lactococcus, showed that sunbirds′ gut-associated bacteria were capable of degrading nicotine and anabasine, consistent with their hypothesised role as detoxifying and nutritional symbionts.

Here is a brief introduction to this compound(494-52-0)COA of Formula: C10H14N2, if you want to know about other compounds related to this compound(494-52-0), you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-(Piperazin-1-yl)nicotinonitrile, is researched, Molecular C10H12N4, CAS is 149554-29-0, about Orally Active 7-Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1-Phosphate Lyase for the Treatment of Multiple Sclerosis.Reference of 6-(Piperazin-1-yl)nicotinonitrile.

Sphingosine 1-phosphate (S1P) lyase has recently been implicated as a therapeutic target for the treatment of multiple sclerosis (MS), based on studies in a genetic mouse model. Potent active site directed inhibitors of the enzyme are not known so far. Here we describe the discovery of (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitrile 5 in a high-throughput screen using a biochem. assay, and its further optimization. This class of compounds was found to inhibit catalytic activity of S1PL by binding to the active site of the enzyme, as seen in the cocrystal structure of derivative 31 with the homodimeric human S1P lyase. 31 induces profound reduction of peripheral T cell numbers after oral dosage and confers pronounced protection in a rat model of multiple sclerosis. In conclusion, this novel class of direct S1P lyase inhibitors provides excellent tools to further explore the therapeutic potential of T cell-targeted therapies in multiple sclerosis and other autoimmune and inflammatory diseases.

Here is a brief introduction to this compound(149554-29-0)Reference of 6-(Piperazin-1-yl)nicotinonitrile, if you want to know about other compounds related to this compound(149554-29-0), you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Identification of novel nucleotide phosphonate analogs with potent anti-HCMV activity, published in 1998-12-15, which mentions a compound: 32780-06-6, Name is (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, Molecular C5H8O3, Safety of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.

We have recently described the discovery of new leads in the area of anti-HCMV research. Further structure-activity relationship studies have allowed us to identify potent and selective anti-HCMV nucleotide analogs. The synthesis as well as structure-activity relationship studies are described.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Aguirre, Luis A.; Davis, Julie K.; Stevenson, Philip C.; Adler, Lynn S. published an article about the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0,SMILESS:C1(C=NC=CC=1)[C@@H]1CCCCN1 ).COA of Formula: C10H14N2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:494-52-0) through the article.

Herbivory can induce chem. changes throughout plant tissues including flowers, which could affect pollinator-pathogen interactions. Pollen is highly defended compared to nectar, but no study has examined whether herbivory affects pollen chem. We assessed the effects of leaf herbivory on nectar and pollen alkaloids in Nicotiana tabacum, and how herbivory-induced changes in nectar and pollen affect pollinator-pathogen interactions. We damaged leaves of Nicotiana tabacum using the specialist herbivore Manduca sexta and compared nicotine and anabasine concentrations in nectar and pollen. We then pooled nectar and pollen by collection periods (within and after one month of flowering), fed them in sep. experiments to bumble bees (Bombus impatiens) infected with the gut pathogen Crithidia bombi, and assessed infections after seven days. We did not detect alkaloids in nectar, and leaf damage did not alter the effect of nectar on Crithidia counts. In pollen, herbivory induced higher concentrations of anabasine but not nicotine, and alkaloid concentrations rose and then fell as a function of days since flowering. Bees fed pollen from damaged plants had Crithidia counts 15 times higher than bees fed pollen from undamaged plants, but only when pollen was collected after one month of flowering, indicating that both damage and time since flowering affected interaction outcomes. Within undamaged treatments, bees fed late-collected pollen had Crithidia counts 10 times lower than bees fed early-collected pollen, also indicating the importance of time since flowering. Our results emphasize the role of herbivores in shaping pollen chem., with consequences for interactions between pollinators and their pathogens.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Chen, Ming; Dong, Guangbin researched the compound: 5,6-Dihydro-2H-pyran-2-one( cas:3393-45-1 ).Reference of 5,6-Dihydro-2H-pyran-2-one.They published the article 《Copper-Catalyzed Desaturation of Lactones, Lactams, and Ketones under pH-Neutral Conditions》 about this compound( cas:3393-45-1 ) in Journal of the American Chemical Society. Keywords: lactone lactam ketone desaturation copper catalyst. We’ll tell you more about this compound (cas:3393-45-1).

A copper-catalyzed desaturation method that is suitable for converting lactones, lactams, and cyclic ketones to their α,β-unsaturated counterparts is reported. The reaction does not require strong base/acid or sulfur/selenium reagents and can be carried out through a simple one-step operation. The protocol uses inexpensive catalysts and reagents and exhibits excellent scalability and functional group tolerance. Notably, tert-Bu alc. is the only stoichiometric byproduct produced, and overoxidn. is not observed The reaction mechanism was studied through control experiments, deuterium labeling, radical clock, ESR, high-resolution mass spectrometry, and kinetic studies. The data obtained are consistent with a reaction pathway involving reversible α-deprotonation by a Cu(II)-OtBu species followed by further oxidation of the resulting Cu enolate.

Here is a brief introduction to this compound(3393-45-1)Reference of 5,6-Dihydro-2H-pyran-2-one, if you want to know about other compounds related to this compound(3393-45-1), you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI