Day: April 6, 2022

Application of 89972-77-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Neuroprotective effect of 4′-(4-methylphenyl)-2,2′:6′,2-terpyridine trihydrochloride, a novel inducer of nerve growth factor. Author is Yamamoto, Kyoko; Yoshikawa, Ryoko; Okuyama, Shigeru; Takahashi, Yuki; Karasawa, Yasuko; Hino, Noriko; Miyoshi, Toshio; Araki, Hiroaki; Hanabusa, Kenji.

We have identified 4′-(4-methylphenyl)-2,2′:6′,2-terpyridine trihydrochloride (SS701), which belongs to a family of a small unique neuroprotective agents. SS701 accelerated the production of nerve growth factor (NGF) in cultured astroglial cells, dose- and time-dependently. In in vivo studies, SS701, when administered 30 min after induced cerebral ischemia, neuroprotective effects on delayed neuronal death in Mongolian gerbils were evident. The neuroprotective effects of SS701 against ischemia-induced delayed neuronal death are attributed to stimulation of the production of NGF.

When you point to this article, it is believed that you are also very interested in this compound(89972-77-0)Application of 89972-77-0 and due to space limitations, I can only present the most important information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Quality Control of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Efficient Chirality Transfer in the SmI2-Mediated Cyclization of Aldehydo β-Alkoxyvinyl Sulfoxides: Asymmetric Synthesis of 3-Hydroxyoxanes.

Stereoselective syntheses of 3-hydroxyoxanes were achieved via efficient chirality transfer in the SmI2-mediated cyclization reactions of aldehydo β-alkoxyvinyl sulfoxides. The observed stereoselectivity is discussed in terms of transition state structures for the reactions. RHF, ab initio, d. functional theory, and zero-point energy calculations were done for Ph β-methoxyvinyl sulfoxide configurations to determine global min. structures.

When you point to this article, it is believed that you are also very interested in this compound(32780-06-6)Quality Control of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one and due to space limitations, I can only present the most important information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5,6-Dihydro-2H-pyran-2-one( cas:3393-45-1 ) is researched.Electric Literature of C5H6O2.Souza, Diana Meneses; Machado, Luciana Lucas; Machado, Angelo Henrique Lira published the article 《First total synthesis of (±)-floribundane B: An approach based on Johnson-Claisen rearrangement of a Morita-Baylis-Hillman adduct》 about this compound( cas:3393-45-1 ) in Tetrahedron Letters. Keywords: floribundane B synthesis Johnson Claisen rearrangement; oleocanthal formal synthesis Johnson Claisen rearrangement. Let’s learn more about this compound (cas:3393-45-1).

The first total synthesis of (±)-floribundane B (I) is reported. Johnson-Claisen rearrangement of a Morita-Baylis-Hillman adduct assembled all of the stereochem. features of this secoiridoid. The formal synthesis of (±)-oleocanthal and the synthesis of a chem. constituent of olive press juice is also reported.

When you point to this article, it is believed that you are also very interested in this compound(3393-45-1)Electric Literature of C5H6O2 and due to space limitations, I can only present the most important information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 494-52-0, is researched, SMILESS is C1(C=NC=CC=1)[C@@H]1CCCCN1, Molecular C10H14N2Journal, Article, Food and Chemical Toxicology called Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties, Author is Schorderet Weber, Sandra; Kaminski, Kacper P.; Perret, Jean-Luc; Leroy, Patrice; Mazurov, Anatoly; Peitsch, Manuel C.; Ivanov, Nikolai V.; Hoeng, Julia, the main research direction is Nicotiana Ctenocephalides Lucilia Caenorhabditis Rhipicephalus Ixodes antiparasitic; Parasite; Repellence; Tick; Tickicide; Tobacco alkaloid; Tobacco extract.Formula: C10H14N2.

Within the traditional pharmacopeia, tobacco (Nicotiana spp.) is often cited as an efficient pesticide. This activity is generally attributed to nicotine, but tobacco plants contain other alkaloids that could potentially contribute to this effect. In this study, we tested methanolic extracts of N. glutinosa, N. glauca, N. debneyi, and N. tabacum (putrescine N-methyltransferase line, burley TN90 and Stella, Virginia ITB 683 and K326), selected according to alkaloid content. Their antiparasitic activity was evaluated in bioassays against adult fleas (Ctenocephalides felis), blowfly (Lucilia cuprina) larva, nematodes (Caenorhabditis elegans), and ticks (Rhipicephalus sanguineus larva and adults, Ixodes ricinus nymphs). None of the extracts killed fleas and blowfly larva effectively at the concentrations tested. Only N. tabacum K326 and N. glutinosa exhibited moderate anthelmintic activity. All extracts significantly repelled R. sanguineus ticks, but not I. ricinus, and the nicotine-rich extracts rapidly knocked down all tick species and stages at high concentrations The link between nicotine and tick knockdown was confirmed by successfully testing the pure alkaloid at concentrations found in the tobacco extracts In contrast, repellent activity could not be correlated to the individually tested alkaloids (nicotine, nornicotine, anabasine, anatabine), although anatabine and nornicotine were active in the tick bioassay at high concentrations

When you point to this article, it is believed that you are also very interested in this compound(494-52-0)Formula: C10H14N2 and due to space limitations, I can only present the most important information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Winter, Andreas; Egbe, Daniel A. M.; Schubert, Ulrich S. published the article 《Rigid π-Conjugated Mono-, Bis-, and Tris(2,2′:6′,2”-terpyridines)》. Keywords: pi conjugated linear star mono bis tris terpyridine synthesis; Horner Wadsworth Emmons reaction pi conjugated terpyridine synthesis; luminescence pi conjugated linear star terpyridine.They researched the compound: 4-(p-Tolyl)-2,2:6,2-terpyridine( cas:89972-77-0 ).Electric Literature of C22H17N3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:89972-77-0) here.

A set of rigid, π-conjugated linear mono- and bisterpyridines and star-shaped tristerpyridines [e.g. I (R = octadecyl) and 1,3,5-C6R13 (R1 = II)] were synthesized using Pd(0)-catalyzed coupling reactions and the Horner-Wadsworth-Emmons reaction. The terpyridyl ligands obtained feature strong emission in the blue range with high quantum yields in dilute solution and thin films.

When you point to this article, it is believed that you are also very interested in this compound(89972-77-0)Electric Literature of C22H17N3 and due to space limitations, I can only present the most important information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-(Piperazin-1-yl)nicotinonitrile, is researched, Molecular C10H12N4, CAS is 149554-29-0, about Design, Synthesis, Biological Screening, and Molecular Docking Studies of Piperazine-Derived Constrained Inhibitors of DPP-IV for the Treatment of Type 2 Diabetes, the main research direction is piperazine derivative preparation antidiabetic screening mol docking DPPIV inhibitor; antihyperglycemic; constrained DPP-IV inhibitor; dipeptidyl peptidyl-IV (DPP-IV) inhibitor; molecular docking; oral glucose tolerance test; piperazine.HPLC of Formula: 149554-29-0.

Novel piperazine-derived conformationally constrained compounds were designed, synthesized, and evaluated for in vitro Dipeptidyl peptidase-IV (DPP-IV) inhibitory activities. From a library of compounds synthesized, 1-(2-(4-(7-Chloro-4-quinolyl)piperazin-1-yl)acetyl)pyrrolidine (2g) was identified as a potential DPP-IV inhibitor exhibiting better inhibitory activity than P32/98, reference inhibitor. The in vivo studies carried out in STZ and db/db mice models indicated that the compound 2g showed moderate antihyperglycemic activity as compared to the marketed drug Sitagliptin. A two-week repeated dose study in db/db mice revealed that compound 2g significantly declined blood glucose levels with no evidence of hypoglycemia risk. Furthermore, it showed improvement in insulin resistance reversal and antidyslipidemic properties. Mol. docking studies established good binding affinity of compound 2g at the DPP-IV active site and are in favor of the observed biol. data. These data collectively suggest that compound 2g is a good lead mol. for further optimization studies.

When you point to this article, it is believed that you are also very interested in this compound(149554-29-0)HPLC of Formula: 149554-29-0 and due to space limitations, I can only present the most important information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 494-52-0, is researched, SMILESS is C1(C=NC=CC=1)[C@@H]1CCCCN1, Molecular C10H14N2Journal, Article, Journal of Chromatography A called Chiral determination of nornicotine, anatabine and anabasine in tobacco by achiral gas chromatography with (1S)-(-)-camphanic chloride derivatization: Application to enantiomeric profiling of cultivars and curing processes, Author is Cai, Kai; Zhao, Huina; Yin, Runsheng; Lin, Yechun; Lei, Bo; Wang, Anping; Pan, Wenjie; Cai, Bin; Gao, Weichang; Wang, Feng, the main research direction is Chiral determination nornicotine anatabine anabasine tobacco; Alkaloids; Chiral derivatization; Cultivars; Curing processes; Tobacco; Validation.Safety of (S)-3-(Piperidin-2-yl)pyridine.

The alkaloid enantiomers are well-known to have different physiol. and pharmacol. effects, and to play an important role in enantioselectivity metabolism with enzymes catalysis in tobacco plants. Here, we developed an improved method for simultaneous and high-precision determination of the individual enantiomers of nornicotine, anatabine and anabasine in four tobacco matrixes, based on an achiral gas chromatog.-nitrogen phosphorus detector (GC-NPD) with commonly available Rtx-200 column using (1S)-(-)-camphanic chloride derivatization. The method development consists of the optimization of extraction and derivatization, screening of achiral column, anal. of the fragmentation mechanisms and evaluation of matrix effect (ME). Under the optimized exptl. conditions, the current method exhibited excellent detection capability for the alkaloid enantiomers, with coefficients of determination (R2) > 0.9989 and normality test of residuals P > 0.05 in linear regression parameters. The ME can be neglected for the camphanic derivatives The limit of detection (LOD) and limit of quantitation (LOQ) ranged from 0.087 to 0.24μg g – 1 and 0.29 to 0.81μg g – 1, resp. The recoveries and within-laboratory relative standard deviations (RSDR) were 94.3%∼104.2% and 0.51%∼3.89%, resp. The developed method was successfully applied to determine the enantiomeric profiling of cultivars and curing processes. Tobacco cultivars had a significant impact on the nornicotine, anatabine, anabasine concentration and enantiomeric fraction (EF) of (R)-nornicotine, whereas the only significant change induced by the curing processes was an increase in the EF of (R)-anabasine.

When you point to this article, it is believed that you are also very interested in this compound(494-52-0)Safety of (S)-3-(Piperidin-2-yl)pyridine and due to space limitations, I can only present the most important information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of C10H14N2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Challenges associated with quantification of selected urinary biomarkers of exposure to tobacco products. Author is Habibagahi, Arezoo; Siddique, Shabana; Harris, Shelley A.; Alderman, Nicholas; Aranda-Rodriguez, Rocio; Farhat, Imen; Chevrier, Jonathan; Kubwabo, Cariton.

Tobacco use, of which cigarette smoking is the most common, is a global health concern and is directly linked to over 7 million premature deaths annually. Measurement of the levels of tobacco-related biomarkers in biol. matrixes reflects human exposure to the chems. in tobacco products. Nicotine, nicotine metabolites, anatabine, and anabasine are specific to tobacco and nicotine containing products. However, as nicotine and its metabolites are ubiquitous in the environment, background contamination during sample preparation can occur, making the quantification of target analytes challenging. The main purpose of the present study was to examine quality control measures needed in the determination of urinary nicotine, nicotine metabolites, anatabine, and anabasine. Urine samples (n = 75) and NIST standard reference materials SRM 3671 and SRM 3672 were analyzed. A one-step extraction procedure using cold acetone was used in this study, which involved no addnl. clean up. The blank matrixes investigated included synthetic urine prepared with HPLC-grade water, synthetic urine prepared with Milli-Q water, and bovine urine. By adopting strategies for minimizing the background levels, very low detection limits for all the target analytes ranging from 0.025 ng/mL for 3-hydroxycotinine to 0.634 ng/mL for nicotine, were achieved. Recoveries ranged between 67% and 118% with RSD values below 20%. Intra-day and inter-day precisions were in the range of 1.1-11.7% and 4.8-25.2%, resp. The levels of all target analytes were higher in daily smokers than in non-smokers, with the largest difference observed for 3-hydroxycotinine. No difference was observed in the levels of target analytes between individuals who were former smokers, who never smoked or who were exposed to environmental tobacco smoke (ETS), except for total nicotine equivalent (TNE), which was significantly higher in non-smokers exposed to environmental tobacco smoke compared with study participants who never smoked. The results obtained from SRM 3671 and SRM 3672 could inform a potential certification of addnl. biomarkers of exposure to tobacco products in those standard reference materials.

When you point to this article, it is believed that you are also very interested in this compound(494-52-0)Synthetic Route of C10H14N2 and due to space limitations, I can only present the most important information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Category: catalyst-ligand. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Synthesis, Structure, Photophysical Properties, and Redox Behavior of Cyclometalated Complexes of Iridium(III) with Functionalized 2,2′-Bipyridines. Author is Neve, Francesco; Crispini, Alessandra; Campagna, Sebastiano; Serroni, Scolastica.

The new functionalized polypyridine ligands 4′-(4-chlorophenyl)-6′-phenyl-2,2′-bipyridine (clpbpy), 4′-(4-tolyl)-6′-phenyl-2,2′-bipyridine (tpbpy), and 4′-(4-carboxyphenyl)-6′-phenyl-2,2′-bipyridine (cpbpy), together with the known 4′-(4-hydroxyphenyl)-6′-phenyl-2,2′-bipyridine (hpbpy) and 4′-(4-tolyl)-2,2′:6′,2”-terpyridine (ttpy) have been used to prepare a new series of Ir(III) cyclometalated compounds [Ir(ppy)2(HL-X)][PF6] (ppy is the monoanion of 2-phenylpyridine; HL-X = hpbpy (1), clpbpy (2), tpbpy (3), cpbpy (4), and ttpy (5)). All the new species have been characterized by IR and 1H NMR, and the crystal structure of 4 is also presented and discussed. All the metal complexes exhibit oxidation mainly centered on an orbital derived from an Ir-(C-) σ-bond and ligand-centered reduction processes; all of them are luminescent from 3MLCT levels both at 77 K in a rigid matrix and at 298 K in fluid solution The redox and absorption properties are more or less insensitive to the remote substituents on the rotationally free 4′-Ph ring, whereas fine-tuning of the luminescence properties is observed on changing substituents. The results show that the “”energy gap law”” for radiationless decay in the weak coupling limit is obeyed by this series of complexes, when complex 5 is excluded. Interestingly, the slope of the linear relationship between ln knr and the emission energy at room temperature is significantly smoother than that reported for other luminescent polypyridine complexes containing different metals. Because of the high luminescence quantum yield and the presence of functionalities in the polypyridine ligand framework, the complexes reported may be considered as useful building blocks for light- and redox-active, multicomponent supramol. systems.

When you point to this article, it is believed that you are also very interested in this compound(89972-77-0)Category: catalyst-ligand and due to space limitations, I can only present the most important information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5,6-Dihydro-2H-pyran-2-one, is researched, Molecular C5H6O2, CAS is 3393-45-1, about Regioselective, Photocatalytic α-Functionalization of Amines, the main research direction is amine iridium photocatalyst regioselective addition reaction DFT study.Application In Synthesis of 5,6-Dihydro-2H-pyran-2-one.

Photocatalytic α-functionalization of amines provided a mild and atom-economical means to synthesized α-branched amines. Prior examples featured sym. or electronically biased substrates. A controllable α-functionalization of amines in which regioselectivity can be tuned with minor changes to the reaction conditions.

When you point to this article, it is believed that you are also very interested in this compound(3393-45-1)Application In Synthesis of 5,6-Dihydro-2H-pyran-2-one and due to space limitations, I can only present the most important information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI