Day: April 6, 2022

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Allergenic α-methylene-γ-butyrolactones. Stereospecific synthesis of (+)- and (-)-γ-methyl-α-methylene-γ-butyrolactones. A study of the specificity of (+) and (-) enantiomers in inducing allergic contact dermatitis, the main research direction is butyrolactone methyl methylene enantiomer; stereoselectivity allergenic butyrolactone; dermatitis allergenic butyrolactone.SDS of cas: 32780-06-6.

Allergenic enantiomeric butyrolactones I (X = α-H, β-Me; α-Me, β-H) were stereoselectively prepared from the corresponding (R)-(-)- and (S)-(+)-glutamic acids and the specificity of the enantiomers in producing allergenic contact dermatitis in sensitized guinea pigs was determined

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Application of 89972-77-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Proton-Activated Amorphous Room-Temperature Phosphorescence for Humidity Sensing and High-Level Data Encryption. Author is Deng, Yuchen; Li, Peng; Sun, Shujuan; Jiang, Haiyan; Ji, Xu; Li, Huanrong.

Supramol. co-assembling terpyridine-derivatives I and II, with nanoclay (LP) are exploited to acquire efficient amorphous room-temperature phosphorescence (RTP). Exptl. and theor. investigations reveal that this co-assembly not only brings about a configuration transformation from the trans-trans (a) to the cis-trans (a”) form via the protonating process, significantly narrowing the singlet-triplet energy gap, thereby effectively facilitating the single-triplet ISC processes, but also well protects the triplet state and suppresses the nonradiative transitions via restricting mol. rotation and vibration by the hydrogen-bond interactions between them. Addnl., the flexible and transparent films, through co-assembling 1@LP (or 2@LP) with polyvinyl alc. (PVA), also display excellent phosphorescence performance. Owing to their distinctive RTP performances, the RH sensing and high-level data encryption are achieved.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Safety of 4-(p-Tolyl)-2,2:6,2-terpyridine. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about 4′-(4-Methylphenyl)-2,2′:6′,2”-terpyridine. Author is Liu, Han-Guo; Qiu, Yong-Cai; Wu, Jian-Zhong.

There are two crystallog. independent mols. in the asym. unit of the title compound, C22H17N3. In each mol., the three pyridyl groups are nearly coplanar, whereas the tolyl groups are twisted out of the plane of the attached pyridyl rings by ∼28°. The mol. components are assembled through C-H···π and π-π interactions [centroid-centroid distances are 3.677(4) and 3.707(7) Å] into a 1-dimensional chain running in the a-axis direction. Crystallog. data and at. coordinates are given.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Reference of 11-Bromoundecanoic acid. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Antioxidant and Biological Activities of Novel Structured Monoacylglycerol Derivatives with Phenolic Acids. Author is Gandhi, Bhukya; Juliya, Johny; Dileep, Veeragoni; Uma Rajeswari, Batchu; Misra, Sunil; Kaki, Shiva Shanker.

Novel structured monoacylglycerol (MAG)-based phenolic lipids are synthesized from11-bromoundecanoic acid, phenolic acids, and solketal. Selected phenolic acids namely 4-hydroxy benzoic, vanillic, syringic, cinnamic, p-coumaric, sinapic, 4-fluorocinnamic, 4-hydroxyphenyl acetic acid, 3-(4-hydroxyphenyl) propanoic and dihydrocaffeic acids are employed for the synthesis of ten novel MAG-based phenolic lipids. The synthesized phenolic lipids are characterized by FT-IR, NMR, and mass spectra anal. All the compounds are evaluated for antioxidant, antimicrobial, and cytotoxic activities. MAG derivative 8g of sinapic acid exhibits excellent antioxidant activity in both DPPH assay and inhibition of lipid oxidation assay. MAG derivative 8f bearing p-coumaric acid shows good antimicrobial activity against both Gram-pos. and Gram-neg. bacterial strains with a min. inhibitory concentration (MIC) value of 6.25 μM mL-1. All the synthesized compounds are found to exhibit cytotoxicity against B16, DU145, and CHO cell lines, while sinapic and p-coumaric acid derivatives exhibit better activities compared to other derivatives

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

HPLC of Formula: 89972-77-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Surmounting tumor resistance to metallodrugs by co-loading a metal complex and siRNA in nanoparticles. Author is Qiao, Hongzhi; Zhang, Lei; Fang, Dong; Zhu, Zhenzhu; He, Weijiang; Hu, Lihong; Di, Liuqing; Guo, Zijian; Wang, Xiaoyong.

Copper complexes are promising anticancer agents widely studied to overcome tumor resistance to metal-based anticancer drugs. Nevertheless, copper complexes per se encounter drug resistance from time to time. Adenosine-5′-triphosphate (ATP)-responsive nanoparticles containing a copper complex CTND and B-cell lymphoma 2 (Bcl-2) small interfering RNA (siRNA) were constructed to cope with the resistance of cancer cells to the complex. CTND and siRNA can be released from the nanoparticles in cancer cells upon reacting with intracellular ATP. The resistance of B16F10 melanoma cells to CTND was terminated by silencing the cellular Bcl-2 gene via RNA interference, and the therapeutic efficacy was significantly enhanced. The nanoparticles triggered a cellular autophagy that amplified the apoptotic signals, thus revealing a novel mechanism for antagonizing the resistance of copper complexes. In view of the extensive association of Bcl-2 protein with cancer resistance to chemotherapeutics, this strategy may be universally applicable for overcoming the ubiquitous drug resistance to metallodrugs.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Comprehensive genome-wide identification, characterization, and expression profiling of MATE gene family in Nicotiana tabacum, the main research direction is Nicotiana MATE transporter family expression profiling; Co-expression; Gene expression; MATE transporters; Nicotiana tabacum.Computed Properties of C10H14N2.

The transporters belonging to the MATE family are involved in the transportation of diverse ligands, including metal ions and small organic mols., and, therefore, play an important role in plant biol. Our genome-wide anal. led to the identification of 138 MATE genes in N. tabacum, which were grouped into four major phylogenetic clades. The expression of several NtMATE genes was reported to be differential in different tissues, namely young leaf, mature leaf, stem, root, and mature flower. The upstream regions of the NtMATE genes were predicted to contain several cis-acting elements associated with hormonal, developmental, and stress responses. Some of the genes were found to display induced expression following Me jasmonate treatment. The co-expression anal. revealed 126 candidate transcription factor genes that might be involved in the transcriptional regulation of 21 NtMATE genes. Certain MATE genes (NtMATE81, NtMATE82, NtMATE88, and NtMATE89) were predicted to be targeted by micro RNAs (nta-miR167a, nta-miR167b, nta-miR167c, nta-miR167d and nta-miR167e). The computational anal. of MATE transporters provided insights into the key amino acid residues involved in the binding of the alkaloids. Further, the putative function of some of the NtMATE transporters was also revealed. The present study develops a solid foundation for the functional characterization of MATE transporter genes in N. tabacum.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Farran, Rajaa; Le-Quang, Long; Mouesca, Jean-Marie; Maurel, Vincent; Jouvenot, Damien; Loiseau, Frederique; Deronzier, Alain; Chauvin, Jerome researched the compound: 4-(p-Tolyl)-2,2:6,2-terpyridine( cas:89972-77-0 ).Application of 89972-77-0.They published the article 《[Cr(ttpy)2]3+ as a multi-electron reservoir for photoinduced charge accumulation》 about this compound( cas:89972-77-0 ) in Dalton Transactions. Keywords: chromium ruthenium polypyridyl photoinduced electron transfer. We’ll tell you more about this compound (cas:89972-77-0).

[Cr(ttpy)2]3+ (ttpy = 4′-(4-methylphenyl)-2,2′:6,2′′-terpyridine) exhibits rich electrochem. and photophys. properties. Cyclic voltammetry performed in CH3CN shows in the cathodic part the presence of three one-electron reversible systems at -0.47, -0.85 and -1.35 V vs. Ag/AgNO3 10-2 M. These systems are attributed to the reduction of the terpyridine ligands with a partial delocalization of the charge on the tolyl for the last reduction event. The three different reduced species were generated by exhaustive electrolysis and characterized by EPR and UV-visible spectroscopy; DFT calculations were performed to locate the spin d. of the electrons added during the reduction Visible light irradiation of [Cr(ttpy)2]3+ induces the population of a luminescent metal-centered excited state with a lifetime of 270 ns in deoxygenated CH3CN. This excited state can be quenched by an electron transfer process with triphenylphosphine (PPh3) or triethanolamine (TEOA). Using TEOA as a sacrificial electron donor, the doubly reduced species (i.e.[Cr(ttpy)2] +) can be generated under continuous irradiation In the presence of [Ru(bpy)3]2+ as an addnl. photosensitizer, the photoreduction of [Cr(ttpy)2]3+ towards [Cr(ttpy)2]+ is accelerated. The trinuclear [{RuII(bpy)2(bpy-O-tpy)}2CrIII]7+ complex ([Ru2Cr]7+) in which a CrIII-bis-terpyridine center is covalently linked to two RuII-tris-bipyridine moieties by oxo bridges has been synthesized. Its electrochem., photophys. and photochem. properties were investigated in deoxygenated CH3CN. Cyclic voltammetry indicates only a poor electronic communication between the different subunits, whereas luminescence experiments show a strong quenching of the RuII* excited state by an intramol. process. Continuous irradiation of [Ru2Cr]7+ under visible conditions in the presence of TEOA leads to [Ru2Cr]4+ where three electrons are stored on the [Cr(ttpy)] subunit.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

SDS of cas: 89972-77-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Synthesis, crystal structure and thermal properties of Cd(II) and Hg(II) terpyridine based compounds. Author is Saghatforoush, Lotfali; Pourmohsen, Mehrdad; Asgari, Parvin.

Cd(II) and Hg(II) compounds of 4′-(4-methylphenyl)-2,2′:6′,2”-terpyridine (Mephtpy), [Cd(Mephtpy)I2] and [Hg(Mephtpy)I2], were synthesized and characterized by CHN elemental anal., FTIR, 1H and 13C NMR, thermal anal. and analyzed structurally by x-ray single-crystal diffraction. X-ray anal. showed that the coordination number in the complexes were the same with an N3I2 coordination sphere. Both metal ions adopt a distorted square-pyramidal geometry. The thermogravimetric analyses showed that the complexes were stable up to 365 and 340°, resp.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 494-52-0, is researched, SMILESS is C1(C=NC=CC=1)[C@@H]1CCCCN1, Molecular C10H14N2Journal, Russian Journal of General Chemistry called Synthesis, Structure, and Biological Activity of Cinnamoyl-Containing Cytisine and Anabasine Alkaloids Derivatives, Author is Nurkenov, O. A.; Nurmaganbetov, Zh. S.; Seilkhanov, T. M.; Fazylov, S. D.; Satpayeva, Zh. B.; Turdybekov, K. M.; Talipov, S. A.; Seydakhmetova, R. B., the main research direction is cytisine cinnamoyl derivative preparation antibacterial antifungal cytotoxic activity; anabasine cinnamoyl derivative preparation antibacterial antifungal activity cytotoxic.Application In Synthesis of (S)-3-(Piperidin-2-yl)pyridine.

The reactions of the cytisine and anabasine alkaloids with cinnamic acid chloride have been studied, and hydrazinolysis of the resulting N-cinnamoylcytisine and N-cinnamoylanabazine has been carried out. The reaction of cinnamoyl isothiocyanate with alkaloids has afforded the corresponding thiourea derivatives Antimicrobial and cytotoxic activity of cinnamoyl-containing derivatives of these alkaloids has been evaluated.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Safety of Basic copper carbonate. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Basic copper carbonate, is researched, Molecular CH2Cu2O5, CAS is 12069-69-1, about A catalytic approach of blending CO2-activating MOF struts for cycloaddition reaction in a helically interlaced Cu(II) amino acid imidazolate framework: DFT-corroborated investigation. Author is Kathalikkattil, Amal Cherian; Gu, Yunjang; Kurisingal, Jintu F.; Lee, Hankyul; Kim, Hyungjun; Choe, Youngson; Park, Dae-Won.

In CO2 transformation catalysis, the synthesis of cyclic carbonates using two classes of MOF catalysts viz., zeolitic imidazolate frameworks (ZIF) and MOFs with carboxylate-capped SBUs have gained large attention. Herein the authors propose the strategy of employing a unified multifunctional framework formed in the metal-centered assembly of imidazole and amino-carboxylates for CO2 transformation, such as propylene carbonate (PC) by the cycloaddition of CO2 with propylene oxide. The framework {[Cu(L-asp)(1,4-bix)0.5]·3H2O}n (CuAspBix) comprises of the amino acid building units, L-aspartic acid (L-Asp) and the flexible ligand, 1,4-bis(imidazole-1-ylmethyl)benzene [1,4-Bix]. The 1,4-Bix ligand with imidazole terminals renders elongated M-M distances and flexibility in comparison with pristine ZIF materials. The cumbersome synthesis procedure yielding poor phase purity of the bulk catalyst in solvothermal conditions were improved by a microwave-assisted synthesis, preserving the structural and physicochem. properties. Minimal energy input or room temperatures for the catalysis occurred via the synergistic participation of CuAspBix and quaternary ammonium bromide salt, demonstrated by d.-functional theory computational studies to propose mechanistic pathway of the reaction. Reaction conditions were optimized by altering the parameters. The heterogeneous catalyst was reused four times without a significant change in activity.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI