Day: April 12, 2022

Synthetic Route of C11H21BrO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Facile synthesis of gold nanoparticles capped with an ammonium-based chiral ionic liquid crystal. Author is Mangaiyarkarasi, R.; Sivaranjini, B.; Umadevi, S..

Herein, we describe a facile synthesis of stable chiral ionic liquid crystal (ILC)-capped gold nanoparticles. A new ILC containing a chiral cholesterol moiety having a terminal triethylammonium group was synthesized which exhibited an enantiotropic lamellar mesophase. Stable, monodisperse citrate-stabilized gold nanoparticles having a size of ∼60 nm were prepared and the citrate ligands on the gold nanoparticles were replaced with chiral ILC through a two-phase ligand exchange process. The resulting chiral ILC-stabilized particles were characterised using UV-visible (UV-Vis) and transmission electron microscopy (TEM) studies. Different from the citrate-stabilized nanoparticles, the ligand exchanged gold nanoparticles were dispersible in organic solvent and resulting dispersion was stable for more than observed period of 3 mo. Furthermore, the chiral ILC-decorated gold nanoparticles were found to be well dispersible in a nematic host without any aggregation and induced a vertical alignment of the nematic director.

In some applications, this compound(2834-05-1)Synthetic Route of C11H21BrO2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-(Piperazin-1-yl)nicotinonitrile(SMILESS: N#CC1=CN=C(N2CCNCC2)C=C1,cas:149554-29-0) is researched.Application In Synthesis of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. The article 《[(S)-γ-(4-Aryl-1-piperazinyl)-L-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:149554-29-0).

In the search for an inhibitor of dipeptidyl peptidase IV (DPP-IV) highly potent both in vitro and in vivo, a series of L-prolylthiazolidine-based DPP-IV inhibitors, e.g., I, having 4-arylpiperazine or 4-arylpiperidine at the γ-position of the proline structure was synthesized. Of these compounds, the 4-(5-nitro-2-pyridyl)piperazine analog I showed a sub-nanomolar (IC50 = 0.92 nmol/L) DPP-IV inhibitory activity and a long-lasting in vivo DPP-IV inhibition profile.

In some applications, this compound(149554-29-0)Synthetic Route of C10H12N4 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Diastereoselective synthesis of 2,5-disubstituted tetrahydrofuran derivatives, published in 2000-09-22, which mentions a compound: 32780-06-6, mainly applied to diastereoselective synthesis THF, Application In Synthesis of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.

5-Substituted lactol I was converted to 2,5-disubstituted THF derivatives by a Lewis acid-promoted reaction with allylsilanes. High trans selectivity (12:1) was obtained when hindered allylsilane Me2C:CHCH2SiMe3 was employed. Addnl., 2,5-cis-disubstituted THF derivatives were obtained in good yields and diastereoselectivities after alkyllithium addition to a lactone, followed by Et3SiH/BF3·OEt2 reduction of the corresponding hemiketals.

In some applications, this compound(32780-06-6)Application In Synthesis of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Name: (S)-3-(Piperidin-2-yl)pyridine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Increased leaf nicotine content by targeting transcription factor gene expression in commercial flue-cured tobacco (Nicotiana tabacum L.). Author is Liu, Hai; Kotova, Tatyana I.; Timko, Michael P..

Nicotine, the most abundant pyridine alkaloid in cultivated tobacco (Nicotiana tabacum L.), is a potent inhibitor of insect and animal herbivory and a neurostimulator of human brain function. Nicotine biosynthesis is controlled developmentally and can be induced by abiotic and biotic stressors via a jasmonic acid (JA)-mediated signal transduction mechanism involving members of the APETALA 2/ethylene-responsive factor (AP2/ERF) and basic helix-loop-helix (bHLH) transcription factor (TF) families. AP2/ERF and bHLH TFs work combinatorically to control nicotine biosynthesis and its subsequent accumulation in tobacco leaves. Here, we demonstrate that overexpression of the tobacco NtERF32, NtERF221/ORC1, and NtMYC2a TFs leads to significant increases in nicotine accumulation in T2 transgenic K326 tobacco plants before topping. Up to 9-fold higher nicotine production was achieved in transgenics overexpressing NtERF221/ORC1 under the control of a constitutive GmUBI3 gene promoter compared to wild-type plants. The constitutive 2XCaMV35S promoter and a novel JA-inducible 4XGAG promoter were less effective in driving high-level nicotine formation. Methyljasmonic acid (MeJA) treatment further elevated nicotine production in all transgenic lines. Our results show that targeted manipulation of NtERF221/ORC1 is an effective strategy for elevating leaf nicotine levels in com. tobacco for use in the preparation of reduced risk tobacco products for smoking replacement therapeutics.

In some applications, this compound(494-52-0)Name: (S)-3-(Piperidin-2-yl)pyridine is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Pan, Qijun; Liu, Yongan; Pang, Wan; Wu, Jingjing; Ma, Xiaoyu; Hu, Xiaojun; Guo, Yong; Chen, Qing-Yun; Liu, Chao published an article about the compound: Basic copper carbonate( cas:12069-69-1,SMILESS:O[Cu]OC(O[Cu]O)=O ).Category: catalyst-ligand. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:12069-69-1) through the article.

This paper reports a convenient copper-catalyzed three-component conversion of arylhydrazine hydrochlorides RNHNH2.HCl (R = 4-bromophenyl, naphthalen-2-yl, quinolin-7-yl, etc.) to arenesulfonyl fluorides RS(O)2F in good yields under mild conditions, using 1,4-diazabicyclo [2.2.2]octane bis(sulfur dioxide) (DABSO) as a sulfonyl source and N-fluorobenzenesulfonimide (NFSI) as a fluorine source based on a radical sulfur dioxide insertion and fluorination strategy. Notably, arylhydrazine hydrochloride is used as a safe precursor of aryl radicals.

In some applications, this compound(12069-69-1)Category: catalyst-ligand is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Computed Properties of C11H21BrO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Design, synthesis, and biological evaluation of Bcr-Abl PROTACs to overcome T315I mutation. Author is Jiang, Liang; Wang, Yuting; Li, Qian; Tu, Zhengchao; Zhu, Sihua; Tu, Sanfang; Zhang, Zhang; Ding, Ke; Lu, Xiaoyun.

Bcr-Abl threonine 315 to isoleucine 315 (T315I) gatekeeper mutation induced drug resistance remains an unmet clin. challenge for the treatment of chronic myeloid leukemia (CML). Chem. degradation of Bcr-AblT315I protein has become a potential strategy to overcome drug resistance. Herein, we first described the design, synthesis, and evaluation of a new class of selective Bcr-AblT315I proteolysis-targeting chimeric (PROTAC) degraders based on GZD824 (reported as Bcr-AblT315I inhibitor by our group). One of the degrader 7o with 6-member carbon chain linkage with pomalidomide exhibits the most potent degradation efficacy with DR of 69.89% and 94.23% at 100 and 300 nmol/L, resp., and has an IC50 value of 26.8 ± 9.7 nmol/L against Ba/F3T315I cells. Further, 7o also displays substantial tumor regression against Ba/F3-Bcr-AblT315I xenograft model in vivo.

In some applications, this compound(2834-05-1)Computed Properties of C11H21BrO2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 32780-06-6, is researched, SMILESS is O=C1O[C@H](CO)CC1, Molecular C5H8O3Journal, Green Chemistry called Chemo-enzymatic synthesis of key intermediates (S)-γ-hydroxymethyl-α,β-butenolide and (S)-γ-hydroxymethyl-γ-butyrolactone via lipase-mediated Baeyer-Villiger oxidation of levoglucosenone, Author is Flourat, A. L.; Peru, A. A. M.; Teixeira, A. R. S.; Brunissen, F.; Allais, F., the main research direction is lipase Baeyer Villiger oxidation levoglucosenone.Reference of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.

Levoglucosenone (LGO), a valuable chiral platform chem. that can be efficiently produced from catalytic fast pyrolysis of cellulose, has been efficiently converted into optically pure (S)-γ-hydroxymethyl-α,β-butenolide (HBO) using a two-step sequence involving a lipase-mediated Baeyer-Villiger oxidation and an acid hydrolysis. In the same fashion, (S)-γ-hydroxymethyl-γ-butyrolactone (2H-HBO) was successfully obtained through a three-step sequence (Baeyer-Villiger, palladium-catalyzed hydrogenation and acid hydrolysis). The use of solid buffers in the lipase-mediated Baeyer-Villiger oxidation has proved beneficial in two ways: not only the reaction time and the enzymic load were both reduced four-fold (from 8 to 2 h and 464 to 113 U mmol-1) to reach conversions ≥83%, but solid buffers also prevented lipase from denaturation, thus preserving its enzymic activity and allowing its use for further oxidation cycles.

In some applications, this compound(32780-06-6)Reference of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Effect of substituent of terpyridines on the DNA-interaction of polypyridyl ruthenium(II) complexes.COA of Formula: C22H17N3.

An octahedral complexes of ruthenium with 2,9-dimethyl-1,10-phenanthroline (dmphen) and substituted terpyridine were synthesized. The RuII complexes were characterized by elemental analyses, thermogravimetric analyses, magnetic moment measurements, FTIR, electronic, 1H NMR and FAB mass spectra. The binding strength and mode of interaction of the complexes with Herring Sperm DNA was studied using absorption titration and viscosity measurement studies. Results suggest that the substituent on terpyridine ligand affects the binding mode and binding ability of the complexes. Effect of time and ionic strength on DNA cleavage ability of complex also was studied by gel electrophoresis. Results suggest that >200 mM concentration of NaCl decreases the cleavage ability of complex.

In some applications, this compound(89972-77-0)COA of Formula: C22H17N3 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 11-Bromoundecanoic acid(SMILESS: O=C(O)CCCCCCCCCCBr,cas:2834-05-1) is researched.SDS of cas: 616-14-8. The article 《Selectivity control in thiol-yne click reactions via visible light induced associative electron upconversion》 in relation to this compound, is published in Chemical Science. Let’s take a look at the latest research on this compound (cas:2834-05-1).

An associative electron upconversion was proposed as a key step determiningthe selectivity of thiol-yne coupling. The developed synthetic approach provided an efficient tool to access a comprehensive range of products-four types of vinyl sulfides were prepared in high yields and selectivity. Practically important transition-metal-free regioselective thiol-yne additionand formation of the demanding Markovnikov-type product by a radical photoredox process. The photochem. process was directly monitored by mass-spectrometry in a specially designed ESI-MS device with green laser excitation in the spray chamber. The proposed reaction mechanism was supported by experiments and DFT calculations

In some applications, this compound(2834-05-1)Application In Synthesis of 11-Bromoundecanoic acid is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Lawler, Tameka S.; Stanfill, Stephen B.; Tran, Hang T.; Lee, Grace E.; Chen, Patrick X.; Kimbrell, J. Brett; Lisko, Joseph G.; Fernandez, Carolina; Caudill, Samuel P.; Rey de Castro, B.; Watson, Clifford H. published the article 《Chemical analysis of snus products from the United States and northern Europe》. Keywords: snus moisture nicotine TSNA United States Europe.They researched the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0 ).Safety of (S)-3-(Piperidin-2-yl)pyridine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:494-52-0) here.

Snus is an oral tobacco product that originated in Sweden. Snus products are available as fine-cut loose tobacco or in pre-portioned porous “”pouches.”” Some snus products undergo tobacco pasteurization during manufacturing, a process that removes or reduces nitrite-forming microbes, resulting in less tobacco-specific nitrosamine content in the product. Some tobacco companies and researchers have suggested that snus is potentially less harmful than traditional tobacco and thus a potential smoking cessation aid or an alternative to continued cigarette consumption. Although snus is available in various countries, limited information exists on snus variants from different manufacturers. Moisture, pH, nicotine, and tobacco-specific N’-nitrosamines (TSNAs) were quantified in 64 snus products made by 10 manufacturers in the United States and Northern Europe (NE). Reported means, standard Errors, and differences are least-square (LS) estimates from bootstrapped mixed effects models, which accounted for correlation among repeated measurements. Minor alkaloids and select flavors were also measured. Among all product types, moisture (27.4%-59.5%), pH (pH 5.87-9.10), total nicotine (6.81-20.6 mg/g, wet), unprotonated nicotine (0.083-15.7 mg/g), and total TSNAs (390-4,910 ng/g) varied widely. The LS-mean unprotonated nicotine concentration of NE portion (7.72 mg/g, SE = 0.963) and NE loose (5.06 mg/g, SE = 1.26) snus were each significantly higher than US portion snus (1.00 mg/g, SE = 1.56). Concentrations of minor alkaloids varied most among products with the highest total nicotine levels. The LS-mean NNN+NNK were higher in snus sold in the US (1360 ng/g, SE = 207) than in NE (836 ng/g, SE = 132) countries. The most abundant flavor compounds detected were pulegone, eucalyptol, and menthol. Phys. and chem. characteristics of US and NE products labeled as snus can vary considerably and should not be considered “”equivalent””. Our findings could inform public health and policy decisions pertaining to snus exposure and potential adverse health effects associated with snus.

In some applications, this compound(494-52-0)Safety of (S)-3-(Piperidin-2-yl)pyridine is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI