Day: April 18, 2022

Related Products of 494-52-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Simultaneous determination of six alkaloids in tobacco and tobacco products by direct analysis of real-time triple quadrupole mass spectrometry with a modified pretreatment method. Author is Li, Chao; Li, E’xian; Ma, Ming; Liu, Xiuming; You, Junheng; Wu, Yiqin; Jiang, Wei; Liu, Zhihua; Qin, Yunhua.

In order to determine six alkaloids (mass fraction) of nicotine, nornicotine, myosmine, anatabine, anabasine, and nicotyrine in tobacco and tobacco products quickly, accurately, and simultaneously, a novel method based on direct anal. of real-time model in situ ionization technique combined tandem mass spectrometry with a modified sample pretreatment was established, in which exptl. parameters such as the type and amount of extraction solvent and injection rate were optimized, resp. The samples of five com. cigarettes and five kinds of tobacco leaves were analyzed by the established method, and the determined values were compared with those obtained using a gas chromatog. with mass spectrometry method: (1) Under optimized conditions (30 mL ultrapure water as extraction solvent and with extraction rate of 0.6 mm/s), anal. could be completed within 10 min. (2) The linear range of the method was 0.002-2000μg/g with R2=0.9957, the recovery ranged from 86.8 to 105.6%, and the limit of detection and the limit of quantification were 0.004-0.835μg/g and 0.013-2.787μg/g, resp. (3) The relative standard deviation between direct anal. of real-time method and the gas chromatog. with mass spectrometry method was 0.34-8.83%. The established method is rapid, reliable, and suitable for the ultrafast determination of six alkaloids in tobacco and tobacco products.

The article 《Simultaneous determination of six alkaloids in tobacco and tobacco products by direct analysis of real-time triple quadrupole mass spectrometry with a modified pretreatment method》 also mentions many details about this compound(494-52-0)Related Products of 494-52-0, you can pay attention to it, because details determine success or failure

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

HPLC of Formula: 89972-77-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Design and Characterization of an Electrically Powered Single Molecule on Gold. Author is Pawlak, Remy; Meier, Tobias; Renaud, Nicolas; Kisiel, Marcin; Hinaut, Antoine; Glatzel, Thilo; Sordes, Delphine; Durand, Corentin; Soe, We-Hyo; Baratoff, Alexis; Joachim, Christian; Housecroft, Catherine E.; Constable, Edwin C.; Meyer, Ernst.

The 4′-(4-tolyl)-2,2′:6′,2”-terpyridine adsorbed on the Au(111) herringbone structure has been studied by combining scanning tunneling microscopy and at. force microscopy. Mols. are controllably translated by electrons excitations over the reconstruction, except at elbows acting as pinning centers. Exptl. data supported by theor. calculations show the formation of coordination bonds between the mol. and Au atoms of the surface. Using force spectroscopy, we quantify local variation of the surface potential and the lateral force required to move the mol. The authors found an elevation of the diffusion barrier at elbows of the reconstruction of ∼100 meV compared to the rest of the surface.

The article 《Design and Characterization of an Electrically Powered Single Molecule on Gold》 also mentions many details about this compound(89972-77-0)HPLC of Formula: 89972-77-0, you can pay attention to it, because details determine success or failure

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2834-05-1, is researched, Molecular C11H21BrO2, about Gold Nanoparticles Thin Films with Thermo- and Photoresponsive Plasmonic Properties Realized with Liquid-Crystalline Ligands, the main research direction is gold nanoparticle film thermoresponsive photoresponsive plasmon liquid crystalline ligand; liquid crystals; nanoparticles; photoresponsive materials; self-assembly; surface plasmon resonance.Product Details of 2834-05-1.

Robust synthesis of large-scale self-assembled nanostructures with long-range organization and a prominent response to external stimuli is critical to their application in functional plasmonics. Here, the 1st example of a material made of liquid crystalline nanoparticles which exhibits UV-light responsive surface plasmon resonance in a condensed state is presented. To obtain the material, metal cores are grafted with 2 types of organic ligands. A promesogenic derivative softens the system and induces rich liquid crystal phase polymorphism. Second, an azobenzene derivative endows nanoparticles with photoresponsive properties. Nanoparticles covered with a mixture of these ligands assemble into long-range ordered structures which exhibit a novel dual-responsivity. The structure and plasmonic properties of the assemblies can be controlled by a change in temperature as well as by UV-light irradiation These results present an efficient way to obtain bulk quantities of self-assembled nanostructured materials with stability that is unattainable by alternative methods such as matrix-assisted or DNA-mediated organization.

The article 《Gold Nanoparticles Thin Films with Thermo- and Photoresponsive Plasmonic Properties Realized with Liquid-Crystalline Ligands》 also mentions many details about this compound(2834-05-1)Product Details of 2834-05-1, you can pay attention to it, because details determine success or failure

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3393-45-1, is researched, Molecular C5H6O2, about Unexpected binuclear O-O cleavage and radical C-H activation mechanism for Cu-catalyzed desaturation of lactone, the main research direction is lactone copper desaturation bond cleavage radical activation mechanism.Application of 3393-45-1.

A d. functional theory study of Cu-catalyzed desaturation of δ-valerolactone into α,β-unsaturated counterparts reveals an unexpected binuclear di-tert-Bu peroxide (DTBP) homolysis with spin-crossover and a radical α-C-H bond activation mechanism. The rate-determining step in the reaction catalyzed by CuIOAc-CyPPh2 is the homolysis of the O-O bond in DTBP with a total free energy barrier of 26.9 kcal mol-1, which is consistent with the observed first-order dependences on LCuI-PR3 and DTBP, as well as the pseudo-zeroth-order with lactone. The α- and β-H transfer steps have 0.3 and 14.8 kcal mol-1 lower barriers than the O-O cleavage process, resp. Such different barriers well explain the observed weak kinetic isotopic effect (KIE) at α-H and no KIE at β-H. In addition, we found that the replacement of CyPPh2 for pyridine in the Cu complexes leads to much higher barriers for O-O bond cleavage and C-H bond activations with the formation of more stable binuclear Cu complexes.

The article 《Unexpected binuclear O-O cleavage and radical C-H activation mechanism for Cu-catalyzed desaturation of lactone》 also mentions many details about this compound(3393-45-1)Application of 3393-45-1, you can pay attention to it or contacet with the author([email protected]; [email protected]) to get more information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 11-Bromoundecanoic acid(SMILESS: O=C(O)CCCCCCCCCCBr,cas:2834-05-1) is researched.Recommanded Product: 2-(Furan-2-yl)-2-oxoacetaldehyde. The article 《Photoreversible Smart Polymers Based on 2π + 2π Cycloaddition Reactions: Nanofilms to Self-Healing Films》 in relation to this compound, is published in Macromolecules (Washington, DC, United States). Let’s take a look at the latest research on this compound (cas:2834-05-1).

A simple nanostructured, photoresponsive film made from a coumarin-modified tetrafunctional monomer, which is both photodegradable and photoreproducible, was prepared using a simple spin-coating process and UV irradiation The film produced from this system self-healed scratches using only UV light, with no need for catalyst, heat, or other stimuli. The photoreversible mechanism was investigated, and a range of techniques were used to characterize the resultant photoproducts after the polymerization and depolymerization processes. IR spectroscopy was used to determine the optimal energy for a complete reversible polymerization reaction, and the mechanism was further confirmed by UV-vis spectroscopy which was able to monitor key structural changes. GPC anal. was used to track the mol. weight changes after the depolymerization reaction, which showed that the polymer was able to be converted back to monomers and oligomers, demonstrating the highly reversible polymerization and suggesting a potential for recyclability. Microhardness measurements of neat and irradiated samples were also used to determine the changes in mech. properties before and after cleavage of the polymer network, and following the recovery of its structure, the latter showed a recovery of up to 91% of its mech. properties.

The article 《Photoreversible Smart Polymers Based on 2π + 2π Cycloaddition Reactions: Nanofilms to Self-Healing Films》 also mentions many details about this compound(2834-05-1)Product Details of 2834-05-1, you can pay attention to it, because details determine success or failure

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Nett, Ryan S.; Dho, Yaereen; Low, Yun-Yee; Sattely, Elizabeth S. published an article about the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0,SMILESS:C1(C=NC=CC=1)[C@@H]1CCCCN1 ).Category: catalyst-ligand. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:494-52-0) through the article.

Plants synthesize many diverse small mols. that affect function of the mammalian central nervous system, making them crucial sources of therapeutics for neurol. disorders. A notable portion of neuroactive phytochems. are lysine-derived alkaloids, but the mechanisms by which plants produce these compounds have remained largely unexplored. To better understand how plants synthesize these metabolites, we focused on biosynthesis of the Lycopodium alkaloids that are produced by club mosses, a clade of plants used traditionally as herbal medicines. Hundreds of Lycopodium alkaloids have been described, including huperzine A (HupA), an acetylcholine esterase inhibitor that has generated interest as a treatment for the symptoms of Alzheimers disease. Through combined metabolomic profiling and transcriptomics, we have identified a developmentally controlled set of biosynthetic genes, or potential regulon, for the Lycopodium alkaloids. The discovery of this putative regulon facilitated the biosynthetic reconstitution and functional characterization of six enzymes that act in the initiation and conclusion of HupA biosynthesis. This includes a type III polyketide synthase that catalyzes a crucial imine-polyketide condensation, as well as three Fe(II)/2-oxoglutarate-dependent dioxygenase (2OGD) enzymes that catalyze transformations (pyridone ring-forming desaturation, piperidine ring cleavage, and redox-neutral isomerization) within downstream HupA biosynthesis. Our results expand the diversity of known chem. transformations catalyzed by 2OGDs and provide mechanistic insight into the function of noncanonical type III PKS enzymes that generate plant alkaloid scaffolds. These data offer insight into the chem. logic of Lys-derived alkaloid biosynthesis and demonstrate the tightly coordinated coexpression of secondary metabolic genes for the biosynthesis of medicinal alkaloids.

The article 《A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis》 also mentions many details about this compound(494-52-0)Category: catalyst-ligand, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Name: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Synthesis of Reblastatin, Autolytimycin, and Non-Benzoquinone Analogues: Potent Inhibitors of Heat Shock Protein 90. Author is Wrona, Iwona E.; Gozman, Alexander; Taldone, Tony; Chiosis, Gabriela; Panek, James S..

The heat shock protein 90-inhibiting natural ansamycin natural products reblastatin I (R = MeO; R1 = H; X = CH2CH2) and autolytimycin I (R = R1 = H; X = CH2CH2), and four of their analogs I [R = MeO; R1 = H, MeOCH2, H2NHCO; X = (Z)-CH:CH, CH2CH2] lacking a quinone moiety are prepared using the chemoselective, regioselective, and stereoselective zirconium-mediated coupling reaction of a methyl-substituted alkyne with an aldehyde to give an (E)-trisubstituted allylic alc. and the copper-catalyzed macroamidation reaction of terminal amides containing a bromoarene as the key steps. The competitive binding of Hsp90α to I [R = H, MeO; R1 = H, MeOCH2, H2NHCO; X = (Z)-CH:CH, CH2CH2], an uncyclized derivative of reblastatin, a reblastatin analog lacking the carbamate ester, geldanamycin, and 17-(allylamino)-17-demethoxygeldanamycin is determined; the inhibition of human myeloid leukemia cells by I [R = MeO; R1 = H, MeOCH2, H2NHCO; X = (Z)-CH:CH, CH2CH2] and by 17-(allylamino)-17-demethoxygeldanamycin (II), a geldanamycin derivative currently under evaluation for treatment of cancer, are determined Reblastatin and autolytimycin I (R = MeO, H; R1 = H; X = CH2CH2) bind heat shock protein 90 with better affinities (26 nM and 36 nM, resp.) than II (110 nM); I (R = MeO, H; R1 = H; X = CH2CH2) are more effective at inhibiting one of the human myeloid leukemia cell lines (Kasumi-1) than II but are less effective than II at inhibiting the other (MOLM-13).

The article 《Synthesis of Reblastatin, Autolytimycin, and Non-Benzoquinone Analogues: Potent Inhibitors of Heat Shock Protein 90》 also mentions many details about this compound(32780-06-6)Name: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, you can pay attention to it, because details determine success or failure

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of C22H17N3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Synthesis, Structural Characterization, Photophysical, Electrochemical, and Anion-Sensing Studies of Luminescent Homo- and Heteroleptic Ruthenium(II) and Osmium(II) Complexes Based on Terpyridyl-imidazole Ligand. Author is Bhaumik, Chanchal; Saha, Debasish; Das, Shyamal; Baitalik, Sujoy.

A series of hetero- and homoleptic tridentate ruthenium(II) and osmium(II) complexes of compositions [(tpy-PhCH3)Ru(tpy-HImzphen)](ClO4)2 (1), [(H2pbbzim)Ru(tpy-HImzphen)](ClO4)2 (2), and [M(tpy-HImzphen)2](ClO4)2 [M = RuII (3) and OsII (4)], where tpy-PhCH3 = 4′-(4-methylphenyl)-2,2′:6′,2”-terpyridine, H2pbbzim = 2,6-bis(benzimidazole-2-yl)pyridine and tpy-HImzphen = 2-(4-[2,2′:6′,2”]terpyridine-4′-yl-phenyl)-1H-phenanthro[9,10-d]imidazole, were synthesized and characterized by using standard anal. and spectroscopic techniques. X-ray crystal structures of three complexes 2, 3, and 4 were determined The absorption spectra, redox behavior, and luminescence properties of the complexes were thoroughly studied. All of the complexes display moderately strong luminescence at room temperature with lifetimes at 10-55 ns. The effect of solvents on the absorption and emission spectral behavior of the complexes also was studied. The anion sensing properties of all the complexes were studied in solution using absorption, emission, and 1H NMR spectral studies and by cyclic voltammetric (CV) measurements. The complexes 1, 3, and 4 act as sensors for F- only, whereas 2 acts as sensor for F-, AcO-, and to some extent for H2PO4-. It is evident that in the presence of excess of anions deprotonation of the imidazole N-H fragment(s) occurs in all cases, an event which is signaled by the development of vivid colors visible with the naked eye. The receptor-anion binding/equilibrium constants were evaluated.

The article 《Synthesis, Structural Characterization, Photophysical, Electrochemical, and Anion-Sensing Studies of Luminescent Homo- and Heteroleptic Ruthenium(II) and Osmium(II) Complexes Based on Terpyridyl-imidazole Ligand》 also mentions many details about this compound(89972-77-0)Synthetic Route of C22H17N3, you can pay attention to it, because details determine success or failure

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Radcliffe, James E.; Fasano, Valerio; Adams, Ralph W.; You, Peiran; Ingleson, Michael J. published an article about the compound: 5,6-Dihydro-2H-pyran-2-one( cas:3393-45-1,SMILESS:O=C1C=CCCO1 ).Category: catalyst-ligand. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3393-45-1) through the article.

Useful α-boryl esters can be synthesized in one step from α,β-unsaturated esters using just a simple to access NHC-BH3 (NHC = N-heterocyclic carbene) and catalytic I2. The scope of this reductive α-borylation methodol. is excellent and includes a range of alkyl, aryl substituted and cyclic and acyclic α,β-unsaturated esters. Mechanistic studies involving reductive borylation of a cyclic α,β-unsaturated ester with NHC-BD3/I2 indicated that concerted hydroboration of the alkene moiety in the α,β-unsaturated ester proceeds instead of a stepwise process involving initial 1,4-hydroboration; this is in contrast to the recently reported reductive α-silylation. The BH2(NHC) unit can be transformed into electrophilic BX2(NHC) moieties (X = halide) and the ester moiety can be reduced to the alc. with the borane unit remaining intact to form β-boryl alcs. The use of a chiral auxiliary, 8-phenylmenthyl ester, also enables effective stereo-control of the newly formed C-B bond. Combined two step ester reduction/borane oxidation forms diols, including excellent e.e. (97%) for the formation of S-3-phenylpropane-1,2-diol. This work represents a simple transition metal free route to form bench stable α-boryl esters from inexpensive starting materials.

The article 《Reductive α-borylation of α,β-unsaturated esters using NHC-BH3 activated by I2 as a metal-free route to α-boryl esters》 also mentions many details about this compound(3393-45-1)Category: catalyst-ligand, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]; [email protected]) to get more information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Effects of plant alkaloids on mitochondrial bioenergetic parameters, published in 2021-08-31, which mentions a compound: 494-52-0, mainly applied to plant alkaloid mitochondrial bioenergetic parameter nicotinic acetylcholine receptor; Alkaloids; Mitochondria; Mitochondria permeability transition pore; Nicotinic acetylcholine receptors, Name: (S)-3-(Piperidin-2-yl)pyridine.

Mitochondria are among the first responders to various stress factors that challenge cell and tissue homeostasis. Various plant alkaloids have been investigated for their capacity to modulate mitochondrial activities. In this study, we used isolated mitochondria from mouse brain and liver tissues to assess nicotine, anatabine and anabasine, three alkaloids found in tobacco plant, for potential modulatory activity on mitochondrial bioenergetics parameters. All alkaloids decreased basal oxygen consumption of mouse brain mitochondria in a dose-dependent manner without any effect on the ADP-stimulated respiration. None of the alkaloids, at 1 nM or 1.25μM concentrations, influenced the maximal rate of swelling of brain mitochondria. In contrast to brain mitochondria, 1.25μM anatabine, anabasine and nicotine increased maximal rate of swelling of liver mitochondria suggesting a toxic effect. Only at 1 mM concentration, anatabine slowed down the maximal rate of Ca2+-induced swelling and increased the time needed to reach the maximal rate of swelling. The observed mitochondrial bioenergetic effects are probably mediated through a pathway independent of nicotinic acetylcholine receptors, as quant. proteomic anal. could not confirm their expression in pure mitochondrial fractions isolated from mouse brain tissue.

The article 《Effects of plant alkaloids on mitochondrial bioenergetic parameters》 also mentions many details about this compound(494-52-0)Name: (S)-3-(Piperidin-2-yl)pyridine, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]) to get more information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI