A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Recommanded Product: 79815-20-6, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 79815-20-6, Name is H-Idc-OH, molecular formula is C9H9NO2. In a Article, authors is Kerrigan, John E.，once mentioned of 79815-20-6
A series of 3-alkoxy-7-amino-4-chloroisocoumarins with various 3-alkoxy substituents have been prepared and evaluated as inhibitors of human leukocyte elastase (HLE).In addition, a new series of acyl, urea, and carbamate derivatives of 7-amino-4-chloro-3-methoxyisocoumarin (1), 7-amino-4-chloro-3-propoxyisocoumarin (3), and 7-amino-4-chloro-3-(2-bromoethoxy)isocoumarin (6) have been synthesized.Most of the synthesized compounds are very potent inhibitors of HLE with kobs/ values between 104 and 106 M-1s-1.Hydrophobic substituents on the 7-amino position of the isocoumarin ring afford the best selectivity and inhibitory potency for HLE.In the 2-bromoethoxy series, compound 24 with a PhNHCONH 7-substituent had a kobs/ value of 1.2 * 106 M-1s-1, was very selective for HLE, and was the most potent inhibitor of HLE tested.Of the extended chain L-phenylalanyl derivatives, the Bz-L-Phe compound 66 with a kobs/ value of 1.8 * 105 M-1s-1 was the most potent inhibitor of HLE in the 3-methoxyisocoumarin series and was also very selective for HLE.Our results indicate that a high degree of selectivity, along with potency, can be introduced into mechanism-based isocoumarin inhibitors.
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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI