20439-47-8, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.20439-47-8, Name is (1R,2R)-Cyclohexane-1,2-diamine, molecular formula is C6H14N2, introducing its new discovery.
Quantitative structure-activity relations for the relative affinities of camp-derivatives with large substituents in positions 2 and 8 for the four different regulatory sites of a proteinkinase
QSAR’s by the MTD-method for a series of 32 derivatives of cAMP with large substituents in position 8 and for a series of 21 derivatives with large substituents in position 2 are obtained. Thiophosphoric acid derivatives are also included. As structural parameters, the relative nitrogen base lipophilicity, the presence of an equatorial or axial S atom and the presence of aliphatic amino group, protonated at pH = 7 are considered. Satisfactory correlational results, including a cross-validation like procedure, are obtained in most cases. The results emphasize structural features important for binding to four sites (AI, BI, AII and BII) of two different protein phosphokinases (cAKI and cAKII). The synthesis and characterization of eight new compounds are also described.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 20439-47-8, help many people in the next few years.20439-47-8
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI