1723-00-8, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1723-00-8, Name is H-D-HoPro-OH, molecular formula is C6H11NO2. In a Article£¬once mentioned of 1723-00-8
Application of design of experiments (DoE) optimization to the one-pot synthesis of 4,6-dihydropteridinones
A design of experiments (DoE) analysis of a tandem SnAr-amidation cyclization reaction between 4-chloropyrimidin-5-amine and (S)-N-methylalanine to form (S)-7,8-dimethyl-7,8-dihydropteridin-6(5H)-one is reported. Five reaction variables were optimized using DoE and conversion was improved from 26% to 74%, with a significant reduction in reaction time while retaining high optical purity. The optimized conditions were applied to the synthesis of a wide variety of analogs and the expanded reaction substrate scope included a variety of amino acids and pyrimidines. Products were obtained in isolated yields up to 95% and enantiomeric excess as high as 98%.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 1723-00-8, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1723-00-8, in my other articles.
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI