Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ HPLC of Formula: C14H12N2O2, Which mentioned a new discovery about 92149-07-0
Copper-Catalyzed Coupling Reactions of Aryl Halides and Phenols by 4,4?-Dimethoxy-2,2?-bipyridine and 4,7-Dimethoxy-1,10-phenanthroline
Several Cu(I) complexes of 2,2?-bipyridines were studied for the catalytic coupling of aryl iodides and phenols and 4,4?-dimethoxy-2,2?-bipyridine was shown to be an effective ligand of CuI in 1:2 (CuI:ligand) ratio for the synthesis of a wide range of diaryl ethers (up to 97% yield) using K3PO4 as base in DMF at 100 C. The catalysis was highly dependent on the reaction temperature and was successfully applied in the coupling with more attractive and challenging substrates, aryl bromides, at 140 C in good-to-excellent yields (78?95%). Moreover, the heteroaromatic effect for the reaction was studied and gave a comparable result with phenyl group (up to 95% yield). Significantly, a structurally related N,N-bidentate ligand, 4,7-dimethoxy-1,10-phenanthroline, exhibited better performance for less-reactive combinations of aryl halides and phenols.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, HPLC of Formula: C14H12N2O2, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 92149-07-0
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI