Brief introduction of (S)-Diphenyl(pyrrolidin-2-yl)methanol

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Synthetic Route of 112068-01-6, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 112068-01-6, in my other articles.

Synthetic Route of 112068-01-6, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 112068-01-6, Name is (S)-Diphenyl(pyrrolidin-2-yl)methanol, molecular formula is C17H19NO. In a Article，once mentioned of 112068-01-6

Highly Enantioselective Epoxidation of alpha,beta-Unsaturated Ketones Catalyzed by Rare-Earth Amides [(Me3Si)2N]3RE(mu-Cl)Li(THF)3 with Phenoxy-Functionalized Chiral Prolinols

A simple and efficient catalytic enantioselective epoxidation of alpha,beta-unsaturated ketones has been successfully developed, which was catalyzed by rare-earth metal amides [(Me3Si)2N]3RE(mu-Cl)Li(THF)3 (RE = Yb (1), La (2), Sm (3), Y (4), Lu (5)) in the presence of phenoxy-functionalized chiral prolinols at room temperature using tert-butylhydroperoxide (TBHP) as the oxidant. The combination of an Yb-based amide 1 and a chiral proligand (S)-2,4-di-tert-butyl-6-((2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methyl)phenol) performed very well, and both the yields and the enantiomeric excess of the chiral epoxides reached up to 99% and 99% ee. (Figure Presented).

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Synthetic Route of 112068-01-6, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 112068-01-6, in my other articles.

Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI