With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.137076-54-1,2-(4,7,10-Tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetic acid,as a common compound, the synthetic route is as follows.
Example 2 (S)-2,2′-bis[bis(3,5-dimethylphenyl)phosphino]-1,1′-binaphthyl Under an argon atmosphere, to a solution (5 ML) of [1,2-bis(diphenylphosphino)-ethane]dichloronickel (42 mg, 0.1 equivalent), (S)-2,2′-bis(trifluoromethanesulfonyloxy)-1,1′-binaphthyl (399 mg, 0.73 MmoL) synthesised in Reference Example 1 and 1,4-diazabicyclo[2,2,2]octane (489 mg, 6.0 equivalents) in DMF was added at room temperature a bis(3,5-dimethylphenyl)phosphine-borane complex (428 mg, 2.3 equivalents) synthesised in Example 1.. The mixture was stirred at room temperature for 30 min. and then at 110C for 96 hrs. DMF was evaporated under reduced pressure and methanol was added to the residue to give the title compound (329 mg, pale-yellow white crystals).. yield 62%.1H-NMR (300 MHz, CDCl3, TMS) delta: 2.06 (s, 12H), 2.13 (s, 12H), 6.70-6.73 (m, 10H), 6.81 (s, 2H), 6.90 (d, 2H, J = 8.46 Hz), 7.01 (dd, 2H, J = 7.14Hz, 7.14Hz), 7.39 (dd, 2H, J = 6.99Hz, 6.99Hz), 7.52 (dd, 2H, J = 8.49Hz, 2.28Hz), 7.84-7.88 (m, 4H).31P-NMR (121 MHz, CDCl3, 85%H3PO4) delta: -14.25 (s). (ref.: 31P-NMR (161 MHz, CDCl3, 85%H3PO4) delta: -14.9.. Journal of Organic Chemistry, vol. 59, p. 3064 (1994)
137076-54-1, The synthetic route of 137076-54-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Takeda Chemical Industries, Ltd.; EP1452537; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI