103946-54-9, 4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE. Peptide Synthesis. The collagen-mimetic peptide H-byp, NH2-(Pro-Hyp-Gly)4-(Pro-Lys(Mtt)-Gly)-(Pro-Hyp-Gly)4-COOH, was synthesized by standard solid phase synthesis on a rink amide Chem Matrixresin. In the manual synthesis, 3 equivalents of Fmoc-amino acids were treated with HBTU (3 equiv.) and diisopropylethylamine(DIEA) (2 equiv) in an NMP solution. For the N-terminal acetylation, the resin was treated with acetic anhydrideand DIEA in DMF for 1 hr. The Mtt protecting group was removed using as described above using 1.8% TFA in DCM.The resin was treated with 2,2?-bipyridine-4,4?-carboxylic acid (3 equiv.), HBTU (3 equiv.), and DIEA (3 equiv.) in NMP.The peptide was cleaved from the resin by treatment for 2 h with TFA/TIPS/H2O (95:2.5:2.5), followed by precipitationwith diethyl ether.
103946-54-9, As the paragraph descriping shows that 103946-54-9 is playing an increasingly important role.
Reference£º
Patent; Purdue Research Foundation; CHMIELEWSKI, Jean, A.; PIRES, Marcos, M.; PRZYBYLA, David, E.; (74 pag.)EP2300033; (2016); B1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI