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Total synthesis of optically pure (+)-Fuligocandin A from L-proline has been achieved in 29% overall yield. The key step, one-pot reductive cyclodehydration of the chiral 2-nitrophenyl-1,3-dicarbonyl compound, proceeds with >98% retention of configuration. This method represents a convenient approach to the synthesis of 2-methylenebenzo[e][1,4]diazepin-5-ones containing one chiral center. A series of benzo[e][1,4]diazepin-5-one derivatives have been successfully synthesized with retention of chirality by the one-pot reaction developed in this work. A possible reductive cyclodehydration mechanism was also proposed.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Reference of 3105-95-1, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 3105-95-1
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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI