With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29841-69-8,(1S,2S)-(-)-1,2-Diphenylethylenediamine,as a common compound, the synthetic route is as follows.
A solution of sulfonyl chloride B (10 mmol) in dichloromethane (25 mL) was slowlyadded to a stirred solution of diamine A (10 mmol), NEt3 (11 mmol) in dichloromethane(25 mL). The resulting mixture was stirred for another 3 hr, washed twice with water (25mL) and dried over Na2SO4. The solvent was removed in vacuo to give a white solid C. Toa solution of D in CH2Cl2 (40 mL) was added NEt3 (11 mmol), isobutyl carbonochloridate(11 mmol) at 0 oC under stirring. After 10 min, C was added. The reaction was allowed towarm to room temperature for another 3 hr. The mixture was washed with 1 M KHSO4solution, saturated NaHCO3 solution, and brine, dried over anhydrous Na2SO4 andconcentrated to get a white solid E. Then, TFA (10 mL) was added to the CH2Cl2 (10 mL)solution of E, and stirred until the reaction finished (1 hr). The pH value of the mixture wasbrought into the range of 10-12 by the addition of 2 N NaOH solution. The aqueousphase was extracted with CH2Cl2 (3 ¡Á 30 mL). The combined organic phase was washedwith brine, dried over anhydrous Na2SO4, and concentrated and purified through flashchromatograph as a white solid F (70% yield).
29841-69-8, The synthetic route of 29841-69-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Tang, Yu; Xu, Jian; Yang, Jian; Lin, Lili; Feng, Xiaoming; Liu, Xiaohua; Chem; vol. 4; 7; (2018); p. 1658 – 1672;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI