Synthetic Route of 1802-30-8, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1802-30-8, name is 2,2′-Bipyridine-5,5′-dicarboxylic acid. In an article，Which mentioned a new discovery about 1802-30-8
Abstract Collagen is the most abundant protein in animals. A variety of indications are associated with the overproduction of collagen, including fibrotic diseases and cancer metastasis. The stability of collagen relies on the posttranslational modification of proline residues to form (2S,4R)-4-hydroxyproline. This modification is catalyzed by collagen prolyl 4-hydroxylases (CP4Hs), which are Fe(II)- and alpha-ketoglutarate (AKG)-dependent dioxygenases located in the lumen of the endoplasmic reticulum. Human CP4Hs are validated targets for treatment of both fibrotic diseases and metastatic breast cancer. Herein, we report on 2,2?-bipyridinedicarboxylates as inhibitors of a human CP4H. Although most 2,2?-bipyridinedicarboxylates are capable of inhibition via iron sequestration, the 4,5?- and 5,5?-dicarboxylates were found to be potent competitive inhibitors of CP4H, and the 5,5?-dicarboxylate was selective in its inhibitory activity. Our findings clarify a strategy for developing CP4H inhibitors of clinical utility.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.1802-30-8. In my other articles, you can also check out more blogs about 1802-30-8
Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI