Chemistry is an experimental science, Recommanded Product: 2,2′-Bipyridine-5,5′-dicarboxylic acid, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1802-30-8, Name is 2,2′-Bipyridine-5,5′-dicarboxylic acid
Four metal complexes [Pd(L1)Cl2·2H 2O] (1), [Pt(L1)Cl2·2H2O] (2), [Pd(L2)Cl2·H2O] (3) and [Pt(L 2)Cl2·H2O] (4) (L1 = 2,2?-bipyridyl-5,5?-dicarboxylic acid, L2 = 2,2?-bipyridyl-4,4?-dicarboxylic acid) have been synthesized under hydrothermal conditions and fully characterized by IR and 1H-NMR spectra, elemental analysis, and X-ray single crystal diffraction analysis. Interactions of these complexes with fish sperm DNA (FS-DNA) were investigated using UV-Vis absorption and fluorescence spectroscopic methods. Further insight was brought by quantum chemistry calculations by means of G03 package and taking B3LYP functional Lanl2dz Gen basis set. Agarose gel electrophoresis run on pBR322 plasmid DNA gave proof that all four complexes exhibit efficient DNA cleavage. Complexes 1-4 manifested cytotoxic specificity and a significant cancer cell inhibitory rate. Independent apoptosis tests under the light microscope, performed on hematoxylin-eosin stained HeLa cells, evidenced morphological changes induced by all the complexes.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 2,2′-Bipyridine-5,5′-dicarboxylic acid, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1802-30-8, in my other articles.
Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI