Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Stereochemical studies. XXX. Stereoselective synthesis of D-ribose from L-glutamic acid.COA of Formula: C5H8O3.
D-Ribose was prepared in 10 steps from L-glutamic acid (I) using the chiral center of I as C-4 of D-ribose. Oxidation of Me 5-O-benzyl-2,3-dideoxy-D-pent-2-enofuranoside with OsO4 or KMnO4 occurred preferentially from the rear side of the C-1 OMe group.
Compound(32780-06-6)COA of Formula: C5H8O3 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one), if you are interested, you can check out my other related articles.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI