Application of 89972-77-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Neuroprotective effect of 4′-(4-methylphenyl)-2,2′:6′,2-terpyridine trihydrochloride, a novel inducer of nerve growth factor. Author is Yamamoto, Kyoko; Yoshikawa, Ryoko; Okuyama, Shigeru; Takahashi, Yuki; Karasawa, Yasuko; Hino, Noriko; Miyoshi, Toshio; Araki, Hiroaki; Hanabusa, Kenji.
We have identified 4′-(4-methylphenyl)-2,2′:6′,2-terpyridine trihydrochloride (SS701), which belongs to a family of a small unique neuroprotective agents. SS701 accelerated the production of nerve growth factor (NGF) in cultured astroglial cells, dose- and time-dependently. In in vivo studies, SS701, when administered 30 min after induced cerebral ischemia, neuroprotective effects on delayed neuronal death in Mongolian gerbils were evident. The neuroprotective effects of SS701 against ischemia-induced delayed neuronal death are attributed to stimulation of the production of NGF.
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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI