With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4568-71-2,3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride,as a common compound, the synthetic route is as follows.
Example 22 3-Ethoxycarbonyl-2-(4-fluoro-3-phenoxy-phenyl)-5-methyl-1-phenylhexane-1,4-dione STR36 142.4 g (0.4 mol) of Example 21 are heated at reflux overnight with 42.4 g (0.4 mol) of benzaldehyde, 10.8 g (0.04 mol) of 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride and 33 ml of triethylamine in 270 ml of ethanol. The solvent is removed in vacuo, and the residue is dissolved in chloroform, washed twice with 1N sulphuric acid, water and saturated bicarbonate solution and dried over sodium sulphate. After concentrating to dryness, 185.2 g of yellowish oil remain. The crude product is sufficiently pure for further processing. Rf =0.17 (petroleum ether/ethyl acetate 10:1).
4568-71-2, The synthetic route of 4568-71-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Bayer Aktiengesellschaft; US4968681; (1990); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI