In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of Long-Chain Alkanoyl Benzenes by an Aluminum(III) Chloride-Catalyzed Destannylative Acylation Reaction, published in 2021-07-02, which mentions a compound: 2834-05-1, Name is 11-Bromoundecanoic acid, Molecular C11H21BrO2, Recommanded Product: 2834-05-1.
This paper describeD the facile synthesis of haloaryl compounds with long-chain alkanoyl substituents by the destannylative acylation of haloaryls bearing tri-n-butyltin (Bu3Sn) substituents. The method allowed the synthesis of many important synthons for novel functional materials in a highly efficient manner. The halo-tri-n-butyltin benzenes were obtained by the lithium-halogen exchange of com. available bis-haloarenes and the subsequent reaction with Bu3SnCl. Under typical Friedel-Crafts conditions, i.e., the presence of an acid chloride and AlCl3, the haloaryls were acylated through destannylation. The reactions proceeded fast (<5 min) at low temperatures and thus were compatible with aromatic halogen substituents. Furthermore, the method was applicable to para-, meta- and ortho-substitution and larger systems, as demonstrated for biphenyls. The generated tin byproducts were efficiently removed by trapping with silica/KF filtration and most long-chain haloaryls were obtained chromatog.-free. Mol. structures of several products were determined by X-ray single-crystal diffraction and the crystal packing was investigated by mapping Hirshfeld surfaces onto individual mols. A feasible reaction mechanism for the destannylative acylation reaction was proposed and supported through d. functional theory (DFT) calculations DFT results in combination with NMR-scale control experiments unambiguously demonstrate the importance of the tin substituent as a leaving group, which enables the acylation. This literature about this compound(2834-05-1)Recommanded Product: 2834-05-1has given us a lot of inspiration, and I hope that the research on this compound(11-Bromoundecanoic acid) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI