The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-(Piperazin-1-yl)nicotinonitrile(SMILESS: N#CC1=CN=C(N2CCNCC2)C=C1,cas:149554-29-0) is researched.Recommanded Product: (S)-3-(Piperidin-2-yl)pyridine. The article 《Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:149554-29-0).
The discovery of a novel series of pyrrolo[1,2-a]pyrazin-1(2H)-one PARP inhibitors is described. Optimization led to compounds that display excellent PARP-1 enzyme potency and inhibit the proliferation of BRCA deficient cells in the low double-digit nanomolar range showing excellent selectivity over BRCA proficient cancer cells.
As far as I know, this compound(149554-29-0)Formula: C10H12N4 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI